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1. 发明申请

WO2009008956A9 SYSTEM AND METHOD FOR USE OF NANOPARTICLES IN IMAGING AND TEMPURATURE MEASUREMENT 审中-公开
公开(公告)号：WO2009008956A9
公开(公告)日：2009-01-15
申请号：PCT/US2008/007626
申请日：2008-06-19
申请人： MARY HITCHCOCK MEMORIAL HOSPITAL , WEAVER, John, B. , BAKER, Ian , HANSEN, Eric, W.
发明人： WEAVER, John, B. , BAKER, Ian , HANSEN, Eric, W.
IPC分类号： A61B5/05 , A61B5/055
摘要： This invention provides a system and method that improves the sensitivity and localization capabilities of Magnetic Particle Imaging (MPI) by using combinations of time- varying and static magnetic fields. Combinations of magnetic fields can be used to distribute the signals coming from the magnetic particles among the harmonics and other frequencies in specific ways to improve sensitivity and to provide localization information to speed up or improve the signal-to-noise ratio (SNR) of imaging and/or eliminate the need for saturation fields currently used in MPI. In various embodiments, coils can be provided to extend the sub-saturation region in which nanoparticles reside; to provide a static field offset to bring nanoparticles nearer to saturation; to introduce even and odd harmonics that can be observed; and/or to introduce combinations of frequencies for more-defined observation of signals from nanoparticles. Further embodiments provide for reading of the signal produced by cyclically saturated magnetic nanoparticles in a sample so as to provide a measurement of the temperature of those nanoparticles. The spectral distribution of the signal generated provides estimates of the temperature of the nanoparticles. Related factors may also be estimated - binding energies of the nanoparticles, phase changes, bound fraction of the particles or stiffness of the materials in which the nanoparticles are imbedded.

2. 发明申请

WO2009008956A2 SYSTEM AND METHOD FOR USE OF NANOPARTICLES IN IMAGING AND TEMPURATURE MEASUREMENT 审中-公开
公开(公告)号：WO2009008956A2
公开(公告)日：2009-01-15
申请号：PCT/US2008007626
申请日：2008-06-19
申请人： DARTMOUTH HITCHCOCK CLINIC , WEAVER JOHN B , BAKER IAN , HANSEN ERIC W
发明人： WEAVER JOHN B , BAKER IAN , HANSEN ERIC W
IPC分类号： A61B5/05 , A61B5/055
CPC分类号： A61B5/05 , A61B5/0515 , B82Y25/00 , H01F1/0045
摘要： This invention provides a system and method that improves the sensitivity and localization capabilities of Magnetic Particle Imaging (MPI) by using combinations of time- varying and static magnetic fields. Combinations of magnetic fields can be used to distribute the signals coming from the magnetic particles among the harmonics and other frequencies in specific ways to improve sensitivity and to provide localization information to speed up or improve the signal-to-noise ratio (SNR) of imaging and/or eliminate the need for saturation fields currently used in MPI. In various embodiments, coils can be provided to extend the sub-saturation region in which nanoparticles reside; to provide a static field offset to bring nanoparticles nearer to saturation; to introduce even and odd harmonics that can be observed; and/or to introduce combinations of frequencies for more-defined observation of signals from nanoparticles. Further embodiments provide for reading of the signal produced by cyclically saturated magnetic nanoparticles in a sample so as to provide a measurement of the temperature of those nanoparticles. The spectral distribution of the signal generated provides estimates of the temperature of the nanoparticles. Related factors may also be estimated - binding energies of the nanoparticles, phase changes, bound fraction of the particles or stiffness of the materials in which the nanoparticles are imbedded.

3. 发明申请

WO2009008956A3 SYSTEM AND METHOD FOR USE OF NANOPARTICLES IN IMAGING AND TEMPURATURE MEASUREMENT 审中-公开
标题翻译：纳米颗粒用于成像和温度测量的系统和方法
公开(公告)号：WO2009008956A3
公开(公告)日：2009-07-23
申请号：PCT/US2008007626
申请日：2008-06-19
申请人： MARY HITCHCOCK MEMORIAL HOSPIT , WEAVER JOHN B , BAKER IAN , HANSEN ERIC W
发明人： WEAVER JOHN B , BAKER IAN , HANSEN ERIC W
IPC分类号： A61B5/05
CPC分类号： A61B5/05 , A61B5/0515 , B82Y25/00 , H01F1/0045
摘要： This invention provides a system and method that improves the sensitivity and localization capabilities of Magnetic Particle Imaging (MPI) by using combinations of time- varying and static magnetic fields. Combinations of magnetic fields can be used to distribute the signals coming from the magnetic particles among the harmonics and other frequencies in specific ways to improve sensitivity and to provide localization information to speed up or improve the signal-to-noise ratio (SNR) of imaging and/or eliminate the need for saturation fields currently used in MPI. In various embodiments, coils can be provided to extend the sub-saturation region in which nanoparticles reside; to provide a static field offset to bring nanoparticles nearer to saturation; to introduce even and odd harmonics that can be observed; and/or to introduce combinations of frequencies for more-defined observation of signals from nanoparticles. Further embodiments provide for reading of the signal produced by cyclically saturated magnetic nanoparticles in a sample so as to provide a measurement of the temperature of those nanoparticles. The spectral distribution of the signal generated provides estimates of the temperature of the nanoparticles. Related factors may also be estimated - binding energies of the nanoparticles, phase changes, bound fraction of the particles or stiffness of the materials in which the nanoparticles are imbedded.
摘要翻译：本发明提供了一种通过使用时变磁场和静磁场的组合来提高磁性粒子成像（MPI）的灵敏度和定位能力的系统和方法。可以使用磁场组合来以特定方式分配来自谐波和其他频率之中的磁性粒子的信号以提高灵敏度并提供定位信息以加速或改善成像的信噪比（SNR）和/或消除目前在MPI中使用的饱和场的需要。在各种实施例中，可提供线圈以延伸纳米颗粒所在的亚饱和区; 以提供静态场偏移以使纳米粒子更接近饱和; 引入可观察到的偶数和奇数谐波; 和/或引入频率的组合以用于来自纳米粒子的信号的更加定义的观察。进一步的实施方式提供了由样品中的循环饱和磁性纳米颗粒产生的信号的读取，以提供这些纳米颗粒的温度的测量。产生的信号的光谱分布提供了纳米颗粒温度的估计。还可以估计相关因素 - 纳米颗粒的结合能，相变，颗粒的结合部分或纳米颗粒所嵌入的材料的硬度。

4. 发明申请

WO0158163A2 SYSTEM FOR DISTRIBUTED MEDIA NETWORK AND META DATA SERVER 审中-公开
标题翻译：分布式媒体网络和元数据服务器系统
公开(公告)号：WO0158163A2
公开(公告)日：2001-08-09
申请号：PCT/US0103675
申请日：2001-02-05
申请人： TUNE TO COM INC , SINCAGLIA NICOLAS W , REBAUD SYLVAIN P , LESTER JAMES P , HANSEN ERIC W , LAMPTON DAVID G , BRATTON TIMOTHY R
发明人： SINCAGLIA NICOLAS W , REBAUD SYLVAIN P , LESTER JAMES P , HANSEN ERIC W , LAMPTON DAVID G , BRATTON TIMOTHY R
IPC分类号： G06F12/00 , G06F13/00 , H04N7/16 , H04N7/173 , H04N21/218 , H04N21/239 , H04N21/472 , H04N21/81 , H04N21/84
CPC分类号： H04N21/2181 , H04N7/17318 , H04N21/2393 , H04N21/472 , H04N21/816 , H04N21/84
摘要： A system and method of operation for a distributed media network and meta data server provides a low cost, efficient, reliable and versatile alternative to traditional media network systems. Multiple media data file servers are designated as primary or alternate data file servers for different media data media files. Related or linked media data files may be distributed throughout a media network which results in lower peak bandwidth usage at each media data file server. Each server in the distributed media network responds more quickly and efficiently due to its limited functionality and scope of media data files that it must server. Media data file servers transfer low bandwidth meta data to client devices allowing a significant increase in the number of clients which can simultaneously log in to a dedicated network server. The distributed system also provides media data owners with greater control over the media data files that they own by allowing the owners to encode, post or remove files from servers that they control and maintain. The alternate media data file servers of the distributed media network also can act as primary file servers during catastrophic errors of the primary media data file servers, thus resulting in a more reliable and fault tolerant media network.
摘要翻译：分布式媒体网络和元数据服务器的系统和操作方法为传统媒体网络系统提供了低成本，高效，可靠和通用的替代方案。多媒体数据文件服务器被指定为不同媒体数据媒体文件的主要或备用数据文件服务器。相关或链接的媒体数据文件可以分布在整个媒体网络中，这导致每个媒体数据文件服务器处的峰值带宽利用率较低。分布式媒体网络中的每个服务器由于其必须服务器的媒体数据文件的功能和范围有限，因此响应更快，高效。媒体数据文件服务器将低带宽元数据传输到客户端设备，允许大量增加可以同时登录到专用网络服务器的客户端数量。分布式系统还通过允许所有者对其控制和维护的服务器进行编码，发布或删除文件，为媒体数据所有者提供对他们拥有的媒体数据文件的更大控制。分布式媒体网络的备用媒体数据文件服务器还可以在主要媒体数据文件服务器的灾难性错误期间充当主要文件服务器，从而导致更可靠和容错的媒体网络。

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