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1. 发明申请

WO2012077853A1 PROCESS FOR PREPARING CASPOFUNGIN AND NOVEL INTERMEDIATES THEREOF 审中-公开
标题翻译：制备CASPOFUNGIN及其新型中间体的方法
公开(公告)号：WO2012077853A1
公开(公告)日：2012-06-14
申请号：PCT/KR2011/000196
申请日：2011-01-12
申请人： CKD BIO CORP. , KANG, Heui-Il , HAM, Yun-Beom , KYONG, Su-Hyun , KANG, Heung-Mo , HAN, Tae-Hee , KANG, Doo-Jin
发明人： KANG, Heui-Il , HAM, Yun-Beom , KYONG, Su-Hyun , KANG, Heung-Mo , HAN, Tae-Hee , KANG, Doo-Jin
IPC分类号： C07D487/14 , C07C211/10
CPC分类号： C07K7/56 , C07D487/14
摘要： The present invention relates to a novel process for preparing the aza cyclohexapeptide compound 1-[(4R,5S)-5-[(2-aminoethyl)amino]-N 2 -(10,12-dimethyl-1-oxotetradecyl)-4-hydroxy-L-ornithine]-5-[(3R)-3-hydroxy-L-ornithine]-pneumocandin B 0 (caspofungin), which can improve the problem due to a pungent odor and toxicity during the process and can prepare caspofungin as a final product at high yield compared to conventional processes, and to novel intermediates which are used in the preparation process.
摘要翻译：本发明涉及一种制备氮杂环己肽化合物1 - [（4R，5S）-5 - [（2-氨基乙基）氨基] -N2-（10,12-二甲基-1-氧代十四烷基）-4- 羟基-L-鸟氨酸] -5 - [（3R）-3-羟基-L-鸟氨酸]肺炎球菌素B0（卡泊芬净），其可以改善由于在该过程中刺激性气味和毒性引起的问题，并且可以制备卡泊芬净最终产品与常规方法相比具有高产率，以及用于制备过程中的新型中间体。

2. 发明申请

WO2011136478A3 METHOD FOR PREPARING TRANSPARENT ANTISTATIC FILMS USING GRAPHENE AND TRANSPARENT ANTISTATIC FILMS PREPARED BY THE SAME 审中-公开
标题翻译：使用石墨制备透明抗静电膜的方法及其制备的透明抗静电膜
公开(公告)号：WO2011136478A3
公开(公告)日：2012-03-01
申请号：PCT/KR2011002350
申请日：2011-04-05
申请人： KOREA INST SCI & TECH , KOO CHONG MIN , HONG SOON MAN , HWANG SEUNG SANG , KWAK SOONJONG , BAEK KYUNG YOUL , MIN KYUNG HO , PARK YOUN DUK , KWAK HEE LA , KIM MYUNG HEE , KIM BO RI , CHOI SEUNG-SOCK , HAN TAE HEE
发明人： KOO CHONG MIN , HONG SOON MAN , HWANG SEUNG SANG , KWAK SOONJONG , BAEK KYUNG YOUL , MIN KYUNG HO , PARK YOUN DUK , KWAK HEE LA , KIM MYUNG HEE , KIM BO RI , CHOI SEUNG-SOCK , HAN TAE HEE
IPC分类号： C09D7/12 , C09D4/02 , C09D5/00 , C09D183/02
CPC分类号： C09D183/04 , C08F222/1006 , C08G77/20 , C08K3/042 , C09D7/70 , C09D11/38 , C09D11/52 , Y10T428/25 , C09D183/06
摘要： The present invention relates to transparent antistatic films using graphene, and methods for preparing the same. The films include conductive particles comprising a single-layer or multi-layer graphene, and a binder. The films are prepared by dispersing graphene in a solvent to obtain a graphene dispersion; dissolving a curable binder to a solvent to obtain a binder solution; mixing the graphene dispersion, the binder solution and optionally an additive to obtain a coating solution; applying the coating solution onto a substrate and drying the solutin to form a coated film; and curing the coated film. According to the present invention, transparent or semitransparent antistatic films having excellent permeability, abrasion resistance, scratch resistance, chemical stability and dimensional stability can be prepared. The films also have superior adhesion to substrates and applicability, and thus may be advantageously applied to rigid or flexible substrates.
摘要翻译：本发明涉及使用石墨烯的透明抗静电膜及其制备方法。膜包括包含单层或多层石墨烯的导电颗粒和粘合剂。通过将石墨烯分散在溶剂中以获得石墨烯分散体来制备膜; 将可固化粘合剂溶解到溶剂中以获得粘合剂溶液; 将石墨烯分散体，粘合剂溶液和任选的添加剂混合以获得涂布溶液; 将涂布溶液涂布在基材上并干燥溶液以形成涂膜; 并固化涂膜。根据本发明，可以制备具有优异的透气性，耐磨性，耐擦伤性，化学稳定性和尺寸稳定性的透明或半透明抗静电膜。该膜还具有优异的与基材的粘合性和适用性，因此可有利地应用于刚性或柔性基材。

3. 发明申请

WO2011115422A2 MICROJET DRUG DELIVERY SYSTEM AND MICROJET INJECTOR 审中-公开
标题翻译： MICROJET药物输送系统和微注射器
公开(公告)号：WO2011115422A2
公开(公告)日：2011-09-22
申请号：PCT/KR2011001834
申请日：2011-03-16
申请人： SNU R&DB FOUNDATION , YOH JAI-ICK , HAN TAE-HEE
发明人： YOH JAI-ICK , HAN TAE-HEE
IPC分类号： A61M5/307 , A61M5/178
CPC分类号： A61M5/30 , A61B2018/263 , A61M5/204 , A61M5/2046 , A61M5/31511
摘要： The present invention relates to a microjet drug delivery system for microjet spraying a drug solution stored inside to inject the same into the bodily tissue of a person to be operated, and a microjet injector. The microjet injector comprises: a pressure chamber completely filled with the liquid for propelling pressure, having an accommodation space with one side opened; an elastic film, which is a film member made of an elastic material, arranged so as to form a closed space by closing the opened one side of the pressure chamber; a drug chamber for accommodating a drug solution in a predetermined inner space, provided adjacent to the pressure chamber with interposing the elastic film therebetween; and a microjet nozzle communicating with the inner space of the pressure chamber so as to be formed as a channel for allowing the drug solution stored inside the pressure chamber to be microjet sprayed to the outside. The microjet drug delivery system provided by the present invention comprises: the microjet injector; an energy focusing device for generating bubbles in the liquid for propelling pressure stored in the pressure chamber by applying a concentrated energy to the liquid for propelling pressure; and a connecting adaptor for selectively detachably coupling the microjet injector to the energy focusing device.
摘要翻译：本发明涉及一种微喷射药物输送系统，用于微喷射储存在内部的药液以将其注射到待操作的人的身体组织中，以及微型喷射器。微型喷射器包括：完全充满液体的压力室，用于推动压力，具有一侧打开的容纳空间; 作为由弹性材料制成的膜构件的弹性膜，通过封闭压力室的打开的一侧而形成封闭空间; 用于将药液容纳在预定的内部空间中的药物室，其设置在与所述压力室相邻的位置处，将所述弹性膜插入其间; 以及与压力室的内部空间连通的微型喷嘴，以形成为将储存在压力室内的药液向微喷射喷射到外部的通道。本发明提供的微喷射药物输送系统包括：微型喷射器; 一种能量聚焦装置，用于在液体中产生气泡，用于通过向液体中施加集中的能量来推动压力存储在压力室中的压力; 以及连接适配器，用于将微喷射喷射器可选地可拆卸地连接到能量聚焦装置。

4. 发明申请

WO2008069451A1 IMPROVED PROCESS FOR THE PREPARATION OF CLEVUDINE AS ANTI-HBV AGENT 审中-公开
标题翻译：用于制备CLEVUDINE作为抗HBV药剂的改进方法
公开(公告)号：WO2008069451A1
公开(公告)日：2008-06-12
申请号：PCT/KR2007/005441
申请日：2007-10-31
申请人： BUKWANG PHARM CO., LTD. , WOO, Seong-Ju , PARK, Hee-Kwang , SONG, Kwang-Ho , HAN, Tae-Hee , KOO, Chang-Hui
发明人： WOO, Seong-Ju , PARK, Hee-Kwang , SONG, Kwang-Ho , HAN, Tae-Hee , KOO, Chang-Hui
IPC分类号： A61K31/501
CPC分类号： C07D405/04
摘要： Disclosed herein is an improved method for preparing l -(2'-deoxy-2'- fluoro-beta-L-arabinofuranosyl) thymine (clevudine) useful as an anti-HBV (hepatitis B vims) agent. The method comprises an improved purification process of 2-O-imidazolylsulfonyl-l,3,5-tri-O-benzoyl-alpha-L-ribofuranoside used as a key intermediate in the preparation of clevudine, and a final deprotection process using an alkaline metal salt, which is safe and easy to handle, as a deprotecting reagent of l-(3,5-di-O-benzoyl-2-deoxy-2-fluoro-beta- L-arabinofuranosyl) thymine so that productivity can be increased.
摘要翻译：本文公开了用作抗HBV（乙型肝炎）药剂的1-（2'-脱氧-2'-氟-β-L-阿拉伯呋喃糖基）胸腺嘧啶（clevudine）的改进方法。该方法包括用作制备克氟维丁的关键中间体的2-O-咪唑基磺酰基-1,3,5-三-O-苯甲酰基-α-L-呋喃核糖苷的改进的纯化方法，以及使用碱性的最终去保护方法金属盐，其是安全且易于处理的，作为1-（3,5-二-O-苯甲酰基-2-脱氧-2-氟-β-L-阿拉伯呋喃糖基）胸腺嘧啶的去保护试剂，从而可以提高生产率。

5. 发明申请

WO2005064579A1 EXPIRATION DATE DISPLAY DEVICE 审中-公开
标题翻译：到期日显示设备
公开(公告)号：WO2005064579A1
公开(公告)日：2005-07-14
申请号：PCT/KR2004/003427
申请日：2004-12-23
申请人： HAN, Tae Hee
发明人： HAN, Tae Hee
IPC分类号： G09F19/00
CPC分类号： G06K19/07703 , B65D2203/10 , G06K19/0723 , G06K19/07758 , G09F23/00
摘要： The invention relates to a expiration date display device wherein the customers may easily perceive that the expiration date is passed by. According to the invention, the accident owing to the goods whose expiration data is passed by like as food poisoning or drugs side effect may be prevented. According to an aspect of the invention, there is provided an expiration date display device comprising: a controller (15) which is attached to the container (10) containing goods like as food medicine, the expiration date of the goods is stored therein, and outputs electric signal when the stored expiration date expires; a battery (20) which is attached to the container (10) and supplies the power to the controller (15); and a display means (30) which is electrically connected to the controller (15) and is exposed at the surface of the container (10), and displays the expiration symbol (25) notifying expiration of the expiration date if the electric signal is outputted from the controller (15).
摘要翻译：本发明涉及一种到期日期显示装置，其中客户可以容易地察觉过期日期过去。根据本发明，可以防止因过期数据通过如食物中毒或药物副作用而导致的事故。根据本发明的一个方面，提供了一种有效期限显示装置，包括：控制器（15），其附接到容纳食品的容器（10），如食品，货物的有效期被存储在其中，当存储的到期日期到期时输出电信号; 电池（20），其连接到所述容器（10）并将电力供给到所述控制器（15）; 以及电连接到控制器（15）并且暴露在容器（10）的表面的显示装置（30），并且如果输出电信号则显示通知有效期限到期的到期符号（25）从控制器（15）。

6. 发明申请

WO2011037388A3 3-DIMENSIONAL NANOSTRUCTURE HAVING NANOMATERIALS STACKED ON GRAPHENE SUBSTRATE AND FABRICATION METHOD THEREOF 审中-公开
标题翻译：具有堆积在石墨基板上的纳米材料的三维纳米结构及其制造方法
公开(公告)号：WO2011037388A3
公开(公告)日：2011-09-09
申请号：PCT/KR2010006461
申请日：2010-09-20
申请人： KOREA ADVANCED INST SCI & TECH , KIM SANG OUK , LEE WON JONG , LEE DUCK HYUN , HAN TAE HEE , KIM JI EUN , LEE JIN AH , LEE KEON JAE
发明人： KIM SANG OUK , LEE WON JONG , LEE DUCK HYUN , HAN TAE HEE , KIM JI EUN , LEE JIN AH , LEE KEON JAE
IPC分类号： B82B3/00 , H01L21/02
CPC分类号： H01L29/0665 , B82Y10/00 , B82Y40/00 , H01J1/304 , H01J9/025 , H01L51/0048 , Y10T428/25 , Y10T428/30
摘要： The present invention relates to a 3-dimensional nanostructure having nanomaterials stacked on a graphene substrate; and more specifically, to a 3-dimensional nanostructure having at least one nanomaterial selected from nanotubes, nanowires, nanorods, nanoneedles and nanoparticles grown on a reduced graphene substrate. The present invention enables the achievement of a synergy effect of the 3-dimensional nanostructure hybridizing 1-dimensional nanomaterials and 2-dimensional graphene. The nanostructure according to the present invention is excellent in flexibility and elasticity, and can easily be transferred to any substrate having a non-planar surface. Also, all junctions in nanomaterials, a metal catalyst and a graphene film system form the ohmic electrical contact, which allows the nanostructure to easily be incorporated into a field-emitting device.
摘要翻译：本发明涉及一种具有层叠在石墨烯衬底上的纳米材料的三维纳米结构; 更具体地说，涉及一种具有至少一种纳米材料的纳米结构的纳米结构，所述纳米材料选自在还原的石墨烯衬底上生长的纳米管，纳米线，纳米针和纳米线。本发明能够实现3维纳米结构与1维纳米材料和2维石墨烯杂交的协同作用。本发明的纳米结构体的柔软性和弹性优异，可以容易地转印到具有非平面的任何基材上。而且，纳米材料中的所有结，金属催化剂和石墨烯膜系统形成欧姆电接触，这允许纳米结构容易地结合到场发射器件中。

7. 发明申请

WO2011136478A2 METHOD FOR PREPARING TRANSPARENT ANTISTATIC FILMS USING GRAPHENE AND TRANSPARENT ANTISTATIC FILMS PREPARED BY THE SAME 审中-公开
标题翻译：使用石墨制备透明抗静电膜的方法及其制备的透明抗静电膜
公开(公告)号：WO2011136478A2
公开(公告)日：2011-11-03
申请号：PCT/KR2011/002350
申请日：2011-04-05
申请人： KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY , KOO, Chong Min , HONG, Soon Man , HWANG, Seung Sang , KWAK, Soonjong , BAEK, Kyung Youl , MIN, Kyung Ho , PARK, Youn Duk , KWAK, Hee La , KIM, Myung Hee , KIM, Bo Ri , CHOI, Seung-Sock , HAN, Tae Hee
发明人： KOO, Chong Min , HONG, Soon Man , HWANG, Seung Sang , KWAK, Soonjong , BAEK, Kyung Youl , MIN, Kyung Ho , PARK, Youn Duk , KWAK, Hee La , KIM, Myung Hee , KIM, Bo Ri , CHOI, Seung-Sock , HAN, Tae Hee
IPC分类号： C09D7/12 , C09D5/00 , C09D183/02 , C09D4/02
CPC分类号： C09D183/04 , C08F222/1006 , C08G77/20 , C08K3/042 , C09D7/70 , C09D11/38 , C09D11/52 , Y10T428/25 , C09D183/06
摘要： The present invention relates to transparent antistatic films using graphene, and methods for preparing the same. The films include conductive particles comprising a single-layer or multi-layer graphene, and a binder. The films are prepared by dispersing graphene in a solvent to obtain a graphene dispersion; dissolving a curable binder to a solvent to obtain a binder solution; mixing the graphene dispersion, the binder solution and optionally an additive to obtain a coating solution; applying the coating solution onto a substrate and drying the solutin to form a coated film; and curing the coated film. According to the present invention, transparent or semitransparent antistatic films having excellent permeability, abrasion resistance, scratch resistance, chemical stability and dimensional stability can be prepared. The films also have superior adhesion to substrates and applicability, and thus may be advantageously applied to rigid or flexible substrates.
摘要翻译：本发明涉及使用石墨烯的透明抗静电膜及其制备方法。膜包括包含单层或多层石墨烯的导电颗粒和粘合剂。通过将石墨烯分散在溶剂中以获得石墨烯分散体来制备膜; 将可固化粘合剂溶解到溶剂中以获得粘合剂溶液; 将石墨烯分散体，粘合剂溶液和任选的添加剂混合以获得涂布溶液; 将涂布溶液涂布在基材上并干燥溶液以形成涂膜; 并固化涂膜。根据本发明，可以制备具有优异的透气性，耐磨性，耐擦伤性，化学稳定性和尺寸稳定性的透明或半透明抗静电膜。该膜还具有优异的与基材的粘合性和适用性，因此可有利地应用于刚性或柔性基材。

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