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1. 发明申请

WO2012009088A2 METHOD AND APPARATUS TO ENCODE FUEL USE DATA WITH GPS DATA AND TO ANALYZE SUCH DATA 审中-公开
标题翻译：用GPS数据编码燃料使用数据并分析这些数据的方法和设备
公开(公告)号：WO2012009088A2
公开(公告)日：2012-01-19
申请号：PCT/US2011/040370
申请日：2011-06-14
申请人： ZONAR SYSTEMS, INC. , BRINTON, Brett , MCQUADE, Charles, Michael , ANDRE, Roger , HANSEN, Joshua
发明人： BRINTON, Brett , MCQUADE, Charles, Michael , ANDRE, Roger , HANSEN, Joshua
IPC分类号： F02D41/30 , G01S19/39 , F02D41/24 , F02D45/00
CPC分类号： G08G1/096805 , B60R16/0236 , G07C5/008 , G07C5/0808 , G08G1/096844 , G08G1/20
摘要： System and method for analyzing position data and fuel injector data from a vehicle equipped with a geographical position system (GPS) and fuel injector sensors to enable fuel use patterns of the vehicle to be analyzed. Data defining a flow of fuel through the vehicle's fuel injectors is combined with temporal data and GPS data to produce fuel use encoded GPS data that is transmitted to a remote computer. The fuel use encoded GPS data can be analyzed to determine how much fuel was used by the vehicle during off road use to enable proper fuel tax computations to be performed. The data can also be used to evaluate the mechanical condition of a vehicle. By monitoring fuel use for a trip repeated numerous times, a decrease in fuel efficiency may indicate a mechanical problem (dirty injectors, fouled spark plugs, etc).
摘要翻译：用于分析来自配备有地理位置系统（GPS）和燃料喷射器传感器的车辆的位置数据和燃料喷射器数据以使得能够分析车辆的燃料使用模式的系统和方法。定义通过车辆燃料喷射器的燃料流量的数据与时间数据和GPS数据组合以产生传输到远程计算机的燃料使用编码的GPS数据。可以分析燃料使用编码的GPS数据以确定在越野使用期间车辆使用多少燃料以实现适当的燃油税计算。数据也可以用来评估车辆的机械状况。通过多次重复监测燃油使用情况，燃油效率的下降可能表明机械故障（污染的喷油器，堵塞的火花塞等）。

2. 发明申请

WO2011025938A3 RAF INHIBITOR COMPOUNDS AND METHODS OF USE THEREOF 审中-公开
标题翻译： RAF抑制剂化合物及其使用方法
公开(公告)号：WO2011025938A3
公开(公告)日：2011-05-05
申请号：PCT/US2010046952
申请日：2010-08-27
申请人： ARRAY BIOPHARMA INC , GENENTECH INC , ALIAGAS IGNACIO , GRADL STEFAN , GUNZNER JANET , LEE WENDY , MATHIEU SIMON , RUDOLPH JOACHIM , WEN ZHAOYANG , ZHAO GUILING , BUCKMELTER ALEXANDRE J , GRINA JONAS , HANSEN JOSHUA D , LAIRD ELLEN , MORENO DAVID , REN LI , WENGLOWSKY STEVEN MARK
发明人： ALIAGAS IGNACIO , GRADL STEFAN , GUNZNER JANET , LEE WENDY , MATHIEU SIMON , RUDOLPH JOACHIM , WEN ZHAOYANG , ZHAO GUILING , BUCKMELTER ALEXANDRE J , GRINA JONAS , HANSEN JOSHUA D , LAIRD ELLEN , MORENO DAVID , REN LI , WENGLOWSKY STEVEN MARK
IPC分类号： C07D239/94 , A61K31/517 , A61K31/519 , A61P35/00 , C07D403/12 , C07D405/12 , C07D471/04
CPC分类号： C07D239/94 , C07D403/12 , C07D405/12 , C07D471/04
摘要： Compounds of Formula I are useful for inhibition of Raf kinases. Methods of using compounds of Formula I and stereoisomers, tautomers, prodrugs and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.
摘要翻译：式I化合物可用于抑制Raf激酶。公开了使用式I化合物及其立体异构体，互变异构体，前药和药学上可接受的盐在体外，原位和体内诊断，预防或治疗哺乳动物细胞中的这些病症或相关病理学病症的方法。

3. 发明申请

WO2009111278A2 RAF INHIBITOR COMPOUNDS AND METHODS OF USE THEREOF 审中-公开
标题翻译： RAF抑制剂化合物及其使用方法
公开(公告)号：WO2009111278A2
公开(公告)日：2009-09-11
申请号：PCT/US2009035380
申请日：2009-02-27
申请人： ARRAY BIOPHARMA INC , GENENTECH INC , AHRENDT KATERI A , BUCKMELTER ALEXANDRE J , GRINA JONAS , HANSEN JOSHUA D , LAIRD ELLEN R , MORENO DAVID , NEWHOUSE BRAD , REN LI , WENGLOWSKY STEVEN MARK , FENG BAINIAN , GUNZNER JANET , MALESKY KIM , MATHIEU SIMON , RUDOLPH JOACHIM , WEN ZHAOYANG , YOUNG WENDY B
发明人： AHRENDT KATERI A , BUCKMELTER ALEXANDRE J , GRINA JONAS , HANSEN JOSHUA D , LAIRD ELLEN R , MORENO DAVID , NEWHOUSE BRAD , REN LI , WENGLOWSKY STEVEN MARK , FENG BAINIAN , GUNZNER JANET , MALESKY KIM , MATHIEU SIMON , RUDOLPH JOACHIM , WEN ZHAOYANG , YOUNG WENDY B
IPC分类号： A61K31/4745
CPC分类号： C07D471/04 , C07C311/08
摘要： Compounds of Formula I are useful for inhibition of Raf kinases. Methods of using compounds of Formula I and stereoisomers, tautomers, prodrugs and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.
摘要翻译：式I化合物可用于抑制Raf激酶。公开了使用式I化合物和立体异构体，互变异构体，前药和其药学上可接受的盐在体外，原位和体内诊断，预防或治疗哺乳动物细胞或相关病理状况中的这种病症的方法。

4. 发明申请

WO2010042282A1 ULTRASOUND SYSTEM HAVING A SIMPLIFIED USER INTERFACE 审中-公开
标题翻译：具有简化用户界面的超声系统
公开(公告)号：WO2010042282A1
公开(公告)日：2010-04-15
申请号：PCT/US2009/055012
申请日：2009-08-26
申请人： SONOSITE, INC. , HANSEN, Joshua, M. , SLIGER, Bradley, J. , LOCKHART, Scott, N. , IVERSON, Thomas
发明人： HANSEN, Joshua, M. , SLIGER, Bradley, J. , LOCKHART, Scott, N. , IVERSON, Thomas
IPC分类号： A61B8/00
CPC分类号： A61B8/00 , A61B8/462
摘要： The present invention is directed to a system and method which allows for a simplified user interface tailored to specific procedures and which allows for mobility and easy sanitation. Advantage is taken of an understanding as to the critical functions that an operator is to perform for a specific range of procedures and tailoring the user input to accommodate only those functions. In one embodiment, the user interface consists of a touch screen and a rotatable knob having positional indents with the indents providing incremental increases or decreases in functionality specific to exams or procedures performed with the sonographic equipment. Using this approach, the complexity normally associated with operating sonographic devices is greatly reduced. The operational controls available from the touch screen are changeable to accommodate different function uses of the sonographic device.
摘要翻译：本发明涉及一种系统和方法，其允许根据具体过程定制的简化的用户界面，并且允许移动性和容易的卫生。对于操作员为特定范围的程序执行的关键功能以及定制用户输入以仅适应这些功能的优点。在一个实施例中，用户接口包括触摸屏和具有位置缩进的可旋转旋钮，其中凹痕具有特定于使用超声波设备执行的检查或程序的功能的增加或减小。使用这种方法，通常与操作超声设备相关联的复杂度大大降低。触摸屏可用的操作控制是可以改变的，以适应超声波设备的不同功能用途。

5. 发明申请

WO2009111278A3 RAF INHIBITOR COMPOUNDS AND METHODS OF USE THEREOF 审中-公开
公开(公告)号：WO2009111278A3
公开(公告)日：2009-09-11
申请号：PCT/US2009/035380
申请日：2009-02-27
申请人： ARRAY BIOPHARMA INC. , GENENTECH, INC. , AHRENDT, Kateri A. , BUCKMELTER, Alexandre J. , GRINA, Jonas , HANSEN, Joshua D. , LAIRD, Ellen R. , MORENO, David , NEWHOUSE, Brad , REN, Li , WENGLOWSKY, Steven Mark , FENG, Bainian , GUNZNER, Janet , MALESKY, Kim , MATHIEU, Simon , RUDOLPH, Joachim , WEN, Zhaoyang , YOUNG, Wendy B.
发明人： AHRENDT, Kateri A. , BUCKMELTER, Alexandre J. , GRINA, Jonas , HANSEN, Joshua D. , LAIRD, Ellen R. , MORENO, David , NEWHOUSE, Brad , REN, Li , WENGLOWSKY, Steven Mark , FENG, Bainian , GUNZNER, Janet , MALESKY, Kim , MATHIEU, Simon , RUDOLPH, Joachim , WEN, Zhaoyang , YOUNG, Wendy B.
IPC分类号： C07D471/04 , C07C311/08 , A61P35/00 , A61K31/437
摘要： Compounds of Formula (I) are useful for inhibition of Raf kinases. Methods of using compounds of Formula (I) and stereoisomers, tautomers, prodrugs and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.

6. 发明申请

WO2019014100A1 ANTIPROLIFERATIVE COMPOUNDS AND METHODS OF USE THEREOF 审中-公开
公开(公告)号：WO2019014100A1
公开(公告)日：2019-01-17
申请号：PCT/US2018/041230
申请日：2018-07-09
申请人： CELGENE CORPORATION , ALEXANDER, Matthew, D. , ARTMAN, Gerald, D., III , BRAY, Gordon, L. , CARMICHAEL, James , CARRANCIO, Soraya , CATHERS, Brian E. , CORREA, Matthew, D. , HANSEN, Joshua , HAVENS, Courtney, G. , KERCHER, Timothy, S. , LOPEZ-GIRONA, Antonia , LU, Xiaoling , MAN, Hon-Wah , NAGY, Mark, A. , NARLA, Rama, K. , PICCOTTI, Joseph, R. , PIERCE, Daniel, W. , TAVARES-GRECO, Paula, A. , WHITEFIELD, Brandon, W. , WONG, Lilly, L. , ZOU, Nanfei
发明人： ALEXANDER, Matthew, D. , ARTMAN, Gerald, D., III , BRAY, Gordon, L. , CARMICHAEL, James , CARRANCIO, Soraya , CATHERS, Brian E. , CORREA, Matthew, D. , HANSEN, Joshua , HAVENS, Courtney, G. , KERCHER, Timothy, S. , LOPEZ-GIRONA, Antonia , LU, Xiaoling , MAN, Hon-Wah , NAGY, Mark, A. , NARLA, Rama, K. , PICCOTTI, Joseph, R. , PIERCE, Daniel, W. , TAVARES-GRECO, Paula, A. , WHITEFIELD, Brandon, W. , WONG, Lilly, L. , ZOU, Nanfei
IPC分类号： A61K31/496 , C07D241/02 , A61K38/05 , A61K31/573 , A61P35/00
摘要： Provided herein is 4-(4-(4-(((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)oxy)methyl)benzyl)piperazin-1-yl)-3-fluorobenzonitrile, or an enantiomer, a mixture of enantiomers, a tautomer, or a pharmaceutically acceptable salt thereof, and methods for treating, preventing or managing multiple myeloma using such compounds. Also provided are pharmaceutical compositions comprising the compounds, and methods of use of the compositions.

7. 发明申请

WO2012009088A3 METHOD AND APPARATUS TO ENCODE FUEL USE DATA WITH GPS DATA AND TO ANALYZE SUCH DATA 审中-公开
标题翻译：用GPS数据编码燃料使用数据并分析这些数据的方法和装置
公开(公告)号：WO2012009088A3
公开(公告)日：2012-04-19
申请号：PCT/US2011040370
申请日：2011-06-14
申请人： ZONAR SYSTEMS INC , BRINTON BRETT , MCQUADE CHARLES MICHAEL , ANDRE ROGER , HANSEN JOSHUA
发明人： BRINTON BRETT , MCQUADE CHARLES MICHAEL , ANDRE ROGER , HANSEN JOSHUA
IPC分类号： F02D41/30 , F02D41/24 , F02D45/00 , G01S19/39
CPC分类号： G08G1/096805 , B60R16/0236 , G07C5/008 , G07C5/0808 , G08G1/096844 , G08G1/20
摘要： System and method for analyzing position data and fuel injector data from a vehicle equipped with a geographical position system (GPS) and fuel injector sensors to enable fuel use patterns of the vehicle to be analyzed. Data defining a flow of fuel through the vehicle's fuel injectors is combined with temporal data and GPS data to produce fuel use encoded GPS data that is transmitted to a remote computer. The fuel use encoded GPS data can be analyzed to determine how much fuel was used by the vehicle during off road use to enable proper fuel tax computations to be performed. The data can also be used to evaluate the mechanical condition of a vehicle. By monitoring fuel use for a trip repeated numerous times, a decrease in fuel efficiency may indicate a mechanical problem (dirty injectors, fouled spark plugs, etc).
摘要翻译：用于分析来自配备有地理位置系统（GPS）和燃料喷射器传感器的车辆的位置数据和燃料喷射器数据的系统和方法，以使车辆的燃料使用模式能够被分析。通过车辆燃料喷射器定义燃料流的数据与时间数据和GPS数据组合，以产生传输到远程计算机的燃料使用编码的GPS数据。可以分析燃料使用编码的GPS数据，以确定车辆在越野道路使用期间使用多少燃料以实现正确的燃油税计算。数据也可用于评估车辆的机械状态。通过多次监视行程的燃料使用，燃油效率的降低可能表示机械问题（脏喷油器，污垢火花塞等）。

8. 发明申请

WO2009111279A1 PYRAZOLE [3, 4-B] PYRIDINE RAF INHIBITORS 审中-公开
标题翻译：吡咯并[3,4-B]吡啶类RAF抑制剂
公开(公告)号：WO2009111279A1
公开(公告)日：2009-09-11
申请号：PCT/US2009/035381
申请日：2009-02-27
申请人： ARRAY BIOPHARMA INC. , GENENTECH, INC. , AHRENDT, Kateri A. , BUCKMELTER, Alexandre J. , DE MEESE, Jason , GRINA, Jonas , HANSEN, Joshua D. , LAIRD, Ellen R. , LUNGHOFER, Paul , MORENO, David , NEWHOUSE, Brad , REN, Li , SEO, Jeongbeob , TIAN, Hongqi , WENGLOWSKY, Steven Mark , FENG, Bainian , GUNZNER, Janet , MALESKY, Kim , MATHIEU, Simon , RUDOLPH, Joachim , WEN, Zhaoyang , YOUNG, Wendy B.
发明人： AHRENDT, Kateri A. , BUCKMELTER, Alexandre J. , DE MEESE, Jason , GRINA, Jonas , HANSEN, Joshua D. , LAIRD, Ellen R. , LUNGHOFER, Paul , MORENO, David , NEWHOUSE, Brad , REN, Li , SEO, Jeongbeob , TIAN, Hongqi , WENGLOWSKY, Steven Mark , FENG, Bainian , GUNZNER, Janet , MALESKY, Kim , MATHIEU, Simon , RUDOLPH, Joachim , WEN, Zhaoyang , YOUNG, Wendy B.
IPC分类号： C07D471/04 , C07C311/08 , A61K31/437 , A61P13/12 , A61P35/00
CPC分类号： C07D471/04 , C07C311/08
摘要： Compounds of Formula I are useful for inhibition of Raf kinases. Methods of using compounds of Formula I and stereoisomers, tautomers, prodrugs and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.
摘要翻译：式I化合物可用于抑制Raf激酶。公开了使用式I化合物和立体异构体，互变异构体，前药和其药学上可接受的盐在体外，原位和体内诊断，预防或治疗哺乳动物细胞或相关病理状况中的这种病症的方法。

9. 发明申请

WO2009111277A9 IMIDAZO [4. 5-B] PYRIDINE DERIVATIVES USED AS RAF INHIBITORS 审中-公开
公开(公告)号：WO2009111277A9
公开(公告)日：2009-09-11
申请号：PCT/US2009/035379
申请日：2009-02-27
申请人： ARRAY BIOPHARMA INC. , GENENTECH, INC. , AHRENDT, Kateri, A. , BUCKMELTER, Alexandre, J. , GRINA, Jonas , HANSEN, Joshua, D. , LAIRD, Ellen, R. , NEWHOUSE, Brad , REN, Li , WENGLOWSKY, Steven, M. , FENG, Bainian , MALESKY, Kim , MATHIEU, Simon , RUDOLPH, Joachim , WEN, Zhaoyang , YOUNG, Wendy, B. , MORENO, David, A.
发明人： AHRENDT, Kateri, A. , BUCKMELTER, Alexandre, J. , GRINA, Jonas , HANSEN, Joshua, D. , LAIRD, Ellen, R. , NEWHOUSE, Brad , REN, Li , WENGLOWSKY, Steven, M. , FENG, Bainian , MALESKY, Kim , MATHIEU, Simon , RUDOLPH, Joachim , WEN, Zhaoyang , YOUNG, Wendy, B. , MORENO, David, A.
IPC分类号： C07D471/04 , C07C311/08 , A61K31/437 , A61P35/00 , A61P13/12
摘要： Compounds of Formula I are useful for inhibition of Raf kinases. Methods of using compounds of Formula I and stereoisomers and pharmaceutically acceptable salts thereof, for in vitro , in situ , and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.

10. 发明申请

WO2012118492A1 HETEROCYCLIC SULFONAMIDES AS RAF INHIBITORS 审中-公开
标题翻译：杂环磺酰胺作为RAF抑制剂
公开(公告)号：WO2012118492A1
公开(公告)日：2012-09-07
申请号：PCT/US2011/026700
申请日：2011-03-01
申请人： ARRAY BIOPHARMA INC. , GENENTECH, INC. , GRINA, Jonas , HANSEN, Joshua D. , LAIRD, Ellen , MATHIEU, Simon , MORENO, David , REN, Li , RUDOLPH, Joachim , WENGLOWSKY, Steven Mark
发明人： GRINA, Jonas , HANSEN, Joshua D. , LAIRD, Ellen , MATHIEU, Simon , MORENO, David , REN, Li , RUDOLPH, Joachim , WENGLOWSKY, Steven Mark
IPC分类号： C07D239/74 , C07D239/88 , C07D239/94 , C07D241/44 , C07D403/04 , C07D405/14 , A61K31/498 , A61K31/517 , A61P35/00
CPC分类号： C07D239/88 , C07D239/74 , C07D239/94 , C07D241/44 , C07D403/04 , C07D405/14
摘要： Compounds of Formula (I) are useful for inhibition of Raf kinases. Methods of using compounds of Formula (I), stereoisomers, tautomers and pharmaceutically acceptable salts thereof, for i n vitro , in situ , and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.
摘要翻译：式（I）的化合物可用于抑制Raf激酶。公开了使用式（I）化合物，立体异构体，互变异构体及其药学上可接受的盐在体外，原位和体内诊断，预防或治疗哺乳动物细胞或相关病理状况中的这种病症的方法。

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