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1. 发明申请

WO2012015952A3 APPARATUS AND METHOD OF DESIGNING OR OPTIMIZING A COLUMN FOR A SEPARATION PROCESS 审中-公开
标题翻译：设计或优化分离过程的色谱柱的设备和方法
公开(公告)号：WO2012015952A3
公开(公告)日：2013-01-24
申请号：PCT/US2011045576
申请日：2011-07-27
申请人： ASPEN TECHNOLOGY INC , HANLEY BRIAN
发明人： HANLEY BRIAN
IPC分类号： G06F17/50 , B01D3/14 , B01D3/42 , B01D53/14 , B01J19/32 , F25J3/00
CPC分类号： B01D3/4211 , B01D53/1412 , B01D53/1475 , B01D53/18 , G06F17/5009 , G06F2217/16 , Y02C10/06
摘要： A method of designing or optimizing a column for a separation process includes the computer implemented steps of, in a digital processor, providing vapor- side and liquid-side mass transfer coefficient expressions and a mass transfer area expression relevant for a subject column, the vapor-side and liquid-side mass transfer coefficient expressions and the mass transfer area expression having been derived from defining a column average height equivalent to a theoretical plate ) as a mathematical relationship in which is proportional to a vapor flow rate, is inversely proportional to effective packing area participating in mass transfer, has a first correction factor with respect to liquid-side mass transfer, and has a second correction factor with respect to vapor-side mass transfer. The expressions are further derived from reducing error of curve fitting empirical data of various columns by using the defined to obtain expressions for the vapor-side and liquid-side mass transfer coefficients and mass transfer area. The method also includes using the provided expressions to determine column height and column width configurations of the subject column, and outputting the determined column height and column width configurations of the subject column.
摘要翻译：设计或优化用于分离过程的色谱柱的方法包括计算机实现的步骤，在数字处理器中，提供蒸气侧和液体传质系数表达式以及与主题柱相关的传质面积表达式，蒸汽侧面和液体传质系数表达式以及从限定与理论塔板相当的塔平均高度得出的传质面积表达式）作为与蒸气流量成比例的数学关系，与有效值成反比参与质量传递的包装区域具有关于液体传质的第一校正因子，并且具有关于蒸气侧传质的第二校正因子。通过使用定义来获得蒸气侧和液体传质系数和传质面积的表达式，进一步得出了各列曲线拟合经验数据的误差。该方法还包括使用所提供的表达式来确定主题列的列高度和列宽度配置，并输出所确定的主题列的列高度和列宽度配置。

2. 发明申请

WO2010088528A2 CERVICAL OPENING SEALING DEVICES 审中-公开
标题翻译：颈椎开放密封装置
公开(公告)号：WO2010088528A2
公开(公告)日：2010-08-05
申请号：PCT/US2010/022601
申请日：2010-01-29
申请人： CYTYC CORPORATION , LAYTON, Russell, K., Jr. , MACLEAN, Lionel, Stewart , FREED, David , HANLEY, Brian
发明人： LAYTON, Russell, K., Jr. , MACLEAN, Lionel, Stewart , FREED, David , HANLEY, Brian
IPC分类号： A61B17/42
CPC分类号： A61B17/42 , A61B2017/3419 , A61B2017/4216 , A61B2017/4225 , A61B2090/064
摘要： A device for sealing a cervical opening includes a support structure, and a seal coupled to the support structure, the seal having a surface for abutting against tissue next to the cervical opening, wherein the seal is tiltable relative to the support structure. A device for sealing a cervical opening includes a support structure, and a member coupled to the support structure, wherein the member is inflatable to create a seal for abutting against cervical tissue. A device for sealing a cervical opening includes a seal having a surface for contacting tissue next to the cervical opening, an opening formed on the surface of the seal, and a vacuum port, wherein the opening is in fluid communication with the vacuum port.
摘要翻译：
一种用于密封颈部开口装置包括支撑结构，以及耦合到所述支撑结构的密封件，其具有用于抵靠组织旁边的宫颈开口，一个表面上的密封件，其中所述密封件是可倾斜的相对到支撑结构。一种用于密封宫颈开口装置包括支撑结构，以及耦合到所述支撑结构上的构件，其中所述构件是可膨胀的，以形成密封用于抵靠宫颈组织。一种用于密封颈部开口装置包括具有用于接触旁边的宫颈开口，形成在所述密封件的表面上的开口，和一个真空口，其中所述开口与所述真空端口流体连通的组织的表面的密封。< / p>

3. 发明申请

WO2017197301A1 SAFE DELIVERY OF CRISPR AND OTHER GENE THERAPIES TO LARGE FRACTIONS OF SOMATIC CELLS IN HUMANS AND ANIMALS 审中-公开
标题翻译：将人体CRISPR和其他基因治疗安全地提供给人体中大量体细胞的成分
公开(公告)号：WO2017197301A1
公开(公告)日：2017-11-16
申请号：PCT/US2017/032470
申请日：2017-05-12
申请人： HANLEY, Brian, P.
发明人： HANLEY, Brian, P.
IPC分类号： A01H1/00 , A01K67/027 , A61K31/7088 , A61K31/7105
摘要： A method for making it possible to deliver nucleic acid sequences to a large fraction of, or even 99.9% and more of the cells in a human body without near certainty of killing the recipient. It can be applied to safely deliver any gene therapy. This invention comprises a set of known compounds, many of them already approved, combined in novel ways to prevent immune system reaction to levels of delivery vehicle (capsid or synthetic carrier) introduced into the body that can be 5 or more orders of magnitude higher than has been demonstrated to cause human death. When used in concert with the disclosed CRISPR expression control method, this method can improve expression and allow better control over the gene therapy's target activity.
摘要翻译：一种使得有可能将核酸序列递送到人体中的大部分或甚至99.9％和更多的细胞而不会确定地杀死接受者的方法。它可以用于安全地提供任何基因治疗。本发明包括一组已知的化合物，其中许多已被批准，以新颖的方式组合，以防止免疫系统对引入体内的递送载体（衣壳或合成载体）水平的反应，所述递送载体（衣壳或合成载体）的剂量可以高5个数量级或更多个数量级已被证明会导致人类死亡。当与公开的CRISPR表达控制方法一起使用时，该方法可以改善表达并且允许更好地控制基因疗法的靶活性。

4. 发明申请

WO2012015952A2 APPARATUS AND METHOD OF DESIGNING OR OPTIMIZING A COLUMN FOR A SEPARATION PROCESS 审中-公开
标题翻译：设计或优化分离过程的色谱柱的装置和方法
公开(公告)号：WO2012015952A2
公开(公告)日：2012-02-02
申请号：PCT/US2011/045576
申请日：2011-07-27
申请人： ASPEN TECHNOLOGY, INC. , HANLEY, Brian
发明人： HANLEY, Brian
IPC分类号： G06F17/50
CPC分类号： B01D3/4211 , B01D53/1412 , B01D53/1475 , B01D53/18 , G06F17/5009 , G06F2217/16 , Y02C10/06
摘要： A method of designing or optimizing a column for a separation process includes the computer implemented steps of, in a digital processor, providing vapor- side and liquid-side mass transfer coefficient expressions and a mass transfer area expression relevant for a subject column, the vapor-side and liquid-side mass transfer coefficient expressions and the mass transfer area expression having been derived from defining a column average height equivalent to a theoretical plate 〈HETP〉) as a mathematical relationship in which 〈HETP〉 is proportional to a vapor flow rate, is inversely proportional to effective packing area participating in mass transfer, has a first correction factor with respect to liquid-side mass transfer, and has a second correction factor with respect to vapor-side mass transfer. The expressions are further derived from reducing error of curve fitting 〈HETP〉 empirical data of various columns by using the defined 〈HETP〉 to obtain expressions for the vapor-side and liquid-side mass transfer coefficients and mass transfer area. The method also includes using the provided expressions to determine column height and column width configurations of the subject column, and outputting the determined column height and column width configurations of the subject column.
摘要翻译：设计或优化用于分离过程的色谱柱的方法包括计算机实现的步骤，在数字处理器中，提供蒸气侧和液体传质系数表达式以及与主题列相关的传质面积表达式，蒸气侧面和液体质量传递系数表达式以及从定义与理论塔板相当的列平均高度得出的传质面积表达式）作为与蒸汽流速成比例的数学关系，与有效值成反比参与质量传递的包装区域具有关于液体传质的第一校正因子，并且具有关于蒸气侧传质的第二校正因子。通过使用定义得到蒸气侧和液体侧传质系数和传质面积的表达式，进一步得出了各列曲线拟合经验数据的误差。该方法还包括使用所提供的表达式来确定主题列的列高度和列宽配置，并输出所确定的列高度和列宽度配置。

5. 发明申请

WO2009045868A1 THERMAL MONITORING 审中-公开
标题翻译：热监测
公开(公告)号：WO2009045868A1
公开(公告)日：2009-04-09
申请号：PCT/US2008/077772
申请日：2008-09-26
申请人： BOSTON SCIENTIFIC SCIMED, INC. , OSKIN, Christopher L. , HANLEY, Brian M. , BARENBOYM, Michael
发明人： OSKIN, Christopher L. , HANLEY, Brian M. , BARENBOYM, Michael
IPC分类号： A61B5/00 , G01K13/00
CPC分类号： A61B5/4381 , A61B5/01 , G01K13/002
摘要： A rectal thermal monitor for transrectal prostate temperature measurement includes a handle arranged in a proximal end portion of the monitor for gripping by a user, an elongate shaft extending from the handle, and a probe portion arranged on a distal end portion of the shaft. The probe portion is arranged at a position opposite the handle portion, and is shaped to facilitate insertion through an anal sphincter and into a rectum of a patient. A temperature sensing element is arranged within the distal probe portion and is adapted and configured to sense a temperature of the prostate of the patient through the rectum wall of the patient. The probe portion can include one or more compliant materials and/or be shaped so as to compress during insertion through the anal sphincter of the patient.
摘要翻译：用于经直肠前列腺温度测量的直肠热监测器包括布置在监护仪的近端部分中的用于由使用者抓握的手柄，从手柄延伸的细长轴和布置在轴的远端部分上的探针部分。探针部分布置在与把手部分相对的位置处，并且被成形为便于通过肛门括约肌插入并进入患者的直肠。温度感测元件布置在远端探针部分内，并且适于和构造成通过患者的直肠壁感测患者的前列腺的温度。探针部分可以包括一种或多种顺应性材料和/或被成形以在插入期间通过患者的肛门括约肌压缩。

6. 发明申请

WO2017197301A4 SAFE DELIVERY OF CRISPR AND OTHER GENE THERAPIES TO LARGE FRACTIONS OF SOMATIC CELLS IN HUMANS AND ANIMALS 审中-公开
公开(公告)号：WO2017197301A4
公开(公告)日：2017-11-16
申请号：PCT/US2017/032470
申请日：2017-05-12
申请人： HANLEY, Brian, P.
发明人： HANLEY, Brian, P.
IPC分类号： A01H1/00 , A01K67/027 , A61K31/7088 , A61K31/7105
摘要： A method for making it possible to deliver nucleic acid sequences to a large fraction of, or even 99.9% and more of the cells in a human body without near certainty of killing the recipient. It can be applied to safely deliver any gene therapy. This invention comprises a set of known compounds, many of them already approved, combined in novel ways to prevent immune system reaction to levels of delivery vehicle (capsid or synthetic carrier) introduced into the body that can be 5 or more orders of magnitude higher than has been demonstrated to cause human death. When used in concert with the disclosed CRISPR expression control method, this method can improve expression and allow better control over the gene therapy's target activity.

7. 发明申请

WO2009143112A1 SIDE-FIRING LASER FIBER WITH GLASS FUSED REFLECTOR AND CAPILLARY AND RELATED METHODS 审中-公开
标题翻译：具有玻璃熔融反射器和毛细管的激光激光光纤和相关方法
公开(公告)号：WO2009143112A1
公开(公告)日：2009-11-26
申请号：PCT/US2009/044462
申请日：2009-05-19
申请人： BOSTON SCIENTIFIC SCIMED, INC. , HANLEY, Brian, M. , HIXON, Jessica , OSKIN, Christopher, L. , SINOFSKY, Edward
发明人： HANLEY, Brian, M. , HIXON, Jessica , OSKIN, Christopher, L. , SINOFSKY, Edward
IPC分类号： A61B18/22
CPC分类号： A61B18/24 , A61B18/22 , A61B2018/2272
摘要： A method and an apparatus according to an embodiment of the invention includes a reflector and an optical fiber end portion disposed within a capillary for use in side-firing optical fibers. The reflector surface can be coated with a multilayer dielectric coating to increase the amount of side-fired laser energy. An outer member or cap can be used to protect the capillary when being inserted through a catheter or endoscope. The endoscope is then at least partially inserted into a patient's body to provide laser-based medical treatment. Multiple grooves can be defined on an outer surface of the optical fiber buffer layer to increase the surface area and improve the mechanical strength of the coupling between the optical fiber and the capillary. In some embodiments, the outer member or cap can also be coupled to the grooved surface portion of the optical fiber buffer layer.
摘要翻译：根据本发明的实施例的方法和装置包括反射器和布置在毛细管内用于侧射光纤的光纤端部。反射器表面可以涂覆有多层电介质涂层以增加侧激光能量的量。当通过导管或内窥镜插入时，可以使用外部构件或帽来保护毛细管。然后将内窥镜至少部分地插入患者体内以提供基于激光的医疗。可以在光纤缓冲层的外表面上限定多个凹槽以增加表面积并提高光纤与毛细管之间的耦合的机械强度。在一些实施例中，外部构件或帽也可以联接到光纤缓冲层的带槽的表面部分。

8. 发明申请

WO2013015979A3 COMPOSITIONS CONTAINING ZINC SALTS AND ISOTHIOCYANATES FOR REDUCTION OF ORAL VOLATILE SULFUR COMPOUNDS (VSCS) 审中-公开
公开(公告)号：WO2013015979A3
公开(公告)日：2013-01-31
申请号：PCT/US2012/046071
申请日：2012-07-10
申请人： WM. WRIGLEY JR. COMPANY , TIAN, Minmin , HANLEY, Brian , DODDS, Michael
发明人： TIAN, Minmin , HANLEY, Brian , DODDS, Michael
IPC分类号： A61K33/30 , A61K31/26 , A61K9/08 , A61P1/02
摘要： Combinations of a zinc salt and an isothiocyanate are provided, and more particularly to a consumer acceptable oral composition containing such combination which is effective in the reduction of volatile sulfur compounds (VSCs).

9. 发明申请

WO2013015979A2 COMPOSITIONS CONTAINING ZINC SALTS AND ISOTHIOCYANATES FOR REDUCTION OF ORAL VOLATILE SULFUR COMPOUNDS (VSCS) 审中-公开
标题翻译：含有锌盐和异硫氰酸酯的组合物用于减少口服挥发性硫化合物（VSCS）
公开(公告)号：WO2013015979A2
公开(公告)日：2013-01-31
申请号：PCT/US2012046071
申请日：2012-07-10
申请人： WRIGLEY W M JUN CO , TIAN MINMIN , HANLEY BRIAN , DODDS MICHAEL
发明人： TIAN MINMIN , HANLEY BRIAN , DODDS MICHAEL
IPC分类号： A61K33/30 , A61K9/08 , A61K31/26 , A61P1/02
CPC分类号： A61K8/46 , A23G1/325 , A23G3/362 , A23G4/064 , A23K20/30 , A61K8/27 , A61K8/36 , A61K8/361 , A61K8/365 , A61K8/4973 , A61K8/676 , A61K9/0056 , A61K9/0058 , A61K9/2018 , A61K31/26 , A61K31/5375 , A61K33/30 , A61Q11/00 , A61K2300/00
摘要： Combinations of a zinc salt and an isothiocyanate are provided, and more particularly to a consumer acceptable oral composition containing such combination which is effective in the reduction of volatile sulfur compounds (VSCs).
摘要翻译：提供锌盐和异硫氰酸酯的组合，更具体地说，涉及含有这种组合的消费者可接受的口服组合物，其有效减少挥发性硫化合物（VSC）。

10. 发明申请

WO2010088528A3 CERVICAL OPENING SEALING DEVICES 审中-公开
标题翻译：开口密封装置
公开(公告)号：WO2010088528A3
公开(公告)日：2010-10-21
申请号：PCT/US2010022601
申请日：2010-01-29
申请人： CYTYC CORP , LAYTON RUSSELL K JR , MACLEAN LIONEL STEWART , FREED DAVID , HANLEY BRIAN
发明人： LAYTON RUSSELL K JR , MACLEAN LIONEL STEWART , FREED DAVID , HANLEY BRIAN
IPC分类号： A61B17/42
CPC分类号： A61B17/42 , A61B2017/3419 , A61B2017/4216 , A61B2017/4225 , A61B2090/064
摘要： A device for sealing a cervical opening includes a support structure, and a seal coupled to the support structure, the seal having a surface for abutting against tissue next to the cervical opening, wherein the seal is tiltable relative to the support structure. A device for sealing a cervical opening includes a support structure, and a member coupled to the support structure, wherein the member is inflatable to create a seal for abutting against cervical tissue. A device for sealing a cervical opening includes a seal having a surface for contacting tissue next to the cervical opening, an opening formed on the surface of the seal, and a vacuum port, wherein the opening is in fluid communication with the vacuum port.
摘要翻译：用于密封颈部开口的装置包括支撑结构和联接到支撑结构的密封件，密封件具有用于邻接颈部开口的组织抵靠的表面，其中密封件相对于支撑结构是可倾斜的。用于密封颈部开口的装置包括支撑结构和联接到支撑结构的构件，其中构件可充气以形成用于邻接宫颈组织的密封。用于密封颈部开口的装置包括具有用于接触颈部开口旁边的组织的表面的密封件，形成在密封件的表面上的开口和真空口，其中开口与真空口流体连通。

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