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1. 发明申请

WO2006067092A3 STEREOSELECTIVE PROCESS AND CRYSTALLINE FORMS OF A CAMPTOTHECIN 审中-公开
公开(公告)号：WO2006067092A3
公开(公告)日：2006-06-29
申请号：PCT/EP2005/056849
申请日：2005-12-16
申请人： SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. , CARMINATI, Paolo , TINTI, Maria Ornella , MARZI, Mauro , GIORGI, Fabrizio , CABRI, Walter , ALPEGIANI, Marco , VERGANI, Domenico , GHETTI, Paolo
发明人： CARMINATI, Paolo , TINTI, Maria Ornella , MARZI, Mauro , GIORGI, Fabrizio , CABRI, Walter , ALPEGIANI, Marco , VERGANI, Domenico , GHETTI, Paolo
IPC分类号： C07D491/22
摘要： A stereoselective process for preparing 7-[(E)-t-butyloxyiminomethyl]- camptothecin (also known as gimatecan) is herein disclosed. With the addition of further dissolution and precipitation steps carried out in appropriate different solvent mixtures, four new crystalline forms of gimatecan are also obtainable by using the same stereoselective process.

2. 发明申请

WO2009016068A1 CRYSTALLINE FORM II OF 7-(DIMETHOXY-METHYL) CAMPTOTHECIN, ITS USE AS INTERMEDIATE AND PRODUCTS OBTAINED THEREFROM 审中-公开
标题翻译： 7-（二甲氧基甲基）氨基甲酸酯的晶体形式II，作为中间体使用，并由其获得的产物
公开(公告)号：WO2009016068A1
公开(公告)日：2009-02-05
申请号：PCT/EP2008/059597
申请日：2008-07-22
申请人： SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. , CABRI, Walter , MARZI, Mauro , GIORGI, Fabrizio , BADALONI, Elena , ARMAROLI, Silvia , MARAZZI, Giuseppe
发明人： CABRI, Walter , MARZI, Mauro , GIORGI, Fabrizio , BADALONI, Elena , ARMAROLI, Silvia , MARAZZI, Giuseppe
IPC分类号： C07D491/22
CPC分类号： C07D491/22
摘要： This invention relates to a process for preparing a crystalline form of (4S)-11-(dimethoxymethyl)-4-ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]qui-no line-3,14(4H,12H)-dione (also named 7-(dimethoxy-methyl)camptothecin). With the provision of a particular crystallization step, in appropriate way, a new crystalline form of the above compound is obtained. The process for the preparation of the polymorph Form II comprises transforming camptothecin to the corresponding 7-(dimethoxy-methyl)-camptothecin, and crystallizing it from methanol.
摘要翻译：本发明涉及制备（4S）-11-（二甲氧基甲基）-4-乙基-4-羟基-1H-吡喃并[3'，4'：6,7]中氮茚并[1,2- b]无线-3,14（4H，12H） - 二酮（也称为7-（二甲氧基甲基）喜树碱）。通过提供特定的结晶步骤，以合适的方式得到上述化合物的新结晶形式。制备多晶型II的方法包括将喜树碱转化成相应的7-（二甲氧基 - 甲基）喜树碱，并将其从甲醇中结晶。

3. 发明申请

WO2006067092A2 STEREOSELECTIVE PROCESS AND CRYSTALLINE FORMS OF A CAMPTOTHECIN 审中-公开
标题翻译：立体选择性方法和结晶形式
公开(公告)号：WO2006067092A2
公开(公告)日：2006-06-29
申请号：PCT/EP2005056849
申请日：2005-12-16
申请人： SIGMA TAU IND FARMACEUTI , CARMINATI PAOLO , TINTI MARIA ORNELLA , MARZI MAURO , GIORGI FABRIZIO , CABRI WALTER , ALPEGIANI MARCO , VERGANI DOMENICO , GHETTI PAOLO
发明人： CARMINATI PAOLO , TINTI MARIA ORNELLA , MARZI MAURO , GIORGI FABRIZIO , CABRI WALTER , ALPEGIANI MARCO , VERGANI DOMENICO , GHETTI PAOLO
CPC分类号： C07D491/22
摘要： A stereoselective process for preparing 7-[(E)-t-butyloxyiminomethyl]- camptothecin (also known as gimatecan) is herein disclosed. With the addition of further dissolution and precipitation steps carried out in appropriate different solvent mixtures, four new crystalline forms of gimatecan are also obtainable by using the same stereoselective process.
摘要翻译：本文公开了制备7 - [（E） - 叔丁氧基亚氨基甲基] - 喜树碱（也称为吉马替康）的立体选择性方法。通过在适当的不同溶剂混合物中进行进一步的溶解和沉淀步骤，还可以通过使用相同的立体选择性方法获得四种新的结晶形式的gimatecan。

4. 发明申请

WO2009019199A1 CRYSTALLINE TEGLICAR 审中-公开
标题翻译：水晶TEGLICAR
公开(公告)号：WO2009019199A1
公开(公告)日：2009-02-12
申请号：PCT/EP2008/060099
申请日：2008-07-31
申请人： SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. , CABRI, Walter , GIORGI, Fabrizio , MARZI, Mauro , TASSONI, Emanuela
发明人： CABRI, Walter , GIORGI, Fabrizio , MARZI, Mauro , TASSONI, Emanuela
IPC分类号： C07C275/14 , C07C275/16 , A61K31/17 , A61P3/10 , A61P9/00
CPC分类号： C07C275/16
摘要： The present invention relates to a new crystalline form of R-4- trimethylammonium-3-(tetradecylcarbamoyl)-amino butyrate (also named crystalline Form I of ST 1326 or teglicar), a process for its preparation and pharmaceutical compositions containing same.
摘要翻译：本发明涉及新的结晶形式的R-4-三甲基铵-3-（十四烷基氨基甲酰基） - 氨基丁酸酯（也称为ST1326或teglicar的晶型I），其制备方法和含有它的药物组合物。

5. 发明申请

WO2008118681A1 COMMUNICATION SYSTEM WITH HEATING ARRANGEMENT IN A RADOME ON A RAILWAY LOCOMOTIVE 审中-公开
标题翻译：通信系统与加速装置在轨道上的铁路机车
公开(公告)号：WO2008118681A1
公开(公告)日：2008-10-02
申请号：PCT/US2008/057308
申请日：2008-03-18
申请人： GENERAL ELECTRIC COMPANY , GIORGI, Fabrizio
发明人： GIORGI, Fabrizio
IPC分类号： G01S13/93 , H01Q1/02 , H01Q1/42 , H01Q1/32
CPC分类号： H01Q1/02 , B61L15/0036 , H01Q1/3275 , H01Q1/42 , H01Q1/422
摘要： A communication system (10), as may be used in a locomotive, is pro¬ vided. The communication system includes a heating system, a communication antenna (12) and a communication electronics (14) disposed in a radome (16) made of a material permeable to electromagnetic radiation. An air gap (18) is defined by one or more walls of the radome and a thermally insulating plate (24) with respect to an inner compartment (26) of the radome. The inner compartment may accommodate an enclosure (28) where the antenna and the electronics are disposed. The heating system includes a heating device (20) for heating air in the air gap. A heated air gap makes it possible to defrost one or more outer surfaces of the radome, without affecting antenna and electronics performance, and without overheating the electronic components in the inner compartment of the radome.
摘要翻译：可以在机车中使用的通信系统（10）。通信系统包括加热系统，通信天线（12）和布置在由可透过电磁辐射的材料制成的天线罩（16）内的通信电子设备（14）。空气隙（18）由雷达罩的一个或多个壁和相对于天线罩的内隔室（26）的绝热板（24）限定。内部隔室可容纳设置有天线和电子设备的外壳（28）。加热系统包括用于加热气隙中的空气的加热装置（20）。加热的空气间隙使得可以除去天线罩的一个或多个外表面，而不影响天线和电子器件性能，并且不会使天线罩的内部隔室中的电子部件过热。

6. 发明申请

WO2003011864A1 DERIVATIVES OF TRIAZOLYL-IMIDAZOPYRIDINE AND OF THE TRIAZOLYLPURINES USEFUL AS LIGANDS OF THE ADENOSINE A2a RECEPTOR AND THEIR USE AS MEDICAMENTS 审中-公开
标题翻译：作为腺苷A2a受体的配体及其作为药物使用的三唑并咪唑并噻唑啉的衍生物有用
公开(公告)号：WO2003011864A1
公开(公告)日：2003-02-13
申请号：PCT/IT2002/000489
申请日：2002-07-25
申请人： SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. , TARZIA, Giorgio , PIERSANTI, Giovanni , MINETTI, Patrizia , DI CESARE, Maria, Assunta , GALLO, Grazia , GIORGI, Fabrizio , GIORGI, Luca
发明人： TARZIA, Giorgio , PIERSANTI, Giovanni , MINETTI, Patrizia , DI CESARE, Maria, Assunta , GALLO, Grazia , GIORGI, Fabrizio , GIORGI, Luca
IPC分类号： C07D473/34
CPC分类号： C07D471/04 , A61K31/198 , A61K31/435 , A61K31/52 , C07D473/34 , A61K2300/00
摘要： Compounds of formula (I) wherein the groups are as defined in the description, said compounds being antagonists of the adenosine A 2a receptor and useful as medicaments, in particular for the treatment of Parkinson's disease are disclosed.
摘要翻译：公开了式（I）化合物，其中基团如说明书中所定义，所述化合物是腺苷A2a受体的拮抗剂，可用作药物，特别是用于治疗帕金森病。

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