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1. 发明申请

WO2012159243A1 USER INTERFACE FOR HANDWRITING INPUTS 审中-公开
标题翻译：用户界面进行手写输入
公开(公告)号：WO2012159243A1
公开(公告)日：2012-11-29
申请号：PCT/CN2011/074387
申请日：2011-05-20
申请人： MICROSOFT CORPORATION , DAI, Juan , ZHOU, Yi , GONG, Xin , CHEN, Liang
发明人： DAI, Juan , ZHOU, Yi , GONG, Xin , CHEN, Liang
IPC分类号： G06F3/041
CPC分类号： G06K9/00436 , G06F3/018 , G06F3/04883
摘要： A method, medium, device, and user interface are provided for receiving a handwriting input and for presenting prediction candidates based on the handwriting input. A pen down event is detected in a writing panel of a user interface. The writing panel is expanded to overlie function keys and a candidate window of the user interface such that those features are made inaccessible for inadvertent selections thereof. Upon detection of a pen up event the writing panel is decreased in size to again reveal the features. Recognition candidates are identified based on the handwriting input. Prediction candidates are also identified based on a highest ranking recognition candidate and are presented in combination with the highest ranking recognition candidate. Prediction candidates are thereby identifiable with the recognition candidate with which they are associated and selection of a prediction candidate and recognition candidate may be performed in single selection input.
摘要翻译：提供了一种方法，媒体，设备和用户界面，用于接收手写输入并基于手写输入呈现预测候选。在用户界面的书写面板中检测到笔直事件。写入面板被扩展以覆盖用户界面的功能键和候选窗口，使得这些特征使得无意识地进行选择。当检测到笔触事件时，写入面板的尺寸减小以再次显示特征。基于手写输入识别识别候选者。预测候选者也基于最高排名识别候选来确定，并且与最高排名的识别候选者一起呈现。因此，预测候选者可以与其相关联的识别候选者识别，并且可以在单选输入中执行预测候选和识别候选的选择。

2. 发明申请

WO2005066189A1 PHOSPHONATES, MONOPHOSPHONAMIDATES, BISPHOSPHONAMIDATES FOR THE TREATMENT OF VIRAL DISEASES 审中-公开
标题翻译：磷酸盐，单磷酰胺，治疗病毒性疾病的双磷酰胺
公开(公告)号：WO2005066189A1
公开(公告)日：2005-07-21
申请号：PCT/US2004/043969
申请日：2004-12-29
申请人： GILEAD SCIENCES, INC. , CHENG, Xiaqin , COOK, Gary, P. , DESAI, Manoj, C. , DOERFFLER, Edward , HE, Gong-Xin , KIM, Choung, U. , LEE, William, A. , ROHLOFF, John, C. , WANG, Jianying , YANG, Zheng-Yu
发明人： CHENG, Xiaqin , COOK, Gary, P. , DESAI, Manoj, C. , DOERFFLER, Edward , HE, Gong-Xin , KIM, Choung, U. , LEE, William, A. , ROHLOFF, John, C. , WANG, Jianying , YANG, Zheng-Yu
IPC分类号： C07F9/44
CPC分类号： C07F9/65616 , Y02P20/55
摘要： Compounds and compositions of Formula (I) are described, useful as anti-proliferative agents, and in particular anti-HPV.
摘要翻译：描述了式（I）的化合物和组合物，其可用作抗增殖剂，特别是抗HPV。

3. 发明申请

WO2012159246A1 DISPLAYING AND INPUTTING SYMBOLS 审中-公开
标题翻译：显示和输入符号
公开(公告)号：WO2012159246A1
公开(公告)日：2012-11-29
申请号：PCT/CN2011/074399
申请日：2011-05-20
申请人： MICROSOFT CORPORATION , ZHANG, Fang , CHE, Chiwei , GONG, Xin
发明人： ZHANG, Fang , CHE, Chiwei , GONG, Xin
IPC分类号： G06F3/048
CPC分类号： G06F3/018 , G06F3/0236 , G06F3/0237
摘要： Methods, systems, devices, and computer-storage media having computer- usable instructions embodied thereon, for displaying and inputting symbols are provided. Bopomofo symbols are phonetic representations of Chinese characters. To accommodate all the Bopomofo symbols on a mobile device keyboard without sacrificing key size, the Bopomofo keys are dynamically disabled based on grammar rules and user inputs. For example, a symbol that is not eligible to follow an input symbol is disabled such that it does not distract a user searching for a symbol in the keyboard. Further, specific keys on a keyboard are dynamically replaced with tone keys once a user inputs a symbol. A user interface for displaying the symbols is, thus, consistent and easy to navigate for a user.
摘要翻译：提供了其上包含有计算机可用指令的方法，系统，设备和计算机存储介质，用于显示和输入符号。 Bopomofo符号是汉字的语音表示。为了在移动设备键盘上容纳所有Bopomofo符号，而不牺牲密钥大小，Bopomofo密钥根据语法规则和用户输入动态禁用。例如，不符合输入符号的符号被禁用，使得它不会分散用户搜索键盘中的符号。此外，一旦用户输入符号，键盘上的特定键被音频键动态地替换。因此，用于显示符号的用户界面对于用户而言是一致且易于导航的。

4. 发明申请

WO2007002912A3 ANTI-PROLIFERATIVE COMPOUNDS, COMPOSITIONS, AND METHODS OF USE THEREOF 审中-公开
标题翻译：抗增生化合物，组合物及其使用方法
公开(公告)号：WO2007002912A3
公开(公告)日：2007-06-28
申请号：PCT/US2006025726
申请日：2006-06-29
申请人： GILEAD SCIENCES INC , CHENG XIAOQIN , COOK GARY P , DESAI MANOJ C , DOERFFLER EDWARD , HE GONG-XIN , KIM CHOUNG U , LEE WILLIAM A , ROHLOFF JOHN C , WANG JIANYING , YANG ZHENG-YU
发明人： CHENG XIAOQIN , COOK GARY P , DESAI MANOJ C , DOERFFLER EDWARD , HE GONG-XIN , KIM CHOUNG U , LEE WILLIAM A , ROHLOFF JOHN C , WANG JIANYING , YANG ZHENG-YU
IPC分类号： C07F9/6561 , A61K31/66 , A61K31/675 , A61P31/12
CPC分类号： C07F9/65616 , Y02P20/55
摘要： Compounds and compositions of Formula I are described, useful as anti-proliferative agents, and in particular anti-HPV, wherein: Y 1A and Y 1B are independently Y 1 ; R X1 is R X ; R X2 is alkenyl of 2 to 18 carbon atoms or alkynyl of 2 to 18 carbon atoms; Y 1 is = O, -O(R X ), =S, -N(R X ), -N(O)(R X ), -N(OR X ), -N(O)(OR X ), or -N(N(R X )(R X )); R X is independently R 1 , R 2 , R 4 , W 3 , or a protecting group; R 1 is independently -H or alkyl of 1 to 18 carbon atoms; R 2 is independently R 3 or R 4 wherein each R 4 is independently substituted with 0 to 3 R 3 groups or taken together at a carbon atom, two R 2 groups form a ring of 3 to 8 carbons and the ring may be substituted with 0 to 3 R 3 groups; R 3 is R 3a , R 3b , R 3c or R 3d , provided that when R 3 is bound to a heteroatom, then R 3 is R 3c or R 3d ; R 3a is -H, -F, -Cl, -Br, -I, -CF 3 , -CN, N 3 , -NO 2 or -OR 4 ; R 3b is = O, -O(R 4 ), =S, -N(R 4 ), -N(O)(R 4 ), -N(OR 4 ), -N(O)(OR 4 ), or -N(N(R 4 )(R 4 )); 3c is -R 4 , -N(R 4 )(R 4 ), -SR 4 , -S(O)R 4 , -S(O) 2 R 4 , -S(O)(OR 4 ), -S(O) 2 (OR 4 ), -OC(R 3b )R 4 , -OC(R 3b )OR 4 , -OC(R 3b )(N(R 4 )(R 4 )), -SC(R 3b )R 4 , -SC(R 3b )OR 4 , -SC(R 3b )(N(R 4 )(R 4 )), -N(R 4 )C(R 3b )R 4 , -N(R 4 )C(R 3b )OR 4 , -N(R 4 )C(R 3b )(N(R 4 )(R 4 )), W 3 or -R 5 W 3 ; R 3d is -C(R 3b )R 4 , -C(R 3b )OR 4 , -C(R 3b )W 3 , -C(R 3b )OW 3 or -C(R 3b )(N(R 4 )(R 4 )); R 4 is -H, or an alkyl of 1 to 18 carbon atoms, alkenyl of 2 to 18 carbon atoms, or alkynyl of 2 to 18 carbon atoms; R 5 is alkylene of 1 to 18 carbon atoms, alkenylene of 2 to 18 carbon atoms, or alkynylene of 2 to 18 carbon atoms; W 3 is W 4 or W 5 ; W 4 is R 6 , -C(R 3b )R 6 , -C(R 3b )W 5 , -SO M2 R 6 , or -SO M2 W 5 , wherein R 6 is R 4 wherein each R 4 is substituted with O to 3 R 3 groups; W 5 is carbocycle or heterocycle wherein W 5 is independently substituted with O to 3 R 2 groups; and M2 is 0, 1 or 2; or pharmaceutically acceptable salts thereof.
摘要翻译：描述了式I的化合物和组合物，其可用作抗增殖剂，特别是抗HPV，其中：Y 1A和Y 1B独立地为Y， 1 ; R X1是R X; R 2 X 2是2至18个碳原子的链烯基或2至18个碳原子的炔基; Y 1是= O，-O（R X），= S，-N（R X）X - ， - N（O）（ N（O，X），-N（O）（OR X）或-N（N（R' SUP> X ）（R ^{X ））; R X独立地为R 1，R 2，R 4，W 3，，或保护基团; R 1独立地是-H或1至18个碳原子的烷基; R 2独立地是R 3或R 4，其中每个R 4独立地被0至3个R 3取代， SUP> 3个或3个碳原子一起取代，2个R 2基团形成3〜8个碳环，该环可以被0〜3个R 3 组 R 3是R 3a，R 3b，R 3c或R i，R 3，条件是当R 3与杂原子结合时，R 3是R 3c或R 3d; R 3a是-H，-F，-Cl，-Br，-I，-CF 3，-CN，N 3 - ， - NO 2或-OR 4; R 3是= O，-O（R 4），= S，-N（R 4）， - N（O）（（OR 4），-N（OR 4）， - N（O）（OR 4）或-N（N（R' SUP> 4 ）（R ^{4 ））; （S 4），-S（R 4），-SR 4，-S（R 4） 4，-S（O）R 4，-S（O）2 R 4，-S（O）（或（S）4），-S（O）2（OR 4），-OC（R 3b）R -OC（R 3b）或OR 4，-OC（R 3b）（N（R 3）（R 4）），-SC（R 3b）R 4，-SC（R SUP）（R 3）（R 4）（R 4）（R 4） /（S）S），-N（R 4）S（R 3b）R 4，-N（R 4） C（R 3b）或者4，-N（R 4）C（R 3））（N（R 4）（R 4）），W 3或-R 5 W > 3 ; R 3 d 3是-C（R 3b）R 4，-C（R 3b）或 - -C（R 3b）W 3，-C（R 3b）OW 3 O， >或-C（R 3b）（N（R 4））（R 4））; R 4是-H或1至18个碳原子的烷基，2至18个碳原子的烯基或2至18个碳原子的炔基; R 5是1至18个碳原子的亚烷基，2至18个碳原子的亚烯基或2至18个碳原子的亚炔基; W 3或W 5是W 4或W 5; R 4是R 6，-C（R 3b）R 6，-C（R'），或3个或更多个，其中，R 1，R 2，R 3，R 5，其中R 6是R 4，其中每个R 4被0至3个R 3取代， / SUP>组 W 5是碳环或杂环，其中W 5独立地被O至3个R 2基团取代; M2为0,1或2; 或其药学上可接受的盐。}}

5. 发明申请

WO2004096818A3 METHOD AND COMPOSITIONS FOR IDENTIFYING ANTI-HIV THERAPEUTIC COMPOUNDS 审中-公开
标题翻译：用于鉴定抗HIV治疗化合物的方法和组合物
公开(公告)号：WO2004096818A3
公开(公告)日：2005-04-07
申请号：PCT/EP0312423
申请日：2003-11-06
申请人： GILEAD SCIENCES INC , BIRKUS GABRIEL , CHEN JAMES M , CHEN XIAOWU , CIHLAR TOMAS , EISENBERG EUGENE J , HATADA MARCOS , HE GONG-XIN , KIM CHOUNG U , LEE WILLIAM A , MCDERMOTT MARTIN J , SWAMINATHAN SUNDARAMOORTHI
发明人： BIRKUS GABRIEL , CHEN JAMES M , CHEN XIAOWU , CIHLAR TOMAS , EISENBERG EUGENE J , HATADA MARCOS , HE GONG-XIN , KIM CHOUNG U , LEE WILLIAM A , MCDERMOTT MARTIN J , SWAMINATHAN SUNDARAMOORTHI
IPC分类号： C12N9/99 , A61K31/4155 , A61K31/66 , A61K31/665 , A61K31/675 , A61P31/18 , A61P43/00 , C07D213/75 , C07D213/85 , C07D231/12 , C07D231/20 , C07D233/42 , C07D239/48 , C07D239/80 , C07D243/04 , C07D265/18 , C07D307/68 , C07D401/06 , C07D403/06 , C07D471/14 , C07D491/04 , C07F20060101 , C07F9/02 , C07F9/38 , C07F9/40 , C07F9/44 , C07F9/58 , C07F9/62 , C07F9/645 , C07F9/6506 , C07F9/6509 , C07F9/6512 , C07F9/653 , C07F9/6533 , C07F9/655 , C07F9/6558 , C07F9/6561 , C07F9/6584 , C12N9/16 , C12Q1/18 , C12Q1/37 , C12Q1/44 , C12Q1/70 , G01N33/04 , G01N33/50
CPC分类号： A61K31/66 , A61K31/675 , C07D213/75 , C07D213/85 , C07D231/12 , C07D231/20 , C07D233/42 , C07D239/49 , C07D239/80 , C07D243/04 , C07D265/18 , C07D307/68 , C07D401/06 , C07D403/06 , C07D471/14 , C07D491/04 , C07F9/4006 , C07F9/582 , C07F9/588 , C07F9/645 , C07F9/65061 , C07F9/65062 , C07F9/65067 , C07F9/650911 , C07F9/650917 , C07F9/650947 , C07F9/65121 , C07F9/65122 , C07F9/65127 , C07F9/65128 , C07F9/65335 , C07F9/65515 , C07F9/65583 , C07F9/6561 , C12N9/16 , C12Q1/18 , C12Q1/37 , C12Q1/44 , C40B40/04 , G01N33/5038 , G01N2333/16 , G01N2500/04
摘要： The invention relates to methods and compositions for identifying compounds having therapeutic activity against human immunodeficiency virus (HIV).
摘要翻译：本发明涉及用于鉴定具有针对人类免疫缺陷病毒（HIV）的治疗活性的化合物的方法和组合物。

6. 发明申请

WO2007002912A2 ANTI-PROLIFERATIVE COMPOUNDS, COMPOSITIONS, AND METHODS OF USE THEREOF 审中-公开
标题翻译：抗增殖化合物，组合物及其使用方法
公开(公告)号：WO2007002912A2
公开(公告)日：2007-01-04
申请号：PCT/US2006/025726
申请日：2006-06-29
申请人： GILEAD SCIENCES, INC. , CHENG, Xiaoqin , COOK, Gary, P. , DESAI, Manoj, C. , DOERFFLER, Edward , HE, Gong-xin , KIM, Choung, U. , LEE, William, A. , ROHLOFF, John, C. , WANG, Jianying , YANG, Zheng-Yu
发明人： CHENG, Xiaoqin , COOK, Gary, P. , DESAI, Manoj, C. , DOERFFLER, Edward , HE, Gong-xin , KIM, Choung, U. , LEE, William, A. , ROHLOFF, John, C. , WANG, Jianying , YANG, Zheng-Yu
IPC分类号： C07F9/6561 , A61P31/12 , A61K31/66
CPC分类号： C07F9/65616 , Y02P20/55
摘要： Compounds and compositions of Formula I are described, useful as anti-proliferative agents, and in particular anti-HPV, wherein: Y 1A and Y 1B are independently Y 1 ; R X1 is R X ; R X2 is alkenyl of 2 to 18 carbon atoms or alkynyl of 2 to 18 carbon atoms; Y 1 is = O, -O(R X ), =S, -N(R X ), -N(O)(R X ), -N(OR X ), -N(O)(OR X ), or -N(N(R X )(R X )); R X is independently R 1 , R 2 , R 4 , W 3 , or a protecting group; R 1 is independently -H or alkyl of 1 to 18 carbon atoms; R 2 is independently R 3 or R 4 wherein each R 4 is independently substituted with 0 to 3 R 3 groups or taken together at a carbon atom, two R 2 groups form a ring of 3 to 8 carbons and the ring may be substituted with 0 to 3 R 3 groups; R 3 is R 3a , R 3b , R 3c or R 3d , provided that when R 3 is bound to a heteroatom, then R 3 is R 3c or R 3d ; R 3a is -H, -F, -Cl, -Br, -I, -CF 3 , -CN, N 3 , -NO 2 or -OR 4 ; R 3b is = O, -O(R 4 ), =S, -N(R 4 ), -N(O)(R 4 ), -N(OR 4 ), -N(O)(OR 4 ), or -N(N(R 4 )(R 4 )); 3c is -R 4 , -N(R 4 )(R 4 ), -SR 4 , -S(O)R 4 , -S(O) 2 R 4 , -S(O)(OR 4 ), -S(O) 2 (OR 4 ), -OC(R 3b )R 4 , -OC(R 3b )OR 4 , -OC(R 3b )(N(R 4 )(R 4 )), -SC(R 3b )R 4 , -SC(R 3b )OR 4 , -SC(R 3b )(N(R 4 )(R 4 )), -N(R 4 )C(R 3b )R 4 , -N(R 4 )C(R 3b )OR 4 , -N(R 4 )C(R 3b )(N(R 4 )(R 4 )), W 3 or -R 5 W 3 ; R 3d is -C(R 3b )R 4 , -C(R 3b )OR 4 , -C(R 3b )W 3 , -C(R 3b )OW 3 or -C(R 3b )(N(R 4 )(R 4 )); R 4 is -H, or an alkyl of 1 to 18 carbon atoms, alkenyl of 2 to 18 carbon atoms, or alkynyl of 2 to 18 carbon atoms; R 5 is alkylene of 1 to 18 carbon atoms, alkenylene of 2 to 18 carbon atoms, or alkynylene of 2 to 18 carbon atoms; W 3 is W 4 or W 5 ; W 4 is R 6 , -C(R 3b )R 6 , -C(R 3b )W 5 , -SO M2 R 6 , or -SO M2 W 5 , wherein R 6 is R 4 wherein each R 4 is substituted with O to 3 R 3 groups; W 5 is carbocycle or heterocycle wherein W 5 is independently substituted with O to 3 R 2 groups; and M2 is 0, 1 or 2; or pharmaceutically acceptable salts thereof.
摘要翻译：描述了式I的化合物和组合物，其可用作抗增殖剂，特别是抗HPV，其中：Y 1A和Y 1B表示抗体， sup独立地是Y ^{1 ; R X1是R X; R X2是2至18个碳原子的链烯基或2至18个碳原子的炔基; Y 1 = O，-O（R X），= S，-N（R X）， - N（O）（ -N（OR X），-N（O）（OR X）或-N（N（R X） SUP> X ）（R ^{X ））; R X独立地为R 1，R 2，R 4，W 3，R 4，R 4，R 4，，或保护基团; R 1独立地为-H或1-18个碳原子的烷基; R 2独立地为R 3或R 4，其中每个R 4独立地被0至3个R 4取代，两个R 2基团形成3至8个碳原子的环并且该环可以被0至3个R 3取代组; R 3是R 3a，R 3b，R 3c或R 3d，其中R 3a，条件是当R 3 3与一个杂原子结合时，则R 3是R 3c或R 3d; R 3a是-H，-F，-Cl，-Br，-I，-CF 3，-CN，N 3， - NO <2>或-OR <4>; （R 4）， - N（R 4）， - N（O）（ -N（OR 4）， - N（O）（OR 4）或-N（N（R 4） SUP> 4 ）（R ^{4 ））; 3c是-R 4，-N（R 4）（R 4），-SR 5，（O）R 4，-S（O）2 R 4，-S（O）（ OR 4），-S（O）2（OR 4），-OC（R 3b）R （R（R 3）4，-OC（R 3b）OR 4，-OC（R 3b）（R 4）），-SC（R 3b）R 4，-SC（R sup）（R（R 4））（R 4）（R 4）R 4（R 4） -N（R 4）C（R 3b）R 4，-N（R 4）（R 3b）OR 4，-N（R 4）C（R 3b））（N（R 4）（R 4））），W 3或-R 5 W ^{3 ; R 3d为-C（R 3b）R 4，-C（R 3b）OR， 4 -C（R 3b）W 3，-C（R 3b）OW 3-sup （R（R 4））或-C（R 3b）（N（R 4）（R 4））; R 4是-H，或1至18个碳原子的烷基，2至18个碳原子的烯基或2至18个碳原子的炔基; R 5是1-18个碳原子的亚烷基，2-18个碳原子的亚烯基或2-18个碳原子的亚炔基; W ^{3 是W 或W ^{5 ; W 4是R 6，-C（R 3b）R 6，-C（R 5） 3b）W 5，-SO 2 R 6或-SO 2 M W ^{组; W 5是碳环或杂环，其中W 5独立地被O至3个R 2基团取代; M2是0,1或2; 或其药学上可接受的盐。}}}}}}}

7. 发明申请

WO2005064008A1 METHOD AND COMPOSITIONS FOR IDENTIFYING ANTI-HIV THERAPEUTIC COMPOUNDS 审中-公开
标题翻译：用于鉴定抗HIV治疗化合物的方法和组合物
公开(公告)号：WO2005064008A1
公开(公告)日：2005-07-14
申请号：PCT/US2004/042991
申请日：2004-12-22
申请人： Gilead Sciences, Inc. , ARIMILLI, Murty N. , BECKER, Mark M. , BIRKUS, Gabriel , BRYANT, Clifford , CHEN, James M. , CHEN, Xiaowu , CIHLAR, Tomas , DASTGAH, Azar , EISENBERG, Eugene J. , FARDIS, Maria , HATADA, Marcos , HE, Gong-Xin , JIN, Haolun , KIM, Choung U. , LEE, William A. , LEE, Christopher P. , LIN, Kuei-Ying , LIU, Hongtao , MACKMAN, Richard L. , MCDERMOTT, Martin J. , MITCHELL, Michael L. , NELSON, Peter H. , PYUN, Hyung-Jung , ROWE, Tanisha D. , SPARACINO, Mark , SWAMINATHAN, Sundaramoorthi , TARIO, James D. , WANG, Jianying , WILLIAMS, Matthew A. , XU, Lianhong , YANG, Zheng-Yu , YU, Richard H. , ZHANG, Jiancun , ZHANG, Lijun
发明人： ARIMILLI, Murty N. , BECKER, Mark M. , BIRKUS, Gabriel , BRYANT, Clifford , CHEN, James M. , CHEN, Xiaowu , CIHLAR, Tomas , DASTGAH, Azar , EISENBERG, Eugene J. , FARDIS, Maria , HATADA, Marcos , HE, Gong-Xin , JIN, Haolun , KIM, Choung U. , LEE, William A. , LEE, Christopher P. , LIN, Kuei-Ying , LIU, Hongtao , MACKMAN, Richard L. , MCDERMOTT, Martin J. , MITCHELL, Michael L. , NELSON, Peter H. , PYUN, Hyung-Jung , ROWE, Tanisha D. , SPARACINO, Mark , SWAMINATHAN, Sundaramoorthi , TARIO, James D. , WANG, Jianying , WILLIAMS, Matthew A. , XU, Lianhong , YANG, Zheng-Yu , YU, Richard H. , ZHANG, Jiancun , ZHANG, Lijun
IPC分类号： C12Q1/44
CPC分类号： A61K31/66 , A61K31/675 , C07D213/75 , C07D213/85 , C07D231/12 , C07D231/20 , C07D233/42 , C07D239/49 , C07D239/80 , C07D243/04 , C07D265/18 , C07D307/68 , C07D401/06 , C07D403/06 , C07D471/14 , C07D491/04 , C07F9/4006 , C07F9/582 , C07F9/588 , C07F9/645 , C07F9/65061 , C07F9/65062 , C07F9/65067 , C07F9/650911 , C07F9/650917 , C07F9/650947 , C07F9/65121 , C07F9/65122 , C07F9/65127 , C07F9/65128 , C07F9/65335 , C07F9/65515 , C07F9/65583 , C07F9/6561 , C12N9/16 , C12Q1/18 , C12Q1/37 , C12Q1/44 , C40B40/04 , G01N33/5038 , G01N2333/16 , G01N2500/04 , G01N2500/20
摘要： Methods are provided for identifying anti-HIV therapeutic compounds substituted with carboxyl ester or phosphonate ester groups. Libraries of such compounds are screened optionally using the novel enzyme GS-7340 Ester Hydrolase. Compositions and methods relating to GS-7340 Ester Hydrolase also are provided.
摘要翻译：提供了用于鉴定被羧基酯或膦酸酯基取代的抗HIV治疗化合物的方法。可以任选地使用新型GS-7340酯水解酶来筛选这些化合物的文库。还提供了与GS-7340酯水解酶有关的组合物和方法。

8. 发明申请

WO2004096818A2 METHOD AND COMPOSITIONS FOR IDENTIFYING ANTI-HIV THERAPEUTIC COMPOUNDS 审中-公开
标题翻译：用于鉴定抗HIV治疗化合物的方法和组合物
公开(公告)号：WO2004096818A2
公开(公告)日：2004-11-11
申请号：PCT/EP2003/012423
申请日：2003-11-06
申请人： GILEAD SCIENCES, INC. , BIRKUS, Gabriel , CHEN, James, M. , CHEN, Xiaowu , CIHLAR, Tomas , EISENBERG, Eugene, J. , HATADA, Marcos , HE, Gong-Xin , KIM, Choung, U. , LEE, William, A. , MCDERMOTT, Martin, J. , SWAMINATHAN, Sundaramoorthi
发明人： BIRKUS, Gabriel , CHEN, James, M. , CHEN, Xiaowu , CIHLAR, Tomas , EISENBERG, Eugene, J. , HATADA, Marcos , HE, Gong-Xin , KIM, Choung, U. , LEE, William, A. , MCDERMOTT, Martin, J. , SWAMINATHAN, Sundaramoorthi
IPC分类号： C07F9/40
CPC分类号： A61K31/66 , A61K31/675 , C07D213/75 , C07D213/85 , C07D231/12 , C07D231/20 , C07D233/42 , C07D239/49 , C07D239/80 , C07D243/04 , C07D265/18 , C07D307/68 , C07D401/06 , C07D403/06 , C07D471/14 , C07D491/04 , C07F9/4006 , C07F9/582 , C07F9/588 , C07F9/645 , C07F9/65061 , C07F9/65062 , C07F9/65067 , C07F9/650911 , C07F9/650917 , C07F9/650947 , C07F9/65121 , C07F9/65122 , C07F9/65127 , C07F9/65128 , C07F9/65335 , C07F9/65515 , C07F9/65583 , C07F9/6561 , C12N9/16 , C12Q1/18 , C12Q1/37 , C12Q1/44 , C40B40/04 , G01N33/5038 , G01N2333/16 , G01N2500/04
摘要： The invention relates to methods and compositions for identifying compounds having therapeutic activity against human immunodeficiency virus (HIV).
摘要翻译：本发明涉及用于鉴定具有针对人类免疫缺陷病毒（HIV）的治疗活性的化合物的方法和组合物。

9. 发明申请

WO2003090691A2 METHOD AND COMPOSITIONS FOR IDENTIFYING ANTI-HIV THERAPEUTIC COMPOUNDS 审中-公开
标题翻译：用于鉴定抗HIV治疗化合物的方法和组合物
公开(公告)号：WO2003090691A2
公开(公告)日：2003-11-06
申请号：PCT/US2003/012943
申请日：2003-04-25
申请人： GILEAD SCIENCES, INC. , BIRKUS, Gabriel , CHEN, James, M. , CHEN, Xiaowu , CIHLAR, Tomas , EISENBERG, Eugene, J. , HATADA, Marcos , HE, Gong-Xin , KIM, Choung, U. , LEE, William, A. , MCDERMOTT, Martin, J. , SWAMINATHAN, Sundaramoorthi
发明人： BIRKUS, Gabriel , CHEN, James, M. , CHEN, Xiaowu , CIHLAR, Tomas , EISENBERG, Eugene, J. , HATADA, Marcos , HE, Gong-Xin , KIM, Choung, U. , LEE, William, A. , MCDERMOTT, Martin, J. , SWAMINATHAN, Sundaramoorthi
IPC分类号： A61K
CPC分类号： A61K31/66 , A61K31/675 , C07D213/75 , C07D213/85 , C07D231/12 , C07D231/20 , C07D233/42 , C07D239/49 , C07D239/80 , C07D243/04 , C07D265/18 , C07D307/68 , C07D401/06 , C07D403/06 , C07D471/14 , C07D491/04 , C07F9/4006 , C07F9/582 , C07F9/588 , C07F9/645 , C07F9/65061 , C07F9/65062 , C07F9/65067 , C07F9/650911 , C07F9/650917 , C07F9/650947 , C07F9/65121 , C07F9/65122 , C07F9/65127 , C07F9/65128 , C07F9/65335 , C07F9/65515 , C07F9/65583 , C07F9/6561 , C12N9/16 , C12Q1/18 , C12Q1/37 , C12Q1/44 , C40B40/04 , G01N33/5038 , G01N2333/16 , G01N2500/04
摘要： Methods are provided for identifying anti-HIV therapeutic compounds substituted with carboxyl ester or phosphonate ester groups. Libraries of such compounds are screened optionally using the novel enzyme GS-7340 Ester Hydrolase. Compositions and methods relating to GS-7340 Ester Hydrolase also are provided.
摘要翻译：提供了用于鉴定被羧基酯或膦酸酯基取代的抗HIV治疗化合物的方法。可以使用新型GS-7340酯水解酶来筛选这些化合物的文库。还提供了与GS-7340酯水解酶有关的组合物和方法。

10. 发明申请

WO0208241A3 PRODRUGS OF PHOSPHONATE NUCLEOTIDE ANALOGUES AND METHODS FOR SELECTING AND MAKING SAME 审中-公开
标题翻译：磷酸核苷类似物的制备方法及其选择和制备方法
公开(公告)号：WO0208241A3
公开(公告)日：2002-08-29
申请号：PCT/US0123104
申请日：2001-07-20
申请人： GILEAD SCIENCES INC , BECKER MARK W , CHAPMAN HARLAN H , CIHLAR TOMAS , EISENBERG EUGENE J , HE GONG-XIN , KERNAN MICHAEL R , LEE WILLIAM A , PRISBE ERNEST J , ROHLOFF JOHN C , SPARACINO MARK L
发明人： BECKER MARK W , CHAPMAN HARLAN H , CIHLAR TOMAS , EISENBERG EUGENE J , HE GONG-XIN , KERNAN MICHAEL R , LEE WILLIAM A , PRISBE ERNEST J , ROHLOFF JOHN C , SPARACINO MARK L
IPC分类号： A61K31/664 , A61K31/675 , A61P31/12 , A61P31/18 , A61P35/00 , C07F9/6561 , C07H19/10 , C07H19/20 , C07H21/00 , C12Q1/18 , G01N33/15 , G01N33/50 , G01N33/53
CPC分类号： C07H19/10 , C07F9/65616 , C07H19/20 , C07H21/00 , C12Q1/18 , G01N33/5011
摘要： A novel method is provided for screening prodrugs of methoxyphosphonate nucleotide analogues to identify prodrugs selectively targeting desired tissues with antiviral or antitumor activity. This method has led to the identification of novel mixed ester-amidates of PMPA for retroviral or hepadnaviral therapy, including compounds of structure (5a) having substituent groups as defined herein. Compositions of these novel compounds in pharmaceutically acceptable excipients and their use in therapy and prophylaxis are provided. Also provided is an improved method for the use of magnesium alkoxide for the preparation of starting materials and compounds for use herein.
摘要翻译：提供了一种新的方法来筛选甲氧基膦酸核苷酸类似物的前药，以鉴定用抗病毒或抗肿瘤活性选择性靶向所需组织的前药。这种方法导致鉴定用于逆转录病毒或肝炎病毒治疗的PMPA的新型混合酯酰胺化物，包括具有如本文所定义的取代基的结构（5a）的化合物。提供这些新化合物在药学上可接受的赋形剂中的组合物及其在治疗和预防中的用途。还提供了一种用于制备用于本文的原料和化合物的烷氧基镁的改进方法。

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