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1. 发明申请

WO2011060080A2 GENES DIFFERENTIALLY EXPRESSED BY CUMULUS CELLS AND ASSAYS USING SAME TO IDENTIFY PREGNANCY COMPETENT OOCYTES 审中-公开
标题翻译：由细胞表达的基因和使用相同的鉴定蛋白质测定蛋白质的测定
公开(公告)号：WO2011060080A2
公开(公告)日：2011-05-19
申请号：PCT/US2010/056252
申请日：2010-11-10
申请人： GEMA DIAGNOSTICS, INC. , CIBELLI, Jose, B. , IAGER, Amy, E. , OTU, Hasan, H.
发明人： CIBELLI, Jose, B. , IAGER, Amy, E. , OTU, Hasan, H.
CPC分类号： G01N33/689 , C12Q1/6881 , C12Q2600/158 , G01N2800/52
摘要： A genetic means of identifying "pregnancy competent" oocytes is provided. The means comprises detecting the level of expression of one or more genes that are expressed at characteristic levels (upregulated or downregulated) in cumulus cells derived from pregnancy competent oocytes. This characteristic gene expression level, or pattern referred to herein as the "pregnancy signature", also can be used to identify subjects with underlying conditions that impair or prevent the development of a viable pregnancy, e.g. , pre-menopausal condition, other hormonal dysfunction, ovarian dysfunction, ovarian cyst, cancer or other cell proliferation disorder, autoimmune disease and the like. In preferred embodiments the pregnancy signature will comprise one or more of ABCA6, NCAM1, OLFML3, PTPRA, SDF4, GPR137B, DDIT4, DUSP1, GPR137B, IDUA, KCTD5, NDNL2, SLC26A3, and TERF2IP.
摘要翻译：提供了鉴定“怀孕能力”卵母细胞的遗传方式。该方法包括检测在来自怀孕感染性卵母细胞的卵丘细胞中以特征水平（上调或下调）表达的一种或多种基因的表达水平。这种特征性基因表达水平或本文称为“怀孕签名”的模式也可用于鉴定有潜在病症的受试者，其损害或预防可行妊娠的发展，例如绝经前期，其他激素功能障碍，卵巢功能障碍，卵巢囊肿，癌症或其他细胞增殖障碍，自身免疫疾病等。在优选实施方案中，怀孕签名将包括ABCA6，NCAM1，OLFML3，PTPRA，SDF4，GPR137B，DDIT4，DUSP1，GPR137B，IDUA，KCTD5，NDNL2，SLC26A3和TERF2IP中的一种或多种。

2. 发明申请

WO2013056252A1 ASSESSMENT OF OOCYTE COMPETENCE BY DETECTING SPSB2 AND/OR TP53I3 GENE EXPRESSION 审中-公开
标题翻译：通过检测SPSB2和/或TP53I3基因表达来评估OOCYTE的能力
公开(公告)号：WO2013056252A1
公开(公告)日：2013-04-18
申请号：PCT/US2012/060296
申请日：2012-10-15
申请人： GEMA DIAGNOSTICS, INC. , WELLS, Dagan , PATRIZIO, Pasquale
发明人： WELLS, Dagan , PATRIZIO, Pasquale
IPC分类号： C12Q1/68 , C12N15/12 , G01N33/68
CPC分类号： C12Q1/6881 , C07K14/4703 , C12N9/0055 , C12Q2600/158 , C12Y110/99002 , G01N33/5091 , G01N33/56966 , G01N33/689 , G01N2800/367
摘要： Methods are provided for evaluating an oocyte for fertilization and implantation comprising analysis of gene expression in cumulus cells wherein the detected genes or polypeptides include at least SPSB2 and TP53I3. For example, methods are provided for determining whether a cumulus cell expresses, or does not express, one or more of a group of markers identified as differently expressed between cumulus cells associated with chromosomally normal oocytes and cumulus cells associated with chromosomally abnormal oocytes. Methods are provided for the detection of marker expression of differentially expressed genes at the RNA level, as well as at the protein level.
摘要翻译：提供了用于评估受精和植入的卵母细胞的方法，包括分析卵丘细胞中的基因表达，其中所检测的基因或多肽至少包括SPSB2和TP53I3。例如，提供了用于确定卵丘细胞是否表达或不表达鉴定为与染色体正常卵母细胞相关的卵丘细胞与与染色体异常卵母细胞相关的卵丘细胞之间不同表达的一组或多种标记的方法。提供了用于在RNA水平以及蛋白质水平检测差异表达基因的标记物表达的方法。

3. 发明申请

WO2011060080A3 GENES DIFFERENTIALLY EXPRESSED BY CUMULUS CELLS AND ASSAYS USING SAME TO IDENTIFY PREGNANCY COMPETENT OOCYTES 审中-公开
标题翻译：基因差异表达的细胞和使用相同的方法来鉴定妊娠期卵母细胞
公开(公告)号：WO2011060080A3
公开(公告)日：2011-11-17
申请号：PCT/US2010056252
申请日：2010-11-10
申请人： GEMA DIAGNOSTICS INC , CIBELLI JOSE B , IAGER AMY E , OTU HASAN H
发明人： CIBELLI JOSE B , IAGER AMY E , OTU HASAN H
IPC分类号： C12Q1/68 , C12N5/075 , C12N15/12 , G01N33/15
CPC分类号： G01N33/689 , C12Q1/6881 , C12Q2600/158 , G01N2800/52
摘要： A genetic means of identifying "pregnancy competent" oocytes is provided. The means comprises detecting the level of expression of one or more genes that are expressed at characteristic levels (upregulated or downregulated) in cumulus cells derived from pregnancy competent oocytes. This characteristic gene expression level, or pattern referred to herein as the "pregnancy signature", also can be used to identify subjects with underlying conditions that impair or prevent the development of a viable pregnancy, e.g., pre-menopausal condition, other hormonal dysfunction, ovarian dysfunction, ovarian cyst, cancer or other cell proliferation disorder, autoimmune disease and the like. In preferred embodiments the pregnancy signature will comprise one or more of ABCA6, NCAM1, OLFML3, PTPRA, SDF4, GPR137B, DDIT4, DUSP1, GPR137B, IDUA, KCTD5, NDNL2, SLC26A3, and TERF2IP.
摘要翻译：提供了识别“怀孕的”卵母细胞的遗传手段。该手段包括检测一个或多个基因的表达水平，所述基因在源自怀孕感受性卵母细胞的卵丘细胞中以特征性水平（上调或下调）表达。这种特征性基因表达水平或本文称为“妊娠特征”的模式也可用于鉴定具有潜在病症的个体，所述个体具有损害或预防活的怀孕的发展，例如绝经前期病症，其他激素功能障碍，卵巢功能障碍，卵巢囊肿，癌症或其他细胞增殖疾病，自身免疫性疾病等。在优选的实施方案中，妊娠签名将包括ABCA6，NCAM1，OLFML3，PTPRA，SDF4，GPR137B，DDIT4，DUSP1，GPR137B，IDUA，KCTD5，NDNL2，SLC26A3和TERF2IP中的一种或多种。

4. 发明申请

WO2013056258A1 GENES DIFFERENTIALLY EXPRESSED BY CUMULUS CELLS AND ASSAYS USING SAME TO IDENTIFY PREGNANCY COMPETENT OOCYTES 审中-公开
标题翻译：由细胞表达的基因和使用相同的鉴定鉴定潜力的化学物质的测定
公开(公告)号：WO2013056258A1
公开(公告)日：2013-04-18
申请号：PCT/US2012/060307
申请日：2012-10-15
申请人： GEMA DIAGNOSTICS, INC. , CIBELLI, Jose, B. , IAGER, Amy, E. , OTU, Hasan, H.
发明人： CIBELLI, Jose, B. , IAGER, Amy, E. , OTU, Hasan, H.
IPC分类号： C12Q1/68 , C12Q1/02 , C12N5/075
CPC分类号： C12Q1/6888 , C12Q1/6881 , C12Q2600/158
摘要： A genetic means of identifying "pregnancy competent" oocytes is provided. The means comprises detecting the level of expression of one or more genes that are expressed at characteristic levels (upregulated or downregulated) in cumulus cells derived from pregnancy competent oocytes. This characteristic gene expression level, or pattern referred to herein as the "pregnancy signature", also can be used to identify subjects with underlying conditions that impair or prevent the development of a viable pregnancy, e.g., pre-menopausal condition, other hormonal dysfunction, ovarian dysfunction, ovarian cyst, cancer or other cell proliferation disorder, autoimmune disease and the like. In preferred embodiments the pregnancy signature will comprise one or more of FGF12, (Hs00374427_ml), GPR137B (Hs00162803_ml), SLC2A9 (Hs00417125_ml), ARID IB (Hs00368175_ml), NR2F6 (Hs00172870_ml), ZNF132 (Hs01036387_ml), FAM36A (Hs00831105_sl), ZNF93 (Hs01656246„sl), RHBDL2 (Hs00384848_ml), DNAJC15 (Hs00387763_ml), MTUS1 (Hs00826834_ml), ND NUP133 (Hs00217272_ml), or their orthologs, splice or allelic variants.
摘要翻译：提供鉴定“怀孕能力”卵母细胞的遗传方式。该方法包括检测在源于妊娠合格卵母细胞的卵丘细胞中以特征水平（上调或下调）表达的一种或多种基因的表达水平。这种特征性基因表达水平或本文称为“怀孕签名”的模式也可以用于鉴定有潜在病症的受试者，其损害或预防可行妊娠的发展，例如绝经前期，其他激素功能障碍，卵巢功能障碍，卵巢囊肿，癌症或其他细胞增殖障碍，自身免疫性疾病等。在优选实施方案中，怀孕签名将包括FGF12，（Hs00374427_ml），GPR137B（Hs00162803_ml），SLC2A9（Hs00417125_ml），ARID IB（Hs00368175_ml），NR2F6（Hs00172870_ml），ZNF132（Hs01036387_ml），FAM36A（Hs00831105_s1），ZNF93 （Hs01656246“sl），RHBDL2（Hs00384848_ml），DNAJC15（Hs00387763_ml），MTUS1（Hs00826834_ml），ND NUP133（Hs00217272_ml）或其直向同源物，剪接或等位基因变体。

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