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1. 发明申请

WO1994012498A1 METHOD OF PREPARING 'beta'-CARBOLINES 审中-公开
标题翻译：用于生产测试新工艺-CARBOLINEN
公开(公告)号：WO1994012498A1
公开(公告)日：1994-06-09
申请号：PCT/DE1993001116
申请日：1993-11-22
申请人： SCHERING AKTIENGESELLSCHAFT , HAFFER, Gregor , NICKISCH, Klaus
发明人： SCHERING AKTIENGESELLSCHAFT
IPC分类号： C07D471/04
CPC分类号： C07D471/04
摘要： Described is a method of preparing beta -carbolines by dehydrating tetrahydro- beta -carbolines with trichloroisocyanuric acid. In formula (I), R , R and R have the meaning given in claim 1.

2. 发明申请

WO1992013857A1 PROCESS FOR PRODUCING ERGOLIN DERIVATIVES 审中-公开
标题翻译：生产谷维素衍生物的方法
公开(公告)号：WO1992013857A1
公开(公告)日：1992-08-20
申请号：PCT/DE1992000088
申请日：1992-02-06
申请人： SCHERING AKTIENGESELLSCHAFT , HUMMEL-MAQUARDT, Heidi , KENNECKE, Mario , WEBER, Alfred , NICKISCH, Klaus , HAFFER, Gregor
发明人： SCHERING AKTIENGESELLSCHAFT
IPC分类号： C07D457/06
CPC分类号： C07D457/06 , C07D457/12 , C12P17/182 , Y10S435/886
摘要： The description relates to a process for producing ergolin derivatives of the general formula (I) in which ..... represents two single bonds or a double and a single bond; R1 is a hydrogen atom or an alkyl group with 1-6 carbon atoms; R2 represents a hydrogen atom or an alkyl group with 1-6 carbon atoms; R3 is a carboxyl group or a grouping of the formula: -CONR4R5 or -NHCQNR6R7 where R4 and R5 are hydrogen or an alkyl radical, possibly substituted by a hydroxy group, with 1-6 carbon atoms and R6 and R7 are an alkyl group containing 1-4 carbon atoms and Q is an oxygen or sulphur atom.
摘要翻译：描述涉及一种制备通式（I）的麦角林衍生物的方法，其中.....代表两个单键或双键和单键; R1是氢原子或具有1-6个碳原子的烷基; R2表示氢原子或具有1-6个碳原子的烷基; R3是羧基或式-CONR4R5或-NHCQNR6R7的基团，其中R4和R5是氢或可能被羟基取代的具有1-6个碳原子的烷基，R6和R7是含有烷基的 1-4个碳原子，Q是氧或硫原子。

3. 发明申请

WO1996007645A1 NEW PROCESS FOR PREPARING 1-PHENYL-IMIDAZOLE DERIVATIVES 审中-公开
标题翻译：新方法制备1-苯基 - 咪唑衍生物
公开(公告)号：WO1996007645A1
公开(公告)日：1996-03-14
申请号：PCT/DE1995001228
申请日：1995-09-04
申请人： SCHERING AKTIENGESELLSCHAFT , KIRSTEIN, Holger , NICKISCH, Klaus , NEH, Harribert , HAFFER, Gregor
发明人： SCHERING AKTIENGESELLSCHAFT
IPC分类号： C07D233/90
CPC分类号： C07D233/90
摘要： A new process is disclosed for preparing 1-phenyl-imidazole derivatives having the formula (I), in which R stands for hydrogen, halogen, nitro, cyano, C1-4-alkyl, C1-4-alkoxy, C1-4-alkylthio, C1-4-alkylsulfonyl, amino or a C1-4-alkyl, C1-4-alkanoyl or sulfonyl-monosubstituted or -disubstituted amino group; n equals 1, 2 or 3; R stands for hydrogen, nitro or amino; R stands for C1-6-alkyl; and R stands for hydrogen, C1-6-alkyl or C1-4-alkoxy-C1-2-alkyl. The process is characterised in that optionally R -substituted 2,4-difluoronitrobenzol is reacted with optionally R n-substituted alkali phenolate and an alkaline salt of a compound having formula (II), in which R and R have the above meanings. If desired, the nitro group is then reductively desaminated. Also disclosed are the new compounds having formula (I).
摘要翻译：它是式1-苯基咪唑衍生物的制备的新方法（I），其中R <1>是氢，卤素，硝基，氰基，C1-4烷基，C1-4烷氧基，C1-4烷硫基， C 1-4 - 烷基磺酰基，氨基，或氨基基团单 - 或C 1-4烷基，C 1-4烷酰基或二取代的磺酰基，n是1，2或3，R <2>为氢，硝基或氨基，R <3> C 1-6烷基和R <4>为氢，C 1-6 - 烷基或C 1-4 - 烷氧基-C 1-2 - 烷基，与所描述的，其特征在于，如果适当的话，其中R <2>被取代的2,4-二氟硝基苯任选<1>ñ取代的碱金属酚盐和式（II）的化合物，其中R <3>和R <4>具有上述含义的碱金属盐，与R如果期望反应和，随后还原脱氨基硝基。本发明还涉及式（I）的新化合物。

4. 发明申请

WO1993001168A1 PROCESS FOR PRODUCING INDOLE DERIVATIVES 审中-公开
标题翻译：生产吲哚衍生物的方法
公开(公告)号：WO1993001168A1
公开(公告)日：1993-01-21
申请号：PCT/DE1992000551
申请日：1992-07-01
申请人： SCHERING AKTIENGESELLSCHAFT BERLING UND BERGKAMEN , HAFFER, Gregor , BÖRNER, Helmut , KÜBLER, Wolfgang , NICKISCH, Klaus
发明人： SCHERING AKTIENGESELLSCHAFT BERLING UND BERGKAMEN
IPC分类号： C07D209/14
CPC分类号： C07D209/14 , C07D209/08
摘要： The description concerns a process for producing indole derivatives in which substitution with an imine is performed in the presence of phosphoric acid, and intermediate products of this process and the production of the intermediate products.

5. 发明申请

WO1991016304A1 PROCESS FOR PRODUCING GRAMINE DERIVATES 审中-公开
标题翻译：生产玉米衍生物的方法
公开(公告)号：WO1991016304A1
公开(公告)日：1991-10-31
申请号：PCT/DE1991000353
申请日：1991-04-23
申请人： SCHERING AKTIENGESELLSCHAFT BERLIN UND BERGKAMEN , KÜBLER, Wolfgang , HAFFER, Gregor , WIERZCHOWSKI, Reiner , NICKISCH, Klaus
发明人： SCHERING AKTIENGESELLSCHAFT BERLIN UND BERGKAMEN
IPC分类号： C07D209/14
CPC分类号： C07D209/14
摘要： A process is disclosed for producing gramine derivates having the formula (I), in which R1 is C¿1-4A; R?4 is C¿1-4? alkyl or C1-4 alkoxy-C1-2 alkyl and R?5 is OR6 or CHR7R8¿, whereas R6 is C¿1-4? alkyl, C3-6 cycloalkyl or an aralkyl rest, if necessary substituted. R?7¿ is hydrogen or C¿1-4? alkyl and R?8¿ is hydrogen, C¿1-4? alkyl, OR?9 or NR10R11¿, whereas R9 is C¿1-4? alkyl and R?10 and R11¿ are identical or different and represent hydrogen, C¿1-14? alkyl or, together with the nitrogen atom, a saturated heterocyclic five or six membered ring which contains if necessary an additional heteroatom and which is if necessary substituted with one to two C1-4 alkyl groups. The process is characterized by the fact that an indol is converted with an imine by acid catalysis in the presence of primary amines.

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