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1. 发明申请

WO2007052308A3 GLYCO-PHOSPHORYLATED BIOLOGICALLY ACTIVE AGENTS 审中-公开
标题翻译： GLYCO-PHOSPHORYLATED生物活性剂
公开(公告)号：WO2007052308A3
公开(公告)日：2009-10-15
申请号：PCT/IN2006000434
申请日：2006-11-01
申请人： BRAIN N BEYOND BIOTECH PVT LTD , HALASYA RAMANATHAN
发明人： HALASYA RAMANATHAN
IPC分类号： C07H11/04
CPC分类号： C07H11/04
摘要： The present invention relates to a compound of formula I: (I) wherein DX is a radical of a biologically active agent comprising atom X; X is selected from O and N; and A is a radical of a saccharide, or an acid, salt, or ester thereof. Further, the invention relates to a pharmaceutical composition comprising compound of formula I, a process of preparing the same and method of management of tumor, inflammation, infection and promoting passage across blood-brain barrier.
摘要翻译：本发明涉及式I化合物：（I）其中DX是包含原子X的生物活性剂的基团; X选自O和N; A是糖或其酸，盐或酯的基团。此外，本发明涉及包含式I化合物的药物组合物，其制备方法以及管理肿瘤，炎症，感染和促进血脑屏障通过的方法。

2. 发明申请

WO2007054977A2 METHOD AND COMPOSITION FOR SKIN DEPIGMENTATION 审中-公开
标题翻译：皮肤发生的方法和组合
公开(公告)号：WO2007054977A2
公开(公告)日：2007-05-18
申请号：PCT/IN2006/000439
申请日：2006-11-08
申请人： BRAIN N' BEYOND BIOTECH PVT. LTD. , HALASYA, Ramanathan
发明人： HALASYA, Ramanathan
IPC分类号： C07H5/10
CPC分类号： C07H5/10
摘要： The present invention relates to a compound of formula I: [(C)-(L')] n -(A)-[(L)-(B)] m wherein (A) is a thioglycosylated cysteine of formula IIa or IIb: IIa IIb; (B) is a melanogenosis-inhibiting peptide comprising peptide sequence selected from a group consisting of: (i). Glu-Asp-Tyr-His-Ser-Leu-Tyr-Gln-Ser-His-Leu; (ii). Ser-Gly-Gly-Tyr-Leu-Pro-Pro-Leu; and (iii). His-Ser-C(O)-NH-(CH2)k-CH2-C(O)-NH-Ser-His; (C) is a tyrosinase inhibitor; n is 0 or 1; m is 0 or 1; m + n is 1 or 2;k is 2-10; X1 is O or NH; R 1 , R 2 , R 7 , and R 8 are each, independently, selected from H, and a bond in a linkage group between (A) and (L); R 3 , R 4 , R 5 , R 6 , R 9 , R 10 , R 11 , and R 12 are each, independently, selected from H, a saccharide, and a bond in a linkage group between (A) and (L'); (L) is a linker which forms linkage groups with thioglycosylated cysteine (A) and melanogenosis-inhibiting peptide (B); and (L') is a linker which forms linkage groups with thioglycosylated cysteine (A) and tyrosinase inhibitor (C).
摘要翻译：本发明涉及式I化合物：[（C） - （L'）] N - （A） - [（L） - （B）] m

3. 发明申请

WO2007054977A3 METHOD AND COMPOSITION FOR SKIN DEPIGMENTATION 审中-公开
标题翻译：皮肤发生的方法和组合
公开(公告)号：WO2007054977A3
公开(公告)日：2009-05-14
申请号：PCT/IN2006000439
申请日：2006-11-08
申请人： BRAIN N BEYOND BIOTECH PVT LTD , HALASYA RAMANATHAN
发明人： HALASYA RAMANATHAN
IPC分类号： C07H15/14 , A61K8/64 , A61K31/7028 , A61K38/14 , A61P17/00 , A61Q19/02 , C07K9/00
CPC分类号： C07H5/10
摘要： The present invention relates to a compound of formula I: [(C)-(L')]n-(A)-[(L)-(B)]mwherein (A) is a thioglycosylated cysteine of formula IIa or IIb: IIa IIb; (B) is a melanogenosis-inhibiting peptide comprising peptide sequence selected from a group consisting of: (i). Glu-Asp-Tyr-His-Ser-Leu-Tyr-Gln-Ser-His-Leu; (ii). Ser-Gly-Gly-Tyr-Leu-Pro-Pro-Leu; and (iii). His-Ser-C(O)-NH-(CH2)k-CH2-C(O)-NH-Ser-His; (C) is a tyrosinase inhibitor; n is 0 or 1; m is 0 or 1; m + n is 1 or 2;k is 2-10; X1 is O or NH; R1, R2, R7, and R8 are each, independently, selected from H, and a bond in a linkage group between (A) and (L); R3, R4, R5, R6, R9, R10, R11, and R12 are each, independently, selected from H, a saccharide, and a bond in a linkage group between (A) and (L'); (L) is a linker which forms linkage groups with thioglycosylated cysteine (A) and melanogenosis-inhibiting peptide (B); and (L') is a linker which forms linkage groups with thioglycosylated cysteine (A) and tyrosinase inhibitor (C).
摘要翻译：本发明涉及式I化合物：[（C） - （L'）] n-（A） - [（L） - （B）] m其中（A）是式IIa或IIb的硫代糖基化半胱氨酸： IIa IIb; （B）是包含选自以下的肽序列的黑素生成抑制肽：（i）。 GLU-ASP-酪氨酸 - 他-SER-LEU-酪氨酸 - 谷氨酰胺 - 丝氨酸的His-Leu;第（ⅱ）。丝氨酸 - 甘氨酸 - 甘氨酸 - 酪氨酸 - 亮氨酸 - 脯氨酸 - 脯氨酸 - 亮氨酸; 和（iii）。他-SER-C（O）-NH-（CH 2）K-CH2-C（O）-NH-SER-他的; （C）是酪氨酸酶抑制剂; n为0或1; m为0或1; m + n为1或2; k为2-10; X1是O或NH; R1，R2，R7和R8各自独立地选自H和（A）和（L）之间的连接基团中的键; R3，R4，R5，R6，R9，R10，R11和R12各自独立地选自H，糖类和（A）和（L'）之间的连接基团中的键。（L）是与硫代糖基化半胱氨酸（A）和黑素生成抑制肽（B）形成连接基团的接头; 和（L'）是与硫代糖基化半胱氨酸（A）和酪氨酸酶抑制剂（C）形成连接基团的连接体。

4. 发明申请

WO2007060692A2 COMPOSITIONS FOR INCREASING BIOAVAILABILITY OF PEPTIDES OR PROTEINS AND METHOD THEREOF 审中-公开
标题翻译：用于增加肽或蛋白质的生物利用度的组合物及其方法
公开(公告)号：WO2007060692A2
公开(公告)日：2007-05-31
申请号：PCT/IN2006/000468
申请日：2006-11-23
申请人： BRAIN N' BEYOND BIOTECH PVT. LTD. , HALASYA, Ramanathan
发明人： HALASYA, Ramanathan
IPC分类号： C07H11/04
CPC分类号： C07H11/04 , A61K47/548 , A61K47/549
摘要： The present invention relates to a compound of formula I: (A)-(L)-(B) I wherein (B) is a hydrophobic moiety; (L) is a linker which which covalently links saccharide (A) and hydrophobic moiety (B); and (A) is a saccharide which is unsubstituted at the hydroxyl group of the anomeric position.
摘要翻译：本发明涉及式I化合物：（A） - （L） - （B）I其中（B）是疏水部分; （L）是共价连接糖（A）和疏水部分（B）的接头; 和（A）是在末端位置的羟基处未被取代的糖。

5. 发明申请

WO2007060692A3 COMPOSITIONS FOR INCREASING BIOAVAILABILITY OF PEPTIDES OR PROTEINS AND METHOD THEREOF 审中-公开
标题翻译：增加肽或蛋白质生物利用度的组合物及其方法
公开(公告)号：WO2007060692A3
公开(公告)日：2009-05-14
申请号：PCT/IN2006000468
申请日：2006-11-23
申请人： BRAIN N BEYOND BIOTECH PVT LTD , HALASYA RAMANATHAN
发明人： HALASYA RAMANATHAN
IPC分类号： C07H11/04
CPC分类号： C07H11/04 , A61K47/548 , A61K47/549
摘要： The present invention relates to a compound of formula I: (A)-(L)-(B) I wherein (B) is a hydrophobic moiety; (L) is a linker which which covalently links saccharide (A) and hydrophobic moiety (B); and (A) is a saccharide which is unsubstituted at the hydroxyl group of the anomeric position.
摘要翻译：本发明涉及式I化合物：（A） - （L） - （B）I其中（B）是疏水部分; （L）是共价连接糖（A）和疏水部分（B）的接头; 和（A）是在末端位置的羟基处未被取代的糖。

6. 发明申请

WO2007052308A2 GLYCO-PHOSPHORYLATED BIOLOGICALLY ACTIVE AGENTS 审中-公开
标题翻译： GLYCO-PHOSPHORYLATED生物活性剂
公开(公告)号：WO2007052308A2
公开(公告)日：2007-05-10
申请号：PCT/IN2006/000434
申请日：2006-11-01
申请人： BRAIN N' BEYOND BIOTECH PVT. LTD. , HALASYA, Ramanathan
发明人： HALASYA, Ramanathan
IPC分类号： C07H11/04
CPC分类号： C07H11/04
摘要： Abstract The present invention relates to a compound of formula I: (I) wherein DX is a radical of a biologically active agent comprising atom X; X is selected from O and N; and A is a radical of a saccharide, or an acid, salt, or ester thereof. Further, the invention relates to a pharmaceutical composition comprising compound of formula I, a process of preparing the same and method of management of tumor, inflammation, infection and promoting passage across blood-brain barrier.
摘要翻译：摘要本发明涉及式I化合物：（I）其中DX是包含原子X的生物活性剂的基团; X选自O和N; A是糖或其酸，盐或酯的基团。此外，本发明涉及包含式I化合物的药物组合物，其制备方法以及管理肿瘤，炎症，感染和促进血脑屏障通过的方法。

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