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    • 5. 发明申请
    • METHOD FOR ADMINISTERING INSULIN TO THE BUCCAL REGION
    • 将胰岛素施用于BUCCAL区域的方法
    • WO0172278A3
    • 2002-04-11
    • PCT/IB0100564
    • 2001-02-21
    • GENEREX PHARM INC
    • MODI PANKAJ
    • A61K9/00A61K9/107A61K38/12A61K38/28
    • A61K9/0043A61K9/0056A61K9/006A61K9/1075A61K38/00A61K38/28
    • A mixed micellar pharmaceutical formulation includes a micellar proteinic pharmaceutical agent, an alkali metal C8 to C22 alkyl sulphate, alkali metal salicylate, a pharmaceutically acceptable edetate and at least one absorption enhancing compounds. The absorption enhancing compounds are selected from the group consisting of lecithin, hyaluronic acid, pharmaceutically acceptable salts of hyaluronic acid, octylphenoxypolyethoxyethanol, glycolic acid, lactic acid, chamomile extract, cucumber extract, oleic acid, linolenic acid, borage oil, evening of primrose oil, trihydroxy oxo cholanylglycine, glycerin, polyglycerin, lysine, polylysine, triolein and mixtures thereof. The amount of each absorption enhancing compound is present in a concentration of from 1 to 10 wt./wt.% of the total formulation, and the total concentration of absorption enhancing compounds are less than 50 wt./wt.% of the formulation.
    • 混合胶束药物制剂包括胶束蛋白质药剂,碱金属C8至C22烷基硫酸盐,碱金属水杨酸盐,药学上可接受的盐酸盐和至少一种吸收增强化合物。 吸收增强化合物选自卵磷脂,透明质酸,透明质酸的药学上可接受的盐,辛基苯氧基聚乙氧基乙醇,乙醇酸,乳酸,洋甘菊提取物,黄瓜提取物,油酸,亚麻酸,琉璃苣油,月见草油的晚上 ,三羟基羰基甘氨酸甘油,甘油,聚甘油,赖氨酸,聚赖氨酸,三油酸甘油酯及其混合物。 每种吸收增强化合物的量以总制剂的1至10重量/重量%的浓度存在,并且吸收增强化合物的总浓度小于制剂的50重量/重量%。