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1. 发明申请

WO2005051992A1 USE OF NEUBLASMIN AS A MAKER FOR TESTIS CANCER 审中-公开
标题翻译：使用NEUBLASMIN作为TESTIS癌症的制造商
公开(公告)号：WO2005051992A1
公开(公告)日：2005-06-09
申请号：PCT/EP2004/053101
申请日：2004-11-25
申请人： NSGENE A/S , GRØNBORG, Mette , BLOM, Nikolaj
发明人： GRØNBORG, Mette , BLOM, Nikolaj
IPC分类号： C07K14/475
CPC分类号： C07K14/475
摘要： The present invention relates to the field of diagnostic and therapeutic use of proteins and genes, in particular to the diagnostic and therapeutic use of a secreted human hormone/growth factor, Neublasmin, and use of the gene coding for Neublasmin in the diagnosis and treatment of testicular disorders, in particular diagnosis and treatment of germ cell tumours and infertility. The invention also relates to use of Neublasmin in the treatment of CNS disorders. Neublasmin is expressed at high levels in human adult testicles and in developing mouse testicles from pn 22 and onwards. Expression of Neublasmin is strongly up-regulated in carcinoma in situ. Expression is also seen in foetal and adult brain.
摘要翻译：本发明涉及蛋白质和基因的诊断和治疗用途领域，特别涉及分泌的人激素/生长因子Neublasmin的诊断和治疗用途，以及编码Neublasmin的基因在诊断和治疗中的用途睾丸疾病，特别是生殖细胞肿瘤和不育症的诊断和治疗。本发明还涉及使用Neublasmin治疗CNS疾病。 Neublasmin在人类成年睾丸中以高水平表达，并在pn 22及以上表达小鼠睾丸。 Neublasmin的表达在原位癌中强烈上调。在胎儿和成人脑中也可见表达。

2. 发明申请

WO2003018779A1 ISOLATION OF CELLS FROM NEURAL CELL POPULATIONS USING ANTIBODIES TO FA1/DLK1 审中-公开
标题翻译：使用抗体对FA1 / DLK1从神经细胞群体中分离细胞
公开(公告)号：WO2003018779A1
公开(公告)日：2003-03-06
申请号：PCT/DK2002/000559
申请日：2002-08-26
申请人： NSGENE A/S , JENSEN, Charlotte, Harken , TEISNER, Børge , GRØNBORG, Mette , WAHLBERG, Lars
发明人： JENSEN, Charlotte, Harken , TEISNER, Børge , GRØNBORG, Mette , WAHLBERG, Lars
IPC分类号： C12N5/00
CPC分类号： C12N5/0623 , A61K35/12 , C12N2503/02
摘要： The present invention relates to the use of antibodies recognising Fetal Antigen-1 (FA1/dlk1) for the detection and isolation of cell subpopulations from neural cell populations, in particular from cell populations from the central nervous system. In one embodiment, the dopaminergic neurons in the Substantia nigra pars compacta are detected and separated from other cell populations in this region of the brain. In another embodiment, neural stem and progenitor cells are isolated from other more committed cells in the CNS. The isolated cells may be used for transplantation, drug screening, production of cell type specific antibodies, and gene discovery.
摘要翻译：本发明涉及识别胎儿抗原-1（FA1 / dlk1）的抗体用于从神经细胞群体特别是来自中枢神经系统的细胞群体中检测和分离细胞亚群的用途。在一个实施方案中，黑质黑质纲中的多巴胺能神经元被检测并与该区域的其它细胞群体分离。在另一个实施方案中，神经干细胞和祖细胞从CNS中其他更致命的细胞分离。分离的细胞可用于移植，药物筛选，细胞型特异性抗体的产生和基因发现。

3. 发明申请

WO2002086106A1 METHOD AND CULTURE MEDIUM FOR PRODUCING NEURAL CELLS EXPRESSINGTYROSINE HYDROXYLASE 审中-公开
标题翻译：用于生产表达酪氨酸羟化酶的神经细胞的方法和培养基
公开(公告)号：WO2002086106A1
公开(公告)日：2002-10-31
申请号：PCT/DK2002/000262
申请日：2002-04-23
申请人： NSGENE A/S , MEIJER, Xia , GRØNBORG, Mette , WAHLBERG, Lars
发明人： MEIJER, Xia , GRØNBORG, Mette , WAHLBERG, Lars
IPC分类号： C12N5/08
CPC分类号： C12N5/0623 , A61K35/12 , C12N5/0619 , C12N2500/25 , C12N2500/46 , C12N2501/01 , C12N2501/105 , C12N2501/11 , C12N2501/113 , C12N2501/115 , C12N2501/119 , C12N2501/13 , C12N2501/23 , C12N2501/235 , C12N2501/392 , C12N2501/395 , C12N2510/04
摘要： The invention provides a method for efficiently generating large numbers of tyrosine hydroxylase (TH) expressing neural cells for neurotransplantation into a host to treat neurodegenerative disease, neurological trauma, stroke, or in other diseases of the nervous system involving loss of neural cells, particularly Parkinson's disease. The method comprises introducing a population of expanded and plated neural progenitor cells to a defined culture medium comprising one or more growth factors belonging to the fibroblast growth factor (FGF) family, a molecule which results in the activation of cyclic AMP (cAMP) dependent protein kinase (PKA) and an agent which activates protein kinase C (PKC).
摘要翻译：本发明提供了一种用于有效地产生大量表达用于神经移植入宿主的神经细胞的酪氨酸羟化酶（TH）的方法，用于治疗神经变性疾病，神经损伤，中风或涉及神经细胞丧失的其他疾病，特别是帕金森病疾病。该方法包括将扩增和铺板的神经祖细胞群引入包含属于成纤维细胞生长因子（FGF）家族的一种或多种生长因子的限定培养基，导致环AMP（cAMP）依赖性蛋白激活的分子激酶（PKA）和激活蛋白激酶C（PKC）的药剂。

4. 发明申请

WO2006013462A2 GROWTH FACTORS NSG28, NSG30, AND NSG32 审中-公开
标题翻译：生长因子NSG28，NSG30和NSG32
公开(公告)号：WO2006013462A2
公开(公告)日：2006-02-09
申请号：PCT/IB2005/002490
申请日：2005-08-01
申请人： NSGENE A/S , PETERSEN, Thomas, Nordahl , WAHLBERG, Lars , BRUNAK, Søren , JOHANSEN, Teit, E. , BLOM, Nikolaj , GRØNBORG, Mette , KUSK, Philip
发明人： PETERSEN, Thomas, Nordahl , WAHLBERG, Lars , BRUNAK, Søren , JOHANSEN, Teit, E. , BLOM, Nikolaj , GRØNBORG, Mette , KUSK, Philip
IPC分类号： C07K14/475
CPC分类号： C07K14/475 , A61K38/00
摘要： Disclosed are NsG28, NsG30, NsG32 polypeptides, nucleic acids encoding NsG28, NsG30, NsG32 polypeptides, and antibodies that bind to NsG28, NsG30, NsG32 polypeptides as well as methods of making and using the same.
摘要翻译：公开了NsG28，NsG30，NsG32多肽，编码NsG28，NsG30，NsG32多肽的核酸，以及结合NsG28，NsG30，NsG32多肽的抗体以及制备和使用它们的方法。

5. 发明申请

WO2006048021A1 USE OF NEUBLASMIN AS A MARKER FOR TESTIS CANCER 审中-公开
标题翻译：使用NEUBLASMIN作为TESTIS癌症标记
公开(公告)号：WO2006048021A1
公开(公告)日：2006-05-11
申请号：PCT/DK2005/000707
申请日：2005-11-04
申请人： NSGENE A/S , GRØNBORG, Mette , BLOM, Nikolaj
发明人： GRØNBORG, Mette , BLOM, Nikolaj
IPC分类号： C07K14/475
CPC分类号： C07K14/4756
摘要： The present invention relates to the field of diagnostic and therapeutic use of proteins and genes, in particular to the diagnostic and therapeutic use of a secreted human hormone/growth factor, Neublasmin, and use of the gene coding for Neublasmin in the diagnosis and treatment of testicular disorders, in particular diagnosis and treatment of germ cell tumours and infertility. The invention also relates to use of Neublasmin in the treatment of CNS disorders. Neublasmin is expressed at high levels in human adult testicles and in developing mouse testicles from pn 22 and onwards. Expression of Neublasmin is strongly up-regulated in carcinoma in situ. Expression is also seen in foetal and adult brain.
摘要翻译：本发明涉及蛋白质和基因的诊断和治疗用途领域，特别涉及分泌的人激素/生长因子Neublasmin的诊断和治疗用途，以及编码Neublasmin的基因在诊断和治疗中的用途睾丸疾病，特别是生殖细胞肿瘤和不育症的诊断和治疗。本发明还涉及使用Neublasmin治疗CNS疾病。在人类成年睾丸中以及从pn22及其以后开发的小鼠睾丸中，表达高水平的Neublasmin。 Neublasmin的表达在原位癌中被强烈上调。在胎儿和成人脑中也可见表达。

6. 发明申请

WO2004108760A2 IMPROVED SECRETION OF NEUBLASTIN 审中-公开
标题翻译：改善分泌物
公开(公告)号：WO2004108760A2
公开(公告)日：2004-12-16
申请号：PCT/DK2004/000411
申请日：2004-06-10
申请人： NSGENE A/S , BIOGEN IDEC MA, INC. , WAHLBERG, Lars, U. , GRØNBORG, Mette , KUSK, Philip , TORNØE, Jens , PEDERSON, Nels, E. , SISK, William, P.
发明人： WAHLBERG, Lars, U. , GRØNBORG, Mette , KUSK, Philip , TORNØE, Jens , PEDERSON, Nels, E. , SISK, William, P.
IPC分类号： C07K14/475
CPC分类号： C12N15/86 , A01K2217/05 , A61K9/0051 , A61K9/0085 , A61K48/0075 , C07K14/4756 , C12N2740/15043 , C12N2740/15052
摘要： The present invention concerns methods and compositions for producing a neublastin polypeptide as well as local delivery of neublastin to specific regions of the nervous system including the central nervous system and the eye for example by gene therapy. The biologically active neublastin polypeptide is produced from a construct not encoding naturally occurring neublastin pro-region, i.e. a construct comprising a nucleic acid with a promoter sequence operably linked to a nucleotide sequence encoding a signal peptide and a neublastin polypeptide, wherein said nucleotide sequence does not encode a neublastin pro-region.
摘要翻译：本发明涉及用于产生新斯的斯多肽多肽的方法和组合物，以及例如通过基因治疗将神经系统局部递送至神经系统的特定区域，包括中枢神经系统和眼睛。生物活性的新斯的斯多肽由不编码天然存在的新伯斯匹林前区的构建体产生，即包含具有可操作地连接到编码信号肽和新伯斯特蛋白多肽的核苷酸序列的启动子序列的核酸的构建体，其中所述核苷酸序列不编码新伯斯坦的亲区。

7. 发明申请

WO2006072601A3 THERAPEUTIC USE OF GROWTH FACTORS, NsG29 AND NsG31 审中-公开
公开(公告)号：WO2006072601A3
公开(公告)日：2006-07-13
申请号：PCT/EP2006/000178
申请日：2006-01-09
申请人： NSGENE A/S , PETERSEN, Thomas, Nordahl , BLOM, Nikolaj , GRØNBORG, Mette , KUSK, Philip , BRUNAK, Søren , JOHANSEN, Teit, E. , WAHLBERG, Lars, U.
发明人： PETERSEN, Thomas, Nordahl , BLOM, Nikolaj , GRØNBORG, Mette , KUSK, Philip , BRUNAK, Søren , JOHANSEN, Teit, E. , WAHLBERG, Lars, U.
IPC分类号： C12N15/12 , C07K14/47 , C07K16/18 , C12N15/63
摘要： The present invention relates to the field of therapeutic use of proteins, genes and cells, in particular to the therapy based on secreted therapeutic proteins, NsG29 and NsG31. NsG29 and NsG31 are members of a newly identified family of growth factors with a specific cystein pattern and characterised by expression in the nevous system. The secreted growth factors have potential for the treatment of disorders of the nervous system. The invention also relates to bioactive NsG29 and NsG31 polypeptide fragments and the corresponding encoding DNA sequences.

8. 发明申请

WO2005095450A2 THERAPEUTIC USE OF A GROWTH FACTOR, NSG33 审中-公开
标题翻译： NSG33的生长因子的治疗用途
公开(公告)号：WO2005095450A2
公开(公告)日：2005-10-13
申请号：PCT/EP2005/051431
申请日：2005-03-30
申请人： NSGENE A/S , GRØNBORG, Mette , KUSK, Philip , BLOM, Nikolaj , PETERSEN, Thomas, Nordahl , JOHANSEN, Teit, E. , BRUNAK, Søren , WAHLBERG, Lars
发明人： GRØNBORG, Mette , KUSK, Philip , BLOM, Nikolaj , PETERSEN, Thomas, Nordahl , JOHANSEN, Teit, E. , BRUNAK, Søren , WAHLBERG, Lars
IPC分类号： C07K14/475
CPC分类号： C07K14/475 , A01K67/027 , A01K2207/05 , A01K2207/20 , A01K2227/105 , A01K2267/0356 , A61K38/00 , A61K38/17 , A61K38/185 , C12N2799/027
摘要： The present invention relates to the field of therapeutic use of proteins, genes and cells. More specifically the invention relates to therapy based on the biological function of a secreted therapeutic protein, NsG33, in particular for the treatment of disorders of the nervous system. NsG33 is a nerve survival and growth factor with antiapoptotic effects on a cell line with neuronal potential and with neuroprotective and/or neurogenesis effects on a neural precursor cell line and on primary striatal cultures. The invention also relates to novel bioactive NsG33 polypeptide fragments and the corresponding encoding DNA sequences.
摘要翻译：本发明涉及蛋白质，基因和细胞的治疗用途领域。更具体地，本发明涉及基于分泌的治疗性蛋白质NsG33的生物学功能的治疗，特别是用于治疗神经系统疾病。 NsG33是神经存活和生长因子，对具有神经元潜力的细胞系具有抗细胞凋亡作用，并且对神经前体细胞系和原始纹状体培养物具有神经保护和/或神经发生作用。本发明还涉及新的生物活性NsG33多肽片段和相应的编码DNA序列。

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