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1. 发明申请

WO1994012482A1 METHOD FOR THE PREPARATION OF 1,3-OXAZOLIDIN 5-CARBOXYLIC ACID 审中-公开
标题翻译：制备1,3-二氧杂环戊烯-5-羧酸的方法
公开(公告)号：WO1994012482A1
公开(公告)日：1994-06-09
申请号：PCT/FR1993001133
申请日：1993-11-18
申请人： RHONE-POULENC RORER S.A. , DENIS, Jean-Noël , GREENE, Andrew , KANAZAWA, Alice
发明人： RHONE-POULENC RORER S.A.
IPC分类号： C07D263/04
CPC分类号： C07D263/04
摘要： Method for the preparation of 1,3-oxazolidin 5-carboxylic acid having the general formula (I) from a product having the general formula (II). In the general forumlas (I) and (II), Ar is an aryl radical, R1 is a benzoyl radical or a radical R2-O-CO- wherein R2 is an alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, bicycloalkyl, phenyl or heterocyclyl radical, Ph is an optionnally substituted phenyl radical, X is the residue of an optically active organic base or an alkoxy radical optionally substitued by a phenyl radical. The acids of formula (I) are particularly useful in preparing taxol, Taxoter or analogs thereof which have remarkable antitumor and antileukemia properties.
摘要翻译：从具有通式（II）的产物制备具有通式（I）的1,3-恶唑烷-5-羧酸的方法。在一般论坛（I）和（II）中，Ar是芳基，R 1是苯甲酰基或基团R 2 -O-CO-，其中R 2是烷基，烯基，炔基，环烷基，环烯基，双环烷基，苯基或杂环基，Ph是选择性取代的苯基，X是任选被苯基取代的光学活性有机碱或烷氧基的残基。式（I）的酸特别可用于制备具有显着的抗肿瘤和抗白血病性质的紫杉醇，泰索贴或其类似物。

2. 发明申请

WO1994007847A1 METHOD FOR THE STEREOSELECTIVE PREPARATION OF A DERIVATIVE OF 'beta'-PHENYLISOSERINE AND ITS USE IN THE PREPARATION OF TAXANE DERIVATIVES 审中-公开
标题翻译： β-苯基间苯二酚衍生物的选择性制备方法及其在制备TAXANE衍生物中的应用
公开(公告)号：WO1994007847A1
公开(公告)日：1994-04-14
申请号：PCT/FR1993000966
申请日：1993-10-04
申请人： RHONE-POULENC RORER S.A. , DENIS, Jean-Noël , GREENE, Andrew , KANAZAWA, Alice
发明人： RHONE-POULENC RORER S.A.
IPC分类号： C07C271/22
CPC分类号： C07C271/22 , C07D305/14 , Y02P20/55
摘要： Method of stereoselective preparation of a derivative of (beta)-phenylisoserine of formula (I) by the action of an N-carbonylbenzylimine of formula (II) on an optically active amide of a protected hydroxyacetic acid of formula (III), followed by hydrolysis of the product obtained. In formulae (I), (II) or (III), R is an optionally substituted phenyl radical or R1-O, Ar is an optionally substituted aryl radical and G1 is a hydroxy function protection grouping. The product of formula (I) is particularly useful in preparing taxol and Taxotere which have remarkable antitumor properties.
摘要翻译：通过式（II）的N-羰基苄基亚胺对式（III）的保护的羟基乙酸的光学活性酰胺的作用立体选择性地制备式（I）的（β） - 苯基异丝氨酸衍生物的方法，随后水解的产品。在式（I），（II）或（III）中，R是任选取代的苯基或R 1 -O，Ar是任选取代的芳基，而G 1是羟基官能保护基。式（I）的产物在制备具有显着抗肿瘤性质的紫杉醇和泰索帝时特别有用。

3. 发明申请

WO2010017276A3 MULTIPLE ELECTRODE COMPOSITE SYSTEMS AND METHODS FOR USE IN ELECTROCARDIOGRAM DETECTION SYSTEMS 审中-公开
标题翻译：多电极复合系统及其在电光检测系统中的应用
公开(公告)号：WO2010017276A3
公开(公告)日：2010-04-01
申请号：PCT/US2009052815
申请日：2009-08-05
申请人： FLEXCON CO INC , BURNHAM KENNETH , GORKHALI SURAJ , GREENE ANDREW
发明人： BURNHAM KENNETH , GORKHALI SURAJ , GREENE ANDREW
IPC分类号： C09J9/00 , A61B5/0408
CPC分类号： A61B5/04087 , A61B5/0408 , A61B5/04085 , A61B5/04284 , A61B5/04286 , A61B2562/0209 , A61B2562/046 , A61B2562/125
摘要： A biomedical sensor system is disclosed that includes a plurality of electrodes (50) and a contiguous adhesive material (52) that is in contact with each of the plurality of electrodes. The adhesive material has a high impedance and is adapted for capacitive coupling. The system may be adapted for ECG analysis. In certain embodiments a method is provided that includes the step of applying a first surface of adhesive material to a patient wherein the adhesive material includes at least two electrodes on second surface thereof that is opposite the first surface. The method also includes the step of receiving a time varying signal a first electrode of the at least two electrodes at a first location such that the time varying signal is not received at a second electrode of the at least two electrodes.
摘要翻译：公开了一种生物医学传感器系统，其包括与多个电极中的每一个接触的多个电极（50）和连续的粘合剂材料（52）。粘合剂材料具有高阻抗并适用于电容耦合。该系统可适用于ECG分析。在某些实施方案中，提供了一种方法，其包括将粘合剂材料的第一表面施加到患者的步骤，其中所述粘合剂材料在其第二表面上包括与第一表面相对的至少两个电极。该方法还包括以下步骤：在第一位置处接收至少两个电极的第一电极的时变信号，使得该时变信号在该至少两个电极的第二电极处未被接收。

4. 发明申请

WO2010009385A1 HIGH IMPEDANCE SIGNAL DETECTION SYSTEMS AND METHODS FOR USE IN ELECTROCARDIOGRAM DETECTION SYSTEMS 审中-公开
标题翻译：高阻抗信号检测系统及其在电光检测系统中的应用
公开(公告)号：WO2010009385A1
公开(公告)日：2010-01-21
申请号：PCT/US2009/050979
申请日：2009-07-17
申请人： FLEXCON COMPANY, INC. , GREENE, Andrew , GORKHALI, Suraj , BURNHAM, Kenneth
发明人： GREENE, Andrew , GORKHALI, Suraj , BURNHAM, Kenneth
IPC分类号： A61B5/0408
CPC分类号： A61B5/04085 , A61B5/0408 , A61B5/04087 , A61B2562/0215
摘要： A biomedical sensor system is disclosed that includes a high impedance conductive electrode having an electrode impedance of at least about 20 kΩ/sq-mil, and a dielectric material on a first side of the electrode for receiving a discharge of an electrical signal from the dielectric material responsive to the presence of a time varying signal adjacent a second side of the dielectric material that is opposite the first side.
摘要翻译：公开了一种生物医学传感器系统，其包括具有至少约20kO / sq密耳的电极阻抗的高阻抗导电电极，以及在电极的第一侧上的用于接收来自电介质的电信号放电的介电材料材料响应于与第一侧相对的电介质材料的第二侧相邻的时变信号的存在。

5. 发明申请

WO2005046658A2 METHODS OF MODULATING ANGIOGENESIS AND CANCER CELL PROLIFERATION 审中-公开
标题翻译：调节血管生成和癌细胞增殖的方法
公开(公告)号：WO2005046658A2
公开(公告)日：2005-05-26
申请号：PCT/US2004037754
申请日：2004-11-12
申请人： MCW RES FOUND INC , ROMAN RICHARD J , GREENE ANDREW , AMARAL SANDRA , SCICLI GUILLERMO , BROWN STEPHEN L , CHEN PING , GUO MENG
发明人： ROMAN RICHARD J , GREENE ANDREW , AMARAL SANDRA , SCICLI GUILLERMO , BROWN STEPHEN L , CHEN PING , GUO MENG
IPC分类号： A61K31/00 , A61K31/155 , A61K31/18 , A61K31/20 , A61K31/255 , A61K31/335 , A61K31/4174 , A61K31/4192 , A61K31/4196 , A61K31/496 , A61K31/537 , A61K31/5375
CPC分类号： A61K31/335 , A61K31/00 , A61K31/155 , A61K31/18 , A61K31/20 , A61K31/255 , A61K31/4174 , A61K31/4192 , A61K31/4196 , A61K31/496 , A61K31/537 , A61K31/5375
摘要： Methods for regulating angiogenesis by modulating the activity of 20-HETE are disclosed. Further disclosed are methods of inhibiting cancer and tumor cell growth by exposing the cancer and tumor cells to 20-HETE inhibitors.
摘要翻译：公开了通过调节20-HETE的活性来调节血管生成的方法。进一步公开的是通过将癌症和肿瘤细胞暴露于20-HETE抑制剂来抑制癌症和肿瘤细胞生长的方法。

6. 发明申请

WO2004082361A2 ELECTRONIC BILL PRESENTATION AND PAYMENT SYSTEM 审中-公开
标题翻译：电子帐单陈述和付款制度
公开(公告)号：WO2004082361A2
公开(公告)日：2004-09-30
申请号：PCT/US2004/007490
申请日：2004-03-12
申请人： CONSOLIDATED BILLING SOLUTIONS, INC. , GREENE, Andrew
发明人： GREENE, Andrew
IPC分类号： G06Q20/00 , G06Q30/00
CPC分类号： G06Q30/04 , G06Q20/10 , G06Q20/102 , G06Q20/14 , G06Q40/00
摘要： An electronic bill presentation and payment (EBPP) system and a method to use the same with application both in the businesstoconsumer and businesstobusiness transactions. The system enables a user of the system to specify a preferred financial institution for paying the consumer bills, and particular biller with which the user consumer does business, allowing both to be accessible on a single Web site. The information regarding the consumer's finances and the consumer's purchases from particular billers need not be shared between the financial institution and the billing company, thus providing improved security and consumer privacy. The look and feel of a singular presentation of financial institution information, biller information, and presenter information on a single page is provided by an advantageous use of Flash X technology which permits the presentation of information from the processor's centralized data base of acquired data from the servers of both the financial institution and billing companies through extraction, transforming and loading (ETL) techniques.
摘要翻译：电子帐单提交和付款（EBPP）系统以及在商业和商业交易中使用相同的应用程序的方法。该系统使得系统的用户能够指定用于支付消费者账单的首选金融机构，以及用户消费者进行业务的特定账单，允许两者在单个网站上可访问。有关消费者财务和消费者从特定账户购买的信息不需要在金融机构和计费公司之间共享，从而提高安全性和消费者隐私。通过Flash X技术的有利使用，提供了金融机构信息，报告信息和演示者信息在单页上的单一呈现的外观和感觉，其允许从处理器的集中数据库呈现来自金融机构和计费公司的服务器通过提取，转换和加载（ETL）技术。

7. 发明申请

WO1997049608A1 HELICOPTER ENGINE FILTER SYSTEM 审中-公开
标题翻译：直升机发动机过滤系统
公开(公告)号：WO1997049608A1
公开(公告)日：1997-12-31
申请号：PCT/IB1996000607
申请日：1996-06-24
申请人： GREENE, Andrew, T. , ROWEN, Andrew, D., B.
IPC分类号： B64D33/02
CPC分类号： B64D33/02 , B64C27/04 , B64D2033/0246
摘要： A specially contoured barrier type filter (14) disposed in front of a helicopter turbine inlet provides for maximized airflow during forward, as well as sideways flight. The contouring additionally reduces the tendency of the filter to clog. A bypass mechanism (32) is provided should the pressure differential across the filter (14) exceed a predetermined value. The bypass configuration achieves a limited particle separation function in order to provide residual protection. An air box (20) attached to the inlet is formed to provide low distortion levels in the airflow entering the engine inlet.
摘要翻译：设置在直升机涡轮机入口前面的特殊轮廓的障壁式过滤器（14）可在向前和侧向飞行期间提供最大的气流。轮廓外形还减少了过滤器堵塞的趋势。如果过滤器（14）上的压力差超过预定值，则提供旁路机构（32）。旁路配置实现了有限的颗粒分离功能，以提供残留保护。形成附接到入口的空气箱（20），以在进入发动机入口的气流中提供低失真水平。

8. 发明申请

WO1994010169A1 METHOD FOR PREPARING TAXANE DERIVATIVES 审中-公开
标题翻译：制备TAXANE衍生物的方法
公开(公告)号：WO1994010169A1
公开(公告)日：1994-05-11
申请号：PCT/FR1993001058
申请日：1993-10-28
申请人： RHONE-POULENC RORER S.A. , DENIS, Jean-Noël , GREENE, Andrew , KANAZAWA, Alice
发明人： RHONE-POULENC RORER S.A.
IPC分类号： C07D413/12
CPC分类号： C07D263/04 , C07D305/14 , C07D413/12 , Y02P20/55
摘要： A method for preparing taxane derivatives of general formula (I) by esterifying protected baccatine III or protected 10-deacetyl baccatin III with an acid of general formula (II). In general formulae (I) and (II), Ar is an aryl radical; R1 and R2 which are the same or different, are a hydrogen atom, an alkyl, phenylalkyl, phenyl, alkoxyphenyl or dialkoxyphenyl radical, or R1 and R2, together with the carbon atom to which they are attached, form a 4-7 membered ring; R3 is an acetyl radical or a hydroxy function protective grouping, and R4 is a hydroxy function protective grouping; R is a phenyl radical or a radical of formula R5-O- wherein R5- is an alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, phenyl or saturated or unsaturated nitrogenous heterocylcyl radical. The products of general formula (I) are particularly useful for preparing taxol, Taxotere and analogues thereof having remarkable antitumor properties.
摘要翻译：通过用通式（II）的酸酯化保护的杆菌肽III或被保护的10-脱乙酰浆果赤霉素III来制备通式（I）的紫杉烷衍生物的方法。在通式（I）和（II）中，Ar是芳基; R 1和R 2相同或不同，是氢原子，烷基，苯基烷基，苯基，烷氧基苯基或二烷氧基苯基，或者R 1和R 2与它们所连接的碳原子一起形成4-7元环 ; R3是乙酰基或羟基功能保护基，R4是羟基官能保护基; R是苯基或式为R5-O-的基团，其中R5-是烷基，烯基，炔基，环烷基，环烯基，苯基或饱和或不饱和的含氮杂环基。通式（I）的产物对于制备具有显着抗肿瘤性质的紫杉醇，泰索帝及其类似物特别有用。

9. 发明申请

WO2010017276A2 MULTIPLE ELECTRODE COMPOSITE SYSTEMS AND METHODS FOR USE IN ELECTROCARDIOGRAM DETECTION SYSTEMS 审中-公开
标题翻译：多电极复合系统及其在电光检测系统中的应用
公开(公告)号：WO2010017276A2
公开(公告)日：2010-02-11
申请号：PCT/US2009/052815
申请日：2009-08-05
申请人： FLEXCON COMPANY, INC. , BURNHAM, Kenneth , GORKHALI, Suraj , GREENE, Andrew
发明人： BURNHAM, Kenneth , GORKHALI, Suraj , GREENE, Andrew
IPC分类号： C09J9/00 , A61B5/0408
CPC分类号： A61B5/04087 , A61B5/0408 , A61B5/04085 , A61B5/04284 , A61B5/04286 , A61B2562/0209 , A61B2562/046 , A61B2562/125
摘要： A biomedical sensor system is disclosed that includes a plurality of electrodes and a contiguous adhesive material that is in contact with each of the plurality of electrodes. In certain embodiments a method is provided that includes the step of applying a first surface of adhesive material to a patient wherein the adhesive material includes at least two electrodes on second surface thereof that is opposite the first surface. The method also includes the step of receiving a time varying signal a first electrode of the at least two electrodes at a first location such that the time varying signal is not received at a second electrode of the at least two electrodes.
摘要翻译：公开了一种生物医学传感器系统，其包括多个电极和与多个电极中的每一个接触的连续的粘合剂材料。在某些实施方案中，提供了一种方法，其包括将粘合剂材料的第一表面施加到患者的步骤，其中所述粘合剂材料在其第二表面上包括与所述第一表面相对的至少两个电极。该方法还包括以下步骤：在第一位置处接收至少两个电极的第一电极的时变信号，使得该时变信号在该至少两个电极的第二电极处未被接收。

10. 发明申请

WO2005046658A3 METHODS OF MODULATING ANGIOGENESIS AND CANCER CELL PROLIFERATION 审中-公开
公开(公告)号：WO2005046658A3
公开(公告)日：2005-05-26
申请号：PCT/US2004/037754
申请日：2004-11-12
申请人： MCW RESEARCH FOUNDATION, INC. , ROMAN, Richard, J. , GREENE, Andrew , AMARAL, Sandra , SCICLI, Guillermo , BROWN, Stephen, L. , CHEN, Ping , GUO, Meng
发明人： ROMAN, Richard, J. , GREENE, Andrew , AMARAL, Sandra , SCICLI, Guillermo , BROWN, Stephen, L. , CHEN, Ping , GUO, Meng
IPC分类号： A61K31/155 , A61K31/5375 , A61K31/18 , A61K31/4192 , A61K31/255 , A61K31/20 , A61K31/4196 , A61K31/4174 , A61K31/496 , A61P35/00 , A61P9/10 , A61P9/12 , A61P11/06 , A61P3/04 , A61P25/28
摘要： Methods for regulating angiogenesis by modulating the activity of 20-HETE are disclosed. Further disclosed are methods of inhibiting cancer and tumor cell growth by exposing the cancer and tumor cells to 20-HETE inhibitors.

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