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1. 发明申请

WO2008121386A2 METHODS OF TREATING BOWEL DISORDERS 审中-公开
标题翻译：治疗鲍威尔病的方法
公开(公告)号：WO2008121386A2
公开(公告)日：2008-10-09
申请号：PCT/US2008/004166
申请日：2008-03-31
申请人： AMGEN INC. , GEIBEL, John P. , HEBERT, Steven C. , MARTIN, David , RUSSELL, Deborah A.
发明人： GEIBEL, John P. , HEBERT, Steven C. , MARTIN, David , RUSSELL, Deborah A.
IPC分类号： A61K31/137 , A61K31/42 , A61K31/427 , A61K31/428 , A61K31/44 , A61P1/00
CPC分类号： A61K31/137 , A61K31/42 , A61K31/427 , A61K31/428 , A61K31/44
摘要： The present invention relates to methods for treating or preventing bowel disorders using calcimimetics.
摘要翻译：本发明涉及使用拟钙剂治疗或预防肠障碍的方法。

2. 发明申请

WO2007089511A2 FAST ACTING INHIBITOR OF GASTRIC ACID SECRETION 审中-公开
标题翻译：快速抑制胃酸分泌抑制剂
公开(公告)号：WO2007089511A2
公开(公告)日：2007-08-09
申请号：PCT/US2007/001950
申请日：2007-01-25
申请人： YALE UNIVERSITY , GEIBEL, John, P. , KIRCHHOFF, Philipp
发明人： GEIBEL, John, P. , KIRCHHOFF, Philipp
IPC分类号： A61K31/555
CPC分类号： A61K31/315 , A61K31/4168 , A61K31/43 , A61K31/65 , A61K31/7048 , A61K33/30 , A61K2300/00
摘要： The present invention relates to the use of pharmaceutically acceptable zinc salts, preferably water soluble zinc salts alone or optionally, in combination with one or more of a protein pump inhibitor (PPI), H2 blocker, anti-H. pylori antibiotic/antimicrobial, cytoprotective agent or a combination agent as otherwise described herein for providing fast action with optional long duration effect in reducing gastric acid secretion, raising the pH of the stomach during resting phase as well as decreasing the duration of stomach acid release during a secretagogue phase and for treating conditions including gastroesophageal reflux disease (GERD), non-erosive reflux disease (NERD), Zollinger-Ellison syndrome (ZE disease), ulcer disease, and gastric cancer, as well as preventing or reducing the likelihood of ulcer disease. In addition, the present methods are useful for treating patients who are non-responsive to proton pump inhibitors (PPI) and as an alternative to traditional therapies or conditions which are caused by rapid and complete inhibition of secretagogue induced acid secretion.
摘要翻译：本发明涉及药学上可接受的锌盐，优选单独的水溶性锌盐或任选地与一种或多种蛋白质泵抑制剂（PPI），H2阻断剂，抗-H的组合的用途。幽门螺杆菌抗生素/抗微生物剂，细胞保护剂或组合剂，如本文另有说明，用于提供快速作用，具有减少胃酸分泌的任选长时间效应，在休息期增加胃的pH以及降低胃酸释放持续时间一种促分泌期，用于治疗胃食管反流病（GERD），非侵蚀性反流病（NERD），佐林格 - 埃利森综合征（ZE），溃疡病和胃癌等病症，以及预防或减少溃疡的可能性疾病。此外，本发明的方法可用于治疗对质子泵抑制剂（PPI）无反应性的患者，并且可用于由促分泌素诱导的酸分泌的快速和完全抑制引起的传统治疗或病症的替代。

3. 发明申请

WO2009017624A3 COMPOSITIONS WITH ENHANCED BIOAVAILABILITY AND FAST ACTING INHIBITOR OF GASTRIC ACID SECRETION 审中-公开
标题翻译：具有增强的生物利用度和快速作用的胃酸分泌抑制剂的组合物
公开(公告)号：WO2009017624A3
公开(公告)日：2009-03-26
申请号：PCT/US2008008878
申请日：2008-07-22
申请人： UNIV YALE , GEIBEL JOHN P , KIRCHHOFF PHILIPP
发明人： GEIBEL JOHN P , KIRCHHOFF PHILIPP
IPC分类号： A61K31/4439 , A61P1/04 , C07D401/12
CPC分类号： A61K33/30 , A61K31/315 , A61K31/4439 , A61K45/06 , A61K2300/00
摘要： The present invention relates to the use of pharmaceutically acceptable zinc salts, preferably water soluble zinc salts alone or optionally, in combination with one or more of a protein pump inhibitor (PPI), H2 blocker, anti-H. pylori antibiotic/antimicrobial, cytoprotective agent or a combination agent as otherwise described herein for providing fast action with optional long duration effect in reducing gastric acid secretion, raising the p? of the stomach during resting phase as well as decreasing the duration of stomach acid release during a secretagogue phase and for treating conditions including gastroesophageal reflux disease (GERD), non-erosive reflux disease (NERD), Zollinger-Ellison syndrome (ZE disease), ulcer disease, and gastric cancer, as well as preventing or reducing the likelihood of ulcer disease. In addition, the present methods are useful for treating patients who are non- responsive to proton pump inhibitors (PPI) and as an alternative to traditional therapies or conditions which are caused by rapid and complete inhibition of secretagogue induced acid secretion. The present invention also relates to the use of one or more water soluble zinc salts, administered in combination with a therapeutic compound or agent (second therapeutic agent) which may be delivered orally with enhanced bioavailability (compared to compounds which are administered in the absence of water soluble zinc salts) or other favorable benefits. In addition, therapeutic agents which exhibit sensitivity to low p? may be advantageously orally administered in combination with an effective amount of at least one water soluble zinc salt. Compositions according to the present invention exhibit greater bioavailability of the active agent when formulated in combination with a water soluble zinc salt in oral dosage form than when administered with the water soluble zinc salt.
摘要翻译：本发明涉及药学上可接受的锌盐，优选单独的水溶性锌盐或任选地与蛋白质泵抑制剂（PPI），H2阻断剂，抗-H中的一种或多种的组合。如本文另外描述的抗幽门螺杆菌抗生素/抗微生物剂，细胞保护剂或组合剂用于提供快速作用和可选的持续时间效应，以减少胃酸分泌，（GERD），非糜烂性反流疾病（NERD），Zollinger-Ellison综合征（ZE疾病），胃食管反流病（GERD）和胃食管反流病溃疡病和胃癌，以及预防或减少溃疡病的可能性。此外，本发明方法可用于治疗对质子泵抑制剂（PPI）无反应的患者以及作为由促分泌素诱导的酸分泌的快速和完全抑制引起的传统治疗或病症的替代方案。本发明还涉及一种或多种水溶性锌盐与可以以增强的生物利用度口服递送的治疗性化合物或试剂（第二治疗剂）组合施用（与在不存在水溶性锌盐）或其他有利益处。另外，对低p值敏感的治疗剂可有利地与有效量的至少一种水溶性锌盐联合口服给药。当与口服剂型中的水溶性锌盐组合配制时，与水溶性锌盐一起给药时，本发明组合物表现出更高的活性剂生物利用度。

4. 发明申请

WO2007089511A3 FAST ACTING INHIBITOR OF GASTRIC ACID SECRETION 审中-公开
标题翻译：快速抑制胃酸分泌抑制剂
公开(公告)号：WO2007089511A3
公开(公告)日：2008-04-10
申请号：PCT/US2007001950
申请日：2007-01-25
申请人： UNIV YALE , GEIBEL JOHN P , KIRCHHOFF PHILIPP
发明人： GEIBEL JOHN P , KIRCHHOFF PHILIPP
IPC分类号： A61K31/555 , A61K31/4439
CPC分类号： A61K31/315 , A61K31/4168 , A61K31/43 , A61K31/65 , A61K31/7048 , A61K33/30 , A61K2300/00
摘要： The present invention relates to the use of pharmaceutically acceptable zinc salts, preferably water soluble zinc salts alone or optionally, in combination with one or more of a protein pump inhibitor (PPI), H2 blocker, anti-H. pylori antibiotic/antimicrobial, cytoprotective agent or a combination agent as otherwise described herein for providing fast action with optional long duration effect in reducing gastric acid secretion, raising the pH of the stomach during resting phase as well as decreasing the duration of stomach acid release during a secretagogue phase and for treating conditions including gastroesophageal reflux disease (GERD), non-erosive reflux disease (NERD), Zollinger-Ellison syndrome (ZE disease), ulcer disease, and gastric cancer, as well as preventing or reducing the likelihood of ulcer disease. In addition, the present methods are useful for treating patients who are non-responsive to proton pump inhibitors (PPI) and as an alternative to traditional therapies or conditions which are caused by rapid and complete inhibition of secretagogue induced acid secretion.
摘要翻译：本发明涉及药学上可接受的锌盐，优选单独的水溶性锌盐或任选地与一种或多种蛋白质泵抑制剂（PPI），H2阻断剂，抗-H的组合的用途。幽门螺杆菌抗生素/抗微生物剂，细胞保护剂或组合剂，如本文另有说明，用于提供快速作用，具有减少胃酸分泌的任选长时间效应，在休息期增加胃的pH以及降低胃酸释放持续时间一种促分泌期，用于治疗胃食管反流病（GERD），非侵蚀性反流病（NERD），佐林格 - 埃利森综合征（ZE），溃疡病和胃癌等病症，以及预防或减少溃疡的可能性疾病。此外，本发明的方法可用于治疗对质子泵抑制剂（PPI）无反应性的患者，并且可用于由促分泌素诱导的酸分泌的快速和完全抑制引起的传统治疗或病症的替代。

5. 发明申请

WO2009017624A2 COMPOSITIONS WITH ENHANCED BIOAVAILABILITY AND FAST ACTING INHIBITOR OF GASTRIC ACID SECRETION 审中-公开
标题翻译：具有增强生物利用度的组合物和胃酸分泌快速抑制剂
公开(公告)号：WO2009017624A2
公开(公告)日：2009-02-05
申请号：PCT/US2008/008878
申请日：2008-07-22
申请人： YALE UNIVERSITY , GEIBEL, John, P. , KIRCHHOFF, Philipp
发明人： GEIBEL, John, P. , KIRCHHOFF, Philipp
IPC分类号： A61K31/4439 , A61P1/04
CPC分类号： A61K33/30 , A61K31/315 , A61K31/4439 , A61K45/06 , A61K2300/00
摘要： The present invention relates to the use of pharmaceutically acceptable zinc salts, preferably water soluble zinc salts alone or optionally, in combination with one or more of a protein pump inhibitor (PPI), H2 blocker, anti-H. pylori antibiotic/antimicrobial, cytoprotective agent or a combination agent as otherwise described herein for providing fast action with optional long duration effect in reducing gastric acid secretion, raising the pΗ of the stomach during resting phase as well as decreasing the duration of stomach acid release during a secretagogue phase and for treating conditions including gastroesophageal reflux disease (GERD), non-erosive reflux disease (NERD), Zollinger-Ellison syndrome (ZE disease), ulcer disease, and gastric cancer, as well as preventing or reducing the likelihood of ulcer disease. In addition, the present methods are useful for treating patients who are non- responsive to proton pump inhibitors (PPI) and as an alternative to traditional therapies or conditions which are caused by rapid and complete inhibition of secretagogue induced acid secretion. The present invention also relates to the use of one or more water soluble zinc salts, administered in combination with a therapeutic compound or agent (second therapeutic agent) which may be delivered orally with enhanced bioavailability (compared to compounds which are administered in the absence of water soluble zinc salts) or other favorable benefits. In addition, therapeutic agents which exhibit sensitivity to low pΗ may be advantageously orally administered in combination with an effective amount of at least one water soluble zinc salt. Compositions according to the present invention exhibit greater bioavailability of the active agent when formulated in combination with a water soluble zinc salt in oral dosage form than when administered with the water soluble zinc salt.
摘要翻译：本发明涉及药学上可接受的锌盐，优选单独的水溶性锌盐或任选地与一种或多种蛋白质泵抑制剂（PPI），H2阻断剂，抗-H的组合的用途。幽门螺杆菌抗生素/抗微生物剂，细胞保护剂或本文另外描述的组合剂，用于提供具有任选长时间效果的快速作用以减少胃酸分泌，提高p < 的胃，并减少在促分泌期期间胃酸释放的持续时间，并用于治疗包括胃食管反流病（GERD），非侵蚀性反流疾病（NERD），佐林格 - 埃利森综合征（ZE）溃疡病和胃癌，以及预防或减少溃疡疾病的可能性。此外，本发明的方法可用于治疗对质子泵抑制剂（PPI）无反应性的患者，并且可用于由促分泌素诱导的酸分泌的快速和完全抑制引起的传统治疗或病症的替代。本发明还涉及一种或多种水溶性锌盐的用途，其与治疗化合物或药剂（第二治疗剂）组合施用，其可以口服提供生物利用度提高（与在不存在水溶性锌盐）或其他有利的益处。另外，对低p敏感性的治疗剂可有利地与有效量的至少一种水溶性锌盐口服给药。当与口服剂型的水溶性锌盐组合时，当与水溶性锌盐一起施用时，根据本发明的组合物表现出更大的活性剂的生物利用度。

6. 发明申请

WO2008121386A3 CALCIMIMETIC COMPOUNDS FOR USE IN THE TREATMENT OF BOWEL DISORDERS 审中-公开
标题翻译：用于治疗BOWEL病症的计算化合物
公开(公告)号：WO2008121386A3
公开(公告)日：2008-12-31
申请号：PCT/US2008004166
申请日：2008-03-31
申请人： AMGEN INC , GEIBEL JOHN P , HEBERT STEVEN C , MARTIN DAVID , RUSSELL DEBORAH A
发明人： GEIBEL JOHN P , HEBERT STEVEN C , MARTIN DAVID , RUSSELL DEBORAH A
IPC分类号： A61K31/137 , A61K31/42 , A61K31/427 , A61K31/428 , A61K31/44 , A61P1/00
CPC分类号： A61K31/137 , A61K31/42 , A61K31/427 , A61K31/428 , A61K31/44
摘要： The present invention relates to methods for treating or preventing bowel disorders using calcimimetics.
摘要翻译：本发明涉及使用拟钙剂治疗或预防肠障碍的方法。

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