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1. 发明申请

WO2006121422A8 ANTIBODIES AGAINST CLOSTRIDIUM DIFFICILE TOXINS AND USES THEREOF 审中-公开
标题翻译：抗梭菌难解毒素的抗体及其用途
公开(公告)号：WO2006121422A8
公开(公告)日：2007-04-26
申请号：PCT/US2005003725
申请日：2005-02-04
申请人： UNIV MASSACHUSETTS , MEDAREX INC , AMBROSINO DONNA , BABCOCK GREGORY J , BROERING THERESA , GRAZIANO ROBERT , HERNANDEZ HECTOR JAVIER , LOWY ISRAEL , MANDELL ROBERT , MOLRINE DEBORAH , THOMAS WILLIAM D JR , ZHANG HUI-FEN
发明人： AMBROSINO DONNA , BABCOCK GREGORY J , BROERING THERESA , GRAZIANO ROBERT , HERNANDEZ HECTOR JAVIER , LOWY ISRAEL , MANDELL ROBERT , MOLRINE DEBORAH , THOMAS WILLIAM D JR , ZHANG HUI-FEN
IPC分类号： C07K16/12 , A61K39/08 , A61K39/395 , A61K39/40 , A61K47/48 , A61P1/00 , A61P1/12 , A61P31/04 , C07H21/04 , C12N1/15 , C12N1/21 , C12N5/06 , C12N5/10 , C12N15/13 , G01N33/554 , G01N33/569
CPC分类号： C07K16/1282 , A61K39/08 , A61K48/00 , A61K2039/505 , A61K2039/507 , C07K2317/21 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C12N15/86 , G01N33/56911 , G01N2333/33 , Y10S424/809 , A61K2300/00
摘要： Antibodies that specifically bind to toxins of C.difficile, antigen binding portions thereof, and methods of making and using the antibodies and antigen binding portions thereof are provided herein.
摘要翻译：本文提供了特异性结合C.difficile毒素的抗体，其抗原结合部分，以及制备和使用抗体及其抗原结合部分的方法。

2. 发明申请

WO2003086459A1 METHODS OF TREATEMENT USING CTLA-4 ANTIBODIES 审中-公开
标题翻译：使用CTLA-4抗体进行治疗的方法
公开(公告)号：WO2003086459A1
公开(公告)日：2003-10-23
申请号：PCT/US2003/011444
申请日：2003-04-11
申请人： MEDAREX, INC. , DAVIS, Thomas , KELER, Tibor , GRAZIANO, Robert , KORMAN, Alan J.
发明人： DAVIS, Thomas , KELER, Tibor , GRAZIANO, Robert , KORMAN, Alan J.
IPC分类号： A61K39/395
CPC分类号： C07K16/2818 , A61K38/00 , A61K39/00 , A61K39/0011 , A61K2039/505 , A61K2039/55516 , C07K16/30
摘要： The present invention provided method of treatment using human sequence antibodies against human CTLA-4. in particular, methods of treating cancer are provided.
摘要翻译：本发明提供了使用针对人CTLA-4的人序列抗体的治疗方法。特别是提供了治疗癌症的方法。

3. 发明申请

WO2003059282A3 HUMAN MONOCLONAL ANTIBODIES AGAINST CD30 审中-公开
公开(公告)号：WO2003059282A3
公开(公告)日：2003-07-24
申请号：PCT/US2003/000440
申请日：2003-01-07
申请人： MEDAREX, INC. , KELER, Tibor , GRAZIANO, Robert , TREML, John , DEO, Yashwant, M.
发明人： KELER, Tibor , GRAZIANO, Robert , TREML, John , DEO, Yashwant, M.
IPC分类号： A61K39/395
摘要： Isolated human monoclonal antibodies which bind to CD30 ( e.g ., human CD30) are disclosed. The human antibodies can be produced in a non-human transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are derivatives of the human antibodies ( e.g ., bispecific antibodies and immunoconjugates), pharmaceutical compositions comprising the human antibodies, non-human transgenic animals and hybridomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.

4. 发明申请

WO2008109533A2 HUMAN ANTIBODIES THAT BIND MULTIPLE IRTA FAMILY PROTEINS, AND USES THEREOF 审中-公开
标题翻译：结合多个IRTA家族蛋白的人抗体及其用途
公开(公告)号：WO2008109533A2
公开(公告)日：2008-09-12
申请号：PCT/US2008055677
申请日：2008-03-03
申请人： MEDAREX INC , GRAZIANO ROBERT , HUANG HAICHUN , YANG LAN , TOY KRISTOPHER , LEBLANC HEIDI N
发明人： GRAZIANO ROBERT , HUANG HAICHUN , YANG LAN , TOY KRISTOPHER , LEBLANC HEIDI N
IPC分类号： A61K39/395
CPC分类号： C07K16/283 , C07K2317/21 , C07K2317/565 , C07K2317/732 , C07K2317/92
摘要： The present disclosure provides isolated monoclonal antibodies that bind to multiple IRTA family proteins with high affinity, particularly human monoclonal antibodies. Preferred antibodies of the invention specifically bind an IRTA4 protein and at least one other IRTA family protein. Nucleic acid molecules encoding the antibodies of this disclosure, expression vectors, host cells and methods for expressing the antibodies of this disclosure are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of this disclosure are also provided. This disclosure also provides methods for detecting IRTA proteins, as well as methods for treating various cancers, such as B cell lymphomas, using anti-IRTA antibodies of this disclosure.
摘要翻译：本公开提供了以高亲和力结合多个IRTA家族蛋白的分离的单克隆抗体，特别是人类单克隆抗体。本发明的优选抗体特异性结合IRTA4蛋白和至少一种其他IRTA家族蛋白。还提供了编码本公开抗体的核酸分子，表达载体，宿主细胞和用于表达本公开抗体的方法。还提供了包含本公开的抗体的免疫缀合物，双特异性分子和药物组合物。本公开还提供了检测IRTA蛋白的方法，以及使用本公开的抗IRTA抗体治疗各种癌症如B细胞淋巴瘤的方法。

5. 发明申请

WO2006121422A2 ANTIBODIES AGAINST CLOSTRIDIUM DIFFICILE TOXINS AND USES THEREOF 审中-公开
标题翻译：抗痘痘毒素抗体及其用途
公开(公告)号：WO2006121422A2
公开(公告)日：2006-11-16
申请号：PCT/US2005/003725
申请日：2005-02-04
申请人： UNIVERSITY OF MASSACHUSETTS , MEDAREX, INC. , AMBROSINO, Donna , BABCOCK, Gregory, J. , BROERING, Theresa , GRAZIANO, Robert , HERNANDEZ, Hector, Javier , LOWY, Israel , MANDELL, Robert , MOLRINE, Deborah , THOMAS, William, D. , ZHANG, Hui-fen
发明人： AMBROSINO, Donna , BABCOCK, Gregory, J. , BROERING, Theresa , GRAZIANO, Robert , HERNANDEZ, Hector, Javier , LOWY, Israel , MANDELL, Robert , MOLRINE, Deborah , THOMAS, William, D. , ZHANG, Hui-fen
IPC分类号： A61K39/40 , A61K47/64 , C07H21/04 , C07K16/12 , C12N5/06 , G01N33/554 , G01N33/569
CPC分类号： C07K16/1282 , A61K39/08 , A61K48/00 , A61K2039/505 , A61K2039/507 , C07K2317/21 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C12N15/86 , G01N33/56911 , G01N2333/33 , Y10S424/809 , A61K2300/00
摘要： Antibodies that specifically bind to toxins of C. difficile , antigen binding portions thereof, and methods of making and using the antibodies and antigen binding portions thereof are provided herein.
摘要翻译：本文提供了特异性结合C.difficile毒素的抗体，其抗原结合部分，以及制备和使用抗体及其抗原结合部分的方法。

6. 发明申请

WO2006002438A3 HUMAN MONOCLONAL ANTIBODIES TO FC GAMMA RECEPTOR I (CD64) 审中-公开
标题翻译：人类单克隆抗体对FC GAMMA受体I（CD64）
公开(公告)号：WO2006002438A3
公开(公告)日：2006-05-04
申请号：PCT/US2005022991
申请日：2005-06-03
申请人： MEDAREX INC , GRAZIANO ROBERT , SUNDARAPANDIYAN KARUNA
发明人： GRAZIANO ROBERT , SUNDARAPANDIYAN KARUNA
IPC分类号： C07K16/28 , A61K39/00 , A61K39/395 , C12N5/10 , C12N5/16 , C12N15/00
CPC分类号： C07K16/283 , C07K2317/21 , C07K2317/56 , C07K2317/76 , C07K2317/77
摘要： The present invention provides isolated monoclonal antibodies, particularly human antibodies, that bind to CD64 with high affinity. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for treating autoimmune disorders, transplant rejection, Graft Versus Host Disease, or cancer and for enhanced presentation of antigen using conjugates of an antigen and an anti-CD64 antibody.
摘要翻译：本发明提供以高亲和力结合CD64的分离的单克隆抗体，特别是人抗体。还提供了编码本发明抗体的核酸分子，表达载体，宿主细胞和用于表达本发明的抗体的方法。还提供了免疫偶联物，双特异性分子和包含本发明抗体的药物组合物。本发明还提供了治疗自身免疫疾病，移植排斥，移植物抗宿主病或癌症的方法，并且使用抗原和抗CD64抗体的缀合物来增强抗原呈递。

7. 发明申请

WO2003064606A2 HUMAN MONOCLONAL ANTIBODIES TO PROSTATE SPECIFIC MEMBRANE ANTIGEN (PSMA) 审中-公开
标题翻译：人类单克隆抗体预防特异性膜抗原（PSMA）
公开(公告)号：WO2003064606A2
公开(公告)日：2003-08-07
申请号：PCT/US2003/002448
申请日：2003-01-28
申请人： MEDAREX, INC. , DEO, Yashwant, M. , GRAZIANO, Robert , HUDSON, Debra , HOLMES, Eric, H. , TINO, William, T. , BLACK, Amelia
发明人： DEO, Yashwant, M. , GRAZIANO, Robert , HUDSON, Debra , HOLMES, Eric, H. , TINO, William, T. , BLACK, Amelia
IPC分类号： C12N
CPC分类号： C07K16/3069 , A61K2039/505 , C07K16/28 , C07K16/283 , C07K2317/21 , C07K2317/31 , C07K2317/54 , C07K2317/56 , C07K2317/565 , C07K2317/732 , C07K2317/77
摘要： Isolated human monoclonal antibodies which bind to PSMA, and related antibody-based compositions and molecules, are disclosed. The human antibodies can be produced in a nonhuman transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, nonhuman transgenic animals and hybridomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.
摘要翻译：公开了与PSMA结合的分离的人单克隆抗体以及相关的基于抗体的组合物和分子。人抗体可以通过经历V-D-J重组和同种型转换能够产生人单克隆抗体多重同种型的非人转基因动物，例如转基因小鼠中产生。还公开了包含人抗体，非人转基因动物和产生人抗体的杂交瘤的药物组合物，以及使用人抗体的治疗和诊断方法。

8. 发明申请

WO0109192A9 HUMAN MONOCLONAL ANTIBODIES TO PROSTATE SPECIFIC MEMBRANE ANTIGEN 审中-公开
标题翻译：人类单克隆抗体预防特异性膜抗原
公开(公告)号：WO0109192A9
公开(公告)日：2002-09-12
申请号：PCT/US0020247
申请日：2000-07-26
申请人： MEDAREX INC , NORTHWEST BIOTHERAPEUTICS INC , DEO YASHWANT , GRAZIANO ROBERT , HUDSON DEBRA , HOLMES ERIC H , TINO WILLIAM T
发明人： DEO YASHWANT , GRAZIANO ROBERT , HUDSON DEBRA , HOLMES ERIC H , TINO WILLIAM T
IPC分类号： A01K67/027 , A61K39/395 , A61P13/08 , A61P35/00 , C07K16/28 , C07K16/30 , C07K16/46 , C07K19/00 , C12N5/10 , C12N5/20 , C12N15/02 , C12N15/09 , C12N15/85 , C12P21/08 , G01N33/574 , G01N33/577
CPC分类号： C12N15/8509 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/075 , A01K2217/30 , A01K2227/105 , A01K2267/01 , A61K2039/505 , C07K16/283 , C07K16/3069 , C07K2317/21 , C07K2317/31 , C07K2317/732 , C07K2317/77
摘要： Isolated human monoclonal antibodies and antigen-binding portions thereof which specifically bind to PSMA are disclosed. Also disclosed are bispecifics which include the antibodies or antibody portions. The human antibodies can be produced in a non-human transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, non-human transgenic animals and hybridomas which produce the human antobodies, and therapeutic and diagnostic methods for using the human antibodies.
摘要翻译：公开了与PSMA特异性结合的分离的人单克隆抗体及其抗原结合部分。还公开了包括抗体或抗体部分的双特异性。人抗体可以通过经历V-D-J重组和同种型转换能够产生人单克隆抗体多重同种型的非人转基因动物，例如转基因小鼠中产生。还公开了包含人抗体，非人转基因动物和产生人载体的杂交瘤的药物组合物，以及使用人抗体的治疗和诊断方法。

9. 发明申请

WO0109186A3 THERAPEUTIC COMPOUNDS COMPRISED OF ANTI-FC RECEPTOR BINDING AGENTS 审中-公开
标题翻译：抗FC受体结合剂包含的治疗化合物
公开(公告)号：WO0109186A3
公开(公告)日：2001-05-31
申请号：PCT/US0020158
申请日：2000-07-25
申请人： MEDAREX INC , DEO YASHWANT M , GOLDSTEIN JOEL , GRAZIANO ROBERT , KELER TIBOR
发明人： DEO YASHWANT M , GOLDSTEIN JOEL , GRAZIANO ROBERT , KELER TIBOR
IPC分类号： C12N15/09 , A61K38/18 , A61K45/00 , A61P31/00 , A61P31/10 , A61P33/00 , A61P35/00 , A61P37/02 , C07K14/485 , C07K16/28 , C07K16/32 , C07K16/42 , C07K19/00 , A61K39/395
CPC分类号： C07K16/283 , A61K38/1808 , A61K2039/505 , C07K14/485 , C07K16/2863 , C07K16/32 , C07K2317/24 , C07K2317/31 , C07K2317/51 , C07K2317/55 , C07K2317/732 , C07K2317/77 , C07K2319/00
摘要： Multispecific molecules which induce effector cell-mediated killing of target cells are disclosed. The molecules are "multispecific" because they bind to multiple (two or more), distinct targets, one of which is an Fc receptor on the surface of an immune cell. Multispecific molecules of the invention include molecules comprised of at least one portion which binds to an Fc receptor, such as an Fc gamma receptor (e.g., Fc gamma RI) or an Fc alpha receptor, and at least one other portion which binds to a different target, such as an antigen on a tumor cell or a pathogen. Multispecific molecules of the invention also include antigen "multimer complexes" comprised of multiple (i.e., two or more) portions which bind to a molecule on an antigen presenting cell (APC), such as an Fc receptor, linked to one or more antigens. These multimer complexes target antigens, such as self-antigens, to APCs to induce and/or enhance internalization (endocytosis), processing and/or presentation of the antigen by the APC. Therefore, these molecules can be used to induce or enhance an immune response either in vivo or in vitro against a normally non-immunogenic protein, such as a self-antigen. In a particular embodiment, at least one portion of the multispecific molecules comprises a humanized or human antibody or antibody fragment (e.g., ScFv or Fab') which binds to an Fc receptor or a receptor on a target cell (e.g., EGF-R or HER2).
摘要翻译：公开了诱导效应细胞介导的靶细胞杀伤的多特异性分子。分子是“多特异性”，因为它们结合多个（两个或更多个）不同的靶，其中之一是免疫细胞表面上的Fc受体。本发明的多特异性分子包括由结合Fc受体的至少一部分组成的分子，例如Fcγ受体（例如，FcγRI）或Fcα受体，以及至少另一部分结合不同的靶，例如肿瘤细胞或病原体上的抗原。本发明的多特异性分子还包括与多个（即两个或更多个）部分结合的抗原“多聚体复合物”，其与一个或多个抗原连接的抗原呈递细胞（APC）如Fc受体上的分子结合。这些多聚体复合物将抗原（例如自身抗原）靶向APC以诱导和/或增强APC的内化（内吞作用），加工和/或呈递抗原。因此，这些分子可以用于诱导或增强体内或体外针对正常非免疫原性蛋白（例如自身抗原）的免疫应答。在特定实施方案中，多特异性分子的至少一部分包含与Fc受体或靶细胞上的受体结合的人源化或人抗体或抗体片段（例如，ScFv或Fab'）（例如，EGF-R或 HER2）。

10. 发明申请

WO2006116192A2 IRTA-1 ANTIBODIES AND THEIR USES 审中-公开
标题翻译： IRTA-1抗体及其用途
公开(公告)号：WO2006116192A2
公开(公告)日：2006-11-02
申请号：PCT/US2006/015256
申请日：2006-04-20
申请人： MEDAREX, INC. , GRAZIANO, Robert , KING, David, J. , KEMPE, Thomas, D. , SRINIVASAN, Mohan , CARDARELLI, Josephine, M. , TRUITT, Morgan , LIU, Jie
发明人： GRAZIANO, Robert , KING, David, J. , KEMPE, Thomas, D. , SRINIVASAN, Mohan , CARDARELLI, Josephine, M. , TRUITT, Morgan , LIU, Jie
IPC分类号： A61K39/395
CPC分类号： C07K16/283 , C07K2317/21 , C07K2317/92
摘要： The present invention provides isolated monoclonal antibodies, particularly human monoclonal antibodies, that specifically bind to IRTA-I with high affinity. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for detecting IRTA-I, as well as methods for treating various B cell malignancies, including Multiple Myeloma and diffuse large B cell lymphomas.
摘要翻译：本发明提供以高亲和力特异性结合IRTA-1的分离的单克隆抗体，特别是人单克隆抗体。还提供了编码本发明抗体的核酸分子，表达载体，宿主细胞和用于表达本发明的抗体的方法。还提供了免疫偶联物双特异性分子和包含本发明抗体的药物组合物。本发明还提供了检测IRTA-1的方法，以及用于治疗各种B细胞恶性肿瘤的方法，包括多发性骨髓瘤和弥漫性大B细胞淋巴瘤。

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