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1. 发明申请

WO2005029015A9 MULTISPECTRAL, MULTIFUSION, LASER-POLARIMETRIC OPTICAL IMAGING SYSTEM 审中-公开
标题翻译：多功能多功能激光多功能光学成像系统
公开(公告)号：WO2005029015A9
公开(公告)日：2005-05-19
申请号：PCT/US2004015046
申请日：2004-05-13
申请人： UNIV AKRON , GIAKOS GEORGE C
发明人： GIAKOS GEORGE C
IPC分类号： G01J20060101 , G01J3/02 , G01J3/28 , G01J3/36 , G01J4/00 , G01J4/04 , G01N21/21 , G01J
CPC分类号： G01J4/04 , G01J3/02 , G01J3/021 , G01J3/0224 , G01J3/2823 , G01J3/36 , G01J3/433 , G01J3/447 , G01N21/21
摘要： A multi-energy polarization imaging method consisting of a multi-fusion, dual-rotating retarder / multiple-energy complete Mueller matrix-based polarimeter and dual-energy capabilities, has been invented. The term multifusion describes the use of several imaging functions altogether such as polarimetric imaging, dual-energy subtraction, multifocal imaging and other. By substracting polarimetric parameters such as degree of polarization, degree of linear polarization, degree of circular polarization, respectively, obtained with interrogation light beams of wavelengths lambda1 and lambda2, he system, enhanced imaging is obtained. The system includes a light source for illuminating a target with a first quantity of light having a first wavelength and a second quantity of light having a second wavelength, the first and second wavelengths being different. A polarization-state generator generates a polarization state for each of the first and second quantities of light, and includes a first polarizer through which the first and second quantities of light are transmitted before entering a first waveplate. A polarization-state receiver evaluates a resulting polarization state of the first and second quantities of light following illumination of the target, the polarization-state receiver including a second waveplate through which the first and second quantittes of light are transmitted before entering a second polarizer. An optical image-capture device captures a first image of the target illuminated by the first quantity of light and a second image of the target illuminated by the second quantity of light. A processing unit assigns a weighting factor to at least one of the first and second images and evaluates a weighted difference between the first and second images to generate a multi-energy image of the target.
摘要翻译：已经发明了一种多能量偏振成像方法，该方法由多融合双旋转延迟器/多能完全基于米勒矩阵的偏振计和双能量能量组成。术语multiusion描述了几种成像功能的使用，如极化成像，双能量减法，多焦点成像等。通过用波长λ1和λ2的询问光束分别获得偏振度，线偏振度，圆偏振度等极化参数，可以获得增强的成像。该系统包括用于利用具有第一波长的第一量光和具有第二波长的第二光量照射目标的光源，第一和第二波长不同。偏振态发生器为第一和第二光量的每一个产生偏振状态，并且包括第一偏振器，在进入第一波片之前第一和第二光量通过该偏振状态透射。极化状态接收器对目标照射后的第一和第二光量的所得极化状态进行评估，所述偏振状态接收器包括第二波片，在进入第二偏振器之前，第一和第二光量子被透射通过。光学图像捕获装置捕获由第一光量照射的目标的第一图像和由第二光量照射的目标的第二图像。处理单元将权重因子分配给第一和第二图像中的至少一个，并且评估第一和第二图像之间的加权差以产生目标的多能量图像。

2. 发明申请

WO2007130001A3 MULTI-SPECTRAL MIXED RADIATION, POLARMETRIC SYSTEMS 审中-公开
标题翻译：多谱混合辐射，POLARMETRIC系统
公开(公告)号：WO2007130001A3
公开(公告)日：2007-12-27
申请号：PCT/US2006011059
申请日：2006-03-28
申请人： UNIV AKRON , GIAKOS GEORGE
发明人： GIAKOS GEORGE
IPC分类号： G01B11/16 , G01J3/447 , G01J4/00 , G01J4/04 , G01N21/21
CPC分类号： G01J3/447 , B82Y10/00 , B82Y20/00 , G01J4/04 , G01N21/21
摘要： The present invention relates to a multi-energy system that generates and/or forms images of targets/structures by applying Mueller matrix imaging principles and/or Stokes polarimetric parameter imaging principles to data obtained by the multi-energy system. In one embodiment, the present invention utilizes at least one energy or light source to generate two or more Mueller matrix and/or Stokes polarization parameters images of a target/structure, and evaluates the Mueller matrix/Stokes polarization parameters multi-spectral difference(s) between the two or more images of the target/structure. As a result, high contrast, high specificity images can be obtained. Additional information can be obtained by and/or from the present invention through the application of image, Mueller matrix decomposition, and/or image reconstruction techniques that operate directly on the Mueller matrix and/or Stokes polarization parameters.
摘要翻译：本发明涉及通过将穆勒矩阵成像原理和/或斯托克斯极化参数成像原理应用于由多能量系统获得的数据来产生和/或形成目标/结构的图像的多能量系统。在一个实施例中，本发明利用至少一个能量或光源来产生目标/结构的两个或更多个穆勒矩阵和/或斯托克斯偏振参数图像，并评估穆勒矩阵/斯托克斯偏振参数多光谱差异）在目标/结构的两个或更多个图像之间。结果，可以获得高对比度，高特异性的图像。通过应用直接在穆勒矩阵和/或斯托克斯偏振参数上操作的图像，穆勒矩阵分解和/或图像重建技术，可以通过和/或从本发明获得附加信息。

3. 发明申请

WO2005029015A2 MULTISPECTRAL, MULTIFUSION, LASER-POLARIMETRIC OPTICAL IMAGING SYSTEM 审中-公开
标题翻译：多光谱，多光谱，激光极向光学成像系统
公开(公告)号：WO2005029015A2
公开(公告)日：2005-03-31
申请号：PCT/US2004/015046
申请日：2004-05-13
申请人： THE UNIVERSITY OF AKRON , GIAKOS, George, C.
发明人： GIAKOS, George, C.
IPC分类号： G01J
CPC分类号： G01J4/04 , G01J3/02 , G01J3/021 , G01J3/0224 , G01J3/2823 , G01J3/36 , G01J3/433 , G01J3/447 , G01N21/21
摘要： A multi-energy polarization imaging method consisting of a multi-fusion, dual-rotating retarder / multiple-energy complete Mueller matrix-based polarimeter and dual-energy capabilities, has been invented. The term multifusion describes the use of several imaging functions altogether such as polarimetric imaging, dual-energy subtraction, multifocal imaging and other. By substracting polarimetric parameters such as degree of polarization, degree of linear polarization, degree of circular polarization, respectively, obtained with interrogation light beams of wavelengths λ 1 and λ 2 , he system, enhanced imaging is obtained. The system includes a light source for illuminating a target with a first quantity of light having a first wavelength and a second quantity of light having a second wavelength, the first and second wavelengths being different. A polarization-state generator generates a polarization state for each of the first and second quantities of light, and includes a first polarizer through which the first and second quantities of light are transmitted before entering a first waveplate. A polarization-state receiver evaluates a resulting polarization state of the first and second quantities of light following illumination of the target, the polarization-state receiver including a second waveplate through which the first and second quantittes of light are transmitted before entering a second polarizer. An optical image-capture device captures a first image of the target illuminated by the first quantity of light and a second image of the target illuminated by the second quantity of light. A processing unit assigns a weighting factor to at least one of the first and second images and evaluates a weighted difference between the first and second images to generate a multi-energy image of the target.
摘要翻译：已经发明了由多融合，双旋转延迟器/多能量完全Mueller基于矩阵的旋光仪和双能量能量组成的多能量偏振成像方法。术语multifusion描述了几种成像功能的使用，例如极化成像，双能量减影，多焦点成像等。通过减去分别用波长λ1和λ2的询问光束获得的极化度，极化度，线偏振度，圆偏振度等极化参数，他系统，获得增强的成像。该系统包括用于利用具有第一波长的第一光量和具有第二波长的第二光量照射目标的光源，第一和第二波长不同。偏振态发生器为第一和第二光量中的每一个产生偏振态，并且包括第一偏振器，在进入第一波片之前，第一和第二光量通过该第一偏振器传输。偏振态接收器评估在目标照射之后第一和第二光量的偏振状态，该偏振状态接收器包括第二波片，在进入第二偏振器之前，第一和第二量子光通过该第二波片传输。光学图像捕获装置捕获由第一数量的光照射的目标的第一图像和由第二数量的光照射的目标的第二图像。处理单元向第一和第二图像中的至少一个分配加权因子并评估第一和第二图像之间的加权差值以生成目标的多能量图像。

4. 发明申请

WO2006124572A3 DUAL WAVELENGTH POLARIZED NEAR-FIELD IMAGING APPARATUS 审中-公开
公开(公告)号：WO2006124572A3
公开(公告)日：2006-11-23
申请号：PCT/US2006/018403
申请日：2006-05-12
申请人： THE UNIVERSITY OF AKRON , GIAKOS, George
发明人： GIAKOS, George
IPC分类号： G01J4/00
摘要： The present invention relates to near-field scanning optical microscopy (NSOM) and near-field/far-field scanning microscopy methods, systems and devices that permit the imaging of biological samples, including biological samples or structures that are smaller than the wavelength of light. In one embodiment, the present invention permits the production of multi-spectral, polarimetric, near-field microscopy systems that can achieve a spatial resolution of less than 100 nanometers. In another embodiment, the present invention permits the production of a multifunctional, multi-spectral, polarimetric, near-field/far-field microscopy that can achieve enhanced sub-surface and in-depth imaging of biological samples. In still another embodiment, the present invention relates to the use of polar molecules as new optical contrast agents for imaging applications ( e.g. , cancer detection).

5. 发明申请

WO2006124572A2 MOLECULAR IMAGING AND NANOPHOTONICS IMAGING AND DETECTION PRINCIPLES AND SYSTEMS, AND CONTRAST AGENTS, MEDIA MAKERS AND BIOMARKERS, AND MECHANISMS FOR SUCH CONTRAST AGENTS 审中-公开
标题翻译：分子成像和纳米成像和检测原理和系统，对比剂，媒体制作者和生物标志物，以及这些对照剂的机制
公开(公告)号：WO2006124572A2
公开(公告)日：2006-11-23
申请号：PCT/US2006018403
申请日：2006-05-12
申请人： UNIV AKRON , GIAKOS GEORGE
发明人： GIAKOS GEORGE
IPC分类号： G01Q60/20 , G02B26/08 , G01Q10/00 , G01Q60/18
CPC分类号： G01Q60/22 , G01J4/04 , G01N21/21 , Y10S977/953
摘要： The present invention relates to near-field scanning optical microscopy (NSOM) and near-field/far-field scanning microscopy methods, systems and devices that permit the imaging of biological samples, including biological samples or structures that are smaller than the wavelength of light. In one embodiment, the present invention permits the production of multi-spectral, polarimetric, near-field microscopy systems that can achieve a spatial resolution of less than 100 nanometers. In another embodiment, the present invention permits the production of a multifunctional, multi-spectral, polarimetric, near-field/far-field microscopy that can achieve enhanced sub-surface and in-depth imaging of biological samples. In still another embodiment, the present invention relates to the use of polar molecules as new optical contrast agents for imaging applications (e.g., cancer detection).
摘要翻译：本发明涉及近场扫描光学显微镜（NSOM）和近场/远场扫描显微镜方法，允许生物样品成像的系统和装置，包括比光的波长小的生物样品或结构。在一个实施例中，本发明允许生产可以实现小于100纳米的空间分辨率的多光谱，极化，近场显微镜系统。在另一个实施方案中，本发明允许生产可实现增强的生物样品的亚表面和深度成像的多功能，多光谱，极化，近场/远场显微镜。在另一个实施方案中，本发明涉及极性分子作为新的光学造影剂用于成像应用（例如，癌症检测）的用途。

6. 发明申请

WO2008130383A9 MOLECULAR AND PHOTONIC NANOSTRUCTURES, OPTICAL BIOMATERIALS, PHOTOSENSITIZERS, MOLECULAR CONTRAST AGENTS, AND METAMATERIALS 审中-公开
标题翻译：分子和光子纳米结构，光生物材料，光敏剂，分子对比剂和元件
公开(公告)号：WO2008130383A9
公开(公告)日：2009-04-09
申请号：PCT/US2007023018
申请日：2007-10-31
申请人： UNIV AKRON , GIAKOS GEORGE
发明人： GIAKOS GEORGE
IPC分类号： G01J4/00
CPC分类号： A61B5/0084 , A61B5/7203
摘要： The present invention generally relates to new photophysical characteristics associated with certain macromolecules, heterogeneous phases with a pronounced index of refraction contrast, and biological complex macromolecules. Given this, in one embodiment the present invention relates to new processes, methods and applications, for enhancing signals and images. In another embodiment, the present invention relates to the design and development of scalable imaging systems and techniques, optical instrumentation and lenses, systems engineering, photonics and optoelectronics, low-power microelectronics, micro-nanotechnology, and sensing/biosensing applications for various applications (e.g., life science applications).
摘要翻译：本发明一般涉及与某些大分子，具有明显的折射率对比的非均相以及生物复合物大分子相关的新的光物理特性。鉴于此，在一个实施例中，本发明涉及用于增强信号和图像的新处理，方法和应用。在另一个实施例中，本发明涉及用于各种应用的可伸缩成像系统和技术，光学仪器和透镜，系统工程，光子学和光电子学，低功率微电子学，微纳米技术和传感/生物传感应用的设计和开发如生命科学应用）。

7. 发明申请

WO2008130383A3 MOLECULAR AND PHOTONIC NANOSTRUCTURES, OPTICAL BIOMATERIALS, PHOTOSENSITIZERS, MOLECULAR CONTRAST AGENTS, AND METAMATERIALS 审中-公开
标题翻译：分子和光子纳米结构，光学生物材料，光敏剂，分子对比剂和元素
公开(公告)号：WO2008130383A3
公开(公告)日：2008-12-11
申请号：PCT/US2007023018
申请日：2007-10-31
申请人： UNIV AKRON , GIAKOS GEORGE
发明人： GIAKOS GEORGE
IPC分类号： G01J4/00
CPC分类号： A61B5/0084 , A61B5/7203
摘要： The present invention generally relates to new photophysical characteristics associated with certain macromolecules, heterogeneous phases with a pronounced index of refraction contrast, and biological complex macromolecules. Given this, in one embodiment the present invention relates to new processes, methods and applications, for enhancing signals and images. In another embodiment, the present invention relates to the design and development of scalable imaging systems and techniques, optical instrumentation and lenses, systems engineering, photonics and optoelectronics, low-power microelectronics, micro-nanotechnology, and sensing/biosensing applications for various applications (e.g., life science applications).
摘要翻译：本发明通常涉及与某些大分子，具有明显的折射率对比度的反相的非均相和生物复合物大分子相关的新的光物理特性。鉴于此，在一个实施例中，本发明涉及用于增强信号和图像的新过程，方法和应用。在另一个实施例中，本发明涉及可扩展成像系统和技术，光学仪器和透镜，系统工程，光子学和光电子学，低功率微电子学，微纳米技术和用于各种应用的感测/生物传感应用的设计和开发（例如生命科学应用）。

8. 发明申请

WO2007130001A2 MULTI-SPECTRAL MIXED RADIATION, POLARMETRIC SYSTEMS 审中-公开
标题翻译：多光谱混合辐射，极化系统
公开(公告)号：WO2007130001A2
公开(公告)日：2007-11-15
申请号：PCT/US2006/011059
申请日：2006-03-28
申请人： THE UNIVERSITY OF AKRON , GIAKOS, George
发明人： GIAKOS, George
IPC分类号： G01J4/00
CPC分类号： G01J3/447 , B82Y10/00 , B82Y20/00 , G01J4/04 , G01N21/21
摘要： The present invention relates to a multi-energy system that generates and/or forms images of targets/structures by applying Mueller matrix imaging principles and/or Stokes polarimetric parameter imaging principles to data obtained by the multi-energy system. In one embodiment, the present invention utilizes at least one energy or light source to generate two or more Mueller matrix and/or Stokes polarization parameters images of a target/structure, and evaluates the Mueller matrix/Stokes polarization parameters multi-spectral difference(s) between the two or more images of the target/structure. As a result, high contrast, high specificity images can be obtained. Additional information can be obtained by and/or from the present invention through the application of image, Mueller matrix decomposition, and/or image reconstruction techniques that operate directly on the Mueller matrix and/or Stokes polarization parameters.
摘要翻译：本发明涉及通过将Mueller矩阵成像原理和/或斯托克斯偏振参数成像原理应用于由多能系统获得的数据来生成和/或形成目标/结构图像的多能量系统。在一个实施例中，本发明利用至少一个能量或光源来产生目标/结构的两个或多个Mueller矩阵和/或斯托克斯极化参数图像，并且评估Mueller矩阵/斯托克斯极化参数多光谱差（s ）在目标/结构的两个或多个图像之间。结果，可以获得高对比度，高特异性图像。通过应用直接在Mueller矩阵和/或斯托克斯极化参数上操作的图像，Mueller矩阵分解和/或图像重建技术，可以获得附加信息和/或从本发明获得附加信息。

9. 发明申请

WO2008130383A4 MOLECULAR AND PHOTONIC NANOSTRUCTURES, OPTICAL BIOMATERIALS, PHOTOSENSITIZERS, MOLECULAR CONTRAST AGENTS, AND METAMATERIALS 审中-公开
标题翻译：分子和光子纳米结构，光学生物材料，光敏剂，分子对比剂和元素
公开(公告)号：WO2008130383A4
公开(公告)日：2009-02-19
申请号：PCT/US2007023018
申请日：2007-10-31
申请人： UNIV AKRON , GIAKOS GEORGE
发明人： GIAKOS GEORGE
IPC分类号： G01J4/00
CPC分类号： A61B5/0084 , A61B5/7203
摘要： The present invention generally relates to new photophysical characteristics associated with certain macromolecules, heterogeneous phases with a pronounced index of refraction contrast, and biological complex macromolecules. Given this, in one embodiment the present invention relates to new processes, methods and applications, for enhancing signals and images. In another embodiment, the present invention relates to the design and development of scalable imaging systems and techniques, optical instrumentation and lenses, systems engineering, photonics and optoelectronics, low-power microelectronics, micro-nanotechnology, and sensing/biosensing applications for various applications (e.g., life science applications).
摘要翻译：本发明通常涉及与某些大分子，具有明显的折射率对比度的反相的非均相和生物复合物大分子相关的新的光物理特性。鉴于此，在一个实施例中，本发明涉及用于增强信号和图像的新过程，方法和应用。在另一个实施例中，本发明涉及可扩展成像系统和技术，光学仪器和透镜，系统工程，光子学和光电子学，低功率微电子学，微纳米技术和用于各种应用的感测/生物传感应用的设计和开发（例如生命科学应用）。

10. 发明申请

WO2008130383A2 MOLECULAR AND PHOTONIC NANOSTRUCTURES, OPTICAL BIOMATERIALS, PHOTOSENSITIZERS, MOLECULAR CONTRAST AGENTS, AND METAMATERIALS 审中-公开
标题翻译：分子和光子纳米结构，光生物材料，光敏剂，分子对比剂和元件
公开(公告)号：WO2008130383A2
公开(公告)日：2008-10-30
申请号：PCT/US2007/023018
申请日：2007-10-31
申请人： THE UNIVERSITY OF AKRON , GIAKOS, George
发明人： GIAKOS, George
IPC分类号： H04N1/23
CPC分类号： A61B5/0084 , A61B5/7203
摘要： The present invention generally relates to new photophysical characteristics associated with certain macromolecules, heterogeneous phases with a pronounced index of refraction contrast, and biological complex macromolecules. Given this, in one embodiment the present invention relates to new processes, methods and applications, for enhancing signals and images. In another embodiment, the present invention relates to the design and development of scalable imaging systems and techniques, optical instrumentation and lenses, systems engineering, photonics and optoelectronics, low-power microelectronics, micro-nanotechnology, and sensing/biosensing applications for various applications ( e.g. , life science applications).
摘要翻译：本发明一般涉及与某些大分子，具有明显的折射率对比的非均相以及生物复合物大分子相关的新的光物理特性。鉴于此，在一个实施例中，本发明涉及用于增强信号和图像的新处理，方法和应用。在另一个实施例中，本发明涉及用于各种应用的可伸缩成像系统和技术，光学仪器和透镜，系统工程，光子学和光电子学，低功率微电子学，微纳米技术和传感/生物传感应用的设计和开发例如，生命科学应用）。

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