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    • 5. 发明申请
    • ELECTROPHILICALLY ENHANCED PHENOLIC COMPOUNDS FOR TREATING INFLAMMATORY RELATED DISEASES AND DISORDERS
    • 电热增强的酚类化合物治疗炎性相关疾病和病症
    • WO2017201042A1
    • 2017-11-23
    • PCT/US2017/032897
    • 2017-05-16
    • GLOBAL BIOLIFE INC.
    • THOMPSON, Daryl, Lee
    • A61P31/14A61K38/21
    • A therapeutic compound has a modified phenolic compound of the general formula (I) wherein at least one of R, R 1 , R 2 , R 3 , and R 4 is an electrophilic group chosen fromhalogen, aldehyde, haloalkane, alkene, butyryl, flurophenol, sulfonamide, flurophenol sulfoxide and the remaining R, R 1 , R 2 , R 3 , and R 4 is are each independently hydrogen, a hydroxyl group, an alkoxy group, a rutinosyl group, a carboxyl group, chromone, benzopyran, a rhamnosyl group, a substituted alkoxy group or a substituted acyloxy group wherein the substituent is chosen from hydroxyl, alkoxy, aryloxy, phenyl, halogen, and amido group. The compound can be used in a therapeutic treatment of inflammatory related diseases and condition.
    • 治疗性化合物具有通式(I)的经修饰的酚类化合物,其中R,R 1,R 2,R 1,R 2, R 3和R 4是选自卤素,醛,卤代烷,烯烃,丁酰基,氟代苯酚,磺酰胺,氟苯酚亚砜的亲电子基团,并且剩余的R 1, 1 R 1,R 2,R 3和R 4各自独立地为氢,羟基,烷氧基, 芸香糖基,羧基,色酮,苯并吡喃,鼠李糖基,取代的烷氧基或取代的酰氧基,其中取代基选自羟基,烷氧基,芳氧基,苯基,卤素和酰胺基。 该化合物可用于治疗炎症相关疾病和病症。