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1. 发明申请

WO2010041039A1 A MEDICAL DEVICE SUITABLE FOR LOCATION IN A BODY LUMEN 审中-公开
标题翻译：适用于身体健康的医疗设备
公开(公告)号：WO2010041039A1
公开(公告)日：2010-04-15
申请号：PCT/GB2009/002434
申请日：2009-10-12
申请人： VERYAN MEDICAL LIMITED , HERATY, Kevin , MULLINS, Liam , GILSON, Paul , BURKE, Martin
发明人： HERATY, Kevin , MULLINS, Liam , GILSON, Paul , BURKE, Martin
IPC分类号： A61F2/90
CPC分类号： A61F2/88 , A61F2/844 , A61F2/91 , A61F2230/0054 , A61F2310/00023
摘要： A stent (1) for deployment in a blood vessel which is movable between an unloaded straight cylindrical state and a loaded curved state. The stent (1) is bendable between a first loaded configuration when the blood vessel is in the unloaded state, and a second loaded configuration when the blood vessel is in the loaded state. The stent (1) has an unloaded configuration which is intermediate the first loaded configuration and the second loaded configuration. Because of the unloaded configuration of the stent (1), the degrees of deformation which the stent (1) undergoes are minimised leading to minimised strains, increased fatigue life, and reduced risk of fracture.
摘要翻译：一种用于展开在血管中的支架（1），其可在未加载的直圆柱状状态和加载弯曲状态之间移动。当血管处于无负载状态时，支架（1）可在第一负载构型之间弯曲，并且当血管处于负载状态时，支架（1）可弯曲。支架（1）具有在第一加载配置和第二加载配置之间的卸载配置。由于支架（1）的卸载构造，支架（1）经受的变形程度被最小化，从而导致最小化的应变，增加的疲劳寿命和降低的骨折风险。

2. 发明申请

WO2010041038A1 A MEDICAL DEVICE 审中-公开
标题翻译：医疗器械
公开(公告)号：WO2010041038A1
公开(公告)日：2010-04-15
申请号：PCT/GB2009/002433
申请日：2009-10-12
申请人： VERYAN MEDICAL LIMITED , HERATY, Kevin , MULLINS, Liam , GILSON, Paul , BURKE, Martin , BLOWICK, Ray
发明人： HERATY, Kevin , MULLINS, Liam , GILSON, Paul , BURKE, Martin , BLOWICK, Ray
IPC分类号： A61F2/84
CPC分类号： A61F2/958
摘要： A stent deployment device comprises an elongate catheter shaft (2), and an inflatable balloon (3). The inflatable balloon (3) is movable between a collapsed configuration and an expanded configuration. In the expanded configuration part of the longitudinal axis of the balloon (3) is curved in three-dimensional space, and part of the balloon (3) is helically shaped. A stent (6) is movable from a collapsed delivery configuration to a partially expanded intermediate configuration, and subsequently from the intermediate configuration to a fully expanded deployed configuration. In the delivery configuration the longitudinal axis of the stent (6) is straight. The longitudinal axis of the stent (6) may be straight or curved in three-dimensional space in the intermediate configuration. In the deployed configuration the longitudinal axis of the stent (6) is curved in three-dimensional space. The balloon (3) in the expanded configuration exerts force on the stent (6). In the deployed configuration the stent (6) in turn exerts force on the internal wall of a blood vessel (5) causing the longitudinal axis of the blood vessel (5) to curve in three-dimensional space.
摘要翻译：支架展开装置包括细长的导管轴（2）和可膨胀气球（3）。可膨胀气囊（3）可在折叠构型和膨胀构型之间移动。在气囊（3）的纵向轴线的膨胀构造部分中，在三维空间中弯曲，并且气球（3）的一部分是螺旋形的。支架（6）可以从折叠的输送配置移动到部分扩展的中间配置，并且随后从中间配置到完全展开的展开配置。在输送构型中，支架（6）的纵向轴线是直的。在中间构造中，支架（6）的纵向轴线可以是三维空间中的直线或弯曲的。在展开的构造中，支架（6）的纵向轴线在三维空间中弯曲。膨胀构造中的气囊（3）对支架（6）施加力。在展开的构造中，支架（6）又在血管（5）的内壁施加力，导致血管（5）的纵向轴线在三维空间中弯曲。

3. 发明申请

WO2010128311A1 A MEDICAL DEVICE SUITABLE FOR LOCATION IN A BODY LUMEN 审中-公开
标题翻译：适用于身体健康的医疗设备
公开(公告)号：WO2010128311A1
公开(公告)日：2010-11-11
申请号：PCT/GB2010/000944
申请日：2010-05-10
申请人： VERYAN MEDICAL LIMITED , TAYLOR, Charles , HERATY, Kevin , MULLINS, Liam
发明人： TAYLOR, Charles , HERATY, Kevin , MULLINS, Liam
IPC分类号： A61F2/82 , A61F2/90 , A61F2/00
CPC分类号： A61F2/90 , A61F2/82 , A61F2/89 , A61F2002/30014 , A61F2002/30018 , A61F2002/30199 , A61F2002/30324 , A61F2002/30326 , A61F2002/30327 , A61F2002/828 , A61F2230/0063 , A61F2250/0018 , A61F2250/0029 , A61F2250/0036 , A61F2250/0037 , A61F2250/0039
摘要： A stent (10) suitable for deployment in a blood vessel to support at least part of an internal wall of the blood vessel comprises a plurality of longitudinally spaced-apart annular elements (11), and a plurality of connecting elements (12) to connect adjacent annular elements (11). Each connecting element (12) is circumf erentially offset from the previous connecting element (12). Upon application of a load to the stent (10), the stent (10) moves from an unloaded configuration to a loaded configuration. In the loaded configuration the longitudinal axis of the stent (10) is curved in three-dimensional space, and the stent (10) is helically shaped.
摘要翻译：适于部署在血管中以支撑血管的内壁的至少一部分的支架（10）包括多个纵向间隔开的环形元件（11）和多个连接元件（12）以连接相邻的环形元件（11）。每个连接元件（12）在周向上偏离先前的连接元件（12）。在对支架（10）施加负载时，支架（10）从卸载构型移动到装载构造。在装载的构造中，支架（10）的纵向轴线在三维空间中弯曲，并且支架（10）是螺旋形的。

4. 发明申请

WO2010041040A1 A STENT SUITABLE FOR DEPLOYMENT IN A BLOOD VESSEL 审中-公开
标题翻译：适用于在血管中部署的STENT
公开(公告)号：WO2010041040A1
公开(公告)日：2010-04-15
申请号：PCT/GB2009/002437
申请日：2009-10-12
申请人： VERYAN MEDICAL LIMITED , HERATY, Kevin , MULLINS, Liam
发明人： HERATY, Kevin , MULLINS, Liam
IPC分类号： A61F2/90
CPC分类号： A61F2/915 , A61F2/90 , A61F2/91 , A61F2250/0018
摘要： A stent (1) comprises a central section (2), a first intermediate section (3), a first end section (4), a second intermediate section (5), and a second end section (6). The stent (1) is movable between a collapsed delivery configuration and an expanded deployment configuration. In the delivery configuration the central section (2), the first intermediate section (3), the first end section (4), the second intermediate section (5), and the second end section (6) are all cylindrically shaped. In the deployment configuration the central section (2) is helically shaped, while the first end section (4) and the second end section (6) remain cylindrically shaped. Each intermediate section (3, 5) acts as a blended region to provide a smooth transition from the helical shape of the central section (2) to the cylindrical shape of the unstented blood vessel. The radial stiffness of the stent (1 ) varies gradually along part of the length of the stent (1). The radial stiffness of the end region of the stent (1) is less than the radial stiffness of a first region located further in from the end of the stent (1). The variation in radial stiffness reduces the area of blood vessel wall which has low wall shear stress, reduces the possibility of recirculation, and reduces the risk of neointimal hyperplasia.
摘要翻译：支架（1）包括中心部分（2），第一中间部分（3），第一端部分（4），第二中间部分（5）和第二端部部分（6）。支架（1）可在折叠的输送配置和扩展的部署配置之间移动。在输送构造中，中心部分（2），第一中间部分（3），第一端部分（4），第二中间部分（5）和第二端部部分（6）都是圆柱形的。在展开构造中，中心部分（2）是螺旋形的，而第一端部部分（4）和第二端部部分（6）保持圆柱形。每个中间部分（3,5）用作混合区域以提供从中心部分（2）的螺旋形状到不连续血管的圆柱形状的平滑过渡。支架（1）的径向刚度随着支架长度的一部分逐渐变化。支架（1）的端部区域的径向刚度小于从支架（1）的端部进一步位于的第一区域的径向刚度。径向刚度的变化减小了具有低壁剪切应力的血管壁面积，降低了再循环的可能性，并降低了新生内膜增生的风险。

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