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1. 发明申请

WO2010045408A2 AUTOMATED DELIVERY OF AEROSOLIZED DRUGS DURING ANESTHESIA WITH SYNCHRONIZED VENTILATION 审中-公开
标题翻译：用同步通气自动输送麻醉期间的气雾化药物
公开(公告)号：WO2010045408A2
公开(公告)日：2010-04-22
申请号：PCT/US2009/060752
申请日：2009-10-15
申请人： THE COOPER HEALTH SYSTEM , ADAMOV, Victor , GOLDBERG, Michael, E. , TORJMAN, Marc , SAFARYN, John, E. , GRATZ, Irwin
发明人： ADAMOV, Victor , GOLDBERG, Michael, E. , TORJMAN, Marc , SAFARYN, John, E. , GRATZ, Irwin
IPC分类号： A61M11/02 , A61M16/01
CPC分类号： A61M16/01 , A61M11/00
摘要： A system for delivery of drugs to a patient while connected to a general anesthesia machine is disclosed, the system comprising (A) a breathing circuit comprising (1) an inhalation tube; (2) an exhalation tube; and (3) a connector having a first side adapted to fluidly connect with the inhalation and exhalation tubes, a second side adapted to fluidly connect with an endotracheal tube or face mask, and a special port adapted to connect with a nebulizer machine or a therapeutic vaporizor; (B) a programmable control module to regulate the timing and volume of anesthetic gases and oxygen delivered to the patient; (B) a ventilator; (C) a nebulizer machine comprising at least two interchangeable liquid or aerosolized drug containers or chambers; the nebulizer machine connected to the breathing circuit via the special port. A method of delivering drugs from a nebulizer while a patient is intubated and connected to a general anesthesia machine using the novel system is also disclosed.
摘要翻译：公开了一种用于在连接到全身麻醉机时将药物递送给患者的系统，该系统包括（A）呼吸回路，其包括（1）吸入管; （2）呼气管; （3）连接器，其具有适于与吸入管和呼出管流体连接的第一侧，适于与气管内管或面罩流体连接的第二侧，以及适于与喷雾器机器或治疗器连接的特殊端口 vaporizor; （B）可编程控制模块，用于调节输送给患者的麻醉气体和氧气的时间和体积; （B）呼吸机; （C）包括至少两个可互换的液体或雾化药物容器或腔室的喷雾器机器; 雾化器机器通过特殊端口连接到呼吸回路。还公开了一种在使用新系统对患者进行插管并连接到全身麻醉机的同时从喷雾器输送药物的方法。

2. 发明申请

WO2013056229A1 THE USE OF (2R, 6R)-HYDROXYNORKETAMINE, (S)-DEHYDRONORKETAMINE AND OTHER STEREOISOMERIC DEHYDRO AND HYDROXYLATED METABOLITES OF (R,S)- KETAMINE IN THE TREATMENT OF DEPRESSION AND NEUROPATHIC PAIN 审中-公开
标题翻译：（2R，6R） - 羟基甲胺胺，（S） - 二氢肉豆蔻酰胺和其他立体异构脱氢酶和（R，S） - 乙酰胺的羟基化代谢物在治疗抑郁症和神经性疼痛中的应用
公开(公告)号：WO2013056229A1
公开(公告)日：2013-04-18
申请号：PCT/US2012/060256
申请日：2012-10-15
申请人： THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES , THE COOPER HEALTH SYSTEM , WAINER, Irving W. , MOADDEL, Ruin , BERNIER, Michel , ZARATE, Carlos A. , TORJMAN, Marc C. , GOLDBERG, Michael E.
发明人： WAINER, Irving W. , MOADDEL, Ruin , BERNIER, Michel , ZARATE, Carlos A. , TORJMAN, Marc C. , GOLDBERG, Michael E.
IPC分类号： C07C225/20 , C07C237/02 , C07D295/155 , C07D295/145 , A61P25/04 , A61P25/28 , A61P25/00 , A61K31/133 , A61K31/122
CPC分类号： A61K31/5375 , A61K31/137 , A61K31/165 , A61K31/222 , A61K31/24 , A61K31/265 , A61K31/4453 , C07B2200/07 , C07C225/20 , C07C229/48 , C07C237/04 , C07C237/20 , C07C2601/14 , C07C2601/16 , C07D295/108 , C07D295/112 , C07D295/15 , C07D295/155
摘要： The disclosure provides pharmaceutical preparations containing (2R,6R)-hydroxynorketamine, or (R)- or (S)-dehydronorketamine, or other stereoisomeric dehydro or hydroxylated ketamine metabolite. (2R,6R)-hydroxynorketamine The disclosure also provides novel ketamine metabolite prodrugs. The disclosure provides methods of treating, bipolar depression, major depressive disorder, neuropathic and chronic pain, including complex regional pain disorder (CRPS) by administering a purified ketamine metabolite or a ketamine metabolite prodrug directly to patients in need of such treatment.
摘要翻译：本公开提供了含有（2R，6R） - 羟基软木胺或（R） - 或（S） - 二氢肉豆amine或其它立体异构脱氢或羟基化的氯胺酮代谢物的药物制剂。（2R，6R） - 羟基肉胺胺本公开还提供了新的氯胺酮代谢物前药。本公开提供通过向需要这种治疗的患者直接施用纯化的氯胺酮代谢物或氯胺酮代谢物前药来治疗，双相抑郁，重性抑郁障碍，神经性和慢性疼痛，包括复杂的局部疼痛障碍（CRPS）的方法。

3. 发明申请

WO2010045408A3 AUTOMATED DELIVERY OF AEROSOLIZED DRUGS DURING ANESTHESIA WITH SYNCHRONIZED VENTILATION 审中-公开
标题翻译：通过同步通气自动输送麻醉药物
公开(公告)号：WO2010045408A3
公开(公告)日：2010-08-12
申请号：PCT/US2009060752
申请日：2009-10-15
申请人： COOPER HEALTH SYSTEM , ADAMOV VICTOR , GOLDBERG MICHAEL E , TORJMAN MARC , SAFARYN JOHN E , GRATZ IRWIN
发明人： ADAMOV VICTOR , GOLDBERG MICHAEL E , TORJMAN MARC , SAFARYN JOHN E , GRATZ IRWIN
IPC分类号： A61M11/02 , A61M16/01
CPC分类号： A61M16/01 , A61M11/00
摘要： A system for delivery of drugs to a patient while connected to a general anesthesia machine is disclosed, the system comprising (A) a breathing circuit comprising (1) an inhalation tube; (2) an exhalation tube; and (3) a connector having a first side adapted to fluidly connect with the inhalation and exhalation tubes, a second side adapted to fluidly connect with an endotracheal tube or face mask, and a special port adapted to connect with a nebulizer machine or a therapeutic vaporizor; (B) a programmable control module to regulate the timing and volume of anesthetic gases and oxygen delivered to the patient; (B) a ventilator; (C) a nebulizer machine comprising at least two interchangeable liquid or aerosolized drug containers or chambers; the nebulizer machine connected to the breathing circuit via the special port. A method of delivering drugs from a nebulizer while a patient is intubated and connected to a general anesthesia machine using the novel system is also disclosed.
摘要翻译：公开了一种在连接到全身麻醉机的情况下向患者输送药物的系统，所述系统包括（A）呼吸回路，包括（1）吸入管; （2）呼气管; 和（3）连接器，其具有适于与吸入和呼气管流体连接的第一侧，适于与气管内导管或面罩流体连接的第二侧和适于与喷雾器或治疗剂连接的特殊端口 vaporizor; （B）可编程控制模块，用于调节输送给患者的麻醉气体和氧气的时间和体积; （B）呼吸机; （C）包括至少两个可互换液体或雾化的药物容器或腔室的喷雾器; 雾化器通过专用端口连接到呼吸回路。还公开了当患者插管并连接到使用新颖系统的全身麻醉机时从喷雾器输送药物的方法。

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