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1. 发明申请

WO0002580A3 THERAPIES USING HEMOPROTEINS 审中-公开
标题翻译：使用HEMOPROTEINS的治疗方法
公开(公告)号：WO0002580A3
公开(公告)日：2000-04-20
申请号：PCT/US9915487
申请日：1999-07-09
申请人： UNIV DUKE , STAMLER JONATHAN S , HAUSLADEN ALFRED
发明人： STAMLER JONATHAN S , HAUSLADEN ALFRED
IPC分类号： A61K38/41 , A61K38/42 , A61K38/50 , A61K31/155 , A61K31/17 , A61K31/195 , A61K31/415
CPC分类号： A61K38/50 , A61K38/41 , A61K38/42 , A61K31/70 , A61K2300/00
摘要： Herein it is shown that hemoproteins (e.g.Ascaris hemoglobin, myoglobin, flavohemoglobins) have NO-consuming and deoxygenase activities. The invention provides a method of reducing the concentration of oxygen and/or nitric oxide in a mammal. The method of the invention comprises administering a therapeutically effective amount of a hemoprotein having NO-activated deoxygenase activity or an enzymatically active fragment thereof to a mammal. The method can be used to treat a mammal having pathologically proliferating cells, such as a tumor. The invention further provides a method of treating a mammal infected with Ascaris sp., comprising administering to said mammal a therapeutically effective amount of an inhibitor of NO-synthase. The NO-consuming activity of a hemeprotein (e.g. flavohemoglobin) can be used in a treatment where constriction of blood vessels is desirabel, or where it is otherwise desirable to reduce NO concentration, as inflammation.
摘要翻译：在本文中，显示血蛋白（例如阿司匹林血红蛋白，肌红蛋白，黄素血红蛋白）具有消耗氧化和脱氧酶活性。本发明提供了降低哺乳动物氧和/或一氧化氮浓度的方法。本发明的方法包括向哺乳动物施用治疗有效量的具有NO活化的脱氧酶活性的血液蛋白或其酶活性片段。该方法可用于治疗具有病理增殖细胞（例如肿瘤）的哺乳动物。本发明还提供了一种治疗感染蛔虫感染的哺乳动物的方法，包括向所述哺乳动物施用治疗有效量的NO合成酶抑制剂。血液蛋白（例如黄体血红蛋白）的消耗NO消耗活性可以用于血管缩窄取消的治疗，或其它方面希望降低NO浓度的炎症。

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