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1. 发明申请

WO2015048740A1 GENOTYPIC AND PHENOTYPIC ANALYSIS OF CIRCULATING TUMOR CELLS TO MONITOR TUMOR EVOLUTION IN PROSTATE CANCER PATIENTS 审中-公开
标题翻译：循环肿瘤细胞在前列腺癌患者中监测肿瘤发生的基因分型和临床分析
公开(公告)号：WO2015048740A1
公开(公告)日：2015-04-02
申请号：PCT/US2014/058304
申请日：2014-09-30
申请人： THE SCRIPPS RESEARCH INSTITUTE , COLD SPRING HARBOR LABORATORY , KUHN, Peter , DAGO RODRIGUEZ, Angel Ernesto , CARLSSON, Anders , LIU, Wei , HICKS, Jim
发明人： KUHN, Peter , DAGO RODRIGUEZ, Angel Ernesto , CARLSSON, Anders , LIU, Wei , HICKS, Jim
IPC分类号： G01N33/574
CPC分类号： G01N33/57434 , G01N33/57488 , G01N33/57492 , G01N2800/52
摘要： The present invention provides methods for predicting response to a hormone-directed therapy or chemotherapy in a prostate cancer (PCa) patient comprising (a) performing a direct analysis comprising immunofluorescent staining and morphological characteristization of nucleated cells in a blood sample obtained from the patient to identify and enumerate circulating tumor cells (CTC); (b) individually characterizing genotypic, morphometric and protein expression parameters to generate a profile for each of the CTCs, and (c) predicting response to hormone-directed therapy in the prostate cancer PCa patient based on said profile. In some embodiments, the methods comprise repeating steps (a) through (c) at one or more timepoints after initial diagnosis of prostate cancer to sequentially monitor said genotypic, morphometric and protein expression parameters.
摘要翻译：本发明提供了用于预测前列腺癌（PCa）患者中激素指导性治疗或化学疗法的应答的方法，其包括（a）进行直接分析，所述直接分析包括从患者获得的血液样品中的有核细胞的免疫荧光染色和形态学特性，识别和列举循环肿瘤细胞（CTC）; （b）单独表征基因型，形态测定和蛋白质表达参数以产生每个CTC的谱，以及（c）基于所述谱，预测前列腺癌PCa患者中激素指导性治疗的反应。在一些实施方案中，所述方法包括在初步诊断前列腺癌之后的一个或多个时间点重复步骤（a）至（c），以顺序监测所述基因型，形态学和蛋白质表达参数。

2. 发明申请

WO2011136866A1 OPTICAL TRANSCEIVER BUILT-IN TEST (BIT) 审中-公开
标题翻译：光学收发器内置测试（BIT）
公开(公告)号：WO2011136866A1
公开(公告)日：2011-11-03
申请号：PCT/US2011/025900
申请日：2011-02-23
申请人： RAYTHEON COMPANY , FEST, Eric, C. , MILLS, James, P. , TRAIL, Nicholas, D. , HICKS, Jim, R.
发明人： FEST, Eric, C. , MILLS, James, P. , TRAIL, Nicholas, D. , HICKS, Jim, R.
IPC分类号： F41G7/22
CPC分类号： G01S7/495 , F41G7/001 , F41G7/224 , F41G7/2246 , F41G7/2253 , F41G7/2293 , G01S7/4818 , G01S7/497 , G01S7/499
摘要： An optical transceiver is provided with a light pipe (50) that intercepts, offsets and redirects a portion of the collimated transmit beam to create a virtual object in the receiver field- of -view (22 ) to perform the BIT. The light pipe comprises an input face and first reflective surface in the transmitter FOV (20) to intercept a portion of the beam along a first axis (38) and re-direct the beam, a second reflective surface and output face in the receiver FOV (22) that re-directs the portion of the beam along a second axis (30) towards the receiver to create the virtual object in the receiver FOV and an optical channel that guides the redirected portion of the beam from the first reflective surface to the second reflective surface to offset the second axis from the first axis. The same detector used during normal operation of the transceiver is used to perform the BIT, which may include a simple "on/off test or a radiometry test. The light pipe may be designed with an acceptance FOV that preserves collimation, which facilitates a measurement of alignment error between the transmit beam and receiver.
摘要翻译：光收发器设置有光管（50），其拦截，偏移和重定向准直发射波束的一部分以在接收机视场（22）中创建虚拟对象以执行BIT。光管包括在发射器FOV（20）中的输入面和第一反射表面，以沿着第一轴线（38）截取光束的一部分并重新引导光束，接收器FOV中的第二反射表面和输出面（22），其将所述光束的沿着第二轴线（30）的部分重新定向到所述接收器以在所述接收器FOV中创建所述虚拟物体;以及光学通道，其将所述光束的重定向部分从所述第一反射表面引导到第二反射表面以使第二轴线偏离第一轴线。在收发器的正常操作期间使用的相同的检测器用于执行BIT，其可以包括简单的“开/关测试或辐射测试”。光管可以被设计成具有保持准直的接受FOV，这有助于测量发射波束和接收机之间的对准误差。

3. 发明申请

WO2007044684A2 OPTICAL FIBER ASSEMBLY WRAPPED ACROSS GIMBAL AXES 审中-公开
标题翻译：光纤组件缠绕在GIMBAL轴上
公开(公告)号：WO2007044684A2
公开(公告)日：2007-04-19
申请号：PCT/US2006/039426
申请日：2006-10-05
申请人： RAYTHEON COMPANY , MILLS, James, P. , GARRETT, David, G. , SUNNE, Wayne, L. , KNAPP, David, J. , BRUNTON, Daniel, W. , ANTHONY, David, G. , ANDERSON, Emmet, R. , HARRISON, Daniel, C. , SMITH, Frank, E., III , HICKS, Jim, R.
发明人： MILLS, James, P. , GARRETT, David, G. , SUNNE, Wayne, L. , KNAPP, David, J. , BRUNTON, Daniel, W. , ANTHONY, David, G. , ANDERSON, Emmet, R. , HARRISON, Daniel, C. , SMITH, Frank, E., III , HICKS, Jim, R.
IPC分类号： H01J5/02 , H01J40/14
CPC分类号： F41G7/224 , F41H13/0056 , G01S7/4818 , G01S7/495
摘要： A control mechanism pins an optical fiber assembly on and off gimbal and between gimbals to route the assembly from an off-gimbal optical source across the gimbal axis/axes to an on-gimbal optical element so that the fiber assembly moves with the rotation of the gimbals. To accommodate a relatively large range of motion, the control mechanism is suitably configured to route the fiber assembly in a “U-shaped” loop with one end pinned off-gimbal in a stationary guide track and the other end pinned on-gimbal point in a rotating guide track so that the loose fiber assembly is constrained in the concentric tracks on and off gimbal. As the gimbal rotates, the loop seats onto one guiding track and peels off of the other guiding track while always maintaining its U-shape. To accommodate a relatively small range of motion in other gimbal configurations, the control mechanism is suitably configured to pin one end of the fiber assembly off-gimbal and pass the fiber assembly directly over the gimbal where it is pinned on the other side of the gimbal. In a multi-gimbal pointer, the fiber assembly preferably exhibits different mechanical stresses as it crosses the different gimbals.
摘要翻译：控制机构将光纤组件插入和关闭万向节和万向节之间，以将组件从万向节光源穿过万向节轴/轴线到达万向节光学元件，使得光纤组件随着万向节。为了适应相对较大的运动范围，控制机构被适当地构造成将光纤组件以“U形”形环路路线固定在固定导轨中，而另一端固定在万向节上旋转的导轨，使得松散的纤维集合体被限制在同步轨道上和/或从万向节关闭。当万向架旋转时，环路将位于一个引导轨道上，并且始终保持其U形状，并从另一导轨上剥离。为了适应其他万向架构中的相对较小的运动范围，控制机构适当地构造成将纤维组件的一端分离成万向节，并将光纤组件直接通过万向节，将其固定在万向节的另一侧。在多万向节指针中，纤维组件优选地在穿过不同的万向节时表现出不同的机械应力。

4. 发明申请

WO2011046644A1 OFF-AXIS REFLECTIVE TRANSMIT TELESCOPE FOR A DIRECTED INFRARED COUNTERMEASURES (DIRCM) SYSTEM 审中-公开
标题翻译：用于指导性红外对策（DIRCM）系统的偏转反射传输电话
公开(公告)号：WO2011046644A1
公开(公告)日：2011-04-21
申请号：PCT/US2010/040225
申请日：2010-06-28
申请人： RAYTHEON COMPANY , SCHAUB, Michael, P. , BRUNTON, Daniel, W. , HICKS, Jim, R. , HANAUSKA, Gregory, P. , RONCONE, Ronald, L. , JUERGENS, Richard, C.
发明人： SCHAUB, Michael, P. , BRUNTON, Daniel, W. , HICKS, Jim, R. , HANAUSKA, Gregory, P. , RONCONE, Ronald, L. , JUERGENS, Richard, C.
IPC分类号： G01S7/495 , F41G3/14 , F41H11/02
CPC分类号： G01S7/495 , F41G7/224 , F41H11/02 , F41H13/0056 , F41H13/0062
摘要： An off-axis reflective transmit telescope for a DIRCM system is mounted on the gimbal along a transmit-axis offset laterally from the optical axis of the receive telescope but nominally aligned with the line-of-sight of the receive telescope to transmit a laser beam. The telescope comprises an optical port optically coupled to a laser to receive and direct the laser beam away from the dome and a reflective optical assembly that reflects the laser beam through the dome. The reflective optical assembly comprises an off-axis mirror segment and a second optical element that together precompensate the laser beam for dome aberrations induced by the lateral offset of the transmit telescope's transmit axis from the optical axis. The off-axis mirror segment comprises a segment of a parent mirror having an aspheric curvature (e.g. parabolic, elliptical or higher-order asphere) about an axis of symmetry. The segment is offset so that it is not centered on the axis of symmetry of the parent mirror. The use of the off-axis mirror segment allows the optical port and any folding mirror to be positioned so that they do not obscure the reflected laser beam. The second optical element may be a segment of a dome corrector parent lens, a prism or a refractive lens formed on the front surface of the off-axis mirror segment.
摘要翻译：用于DIRCM系统的离轴反射式透射望远镜沿着从接收望远镜的光轴横向偏移的透射轴安装在万向节上，但是与接收望远镜的视线对准，以传输激光束。望远镜包括光学端口，其光学耦合到激光器以将激光束接收并引导离开圆顶，以及反射光学组件，其反射激光束通过圆顶。反射光学组件包括离轴镜部分和第二光学元件，其一起预先补偿激光束，用于由透射望远镜的透射轴线从光轴的横向偏移引起的圆顶像差。离轴镜片段包括围绕对称轴具有非球面曲率（例如抛物线形，椭圆形或高阶非球面）的父镜的一段。该段被偏移，使得它不以母镜的对称轴为中心。使用离轴镜分段允许光学端口和任何折叠反射镜被定位，使得它们不会使反射的激光束模糊。第二光学元件可以是形成在离轴镜部分的前表面上的圆顶校正器母体透镜，棱镜或折射透镜的部分。

5. 发明申请

WO2007044684A3 OPTICAL FIBER ASSEMBLY WRAPPED ACROSS GIMBAL AXES 审中-公开
标题翻译：光纤组件包裹在GIMBAL AXES上
公开(公告)号：WO2007044684A3
公开(公告)日：2008-12-11
申请号：PCT/US2006039426
申请日：2006-10-05
申请人： RAYTHEON CO , MILLS JAMES P , GARRETT DAVID G , SUNNE WAYNE L , KNAPP DAVID J , BRUNTON DANIEL W , ANTHONY DAVID G , ANDERSON EMMET R , HARRISON DANIEL C , SMITH FRANK E III , HICKS JIM R
发明人： MILLS JAMES P , GARRETT DAVID G , SUNNE WAYNE L , KNAPP DAVID J , BRUNTON DANIEL W , ANTHONY DAVID G , ANDERSON EMMET R , HARRISON DANIEL C , SMITH FRANK E III , HICKS JIM R
IPC分类号： G01D13/22
CPC分类号： F41G7/224 , F41H13/0056 , G01S7/4818 , G01S7/495
摘要： A control mechanism pins an optical fiber assembly on and off gimbal and between gimbals to route the assembly from an off-gimbal optical source across the gimbal axis/axes to an on-gimbal optical element so that the fiber assembly moves with the rotation of the gimbals. To accommodate a relatively large range of motion, the control mechanism is suitably configured to route the fiber assembly in a "U-shaped" loop with one end pinned off-gimbal in a stationary guide track and the other end pinned on-gimbal point in a rotating guide track so that the loose fiber assembly is constrained in the concentric tracks on and off gimbal. As the gimbal rotates, the loop seats onto one guiding track and peels off of the other guiding track while always maintaining its U-shape. To accommodate a relatively small range of motion in other gimbal configurations, the control mechanism is suitably configured to pin one end of the fiber assembly off-gimbal and pass the fiber assembly directly over the gimbal where it is pinned on the other side of the gimbal. In a multi-gimbal pointer, the fiber assembly preferably exhibits different mechanical stresses as it crosses the different gimbals.
摘要翻译：控制机构将光纤组件插入和关闭万向节和万向节之间，以将组件从万向节光源穿过万向节轴/轴线传送到万向节光学元件，使得光纤组件随着万向节。为了适应相对较大的运动范围，控制机构适当地构造成将光纤组件以“U形”形环路路线固定在一个固定导轨中，另一端固定在万向节点上旋转的导轨，使得松散的纤维集合体被限制在同步轨道上，并且关闭万向节。当万向节旋转时，环路将位于一个引导轨道上，并且始终保持其U形状，并从另一导轨上剥离。为了适应其他万向架构中的相对较小的运动范围，控制机构适当地构造成将纤维组件的一端分离成万向节，并将纤维组件直接通过万向节，其中它被固定在万向节的另一侧。在多万向节指针中，纤维组件优选地在穿过不同的万向节时表现出不同的机械应力。

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