专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2006072792A2 COMPOUNDS WHICH BIND TO THE ACTIVE SITE OF PROTEIN KINASE ENZYMES 审中-公开
标题翻译：与蛋白激酶酶活性位点结合的化合物
公开(公告)号：WO2006072792A2
公开(公告)日：2006-07-13
申请号：PCT/GB2006/000034
申请日：2006-01-06
申请人： BIOFOCUS DISCOVERY LIMITED , BIRAULT, Veronique , HARRIS, Clifford, John , CROSSLEY, Roger
发明人： BIRAULT, Veronique , HARRIS, Clifford, John , CROSSLEY, Roger
IPC分类号： A61K31/44 , A61K31/4418 , A61K31/4433 , A61K31/4965 , A61K31/497 , A61P25/00 , A61P25/16 , A61P25/28 , A61P27/02 , A61P29/00
CPC分类号： A61K31/44 , A61K31/4418 , A61K31/4433 , A61K31/4965 , A61K31/497
摘要： One or more compounds that are inhibitors of a serine/ threonine kinase, more particularly Rho kinase (ROK, ROCK) can be used in the manufacture of a medicament for treatment or prophylaxis of a condition selected from: an ocular condition including age related macular degeneration, lacrimal gland disease or diabetic retinopathy, or suppression of neurite growth and hence a condition requiring nerve cell extension and connectivity, neuronal regeneration, inducing new axonal growth and promotion of axonal (re)wiring, repairing damage to neurons in the CNS caused by trauma (eg stroke, traumatic brain injury etc.) or neurodegeneration (eg Alzheimer's, Parkinson's etc), repair and recovery from and treatment of disorders such as spinal cord injury and in reducing the subsequent effects thereof, or pain caused by nerve cell damage such as following trauma or amputation for example in the treatment of neuropathic pain. The compounds are selected from the specific group of compounds that comprises or consists of compounds of formula (I) or (II) wherein R1, R2, R3, R4, R5 and R6 are defined herein.
摘要翻译：作为丝氨酸/苏氨酸激酶抑制剂，尤其是Rho激酶（ROK，ROCK）的一种或多种化合物可用于制备用于治疗或预防选自以下的病症的药物：包括年龄相关性黄斑变性，泪腺疾病或糖尿病性视网膜病变或抑制神经突生长，因此需要神经细胞延伸和连接，神经元再生，诱导新的轴突生长和促进轴突（重新）接线，修复由创伤引起的CNS中的神经元损伤的病症（例如中风，创伤性脑损伤等）或神经变性（例如阿尔茨海默氏症，帕金森病等），修复和恢复并治疗诸如脊髓损伤和减轻其后续作用的疾病或由神经细胞损伤引起的疼痛，例如在创伤或截肢后，例如治疗神经性疼痛。化合物选自包含式I或II的化合物或其组成的特定组的化合物，其中R 1，R 2，R 3，R 4，R 5和R 6在本文中定义。

2. 发明申请

WO2005085252A1 IMIDAZO ‘1,2-A’ PYRAZINE COMPOUNDS WHICH INTERACT WITH PROTEIN KINASES 审中-公开
标题翻译：与蛋白激酶相互作用的咪达佐'1,2-A'吡嗪化合物
公开(公告)号：WO2005085252A1
公开(公告)日：2005-09-15
申请号：PCT/GB2005/000842
申请日：2005-03-04
申请人： BIOFOCUS DISCOVERY LIMITED , BIRAULT, Veronique , HARRIS, Clifford, John , HARRISON, Stephen, Anthony
发明人： BIRAULT, Veronique , HARRIS, Clifford, John , HARRISON, Stephen, Anthony
IPC分类号： C07D487/04
CPC分类号： C07D487/04
摘要： The present invention relates to a novel compounds of formula I, to pharmaceutical compounds, to processes for their preparation, as well as to the use of the compounds in the inhibition of protein kinases, in particular serine/threonine kinases, more particularly mitogen activated protein kinase, more particularly the c-Jun NH2-teminal kinases (JNKs). The invention also relates to the compounds for use in medicine and particularly n the prevention and/or treatment of a wide variety of diseases including inflammatory disorders, cancer, angiogenesis, diabetes, metabolic disease and neurological disorders.
摘要翻译：本发明涉及式I化合物，药物化合物，其制备方法以及该化合物在抑制蛋白激酶，特别是丝氨酸/苏氨酸激酶中的用途，更具体地说，有丝分裂原活化蛋白激酶，更特别是c-Jun NH2-末期激酶（JNK）。本发明还涉及用于医药，特别是预防和/或治疗多种疾病的化合物，包括炎性疾病，癌症，血管生成，糖尿病，代谢疾病和神经障碍。

3. 发明申请

WO2009024585A3 IMIDAZO [1,2-A] PYRAZINE COMPOUNDS FOR TREATMENT OF VIRAL INFECTIONS SUCH AS HEPATITIS 审中-公开
公开(公告)号：WO2009024585A3
公开(公告)日：2009-02-26
申请号：PCT/EP2008/060896
申请日：2008-08-20
申请人： BIOFOCUS DPI LIMITED , MACLEOD, Angus , MITCHELL, Dale Robert , PALMER, Nicholas John , PARSY, Christophe Claude , GOLDSMITH, Michael Daniel , HARRIS, Clifford John
发明人： MACLEOD, Angus , MITCHELL, Dale Robert , PALMER, Nicholas John , PARSY, Christophe Claude , GOLDSMITH, Michael Daniel , HARRIS, Clifford John
IPC分类号： C07D487/04 , A61K31/4985 , A61P31/00
摘要： Novel imidazopyrazine compounds are disclosed that have a formula represented by the following: Formula (I). The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a viral infection, in particular a HCV, HRV, Sb and/or CVB in a patient in need thereof.

4. 发明申请

WO2004076458A1 PYRAZOLO[1,5-A]PYRIMIDINE DERIVATIVES 审中-公开
标题翻译：吡咯并[1,5-A]吡嗪衍生物
公开(公告)号：WO2004076458A1
公开(公告)日：2004-09-10
申请号：PCT/JP2004/002522
申请日：2004-03-01
申请人： TEIJIN PHARMA LIMITED , KATAOKA, Kenichiro , SUZUKI, Naotaka , KOSUGI, Tomomi , IMAI, Minoru , MAKINO, Hiroaki , TAKAKUWA, Mika , UNOKI, Gen , FUJINO, Aiko , OUE, Yasuhiro , YAMAKOSHI, Yuko , SUGIURA, Satoshi , MITCHELL, Dale Robert , SIMPSON, Donald James , HARRIS, Clifford John , LE, Joelle
发明人： KATAOKA, Kenichiro , SUZUKI, Naotaka , KOSUGI, Tomomi , IMAI, Minoru , MAKINO, Hiroaki , TAKAKUWA, Mika , UNOKI, Gen , FUJINO, Aiko , OUE, Yasuhiro , YAMAKOSHI, Yuko , SUGIURA, Satoshi , MITCHELL, Dale Robert , SIMPSON, Donald James , HARRIS, Clifford John , LE, Joelle
IPC分类号： C07D487/04
CPC分类号： C07D487/04
摘要： The Pyrazolo[1,5-a]pyrimidine derivatives represented by formula I and their pharmaceutically acceptable salts exhibit excellent kinase inhibiting activity. Drugs comprising the compounds as effective ingredients are therefore expected to be useful as therapeutic or prophylactic agents for a protein kinase mediated disorder in which kinase is implicated, such as inflammatory disease, autoimmune disease, destructive bone disorder, cancer and/or tumour growth. H,N,R 3
摘要翻译：由式I表示的吡唑并[1,5-a]嘧啶衍生物及其药学上可接受的盐表现出优异的激酶抑制活性。因此，包含化合物作为有效成分的药物预期可用作其中涉及激酶的蛋白激酶介导的病症的治疗或预防剂，例如炎性疾病，自身免疫疾病，破坏性骨病，癌症和/或肿瘤生长。 H，N，R <3>

5. 发明申请

WO2009024585A2 IMIDAZOPYRAZINE COMPOUNDS 审中-公开
标题翻译：咪唑并吡嗪化合物
公开(公告)号：WO2009024585A2
公开(公告)日：2009-02-26
申请号：PCT/EP2008060896
申请日：2008-08-20
申请人： BIOFOCUS DPI LTD , MACLEOD ANGUS , MITCHELL DALE ROBERT , PALMER NICHOLAS JOHN , PARSY CHRISTOPHE CLAUDE , GOLDSMITH MICHAEL DANIEL , HARRIS CLIFFORD JOHN
发明人： MACLEOD ANGUS , MITCHELL DALE ROBERT , PALMER NICHOLAS JOHN , PARSY CHRISTOPHE CLAUDE , GOLDSMITH MICHAEL DANIEL , HARRIS CLIFFORD JOHN
IPC分类号： C07D487/04 , A61K31/4985 , A61P31/00
CPC分类号： C07D487/04
摘要： Novel imidazopyrazine compounds are disclosed that have a formula represented by the following: Formula (I). The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a viral infection, in particular a HCV, HRV, Sb and/or CVB in a patient in need thereof.
摘要翻译：公开了具有由下式表示的式的新型咪唑并吡嗪化合物：式（I）。化合物可以制备成药物组合物，并且可用于预防和治疗有需要的患者中的病毒感染，特别是HCV，HRV，Sb和/或CVB。

6. 发明申请

WO2007131991A1 IMIDAZOLOPYRAZINE COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE AND INFLAMMATORY DISEASES 审中-公开
标题翻译：用于治疗变应性和炎症性疾病的咪唑吡嗪化合物
公开(公告)号：WO2007131991A1
公开(公告)日：2007-11-22
申请号：PCT/EP2007/054654
申请日：2007-05-14
申请人： GALAPAGOS N.V. , BRYS, Reginald Christophe Xavier , EDWARDS, Paul , SCHMIDT, Wolfgang , ANDREWS, Martin James Inglis , CHAMBERS, Mark Stuart , CLASE, Juha Andrew , BIRAULT, Veronique , HIRST, Kim Louise , MACLEOD, Angus , BAR, Gregory , HARRIS, Clifford John , HUXLEY, Philip
发明人： BRYS, Reginald Christophe Xavier , EDWARDS, Paul , SCHMIDT, Wolfgang , ANDREWS, Martin James Inglis , CHAMBERS, Mark Stuart , CLASE, Juha Andrew , BIRAULT, Veronique , HIRST, Kim Louise , MACLEOD, Angus , BAR, Gregory , HARRIS, Clifford John , HUXLEY, Philip
IPC分类号： C07D487/04 , A61K31/4985 , A61P19/02
CPC分类号： C07D487/04
摘要： Novel imidazo[1,2-a]pyrazine compounds are disclosed that have a formula ( I ) represented by the following:The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, arthritis, inflammation, and others.
摘要翻译：公开了具有由以下表示的式（I）的新型咪唑并[1,2-a]吡嗪化合物：所述化合物可以制备为药物组合物，并且可用于预防和治疗哺乳动物中的各种病症包括人，包括非限制性的例子，关节炎，炎症等。

7. 发明申请

WO2006072792A3 COMPOUNDS WHICH BIND TO THE ACTIVE SITE OF PROTEIN KINASE ENZYMES 审中-公开
标题翻译：与蛋白激酶酶活性位点结合的化合物
公开(公告)号：WO2006072792A3
公开(公告)日：2007-01-11
申请号：PCT/GB2006000034
申请日：2006-01-06
申请人： GALAPAGOS NV , BIRAULT VERONIQUE , HARRIS CLIFFORD JOHN , CROSSLEY ROGER
发明人： BIRAULT VERONIQUE , HARRIS CLIFFORD JOHN , CROSSLEY ROGER
IPC分类号： A61K31/44 , A61K31/4418 , A61K31/4433 , A61K31/4965 , A61K31/497 , A61P25/00 , A61P25/16 , A61P25/28 , A61P27/02 , A61P29/00
CPC分类号： A61K31/44 , A61K31/4418 , A61K31/4433 , A61K31/4965 , A61K31/497
摘要： One or more compounds that are inhibitors of a serine/ threonine kinase, more particularly Rho kinase (ROK, ROCK) can be used in the manufacture of a medicament for treatment or prophylaxis of a condition selected from: an ocular condition including age related macular degeneration, lacrimal gland disease or diabetic retinopathy, or suppression of neurite growth and hence a condition requiring nerve cell extension and connectivity, neuronal regeneration, inducing new axonal growth and promotion of axonal (re)wiring, repairing damage to neurons in the CNS caused by trauma (eg stroke, traumatic brain injury etc.) or neurodegeneration (eg Alzheimer's, Parkinson's etc), repair and recovery from and treatment of disorders such as spinal cord injury and in reducing the subsequent effects thereof, or pain caused by nerve cell damage such as following trauma or amputation for example in the treatment of neuropathic pain. The compounds are selected from the specific group of compounds that comprises or consists of compounds of formula (I) or (II) wherein R1, R2, R3, R4, R5 and R6 are defined herein.
摘要翻译：作为丝氨酸/苏氨酸激酶抑制剂，尤其是Rho激酶（ROK，ROCK）的一种或多种化合物可用于制备用于治疗或预防选自以下的病症的药物：包括年龄相关性黄斑变性，泪腺疾病或糖尿病性视网膜病变或抑制神经突生长，因此需要神经细胞延伸和连接，神经元再生，诱导新的轴突生长和促进轴突（重新）接线，修复由创伤引起的CNS中的神经元损伤的病症（例如中风，创伤性脑损伤等）或神经变性（例如阿尔茨海默氏症，帕金森病等），修复和恢复并治疗诸如脊髓损伤和减轻其后续作用的疾病或由神经细胞损伤引起的疼痛，例如在创伤或截肢后，例如治疗神经性疼痛。化合物选自包含式I或II的化合物或其组成的特定组的化合物，其中R 1，R 2，R 3，R 4，R 5和R 6在本文中定义。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式