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1. 发明申请

WO2004018434A1 PYRIMIDINE COMPOUNDS 审中-公开
标题翻译：吡嗪化合物
公开(公告)号：WO2004018434A1
公开(公告)日：2004-03-04
申请号：PCT/EP2003/009221
申请日：2003-08-19
申请人： GLAXO GROUP LIMITED , EATHERTON, Andrew, John , GIBLIN, Gerard, Martin, Paul , GREEN, Richard, Howard (Deceased) , MITCHELL, William, Leonard , NAYLOR, Alan , RAWLINGS, Derek, Anthony , SLINGSBY, Brian, Peter , WHITTINGTON, Andrew, Richard
发明人： EATHERTON, Andrew, John , GIBLIN, Gerard, Martin, Paul , GREEN, Richard, Howard (Deceased) , MITCHELL, William, Leonard , NAYLOR, Alan , RAWLINGS, Derek, Anthony , SLINGSBY, Brian, Peter , WHITTINGTON, Andrew, Richard
IPC分类号： C07D239/42
CPC分类号： C07D239/42 , C07D401/12
摘要： The present invention relates to novel pyrimidine derivatives, pharmaceutical compositions containing these compounds and their use in the treatment of diseases, particularly pain, which diseases are caused directly or indirectly by an increase or decrease in activity of the cannabinoid receptor.
摘要翻译：本发明涉及新颖的嘧啶衍生物，含有这些化合物的药物组合物及其用于治疗由大麻素受体的活性增加或减少而直接或间接引起的疾病，特别是疼痛的疾病。

2. 发明申请

WO9501170A3 USE OF PHENETHANOLAMINE DERIVATIVES IN THE TREATMENT OF GASTROINTESTINAL DISORDERS 审中-公开
标题翻译：苯乙醇胺衍生物在治疗胃肠疾病中的应用
公开(公告)号：WO9501170A3
公开(公告)日：2002-02-14
申请号：PCT/EP9402106
申请日：1994-06-29
申请人： GLAXO GROUP LTD , STORER RICHARD , FOXTON MICHAEL WALTER , HARTLEY CHARLES DAVID , GREEN RICHARD HOWARD , TRAVERS STUART
发明人： STORER RICHARD , FOXTON MICHAEL WALTER , HARTLEY CHARLES DAVID , GREEN RICHARD HOWARD , TRAVERS STUART
IPC分类号： A61K45/06 , A61K31/135 , A61K31/195 , A61P1/00 , A61P1/04 , A61P29/00 , A61K31/165
CPC分类号： A61K31/195 , A61K31/135
摘要： The use of compounds of formula (I) in which: R is hydrogen, methyl or hydroxymethyl; R is substituted alkyl; R and R are each hydrogen, halogen, hydroxy, alkoxy, carboxy, alkoxycarbonyl, alkyl, nitro, haloalkyl group, or substituted alkyl; X is oxygen or sulphur; and Ar is optionally substituted phenyl or naphtyl; and pharmaceutically acceptable salts thereof in the treatment of gastrointestinal disorders is described.
摘要翻译：式（I）化合物的用途，其中：R 0是氢，甲基或羟甲基; R 1是取代的烷基; R 2和R 3各自为氢，卤素，羟基，烷氧基，羧基，烷氧基羰基，烷基，硝基，卤代烷基或取代的烷基; X是氧或硫; 和Ar是任选取代的苯基或萘基; 和其药学上可接受的盐在治疗胃肠道疾病中的用途。

3. 发明申请

WO2004018433A1 PYRIMIDINE DERIVATIVES AND THEIR USE AS CB2 MODULATORS 审中-公开
标题翻译：吡啶衍生物及其作为CB2调节剂的用途
公开(公告)号：WO2004018433A1
公开(公告)日：2004-03-04
申请号：PCT/EP2003/009217
申请日：2003-08-19
申请人： GLAXO GROUP LIMITED , EATHERTON, Andrew, John , GIBLIN, Gerard, Martin, Paul , GREEN, Richard, Howard (Deceased) , MITCHELL, William, Leonard , NAYLOR, Alan , RAWLINGS, Derek, Anthony , SLINGSBY, Brian, Peter , WHITTINGTON, Andrew, Richard
发明人： EATHERTON, Andrew, John , GIBLIN, Gerard, Martin, Paul , GREEN, Richard, Howard (Deceased) , MITCHELL, William, Leonard , NAYLOR, Alan , RAWLINGS, Derek, Anthony , SLINGSBY, Brian, Peter , WHITTINGTON, Andrew, Richard
IPC分类号： C07D239/42
CPC分类号： C07D239/42 , C07D401/06 , C07D401/12 , C07D403/06 , C07D405/12 , C07D409/12
摘要： This relates to novel pyrimidine derivatives, pharmaceutical compositions containing these compounds and their use in the treatment of diseases, particularly pain, which diseases are caused directly or indirectly by an increase or decrease in activity of the cannabinoid receptor.
摘要翻译：这涉及新颖的嘧啶衍生物，含有这些化合物的药物组合物及其在治疗疾病特别是疼痛中的用途，所述疾病通过大麻素受体的活性的增加或减少而直接或间接引起。

4. 发明申请

WO1997021665A1 ARYLETHANOLAMINE DERIVATIVES AND THEIR USE AS AGONISTS OF ATYPICAL BETA-ADRENOCEPTORS 审中-公开
标题翻译：芳香胺衍生物及其作为原子反应的激动剂使用
公开(公告)号：WO1997021665A1
公开(公告)日：1997-06-19
申请号：PCT/EP1996005469
申请日：1996-12-06
申请人： GLAXO GROUP LIMITED , GREEN, Richard, Howard , FOXTON, Michael, Walter
发明人： GLAXO GROUP LIMITED
IPC分类号： C07C229/42
CPC分类号： C07D209/08 , C07C217/84 , C07C229/42 , C07D215/04
摘要： The present invention relates to phenethanolamine derivatives of formula (I) wherein R represents an aryl group optionally substituted by one or more substituents selected from halogen, hydroxy, C1-6alkoxy, C1-6alkyl, nitro, cyano, hydroxymethyl and trifluoromethyl; R represents hydrogen or C1-6alkyl; R represents a group (A) where the ring is substituted by one to four further substituents selected from C1-6alkyl, halogen, trifluoromethyl, and C1-6alkoxy; or R represents a group (B) where the aromatic ring is optionally substituted by up to three further substituents selected from C1-6alkyl, halogen, trifluoromethyl, and C1-6alkoxy; R represents hydrogen, or C1-6alkyl; R represents ZCH2CO2H wherein Z represents a bond, or O; Y represents (CH2)n where n is 1-3; and physiologically acceptable derivatives thereof; to processes for their preparation; and their use in the treatment of conditions susceptible of amelioration by an atypical beta-adrenoceptor agonist.
摘要翻译：本发明涉及式（I）的苯乙醇胺衍生物，其中R 1表示任选被一个或多个选自卤素，羟基，C 1-6烷氧基，C 1-6烷基，硝基，氰基，羟甲基和三氟甲基的取代基取代的芳基; R 2表示氢或C 1-6烷基; R 3表示其中环被1-4个其它取代基取代的基团（A），所述取代基选自C 1-6烷基，卤素，三氟甲基和C 1-6烷氧基; 或R 3表示其中芳环任选被至多三个选自C 1-6烷基，卤素，三氟甲基和C 1-6烷氧基的其它取代基取代的基团（B）; R 4表示氢或C 1-6烷基; R 5表示ZCH 2 CO 2 H，其中Z表示键或O; Y表示（CH2）n，其中n为1-3; 及其生理上可接受的衍生物; 进行准备; 以及它们用于治疗易受非典型β-肾上腺素受体激动剂改善的病症。

5. 发明申请

WO0138311A3 PYRIMIDINE DERIVATIVES AS SELECTIVE INHIBITORS OF COX-2 审中-公开
标题翻译：作为COX-2的选择性抑制剂的吡嗪衍生物
公开(公告)号：WO0138311A3
公开(公告)日：2001-11-01
申请号：PCT/EP0011673
申请日：2000-11-23
申请人： GLAXO GROUP LTD , GREEN RICHARD HOWARD , HARTLEY CHARLES DAVID , NAYLOR ALAN , PAYNE JEREMY JOHN , PEGG NEIL ANTHONY
发明人： GREEN RICHARD HOWARD , HARTLEY CHARLES DAVID , NAYLOR ALAN , PAYNE JEREMY JOHN , PEGG NEIL ANTHONY
IPC分类号： A61K31/505 , A61P1/00 , A61P1/02 , A61P1/04 , A61P3/02 , A61P3/10 , A61P5/00 , A61P5/14 , A61P9/00 , A61P9/10 , A61P11/16 , A61P13/12 , A61P15/06 , A61P15/08 , A61P17/00 , A61P17/02 , A61P17/04 , A61P17/06 , A61P19/02 , A61P19/06 , A61P21/00 , A61P21/04 , A61P25/00 , A61P25/02 , A61P25/04 , A61P25/06 , A61P25/08 , A61P25/14 , A61P25/28 , A61P27/02 , A61P29/00 , A61P29/02 , A61P31/12 , A61P31/16 , A61P31/18 , A61P35/00 , A61P35/04 , A61P43/00 , C07D239/42
CPC分类号： C07D239/42
摘要： The invention provides the compounds of formula (I) and pharmaceutically acceptable derivatives thereof, in which: R and R are independently selected from H, C1-6alkyl, C2-6alkenyl, C3-6alkynyl, C3-10cycloalkylC0-6alkyl or C4-12bridged cycloalkane; and R is C1-6alkyl or NH2. Compounds of formula (I) are potent and selective inhibitors of COX-2 and are of use in the treatment of the pain, fever, inflammation of a variety of conditions and diseases.
摘要翻译：本发明提供式（I）化合物及其药学上可接受的衍生物，其中：R 1和R 2独立地选自H，C 1-6烷基，C 2-6烯基，C 3-6炔基，C 3-10环烷基C 0〜 C6烷基或C4-12桥连环烷烃; 和R 3是C 1-6烷基或NH 2。式（I）化合物是COX-2的有效和选择性抑制剂，可用于治疗疼痛，发热，各种病症和疾病的炎症。

6. 发明申请

WO1995001170A2 USE OF PHENETHANOLAMINE DERIVATIVES IN THE TREATMENT OF GASTROINTESTINAL DISORDERS 审中-公开
标题翻译：苯乙醇胺衍生物在治疗胃肠疾病中的应用
公开(公告)号：WO1995001170A2
公开(公告)日：1995-01-12
申请号：PCT/EP1994002106
申请日：1994-06-29
申请人： GLAXO GROUP LIMITED , STORER, Richard , FOXTON, Michael, Walter , HARTLEY, Charles, David , GREEN, Richard, Howard , TRAVERS, Stuart
发明人： GLAXO GROUP LIMITED
IPC分类号： A61K31/165
CPC分类号： A61K31/195 , A61K31/135
摘要： The use of compounds of formula (I) in which: R is hydrogen, methyl or hydroxymethyl; R is substituted alkyl; R and R are each hydrogen, halogen, hydroxy, alkoxy, carboxy, alkoxycarbonyl, alkyl, nitro, haloalkyl group, or substituted alkyl; X is oxygen or sulphur; and Ar is optionally substituted phenyl or naphtyl; and pharmaceutically acceptable salts thereof in the treatment of gastrointestinal disorders is described.
摘要翻译：式（I）化合物的用途，其中：R 0是氢，甲基或羟甲基; R 1是取代的烷基; R 2和R 3各自为氢，卤素，羟基，烷氧基，羧基，烷氧基羰基，烷基，硝基，卤代烷基或取代的烷基; X是氧或硫; 和Ar是任选取代的苯基或萘基; 和其药学上可接受的盐在治疗胃肠道疾病中的用途。

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