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1. 发明申请

WO1996001427A1 DETECTION METHOD 审中-公开
标题翻译：检测方法
公开(公告)号：WO1996001427A1
公开(公告)日：1996-01-18
申请号：PCT/GB1995001587
申请日：1995-07-03
申请人： ABERDEEN UNIVERSITY , HARRIS, William, Joseph , PORTER, Andrew, Justin, Radcliffe , SHELTON, Stephen, Andrew
发明人： ABERDEEN UNIVERSITY
IPC分类号： G01N33/53
CPC分类号： G01N33/54313 , G01N33/5308
摘要： The present invention relates to a method for the detection of at least one of a group of chemical species which method comprises: contacting an admixture of the group of chemical species with dry solid phase microbeads and allowing or causing the group to adhere onto the microbead surfaces to form coated microbeads, suspending said coated microbeads in a biologically acceptable vehicle and injecting them into a suitable animal host and recovering antisera from said host and utilising said so-formed antisera to bind to any one of said group in a sample; preferably the group of chemical species include polyhalogenated aromatic hydrocarbons such as PCBs. The invention also provides a method for removing such chemical species from the liquid stream.
摘要翻译：本发明涉及一种用于检测一组化学物质中的至少一种的方法，该方法包括：将化学物质组的混合物与干固相微珠接触，并允许或使该基团附着在微珠表面上将所述涂覆的微珠悬浮在生物可接受的载体中并将其注入合适的动物宿主中并从所述宿主中回收抗血清并利用所述形成的抗血清结合样品中的任何一个组; 优选地，化学物质组包括多卤代芳族烃如PCB。本发明还提供了一种从液体流中除去这些化学物质的方法。

2. 发明申请

WO1994009131A1 RECOMBINANT SPECIFIC BINDING PROTEIN 审中-公开
标题翻译：重组特异性结合蛋白
公开(公告)号：WO1994009131A1
公开(公告)日：1994-04-28
申请号：PCT/GB1993002133
申请日：1993-10-15
申请人： SCOTGEN LIMITED , HARRIS, William, Joseph , EMERY, Stephen, Charles , WINTER, Gregory, Paul , CARR, Francis, Joseph , MCGREGOR, Duncan, Patrick
发明人： SCOTGEN LIMITED
IPC分类号： C12N15/12
CPC分类号： C07K16/468 , A61K38/00
摘要： A specific binding protein having first and second binding regions, e.g. antibody Fv fragments, which specifically recognise and bind to target entities, said binding regions being contained at least in part on respectively first and second polypeptide chains, said chains additionally incorporating respectively first and second associating domains, e.g. antibody VH and VL domains, which are capable of binding to each other, causing the first and second polypeptide chains to combine, thereby providing a single protein incorporating the binding specificities of said first and second binding regions. The first and second binding regions may recognise different target entities, giving a bispecific binding protein. Preferably the associating domains are derived from a human protein (i.e. one which has been exposed to the human immune system), so that the protein is less likely to provoke the human immune system when administered therapeutically. The binding protein is suitably produced by recombinant DNA expression.
摘要翻译：具有第一和第二结合区的特异性结合蛋白，例如抗体Fv片段，其特异性识别并结合靶物质，所述结合区至少部分地分别包含第一和第二多肽链，所述链另外包含第一和第二缔合结构域，例如，抗体VH和VL结构域，其能够彼此结合，导致第一和第二多肽链结合，从而提供掺入所述第一和第二结合区的结合特异性的单一蛋白质。第一和第二结合区可以识别不同的靶实体，得到双特异性结合蛋白。优选地，缔合结构域衍生自人蛋白质（即已经暴露于人类免疫系统的蛋白质），使得当治疗施用时蛋白质不太可能引起人免疫系统。结合蛋白通过重组DNA表达适当地产生。

3. 发明申请

WO1993017105A1 ALTERED ANTIBODIES, PRODUCTS AND PROCESSES RELATING THERETO 审中-公开
标题翻译：改变的抗体，产品和工艺与此有关
公开(公告)号：WO1993017105A1
公开(公告)日：1993-09-02
申请号：PCT/GB1993000363
申请日：1993-02-19
申请人： SCOTGEN LIMITED , WINTER, Gregory, Paul , CARR, Francis, Joseph , HARRIS, William, Joseph
发明人： SCOTGEN LIMITED
IPC分类号： C12N15/13
CPC分类号： C07K16/1027 , A61K38/00 , C07K16/465 , C07K2317/24
摘要： The present invention relates to altered antibodies which are substantially immuno silent by virtue of their containing selected germ-line amino acid residues which replace one or more corresponding somatically mutated residues in a native antibody. In a process for making a gene for use in preparing such an antibody, one or more somatically mutated amino acid residues in a native antibody are identified as suitable candidate(s) for alteration. A nucleotide coding sequence is made which codes for selected germ-line amino acid residues to replace the one or more somatically mutated amino acid residues. The altered antibody can have variable (V) regions which comprise complementarity determining regions (CDRs) which provide the antibody with capacity to bind a specific antigen; and a selected and predominantly germ-line framework. In processes for making a gene for use in the preparation of such an antibody, there are the steps of (i) obtaining CDR encoding nucleotide sequences which encode CDRs with specificity for the specific antigen and (ii) combining these CDR encoding nucleotide sequences with framework encoding nucleotide sequences which encode the selected germ-line framework.
摘要翻译：本发明涉及通过其含有选择的天然抗体中一个或多个相应的体细胞突变残基的选择的种系氨基酸残基基本上免疫沉默的抗体。在制备用于制备这种抗体的基因的方法中，天然抗体中的一个或多个体细胞突变的氨基酸残基被鉴定为用于改变的合适的候选物。编码编码选择的种系氨基酸残基以代替一个或多个体细胞突变的氨基酸残基的核苷酸编码序列。改变的抗体可以具有可变（V）区，其包含提供抗体结合特异性抗原的能力的互补决定区（CDR）; 和所选择的并且主要种系框架。在制备用于制备这种抗体的基因的方法中，存在以下步骤：（i）获得CDR编码核苷酸序列，其编码对特异性抗原具有特异性的CDR，以及（ii）将这些CDR编码核苷酸序列与框架编码所选择的种系框架编码核苷酸序列。

4. 发明申请

WO1994009136A1 RECOMBINANT HUMANIZED ANTI-CYTOMEGALOVIRUS ANTIBODIES 审中-公开
标题翻译：重组人类抗细胞免疫球蛋白抗体
公开(公告)号：WO1994009136A1
公开(公告)日：1994-04-28
申请号：PCT/GB1993002134
申请日：1993-10-15
申请人： KETTOCK LODGE, CAMPUS 2 , HARRIS, William, Joseph , CARR, Francis, Joseph , HAMILTON, Anita, Anne
发明人： KETTOCK LODGE, CAMPUS 2
IPC分类号： C12N15/13
CPC分类号： C07K16/088 , A61K38/00 , C07K16/461 , C07K2317/24
摘要： A humanised monoclonal antibody, or antigen-binding fragment thereof, which binds to the gH glycoprotein of HCMV, and has HCMV-neutralising activity. Its CDRs are derived from a non-human antibody and its FRs are derived from a human antibody. Certain amino acids of the human FRs have been altered to improve the HCMV-specificity and/or affinity of the antibody.
摘要翻译：与HCMV的gH糖蛋白结合并具有HCMV中和活性的人源化单克隆抗体或其抗原结合片段。其CDRs来自非人抗体，其FR来自人抗体。已经改变人FR的某些氨基酸以改善抗体的HCMV特异性和/或亲和力。

5. 发明申请

WO2004018517A3 POLYPEPTIDE HAVING GnSAF ACTIVITY AND SYNTHETIC ANTIBODIES 审中-公开
标题翻译：具有GnSAF活性和合成抗体的多肽
公开(公告)号：WO2004018517A3
公开(公告)日：2004-07-08
申请号：PCT/GB0303010
申请日：2003-07-14
申请人： UNIV ABERDEEN , FOWLER PAUL ALFRED FRANCOIS , HARRIS WILLIAM JOSEPH
发明人： FOWLER PAUL ALFRED FRANCOIS , HARRIS WILLIAM JOSEPH
IPC分类号： A61K38/00 , C07K14/575 , C12N15/16 , A61K38/22 , A61K39/00 , C07K16/26 , C12N15/86
CPC分类号： C07K14/575 , A61K38/00
摘要： There is provided an isolated polypeptide/protein, which has gonadotrophin surge-attenuating factor (GnSAF) bioactivity, and to synthetic antibodies recognising this bioactivity.
摘要翻译：提供了分离的多肽/蛋白质，其具有促性腺激素减少因子（GnSAF）生物活性，以及识别该生物活性的合成抗体。

6. 发明申请

WO2004018517A2 POLYPEPTIDE AND SYNTHETIC ANTIBODIES 审中-公开
标题翻译：多肽和合成抗体
公开(公告)号：WO2004018517A2
公开(公告)日：2004-03-04
申请号：PCT/GB2003/003010
申请日：2003-07-14
申请人： ABERDEEN UNIVERSITY , FOWLER, Paul, Alfred, Francois , HARRIS, William, Joseph
发明人： FOWLER, Paul, Alfred, Francois , HARRIS, William, Joseph
IPC分类号： C07K14/705
CPC分类号： C07K14/575 , A61K38/00
摘要： There is provided an isolated polypeptide/protein, which has gonadotrophin surge-attenuating factor (GnSAF) bioactivity, and to synthetic antibodies recognising this bioactivity.
摘要翻译：提供了分离的多肽/蛋白质，其具有促性腺激素减少因子（GnSAF）生物活性，以及识别该生物活性的合成抗体。

7. 发明申请

WO1991006674A1 METHOD AND DEVICE FOR THE DETECTION OF ANTIBIOTIC RESISTANCE 审中-公开
标题翻译：用于检测抗生素耐药性的方法和装置
公开(公告)号：WO1991006674A1
公开(公告)日：1991-05-16
申请号：PCT/GB1990001697
申请日：1990-11-06
申请人： SCOTGEN LTD. , HARRIS, William, Joseph , CARR, Francis, Joseph
发明人： SCOTGEN LTD.
IPC分类号： C12Q01/68
CPC分类号： C12Q1/6834 , C12Q1/18 , C12Q1/6876 , C12Q1/689
摘要： A method for the quick and easy detection of antibiotic resistance in a sample and a kit that incorporates this method. The method involves providing a support; a first probe capable of specifically binding to part of the nucleic acid encoding the antibiotic resistance, and which is immobilisable on the support before and during the test procedure; a second probe capable of specifically binding another part of the nucleic acid encoding the antibiotic resistance, this second probe being labelled so as to be capable of producing a signal; allowing nucleic acid from the sample to come into contact with the first probe and the labelled second probe; detecting any signal from the labelled second probe bound to the support by cohybridisation of the immobilised first probe and the labelled probe to antibiotic resistance nucleic acid.
摘要翻译：用于快速和容易地检测样品中的抗生素抗性的方法和包含该方法的试剂盒。该方法涉及提供支持; 能够特异性结合编码抗生素抗性的核酸的一部分的第一探针，并且其可在测试过程之前和期间固定在载体上; 能够特异性结合编码抗生素抗性的核酸的另一部分的第二探针，该第二探针被标记以能够产生信号; 允许来自样品的核酸与第一探针和标记的第二探针接触; 通过将固定化的第一探针和标记的探针共同杂交到抗生素抗性核酸上，检测与标记的第二探针结合的载体的任何信号。

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