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1. 发明申请

WO2003039489A3 ENDOCRINE PANCREAS DIFFERENTIATION OF ADIPOSE TISSUE-DERIVED STROMAL CELLS AND USES THEREOF 审中-公开
公开(公告)号：WO2003039489A3
公开(公告)日：2003-05-15
申请号：PCT/US2002/036373
申请日：2002-11-12
申请人： ARTECEL SCIENCES, INC. , CHEATHAM, Bentley , HALVORSEN, Yuan-Di, C. , GIMBLE, Jeffrey, M.
发明人： CHEATHAM, Bentley , HALVORSEN, Yuan-Di, C. , GIMBLE, Jeffrey, M.
IPC分类号： C12N5/05
摘要： The invention provides cells, compositions and methods based on the differentiation of adipose tissue-derived stromal cells into a cell expressing at least one genotypic or phenotypic characteristic of a pancreas cell. The cells produced in the method are useful in providing a source of differentiated and functional cells for research, implantation, transplantation and development of tissue engineered products for the treatment of diseases of the pancreas and pancreatic tissue repair.

2. 发明申请

WO2003039489A2 ENDOCRINE PANCREAS DIFFERENTIATION OF ADIPOSE TISSUE-DERIVED STROMAL CELLS AND USES THEREOF 审中-公开
标题翻译： ADIPOSE组织衍生的结构细胞的内皮素胰岛素分化及其用途
公开(公告)号：WO2003039489A2
公开(公告)日：2003-05-15
申请号：PCT/US2002/036373
申请日：2002-11-12
申请人： ARTECEL SCIENCES, INC. , CHEATHAM, Bentley , HALVORSEN, Yuan-Di, C. , GIMBLE, Jeffrey, M.
发明人： CHEATHAM, Bentley , HALVORSEN, Yuan-Di, C. , GIMBLE, Jeffrey, M.
IPC分类号： A61K
CPC分类号： C12N5/0676 , A61K35/12 , A61K2035/126 , C12N2501/115 , C12N2502/1305 , C12N2506/1384 , C12N2510/00
摘要： The invention provides cells, compositions and methods based on the differentiation of adipose tissue-derived stromal cells into a cell expressing at least one genotypic or phenotypic characteristic of a pancreas cell. The cells produced in the method are useful in providing a source of differentiated and functional cells for research, implantation, transplantation and development of tissue engineered products for the treatment of diseases of the pancreas and pancreatic tissue repair.
摘要翻译：本发明提供基于将脂肪组织来源的基质细胞分化成表达胰腺细胞的至少一种基因型或表型特征的细胞的细胞，组合物和方法。在该方法中产生的细胞可用于提供用于研究，植入，移植和开发用于治疗胰腺疾病和胰腺组织修复的组织工程化产品的分化和功能性细胞来源。

3. 发明申请

WO2004048512A3 NOVEL PROTEINS AND NUCLEIC ACIDS ENCODING SAME 审中-公开
公开(公告)号：WO2004048512A3
公开(公告)日：2004-06-10
申请号：PCT/US2002/038371
申请日：2002-12-03
申请人： CURAGEN CORPORATION , AGEE, Michele, L. , ALSOBROOK, John, P., II , ANDERSON, David, W. , BERGHS, Constance , BOLDOG, Ferenc, L. , BURGESS, Catherine, E. , CATTERTON, Elina , DIPIPPO, Vincent, A. , EDINGER, Shlomit, R. , EISEN, Andrew , ELLERMAN, Karen , GANGOLLI, Esha, A. , GERLACH, Valerie, L. , GORMAN, Linda , GOULD-ROTHBERG, Bonnie, E. , GUO, Xiaojia , HERRMANN, John, L. , HALVORSEN, Yuan-Di , JI, Weizhen , KEKUDA, Ramesh , KHRAMTSOV, Nikolai, V. , LAROCHELLE, William, J. , LEPLEY, Denise, M. , LI, Li , MACDOUGALL, John, R. , MILLER, Charles, E. , ORT, Tatiana , PADIGARU, Muralidhara , PATTURAJAN, Meera , PENA, Carol, E., A. , PEYMAN, John, A. , RIEGER, Daniel, K. , ROTHENBERG, Mark, E. , SHENOY, Suresh, G. , SMITHSON, Glennda , SPADERNA, Steven, K. , SPYTEK, Kimberly, A. , STONE, David, J. , TAUPIER, Raymond, J., Jr. , VERNET, Corine, A., M. , VOSS, Edward, Z. , ZHONG, Mei
发明人： AGEE, Michele, L. , ALSOBROOK, John, P., II , ANDERSON, David, W. , BERGHS, Constance , BOLDOG, Ferenc, L. , BURGESS, Catherine, E. , CATTERTON, Elina , DIPIPPO, Vincent, A. , EDINGER, Shlomit, R. , EISEN, Andrew , ELLERMAN, Karen , GANGOLLI, Esha, A. , GERLACH, Valerie, L. , GORMAN, Linda , GOULD-ROTHBERG, Bonnie, E. , GUO, Xiaojia , HERRMANN, John, L. , HALVORSEN, Yuan-Di , JI, Weizhen , KEKUDA, Ramesh , KHRAMTSOV, Nikolai, V. , LAROCHELLE, William, J. , LEPLEY, Denise, M. , LI, Li , MACDOUGALL, John, R. , MILLER, Charles, E. , ORT, Tatiana , PADIGARU, Muralidhara , PATTURAJAN, Meera , PENA, Carol, E., A. , PEYMAN, John, A. , RIEGER, Daniel, K. , ROTHENBERG, Mark, E. , SHENOY, Suresh, G. , SMITHSON, Glennda , SPADERNA, Steven, K. , SPYTEK, Kimberly, A. , STONE, David, J. , TAUPIER, Raymond, J., Jr. , VERNET, Corine, A., M. , VOSS, Edward, Z. , ZHONG, Mei
IPC分类号： C07K1/00
摘要： The present invention provides novel isolated polynucleotides and small molecule target polypeptides encoded by the polynucleotides. Antibodies that immunospecifically bind to a novel small molecule target polypeptide or any derivative, variant, mutant or fragment of that polypeptide, polynucleotide or antibody are disclosed, as are methods in which the small molecule target polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states. More specifically, the present invention discloses methods of using recombinantly expressed and/or endogenously expressed proteins in various screening procedures for the purpose of identifying therapeutic antibodies and therapeutic small molecules associated with diseases. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

4. 发明申请

WO2003084468A3 IMPROVEMENTS OF ADIPOCYTIC DIFFERENTIATED ADIPOSE DERIVED ADULT STEM CELLS AND USES THEREOF 审中-公开
公开(公告)号：WO2003084468A3
公开(公告)日：2003-10-16
申请号：PCT/US2003/010182
申请日：2003-04-03
申请人： ARTECEL SCIENCES, INC. , HALVORSEN, Yuan-Di, C. , GIMBLE, Jeffrey, M. , FRANKLIN, William , WILKISON, William, O.
发明人： HALVORSEN, Yuan-Di, C. , GIMBLE, Jeffrey, M. , FRANKLIN, William , WILKISON, William, O.
IPC分类号： C12N5/06
摘要： The present invention is differentiated adipose tissue-derived stromal cells that exhibit the improved properties of increased extracellular matrix proteins and/or a lower amount of lipid than a mature isolated adipocyte. Methods for the expansion and differentiation of these cells are also provided. The cells of the invention are used for the treatment, repair, correction and/or regeneration of soft tissue cosmetic defects.

5. 发明申请

WO2003040346A3 METHODS AND COMPOSITIONS FOR THE USE OF STROMAL CELLS TO SUPPORT EMBRYONIC AND ADULT STEM CELLS 审中-公开
公开(公告)号：WO2003040346A3
公开(公告)日：2003-05-15
申请号：PCT/US2002/036317
申请日：2002-11-12
申请人： ARTECEL SCIENCES, INC. , LUFT, Christopher , WILKISON, William, O. , CHEATHAM, Bentley , GIMBLE, Jeffrey, M. , HALVORSEN, Yuan-Di, C.
发明人： LUFT, Christopher , WILKISON, William, O. , CHEATHAM, Bentley , GIMBLE, Jeffrey, M. , HALVORSEN, Yuan-Di, C.
IPC分类号： C12N5/02
摘要： The invention provides cells, compositions and methods based on the use of stromal cells to support the proliferation of undifferentiated embryonic or adult stem cells in vitro. The stem cells produced in the method are useful in providing a source of uncommitted or differentiated and functional cells for research, transplantation and development of tissue engineered products for the treatment of human diseases and traumatic tissue injury repair in any tissue or organ site within the body.

6. 发明申请

WO0044882A8 METHODS AND COMPOSITIONS FOR THE DIFFERENTIATION OF HUMAN PREADIPOCYTES INTO ADIPOCYTES 审中-公开
标题翻译：将人类前脂肪细胞分化为脂肪细胞的方法和组合物
公开(公告)号：WO0044882A8
公开(公告)日：2001-03-22
申请号：PCT/US0002208
申请日：2000-01-28
申请人： ZEN BIO INC , HALVORSEN YUAN DI CHANG , WILKISON WILLIAM O
发明人： HALVORSEN YUAN-DI CHANG , WILKISON WILLIAM O
IPC分类号： A61L27/38 , C12N5/02 , C12N5/077 , C12N5/08
CPC分类号： A61L27/3804 , A61L27/3895 , C12N5/0653 , C12N2501/01 , C12N2501/33 , C12N2501/385 , C12N2501/39 , C12N2503/02
摘要： The present invention provides methods and compositions for the consistent and quantitative differentiation of human preadipocytes isolated from adipose tissue into adipocytes bearing biochemical, genetic, and physiological characteristics similar to that observed in isolated primary adipocytes. The methods of the invention comprise incubating isolated human preadipocytes, plated at least about 25,000 cells/cm , in a medium containing, glucose, a cyclic AMP inducer such as isobutylmethylxanthine or forskolin, a glucocorticoid or glucocorticoid analogue, insulin or an insulin analogue and a PPAR gamma agonist or a RXR agonist. Also provided are methods for preparing three dimensional biomatrices containing adipocytes differentiated by the methods of the invention. The compositions of the invention include human adipocytes differentiated by the methods of the invention, three-dimensional matrices of adipocytes, and transfected adipocytes. The methods and compositions have use in the drug discovery of compounds having relevance to the disease states of diabetes, obesity, and cardiovascular disease and in the studies of these diseases, and in the grafting of fat tissue.
摘要翻译：本发明提供了用于将从脂肪组织分离的人前脂肪细胞一致和定量分化成具有与在分离的原代脂肪细胞中观察到的类似的生化，遗传和生理学特征的脂肪细胞的方法和组合物。本发明的方法包括在含有葡萄糖，环状AMP诱导剂如异丁基甲基黄嘌呤或毛喉素，糖皮质激素或糖皮质激素类似物，胰岛素或胰岛素的培养基中温育分离的人前脂肪细胞，至少约25,000个细胞/平方厘米类似物和PPARγ激动剂或RXR激动剂。还提供了用于制备含有通过本发明的方法分化的脂肪细胞的三维生物基质的方法。本发明的组合物包括通过本发明的方法分化的人脂肪细胞，脂肪细胞的三维基质和转染的脂肪细胞。该方法和组合物可用于药物发现中与糖尿病，肥胖症和心血管疾病的疾病状态相关的化合物，以及这些疾病的研究以及脂肪组织的移植。

7. 发明申请

WO0044882A2 METHODS AND COMPOSITIONS FOR THE DIFFERENTIATION OF HUMAN PREADIPOCYTES INTO ADIPOCYTES 审中-公开
标题翻译：将人类前体细胞分化成ADIPOCY的方法和组合物
公开(公告)号：WO0044882A2
公开(公告)日：2000-08-03
申请号：PCT/US0002208
申请日：2000-01-28
申请人： ZEN BIO INC , HALVORSEN YUAN DI CHANG , WILKISON WILLIAM O
发明人： HALVORSEN YUAN-DI CHANG , WILKISON WILLIAM O
IPC分类号： A61L27/38 , C12N5/02 , C12N5/077 , C12N5/08
CPC分类号： A61L27/3804 , A61L27/3895 , C12N5/0653 , C12N2501/01 , C12N2501/33 , C12N2501/385 , C12N2501/39 , C12N2503/02
摘要： The present invention provides methods and compositions for the consistent and quantitative differentiation of human preadipocytes isolated from adipose tissue into adipocytes bearing biochemical, genetic, and physiological characteristics similar to that observed in isolated primary adipocytes. The methods of the invention comprise incubating isolated human preadipocytes, plated at least about 25,000 cells/cm , in a medium containing, glucose, a cyclic AMP inducer such as isobutylmethylxanthine or forskolin, a glucocorticoid or glucocorticoid analogue, insulin or an insulin analogue and a PPAR gamma agonist or a RXR agonist. Also provided are methods for preparing three dimensional biomatrices containing adipocytes differentiated by the methods of the invention. The compositions of the invention include human adipocytes differentiated by the methods of the invention, three-dimensional matrices of adipocytes, and transfected adipocytes. The methods and compositions have use in the drug discovery of compounds having relevance to the disease states of diabetes, obesity, and cardiovascular disease and in the studies of these diseases, and in the grafting of fat tissue.
摘要翻译：本发明提供了用于将从脂肪组织分离的人前脂肪细胞一致和定量分化为具有与分离的原代脂肪细胞中观察到的生物化学，遗传和生理特征相似的脂肪细胞的方法和组合物。本发明的方法包括在含有葡萄糖，环状AMP诱导剂如异丁基甲基黄嘌呤或毛喉素，糖皮质激素或糖皮质激素类似物，胰岛素或胰岛素的培养基中培养分离的人前脂肪细胞，至少约25,000个细胞/ cm 2 类似物和PPARγ激动剂或RXR激动剂。还提供了通过本发明的方法分化的含有脂肪细胞的三维生物基质的制备方法。本发明的组合物包括通过本发明的方法分化的人脂肪细胞，脂肪细胞的三维基质和转染的脂肪细胞。所述方法和组合物可用于药物发现与糖尿病，肥胖症和心血管疾病的疾病状态以及这些疾病的研究相关的化合物，以及在脂肪组织的移植中。

8. 发明申请

WO2003040346A2 METHODS AND COMPOSITIONS FOR THE USE OF STROMAL CELLS TO SUPPORT EMBRYONIC AND ADULT STEM CELLS 审中-公开
标题翻译：使用结构细胞支持胚胎干细胞和成熟干细胞的方法和组合物
公开(公告)号：WO2003040346A2
公开(公告)日：2003-05-15
申请号：PCT/US2002/036317
申请日：2002-11-12
申请人： ARTECEL SCIENCES, INC. , LUFT, Christopher , WILKISON, William, O. , CHEATHAM, Bentley , GIMBLE, Jeffrey, M. , HALVORSEN, Yuan-Di, C.
发明人： LUFT, Christopher , WILKISON, William, O. , CHEATHAM, Bentley , GIMBLE, Jeffrey, M. , HALVORSEN, Yuan-Di, C.
IPC分类号： C12N
CPC分类号： C12N5/0653 , C12N5/0606 , C12N5/0647 , C12N2501/01 , C12N2501/115 , C12N2501/235 , C12N2502/1305 , C12N2502/99
摘要： The invention provides cells, compositions and methods based on the use of stromal cells to support the proliferation of undifferentiated embryonic or adult stem cells in vitro. The stem cells produced in the method are useful in providing a source of uncommitted or differentiated and functional cells for research, transplantation and development of tissue engineered products for the treatment of human diseases and traumatic tissue injury repair in any tissue or organ site within the body.
摘要翻译：本发明提供了基于使用基质细胞在体外支持未分化胚胎或成体干细胞增殖的细胞，组合物和方法。在该方法中产生的干细胞可用于提供用于研究，移植和开发组织工程产品的未提供或分化和功能性细胞的来源，用于治疗人体内的任何组织或器官部位中的人类疾病和创伤性组织损伤修复。

9. 发明申请

WO2003084468A2 IMPROVEMENTS OF ADIPOCYTIC DIFFERENTIATED ADIPOSE DERIVED ADULT STEM CELLS AND USES THEREOF 审中-公开
标题翻译： ADIPOCYTIC DIFFERENTIATED ADIPOSE DERIVED ADTIC STEM CELLS的改进及其用途
公开(公告)号：WO2003084468A2
公开(公告)日：2003-10-16
申请号：PCT/US2003/010182
申请日：2003-04-03
申请人： ARTECEL SCIENCES, INC. , HALVORSEN, Yuan-Di, C. , GIMBLE, Jeffrey, M. , FRANKLIN, William , WILKISON, William, O.
发明人： HALVORSEN, Yuan-Di, C. , GIMBLE, Jeffrey, M. , FRANKLIN, William , WILKISON, William, O.
IPC分类号： A61K
CPC分类号： C12N5/0653 , A61K35/12 , C12N2501/385
摘要： The present invention is differentiated adipose tissue-derived stromal cells that exhibit the improved properties of increased extracellular matrix proteins and/or a lower amount of lipid than a mature isolated adipocyte. Methods for the expansion and differentiation of these cells are also provided. The cells of the invention are used for the treatment, repair, correction and/or regeneration of soft tissue cosmetic defects.
摘要翻译：本发明是分化的脂肪组织来源的基质细胞，其表现出与成熟分离的脂肪细胞相比增加的细胞外基质蛋白的性质和/或较少量的脂质。还提供了这些细胞的扩增和分化的方法。本发明的细胞用于软组织美容缺陷的治疗，修复，矫正和/或再生。

10. 发明申请

WO0160331A3 COMPOSITIONS FOR PREVENTING CELLULITE IN MAMMALIAN SKIN 审中-公开
标题翻译：用于预防妈妈皮肤中的细胞的组合物
公开(公告)号：WO0160331A3
公开(公告)日：2002-01-17
申请号：PCT/US0104984
申请日：2001-02-15
申请人： ZEN BIO INC , HALVORSEN YUAN DI CHANG , LEA CURRIE YOLANDA RENEE , PIERACCINI PETER , SEN ANINDITA , WILKISON WILLIAM O
发明人： HALVORSEN YUAN-DI CHANG , LEA-CURRIE YOLANDA RENEE , PIERACCINI PETER , SEN ANINDITA , WILKISON WILLIAM O
IPC分类号： A61K8/36 , A61K8/67 , A61Q19/06 , A61K7/48
CPC分类号： A61K8/361 , A61K8/67 , A61Q19/06
摘要： The present invention relates to a method for combating cellulite or reducing localized fatty excesses which comprises administering to a person having cellulite or localized fatty excesses a body slimming amount of a composition containing 10-trans, 12-cis conjugated linoleic acid.
摘要翻译：本发明涉及一种防止脂肪团或减少局部脂肪过量的方法，其包括向具有脂肪团或局部脂肪过量的人施用减肥量的含有10-反式，12-顺式共轭亚油酸的组合物。

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