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1. 发明申请

WO1989004834A1 IMMUNOGLOBULIN E COMPETITOR 审中-公开
标题翻译：免疫球蛋白E竞争者
公开(公告)号：WO1989004834A1
公开(公告)日：1989-06-01
申请号：PCT/GB1988001018
申请日：1988-11-18
申请人： RESEARCH CORPORATION LIMITED , GOULD, Hannah, Jane , HELM, Birgit, Anna , MARSH, Philip, John, Henry, Benedict
发明人： RESEARCH CORPORATION LIMITED
IPC分类号： C07K07/00
CPC分类号： C07K16/00 , A61K38/00 , C07K16/4291
摘要： A polypeptide competitor or analogue for human Immunoglobulin E (IgE) low affinity sites comprises a polypeptide which has a sequence of amino acid which has a sequence of amino acids which is shown in Table I. This amino acid sequence corresponds to amino acids 340 to 439 of the epsilon heavy chain of IgE. A particularly preferred polypeptide competitor has a sequence of amino acids corresponding to amino acids 340 to 547 of the epsilon heavy chain of IgE as set out in Table V herein, which also shows the corresponding DNA sequence coding therefor. Such a polypeptide may also include additional short sequences at the beginning and/or end of the core sequence which are physiologically harmless and do not contribute to the ability of the core sequence to compete with native IgE for the low affinity receptor sites on human cells. The polypeptide may be produced synthetically or by expression from Escherichia coli containing a plasmid having a DNA segment coding for the polypeptide.
摘要翻译：用于人免疫球蛋白E（IgE）低亲和位点的多肽竞争剂或类似物包含具有氨基酸序列的多肽，其氨基酸序列如表I所示。该氨基酸序列对应于氨基酸340至439 的IgE重链。特别优选的多肽竞争剂具有对应于本文表V中列出的IgE的ε重链的氨基酸340至547的氨基酸序列，其也显示了编码的相应DNA序列。这样的多肽还可以在核心序列的起始和/或末端包括生理上无害的附加短序列，并且对核心序列与天然IgE与人细胞上的低亲和力受体位点竞争的能力没有贡献。多肽可以由含有编码多肽的DNA区段的质粒的大肠杆菌合成或表达产生。

2. 发明申请

WO1995014779A1 MUTATED HIG-E FRAGMENTS AND DERIVATIVE THEREOF 审中-公开
标题翻译：突破的HIG-E片段及其衍生物
公开(公告)号：WO1995014779A1
公开(公告)日：1995-06-01
申请号：PCT/GB1994002561
申请日：1994-11-22
申请人： 3i RESEARCH EXPLOITATION LIMITED , CELLTECH THERAPEUTICS LIMITED , GOULD, Hannah, Jane , YOUNG, Robert, James , SUTTON, Brian, John , OWENS, Raymond, John
发明人： 3i RESEARCH EXPLOITATION LIMITED , CELLTECH THERAPEUTICS LIMITED
IPC分类号： C12N15/13
CPC分类号： C07K16/283 , A61K38/00
摘要： The invention provides a mutated glycosylated polypeptide which includes at least a part of the hIgE-Fc chain of sufficient length to bind to Fc ELEMENT RI and/or Fc ELEMENT RII receptor sites on human cells wherein Cys 225 has been mutated by replacement with another amino acid residue or has been deleted, optionally together with Val 224 and Ser 226 or with Val 224 Ser 226 and Arg 227, and wherein at least one of the sites Asn 394 and, if present, Asn 265 and/or Asn 371 bears a glycoside chain.
摘要翻译：本发明提供了突变的糖基化多肽，其包括至少一部分具有足够长度的hIgE-Fc链，以结合人细胞上的Fc ELEMENT RI和/或Fc ELEMENT RII受体位点，其中Cys 225已经被另一个氨基酸残基或已经被缺失，任选地与Val 224和Ser 226或Val 224 Ser 226和Arg 227一起缺失，并且其中至少一个位点Asn 394和（如果存在的话）Asn 265和/或Asn 371带有糖苷链。

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