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2. 发明申请

WO2006102114A2 METHODS OF MODULATING ROS PRODUCTION AND APOPTOSIS 审中-公开
标题翻译：调节罗非鱼生产和疫苗的方法
公开(公告)号：WO2006102114A2
公开(公告)日：2006-09-28
申请号：PCT/US2006009788
申请日：2006-03-17
申请人： UNIV CALIFORNIA , PANDOL STEPHEN J , GUKOVSKAYA ANNA S , EDDERKAOUI MOUAD , FISCHER LARS
发明人： PANDOL STEPHEN J , GUKOVSKAYA ANNA S , EDDERKAOUI MOUAD , FISCHER LARS
IPC分类号： A61K48/00
CPC分类号： G01N33/57484 , A61K31/00 , A61K45/06 , A61K2300/00
摘要： Disclosed herein are methods for treating, inhibiting, or modulating a cancer in a subject which comprise preventing, inhibiting, or modulating attachment of extracellular matrix proteins to the cancer cells through their integrin receptors; and by inhibiting NADPH oxidase and/or 5-lipoxygenase, two generators of reactive oxygen species in the pancreatic cancer cell. Also disclosed herein, are methods using Nox4 to assay, detect, monitor, or measure a cancer in a subject. Specifically, the present invention provides methods and assays for diagnosing, detecting, or monitoring pancreatic cancer in subjects comprising detecting, determining, or assaying the presence of Nox4 in test samples including bodily fluids and tissues obtained from the subjects. The methods and assays of the present invention can be used for screening for pancreatic cancer in populations as well as for imaging procedures to determine the location(s) of the cancer in the body.
摘要翻译：本文公开了用于治疗，抑制或调节受试者中的癌症的方法，其包括通过其整联蛋白受体预防，抑制或调节细胞外基质蛋白与癌细胞的连接; 并通过抑制NADPH氧化酶和/或5-脂氧合酶，胰腺癌细胞中的两种活性氧产生剂。本文还公开的是使用Nox4测定，检测，监测或测量受试者中的癌症的方法。具体地，本发明提供用于诊断，检测或监测受试者中胰腺癌的方法和测定法，包括检测，测定或测定包含从受试者获得的体液和组织的测试样品中Nox4的存在。本发明的方法和测定可用于筛选人群中的胰腺癌以及用于确定癌症在体内的位置的成像过程。

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