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1. 发明申请

WO2005089803A2 PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF SKIN DISEASES COMPRISING A COMBINATION OF EPINASTINE AND ONE OR MORE ADDITIONAL MINERALS OR ONE OR MORE CRUDE DRUGS 审中-公开
标题翻译：用于治疗包含EPINASTINE和一种或多种其他矿物质或一种或多种原料药组合的皮肤疾病的药物组合物
公开(公告)号：WO2005089803A2
公开(公告)日：2005-09-29
申请号：PCT/EP2005/002947
申请日：2005-03-19
申请人： BOEHRINGER INGELHEIM INTERNATIONAL GMBH , BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG , HAYASHI, Tetsuo , KATSUYAMA, Shinichiro , OKADA, Minoru , UMEHARA, Norimitsu
发明人： HAYASHI, Tetsuo , KATSUYAMA, Shinichiro , OKADA, Minoru , UMEHARA, Norimitsu
IPC分类号： A61K45/06
CPC分类号： A61K45/06 , A61K31/5517 , A61K33/00 , A61K36/076 , A61K36/23 , A61K36/233 , A61K36/234 , A61K36/25 , A61K36/282 , A61K36/346 , A61K36/484 , A61K36/538 , A61K36/575 , A61K36/634 , A61K36/708 , A61K36/736 , A61K36/744 , A61K36/8994 , A61K36/90 , A61K36/9068 , A61K2300/00
摘要： The present invention relates to pharmaceutical compositions for the treatment of skin diseases. Particularly, the compositions described in the present invention are highly effective for the treatment of skin diseases associated with allergic reactions among a variety of symptoms derived from skin diseases. These compositions comprise an antihistaminic-effective amount of epinastine or a pharmaceutically acceptable salt thereof and one or more additional pharmaceutically acceptable minerals or one or more pharmaceutically acceptable crude drugs. The compositions may also comprise pharmaceutically acceptable additives.
摘要翻译：本发明涉及治疗皮肤病的药物组合物。特别地，本发明中描述的组合物对于治疗与皮肤疾病各种症状之间的过敏反应相关的皮肤疾病是非常有效的。这些组合物包含抗组胺有效量的依他斯汀或其药学上可接受的盐和一种或多种另外的药学上可接受的矿物质或一种或多种药学上可接受的生药。组合物还可以包含药学上可接受的添加剂。

2. 发明申请

WO2004087167A3 PHARMACEUTICAL COMPOSITIONS COMPRISING EPINASTINE FOR THE TREATMENT OF SKIN DISEASES 审中-公开
标题翻译：包含EPINASTINE的药物组合物用于治疗皮肤病
公开(公告)号：WO2004087167A3
公开(公告)日：2004-11-25
申请号：PCT/EP2004003440
申请日：2004-04-01
申请人： BOEHRINGER INGELHEIM INT , BOEHRINGER INGELHEIM PHARMA , OKADA MINORU , TAKAHASHI AKIRA , UMEHARA NORIMITSU , MATSUMOTO KAZUKI , HAYASHI TETSUO , ONUKI YOICHI
发明人： OKADA MINORU , TAKAHASHI AKIRA , UMEHARA NORIMITSU , MATSUMOTO KAZUKI , HAYASHI TETSUO , ONUKI YOICHI
IPC分类号： A61K31/19 , A61K31/55 , A61K31/7034 , A61K45/06 , A61P17/00 , A61P17/04 , A61K31/195 , A61K31/197 , A61K31/198
CPC分类号： A61K45/06 , A61K31/19 , A61K31/55 , A61K31/7034 , A61K2300/00
摘要： The present invention relates to new pharmaceutical compositions for the treatment of skin disease. The composition comprises an antihistaminic-effective amount of Epinastine or a pharmaceutically acceptable salt thereof as a pharmacologically active compound and at least one compound selected from the group consisting of one or more sulfur containing amino acid(s) or peptide(s) as biologically active donor of a -S- or -SH group, at least one vitamin of the B group, at least one vitamin having antioxidant properties and an antiphlogistic-effective amount of an antiphlogistic compound. The compositions also may comprise pharmaceutically acceptable additives.
摘要翻译：本发明涉及用于治疗皮肤病的新药物组合物。该组合物包含抗组胺药 - 有效量的依匹那丁或其药学上可接受的盐作为药理学活性化合物和至少一种选自一种或多种含硫氨基酸或肽作为生物学活性的化合物 -S-或-SH基团的供体，至少一种B族维生素，至少一种具有抗氧化性质的维生素和抗炎有效量的抗炎化合物。组合物还可以包含药学上可接受的添加剂

3. 发明申请

WO2004087167A2 PHARMACEUTICAL COMPOSITIONS COMPRISING EPINASTINE FOR THE TREATMENT OF SKIN DISEASES 审中-公开
标题翻译：包含EPINASTINE用于治疗皮肤疾病的药物组合物
公开(公告)号：WO2004087167A2
公开(公告)日：2004-10-14
申请号：PCT/EP2004/003440
申请日：2004-04-01
申请人： BOEHRINGER INGELHEIM INTERNATIONAL GMBH , BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG , OKADA, Minoru , TAKAHASHI, Akira , UMEHARA, Norimitsu , MATSUMOTO, Kazuki , HAYASHI, Tetsuo , ONUKI, Yoichi
发明人： OKADA, Minoru , TAKAHASHI, Akira , UMEHARA, Norimitsu , MATSUMOTO, Kazuki , HAYASHI, Tetsuo , ONUKI, Yoichi
IPC分类号： A61K31/55
CPC分类号： A61K45/06 , A61K31/19 , A61K31/55 , A61K31/7034 , A61K2300/00
摘要： The present invention relates to new pharmaceutical compositions for the treatment of skin disease. The composition comprises an antihistaminic-effective amount of Epinastine or a pharmaceutically acceptable salt thereof as a pharmacologically active compound and at least one compound selected from the group consisting of one or more sulfur containing amino acid(s) or peptide(s) as biologically active donor of a -S- or -SH group, at least one vitamin of the B group, at least one vitamin having antioxidant properties and an antiphlogistic-effective amount of an antiphlogistic compound. The compositions also may comprise pharmaceutically acceptable additives.
摘要翻译：本发明涉及用于治疗皮肤病的新型药物组合物。组合物包含抗组胺有效量的依伐他汀或其药学上可接受的盐作为药理活性化合物和至少一种选自一种或多种作为生物活性的含硫氨基酸或肽的化合物 -S-或-SH基团的供体，B基团中的至少一种维生素，至少一种具有抗氧化性质的维生素和消炎有效量的消炎化合物。组合物还可以包含药学上可接受的添加剂。

4. 发明申请

WO2005089803A3 PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF SKIN DISEASES COMPRISING A COMBINATION OF EPINASTINE AND ONE OR MORE ADDITIONAL MINERALS OR ONE OR MORE CRUDE DRUGS 审中-公开
标题翻译：用于治疗包含EPINASTINE和一种或多种其他矿物质或一种或多种原药的组合的皮肤疾病的药物组合物
公开(公告)号：WO2005089803A3
公开(公告)日：2006-11-16
申请号：PCT/EP2005002947
申请日：2005-03-19
申请人： BOEHRINGER INGELHEIM INT , BOEHRINGER INGELHEIM PHARMA , HAYASHI TETSUO , KATSUYAMA SHINICHIRO , OKADA MINORU , UMEHARA NORIMITSU
发明人： HAYASHI TETSUO , KATSUYAMA SHINICHIRO , OKADA MINORU , UMEHARA NORIMITSU
IPC分类号： A61K45/06 , A61K31/5517 , A61K33/00 , A61K36/076 , A61K36/23 , A61K36/233 , A61K36/234 , A61K36/25 , A61K36/282 , A61K36/346 , A61K36/484 , A61K36/538 , A61K36/575 , A61K36/634 , A61K36/708 , A61K36/736 , A61K36/744 , A61K36/8994 , A61K36/90 , A61K36/9068 , A61P17/00
CPC分类号： A61K45/06 , A61K31/5517 , A61K33/00 , A61K36/076 , A61K36/23 , A61K36/233 , A61K36/234 , A61K36/25 , A61K36/282 , A61K36/346 , A61K36/484 , A61K36/538 , A61K36/575 , A61K36/634 , A61K36/708 , A61K36/736 , A61K36/744 , A61K36/8994 , A61K36/90 , A61K36/9068 , A61K2300/00
摘要： The present invention relates to pharmaceutical compositions for the treatment of skin diseases. Particularly, the compositions described in the present invention are highly effective for the treatment of skin diseases associated with allergic reactions among a variety of symptoms derived from skin diseases. These compositions comprise an antihistaminic-effective amount of epinastine or a pharmaceutically acceptable salt thereof and one or more additional pharmaceutically acceptable minerals or one or more pharmaceutically acceptable crude drugs. The compositions may also comprise pharmaceutically acceptable additives.
摘要翻译：本发明涉及用于治疗皮肤病的药物组合物。特别地，本发明中描述的组合物对于治疗与皮肤疾病各种症状中的过敏反应相关的皮肤疾病是非常有效的。这些组合物包含抗组胺有效量的依诺斯汀或其药学上可接受的盐和一种或多种另外的药学上可接受的矿物质或一种或多种药学上可接受的生药。组合物还可以包含药学上可接受的添加剂。

5. 发明申请

WO2004014353A1 PHARMACEUTICAL FORMULATIONS COMPRISING COMBINATIONS OF EPINASTINE, PSEUDOEPHEDRINE AND METHYLEPHEDRINE 审中-公开
标题翻译：包含EPINASTINE，PSEUDOEPHEDRINE和METHYLEPHEDRINE的组合的药物制剂
公开(公告)号：WO2004014353A1
公开(公告)日：2004-02-19
申请号：PCT/EP2003/007687
申请日：2003-07-16
申请人： BOEHRINGER INGELHEIM INTERNATIONAL GMBH , HAYASHI, Tetsuo , MATSUMOTO, Kazuki , UMEHARA, Norimitsu
发明人： HAYASHI, Tetsuo , MATSUMOTO, Kazuki , UMEHARA, Norimitsu
IPC分类号： A61K31/137
CPC分类号： A61K31/55 , A61K9/2054 , A61K9/2059 , A61K9/209 , A61K9/4866 , A61K9/5084 , A61K31/137
摘要： The present invention relates to novel oral pharmaceutical compositions comprising as pharmaceutically active compounds a combination of an antihistaminic-effective amount of Epinastine or a pharmaceutically acceptable salt thereof, a decongestant-effective amount of Pseudoephedrine or a pharmaceutically acceptable salt thereof and Methylephedrine (Methylephrine) in a decongestant-effective amount or a pharmaceutically acceptable salt thereof. The formulation further comprises suitable pharmaceutically acceptable carriers or excipients.
摘要翻译：本发明涉及新的口服药物组合物，其包含作为药物活性化合物的抗组胺有效量的依他斯汀或其药学上可接受的盐，减充血剂有效量的伪麻黄碱或其药学上可接受的盐和Methylephedrine（Methylephrine）减充血剂有效量或其药学上可接受的盐。制剂还包含合适的药学上可接受的载体或赋形剂。

6. 发明申请

WO1997038024A1 OLEFIN POLYMERIZATION CATALYST, OLEFIN POLYMERIZATION METHOD, OLEFIN POLYMER COMPOSITIONS, AND THERMOFORMED ARTICLES 审中-公开
标题翻译：烯烃聚合催化剂，烯烃聚合方法，烯烃聚合物组合物和热成型制品
公开(公告)号：WO1997038024A1
公开(公告)日：1997-10-16
申请号：PCT/JP1997001217
申请日：1997-04-09
申请人： MITSUI PETROCHEMICAL INDUSTRIES, LTD. , SUGIMURA, Kenji , YOROZU, Kiyotaka , SUZUKI, Yasuhiko , HAYASHI, Tetsuo , MATSUNAGA, Shin-ya
发明人： MITSUI PETROCHEMICAL INDUSTRIES, LTD.
IPC分类号： C08F04/70
CPC分类号： C08F10/00 , C08F4/61904 , C08F4/65925 , C08F110/06 , C08F210/06 , C08F210/16 , C08F2410/04 , C08L23/02 , C08L23/06 , C08L23/0815 , C08L2205/02 , C08L2314/06 , Y02P20/52 , C08L2666/04 , C08F2500/17 , C08F2500/08 , C08F2500/03 , C08F210/08 , C08F210/14 , C08F4/7006
摘要： A catalyst having a high polymerization activity and capable of providing olefin polymers having a wide molecular weight distribution, which comprises (a) a metallocene compound (a-1) or a titanium catalyst component (a-2) comprising magnesium, titanium, and a halogen as indispensable components, (b) a group 8-10 transition metal compound represented by general formula (I'), and a cocatalyst, wherein M represents Pd, Ni, or Pt; X and X represent N or P; R and R represent H or a hydrocarbon radical; R and R represent a halogen or a hydrocarbon radical; and R and R represent H or a hydrocarbon radical. An olefin polymer composition which has excellent rigidity and impact resistance is prepared by using a catalyst containing the above transition metal compound (b), and comprises a noncrystalline olefin polymer having an intrinsic viscosity, a glass transition temperature, and a density in respective particular ranges and a conventional olefin polymer other than the above olefin polymer. Another olefin polymer composition which has excellent mechanical properties and heat resistance is prepared by using a catalyst containing the above transition metal compound (b), and comprises a crystalline olefin polymer having an intrinsic viscosity, a melting point, and a density in respective particular ranges and a conventional olefin polymer other than the above olefin polymer.
摘要翻译：一种具有高聚合活性并且能够提供具有宽分子量分布的烯烃聚合物的催化剂，其包含（a）茂金属化合物（a-1）或包含镁，钛和钛的钛催化剂组分（a-2）卤素作为不可或缺的组分，（b）由通式（I'）表示的8-10族过渡金属化合物和助催化剂，其中M表示Pd，Ni或Pt; X 1和X 2代表N或P; R 1和R 2代表H或烃基; R 4和R 5代表卤素或烃基; R 6和R 7代表H或烃基。具有优异的刚性和耐冲击性的烯烃聚合物组合物通过使用含有上述过渡金属化合物（b）的催化剂制备，并且包含在各特定范围内具有特性粘度，玻璃化转变温度和密度的非结晶烯烃聚合物和除上述烯烃聚合物以外的常规烯烃聚合物。通过使用含有上述过渡金属化合物（b）的催化剂制备具有优异的机械性能和耐热性的另一种烯烃聚合物组合物，并且包含在特定范围内具有特性粘度，熔点和密度的结晶烯烃聚合物和除上述烯烃聚合物以外的常规烯烃聚合物。

7. 发明申请

WO1996001301A1 LUBRICATING OIL CONTAINING AROMATIC ETHER COMPOUND 审中-公开
标题翻译：润滑油含有芳族化合物
公开(公告)号：WO1996001301A1
公开(公告)日：1996-01-18
申请号：PCT/JP1995001354
申请日：1995-07-06
申请人： MITSUI PETROCHEMICAL INDUSTRIES, LTD. , TANAKA, Masahide , ISHIBASHI, Masayasu , HAYASHI, Takashi , OYOSHI, Hajime , HAYASHI, Tetsuo , MIZUI, Kinya
发明人： MITSUI PETROCHEMICAL INDUSTRIES, LTD.
IPC分类号： C10M105/18
CPC分类号： C10M105/18 , C10M105/54 , C10M107/34 , C10M107/38 , C10M171/008 , C10M2207/04 , C10M2209/103 , C10M2209/104 , C10M2209/105 , C10M2209/106 , C10M2211/042 , C10M2211/06 , C10M2213/00 , C10M2213/04 , C10M2213/06 , C10N2240/00 , C10N2240/22 , C10N2240/30 , C10N2240/50 , C10N2240/52 , C10N2240/54 , C10N2240/56 , C10N2240/58 , C10N2240/60 , C10N2240/66
摘要： A lubricating oil containing an aromatic ether compound represented by the general formula (R )nPh-O-(R O)mR , wherein nR s represent each independently a specified hydrocarbon group, a hydrocarbon group having an ether linkage, or a hydrocarbon group having an alkoxy group or a halogen atom; mR s represent each independently a C2-C4 alkylene group; R represents a C1-C12 hydrocarbon group; Ph represents an aromatic substituent; n represents an integer of 1 to 5; and m represents an integer of 1 to 30. This oil is excellent in lubricity, cleanness and electrical insulation, has a high viscosity and excellent sealing and antiwear characteristics, and is excellent in compatibility with R-134a and the like. Hence it is suited for use as a lubricant for refrigerators using R-134a as the refrigerant, such as electric refrigerators and room air-conditioners.
摘要翻译：含有由通式（R 1）n Ph-O-（R 2 O）m R 3表示的芳族醚化合物的润滑油，其中nR 1表示各自独立的特定烃基，具有醚键的烃基或具有烷氧基或卤素原子的烃基; mR 2各自独立地表示C 2 -C 4亚烷基; R 3表示C 1 -C 12烃基; Ph表示芳香族取代基; n表示1〜5的整数， m表示1〜30的整数。该油的润滑性，清洁性和电绝缘性优异，粘度高，密封性和抗磨损性优异，与R-134a等的相容性优异。因此，适用于使用R-134a作为制冷剂的电冰箱的润滑剂，例如电冰箱和室内空调。

8. 发明申请

WO1992005140A1 POLYCARBONATE, USE THEREOF, PRODUCTION THEREOF, AND PURIFICATION THEREOF 审中-公开
标题翻译：聚碳酸酯，其用途及其制备及其纯化
公开(公告)号：WO1992005140A1
公开(公告)日：1992-04-02
申请号：PCT/JP1991001220
申请日：1991-09-13
申请人： MITSUI PETROCHEMICAL INDUSTRIES, LTD. , TANAKA, Masahide , KISO, Yoshihisa , TAKAHATA, Kazunori , HAYASHI, Tetsuo , SHIMAMOTO, Kenji , MIZUI, Kinya , FUJIMOTO, Tadaaki , NAKAMURA, Kosei
发明人： MITSUI PETROCHEMICAL INDUSTRIES, LTD.
IPC分类号： C07C69/96
CPC分类号： H01B3/20 , C07C69/96 , C07H15/08 , C08G64/0208 , C10M105/48 , C10M171/008 , C10M2207/32 , C10M2209/00 , C10M2209/02 , C10M2209/10 , C10N2240/00 , C10N2240/04 , C10N2240/042 , C10N2240/044 , C10N2240/046 , C10N2240/08 , C10N2240/201 , C10N2240/202 , C10N2240/22 , C10N2240/30 , C10N2240/402 , C10N2240/403 , C10N2240/404 , C10N2240/405 , C10N2240/406 , C10N2240/407 , C10N2240/408 , C10N2240/409 , C10N2240/50 , C10N2240/52 , C10N2240/54 , C10N2240/56 , C10N2240/58 , C10N2240/60 , C10N2240/66
摘要： The polycarbonate of the invention includes ones based on sucrose, oligosaccharides other than it, and monosaccharides each having a specified cyclic structure; ones derived from specified saccharides not containing any cyclic structure; ones having a skeleton of pentaerythritol, neopentyl glycol or trimethylolethane; and specified ones. The lubricant and electrical insulation oil of the invention contain the polycarbonate.

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