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1. 发明申请

WO2013068476A1 NEUROTOXINS EXHIBITING SHORTENED BIOLOGICAL ACTIVITY 审中-公开
标题翻译：神经毒素展示生物活性
公开(公告)号：WO2013068476A1
公开(公告)日：2013-05-16
申请号：PCT/EP2012/072158
申请日：2012-11-08
申请人： MERZ PHARMA GMBH & CO. KGAA , SCHMIDT, Michael , FREVERT, Jürgen , HOFMANN, Fred , GROER, Gerhard
发明人： SCHMIDT, Michael , FREVERT, Jürgen , HOFMANN, Fred , GROER, Gerhard
IPC分类号： C07K14/47 , C07K14/435 , C07K14/33 , C12N5/00 , A61K38/00
CPC分类号： C12N9/52 , A61K38/4893 , C07K14/4746 , C12Y304/24069
摘要： The present invention relates to the pharmaceutical field. Specifically, it contemplates a polynucleotide encoding a neurotoxin polypeptide exhibiting a reduced duration of the biological effect in a subject, wherein said polypeptide comprises at least one E3 ligase recognition motif in the light chain, wherein said E3 ligase recognition motif is preferably abinding motif for the E3 ligase MDM2. The invention further pertains to polypeptides encoded by the polynucleotide of the invention as well as polypeptides comprising one or more amino acid substitutions. Further encompassed by the present invention are vectors and host cells comprising the said polynucleotide, polypeptides encoded thereby and antibodies specifically binding to the polypeptides. Moreover, the invention relates to medicaments comprising said polynucleotides and polypeptides, as well as specific therapeutic applications thereof. Furthermore, the present invention contemplates methods for the manufacture of the polypeptides and medicaments.
摘要翻译：本发明涉及制药领域。具体地，其考虑了编码神经毒素多肽的多核苷酸，其在受试者中显示生物效应的持续时间减少，其中所述多肽在轻链中包含至少一个E3连接酶识别基序，其中所述E3连接酶识别基序优选为 E3连接酶MDM2。本发明还涉及由本发明的多核苷酸编码的多肽以及包含一个或多个氨基酸取代的多肽。本发明还包括载体和宿主细胞，其包含所述多核苷酸，由其编码的多肽和与多肽特异性结合的抗体。此外，本发明涉及包含所述多核苷酸和多肽的药物，以及其具体的治疗应用。此外，本发明考虑了制备多肽和药物的方法。

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