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1. 发明申请

WO2004091487A2 HEMOPHILIA TREATMENT BY INHALATION OF COAGULATION FACTORS 审中-公开
标题翻译：通过吸入凝血因子治疗的HEMOPHILIA治疗
公开(公告)号：WO2004091487A2
公开(公告)日：2004-10-28
申请号：PCT/US2004/010833
申请日：2004-04-08
申请人： WYETH , NEKTAR THERAPEUTICS , SCHAUB, Robert, G. , DORNER, Andrew, J. , GONG, David, K. , HASTEDT, Jayne, E. , WEBB, Chandra, A. , KEITH, James, C., Jr.
发明人： SCHAUB, Robert, G. , DORNER, Andrew, J. , GONG, David, K. , HASTEDT, Jayne, E. , WEBB, Chandra, A. , KEITH, James, C., Jr.
IPC分类号： A61K
CPC分类号： A61M15/0028 , A61K9/0075 , A61K9/1611 , A61K9/1617 , A61K9/1623 , A61K38/4846 , A61M11/02 , A61M2202/064
摘要： Hemophilia treatment by the inhalation of coagulation factors. Dry powder Factor IX is aerosolized to a mass median aerodynamic diameter of 4 µm or less, with at least 90% monomer content, at least 80% activity level, and 10% water or less. The aerosol is slowly, and deeply inhaled into the lung, and followed by a maximal exhale.
摘要翻译：血友病治疗吸入凝血因子。干粉因子IX雾化至4μm或更小的质量中值空气动力学直径，具有至少90％的单体含量，至少80％的活性水平和10％的水或更少的水分。气溶胶缓慢吸入肺部，最后呼气。

2. 发明申请

WO2005079755A2 INTERLEUKIN-13 ANTAGONIST POWDERS, SPRAY-DRIED PARTICLES, AND METHODS 审中-公开
标题翻译：白介素-13拮抗剂粉末，喷雾颗粒和方法
公开(公告)号：WO2005079755A2
公开(公告)日：2005-09-01
申请号：PCT/US2005/004750
申请日：2005-02-14
申请人： NEKTAR THERAPEUTICS , GONG, David, K. , HASTEDT, Jayne, E. , PATTON, John, S.
发明人： GONG, David, K. , HASTEDT, Jayne, E. , PATTON, John, S.
IPC分类号： A61K9/00
CPC分类号： A61K9/1623 , A61K9/0075 , A61K9/1688 , A61K38/00 , C07K14/7155 , C07K2319/30 , Y02A50/423
摘要： A powder includes IL-13 antagonist, wherein the powder has a mass median aerodynamic diameter (MMAD) of less than about 10 µm. A composition includes a spray-dried particle including IL-13 antagonist. A method of administering IL-13 antagonist to the lungs of a subject includes: dispersing a dry powder composition involving IL-13 antagonist to form an aerosol; and delivering the aerosol to the lungs of the subject by inhalation of the aerosol by the subject, thereby ensuring delivery of the IL-13 antagonist to the lungs of the subject. A method of treating an IL-13-related condition includes: pulmonarily administering a therapeutically effective amount of a dry powder including IL-13 antagonist. A method of preparing IL-13 antagonist-containing powder involves: combining IL-13 antagonist, optional excipient, and solvent to form a mixture or solution; and spray drying the mixture or solution to obtain the powder.
摘要翻译：粉末包括IL-13拮抗剂，其中粉末的质量中值空气动力学直径（MMAD）小于约10μm。组合物包括包含IL-13拮抗剂的喷雾干燥颗粒。对受试者的肺部施用IL-13拮抗剂的方法包括：分散涉及IL-13拮抗剂的干粉组合物以形成气溶胶; 并通过吸入受试者的气溶胶将气溶胶递送到受试者的肺部，由此确保将IL-13拮抗剂递送至受试者的肺。治疗IL-13相关病症的方法包括：肺部给予治疗有效量的包括IL-13拮抗剂的干燥粉末。制备含IL-13拮抗剂的粉末的方法包括：将IL-13拮抗剂，任选的赋形剂和溶剂混合以形成混合物或溶液; 并喷雾干燥混合物或溶液以获得粉末。

3. 发明申请

WO2005079755A3 INTERLEUKIN-13 ANTAGONIST POWDERS, SPRAY-DRIED PARTICLES, AND METHODS 审中-公开
标题翻译：白介素-13拮抗剂粉末，喷雾颗粒和方法
公开(公告)号：WO2005079755A3
公开(公告)日：2006-04-06
申请号：PCT/US2005004750
申请日：2005-02-14
申请人： NEKTAR THERAPEUTICS , GONG DAVID K , HASTEDT JAYNE E , PATTON JOHN S
发明人： GONG DAVID K , HASTEDT JAYNE E , PATTON JOHN S
IPC分类号： A61K9/00 , A61K9/16 , A61K38/00 , A61K38/17 , A61K39/395 , A61L9/04 , C07K14/715 , A61K9/14 , A61P11/06
CPC分类号： A61K9/1623 , A61K9/0075 , A61K9/1688 , A61K38/00 , C07K14/7155 , C07K2319/30
摘要： A powder includes IL-13 antagonist, wherein the powder has a mass median aerodynamic diameter (MMAD) of less than about 10 µm. A composition includes a spray-dried particle including IL-13 antagonist. A method of administering IL-13 antagonist to the lungs of a subject includes: dispersing a dry powder composition involving IL-13 antagonist to form an aerosol; and delivering the aerosol to the lungs of the subject by inhalation of the aerosol by the subject, thereby ensuring delivery of the IL-13 antagonist to the lungs of the subject. A method of treating an IL-13-related condition includes: pulmonarily administering a therapeutically effective amount of a dry powder including IL-13 antagonist. A method of preparing IL-13 antagonist-containing powder involves: combining IL-13 antagonist, optional excipient, and solvent to form a mixture or solution; and spray drying the mixture or solution to obtain the powder.
摘要翻译：粉末包括IL-13拮抗剂，其中粉末的质量中值空气动力学直径（MMAD）小于约10μm。组合物包括包含IL-13拮抗剂的喷雾干燥颗粒。对受试者的肺部施用IL-13拮抗剂的方法包括：分散涉及IL-13拮抗剂的干粉组合物以形成气溶胶; 并通过吸入受试者的气溶胶将气溶胶递送到受试者的肺部，由此确保将IL-13拮抗剂递送至受试者的肺。治疗IL-13相关病症的方法包括：肺部给予治疗有效量的包括IL-13拮抗剂的干燥粉末。制备含IL-13拮抗剂的粉末的方法包括：将IL-13拮抗剂，任选的赋形剂和溶剂混合以形成混合物或溶液; 并喷雾干燥混合物或溶液以获得粉末。

4. 发明申请

WO2004091487A3 HEMOPHILIA TREATMENT BY INHALATION OF COAGULATION FACTORS 审中-公开
标题翻译：通过吸入凝血因子治疗的HEMOPHILIA治疗
公开(公告)号：WO2004091487A3
公开(公告)日：2005-05-06
申请号：PCT/US2004010833
申请日：2004-04-08
申请人： WYETH CORP , NEKTAR THERAPEUTICS , SCHAUB ROBERT G , DORNER ANDREW J , GONG DAVID K , HASTEDT JAYNE E , WEBB CHANDRA A , KEITH JAMES C JR
发明人： SCHAUB ROBERT G , DORNER ANDREW J , GONG DAVID K , HASTEDT JAYNE E , WEBB CHANDRA A , KEITH JAMES C JR
IPC分类号： A61J3/02 , A61K20060101 , A61K9/00 , A61K9/12 , A61K9/16 , A61K38/00 , A61K38/37 , A61K38/48 , A61L9/04 , A61M11/02 , A61M15/00
CPC分类号： A61M15/0028 , A61K9/0075 , A61K9/1611 , A61K9/1617 , A61K9/1623 , A61K38/4846 , A61M11/02 , A61M2202/064
摘要： Hemophilia treatment by the inhalation of coagulation factors. Dry powder Factor IX is aerosolized to a mass median aerodynamic diameter of 4 µm or less, with at least 90% monomer content, at least 80% activity level, and 10% water or less. The aerosol is slowly, and deeply inhaled into the lung, and followed by a maximal exhale.
摘要翻译：血友病治疗吸入凝血因子。干粉因子IX雾化至4μm或更小的质量中值空气动力学直径，具有至少90％的单体含量，至少80％的活性水平和10％的水或更少的水分。气溶胶缓慢吸入肺部，最后呼气。

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