专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2006012308A1 BISARYLUREA DERIVATIVES USEFUL FOR INHIBITING CHK1 审中-公开
标题翻译：用于抑制CHK1的双胺衍生物
公开(公告)号：WO2006012308A1
公开(公告)日：2006-02-02
申请号：PCT/US2005/022515
申请日：2005-06-24
申请人： ICOS CORPORATION , BURGESS, Laurence, Edward , COOK, Adam, Wade , FISCHER, Kimba, L. , GAUDINO, John, Joseph , SCHLACHTER, Stephen, T.
发明人： BURGESS, Laurence, Edward , COOK, Adam, Wade , FISCHER, Kimba, L. , GAUDINO, John, Joseph , SCHLACHTER, Stephen, T.
IPC分类号： C07D401/12
CPC分类号： C07D405/14 , C07D241/20 , C07D401/12
摘要： Aryl- and heteroaryl-substituted urea compounds useful in the treatment of diseases and conditions related to DNA damage or lesions in DNA replication are disclosed. Methods of making the compounds, and their use as therapeutic agents, for example, in treating cancer and other diseases characterized by defects in DNA replication, chromosome segregation, or cell division also are disclosed. Formula (I).
摘要翻译：公开了可用于治疗与DNA复制中的DNA损伤或病变相关的疾病和病症的芳基和杂芳基取代的脲化合物。还公开了制备化合物的方法及其作为治疗剂的用途，例如用于治疗癌症和其它以DNA复制，染色体分离或细胞分裂缺陷为特征的疾病。式（I）。

2. 发明申请

WO0204412A3 TYROSINE DERIVATIVES AS PHOSPHATASE INHIBITORS 审中-公开
标题翻译：酪氨酸衍生物作为磷酸酶抑制剂
公开(公告)号：WO0204412A3
公开(公告)日：2002-08-22
申请号：PCT/US0141271
申请日：2001-07-05
申请人： ARRAY BIOPHARMA INC , BURGESS LAURENCE E , GAUDINO JOHN , GRONEBERG ROBERT D , NORMAN MARK H , RODRIGUEZ MARTHA E , SUN XICHENG , WALLACE ELI M , AMGEN INC
发明人： BURGESS LAURENCE E , GAUDINO JOHN , GRONEBERG ROBERT D , NORMAN MARK H , RODRIGUEZ MARTHA E , SUN XICHENG , WALLACE ELI M
IPC分类号： A61K31/192 , A61K31/194 , A61K31/196 , A61K31/341 , A61K31/4045 , A61K31/41 , A61K31/4402 , A61P3/10 , A61P7/12 , A61P35/00 , A61P43/00 , C07C237/22 , C07C311/13 , C07C311/19 , C07C311/29 , C07D209/14 , C07D209/16 , C07D213/40 , C07D257/04 , C07D307/52 , A61K31/165 , A61K31/166
CPC分类号： C07D213/40 , C07C237/22 , C07C311/13 , C07C311/19 , C07C311/29 , C07D209/14 , C07D209/16 , C07D257/04 , C07D307/52
摘要： Disclosed are compounds of the Formula (I), and pharmaceutically acceptable salts and prodrugs thereof, wherein A, B, R , R , R , R and R are as defined in the specification. Such compounds are tyrosine phosphatase inhibitors and useful in the treatment or prevention of Type II Diabetes Mellitus. Also encompassed by the invention are formulations comprising the noted compounds, processes for preparing such compounds, a method for treating or preventing Type II Diabetes Mellitus.
摘要翻译：公开了式（I）化合物及其药学上可接受的盐和前药，其中A，B，R 1，R 2，R 3，R 4和R 5如上所定义在规范中。这些化合物是酪氨酸磷酸酶抑制剂，可用于治疗或预防II型糖尿病。本发明还包括包含所述化合物的制剂，制备这些化合物的方法，治疗或预防II型糖尿病的方法。

3. 发明申请

WO2013130976A1 SERINE/THREONINE KINASE INHIBITORS 审中-公开
标题翻译：丝氨酸/螺旋激酶抑制剂
公开(公告)号：WO2013130976A1
公开(公告)日：2013-09-06
申请号：PCT/US2013/028622
申请日：2013-03-01
申请人： ARRAY BIOPHARMA INC. , GENENTECH, INC. , BLAKE, James F. , CHICARELLI, Mark Joseph , GARREY, Rustam Ferdinand , GAUDINO, John , GRINA, Jonas , MORENO, David A. , MOHR, Peter J. , REN, Li , SCHWARZ, Jacob , CHEN, Huifen , ROBARGE, Kirk , ZHOU, Aihe
发明人： BLAKE, James F. , CHICARELLI, Mark Joseph , GARREY, Rustam Ferdinand , GAUDINO, John , GRINA, Jonas , MORENO, David A. , MOHR, Peter J. , REN, Li , SCHWARZ, Jacob , CHEN, Huifen , ROBARGE, Kirk , ZHOU, Aihe
IPC分类号： C07D401/14 , C07D405/14 , C07D413/14 , C07D401/04 , C07D409/14 , C07D417/14 , C07D471/04 , C07F9/6558 , C07F9/6596 , A61K31/435 , A61K31/506 , A61P29/00 , A61P35/00
CPC分类号： C07D401/04 , A61K31/444 , A61K31/506 , A61K31/513 , A61K31/53 , A61K45/06 , C07D401/14 , C07D403/04 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07F9/65586
摘要： Compounds of Formula I or a stereoisomer, tautomer, prodrug or pharmaceutically acceptable salt thereof are provided, which are useful for the treatment of hyperproliferative, pain and inflammatory diseases. Methods of using compounds of Formula I or a stereoisomer, tautomer, prodrug or pharmaceutically acceptable salt thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.
摘要翻译：提供式I化合物或其立体异构体，互变异构体，前药或其药学上可接受的盐，其可用于治疗过度增生，疼痛和炎性疾病。公开了使用式I化合物或其立体异构体，互变异构体，前药或其药学上可接受的盐在体外，原位和体内诊断，预防或治疗哺乳动物细胞或相关病理状况中的这种病症的方法。

4. 发明申请

WO2008063202A3 HETEROBICYCLIC THIOPHENE COMPOUNDS FOR THE TREATMENT OF CANCER 审中-公开
公开(公告)号：WO2008063202A3
公开(公告)日：2008-05-29
申请号：PCT/US2007/002352
申请日：2007-01-30
申请人： ARRAY BIOPHARMA INC. , BLAKE, James, F. , BOYD, Steven , DE MEESE, Jason , GAUDINO, John, J. , MARLOW, Allison, L. , SEO, Jeongbeob , THOMAS, Allen, A. , TIAN, Hongqi
发明人： BLAKE, James, F. , BOYD, Steven , DE MEESE, Jason , GAUDINO, John, J. , MARLOW, Allison, L. , SEO, Jeongbeob , THOMAS, Allen, A. , TIAN, Hongqi
IPC分类号： C07D495/04 , C07D519/00 , A61K31/4353 , A61P35/00
摘要： Compounds of Formula I and pharmaceutically acceptable salts thereof, are useful for inhibiting receptor tyrosine kinases and for treating disorders mediated thereby. Methods of using compounds of Formula I and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.

5. 发明申请

WO2007146824A2 QUINOLINE COMPOUNDS AND METHODS OF USE 审中-公开
标题翻译：喹啉化合物及其使用方法
公开(公告)号：WO2007146824A2
公开(公告)日：2007-12-21
申请号：PCT/US2007/070787
申请日：2007-06-08
申请人： ARRAY BIOPHARMA INC. , GENENTECH, INC. , GAUDINO, John , BOYD, Steven Armen , MARLOW, Allison L. , KAPLAN, Tomas , FONG, Kin Chiu , SEO, Jeongbeob , TIAN, Hongqi , BLAKE, James , KOCH, Kevin
发明人： GAUDINO, John , BOYD, Steven Armen , MARLOW, Allison L. , KAPLAN, Tomas , FONG, Kin Chiu , SEO, Jeongbeob , TIAN, Hongqi , BLAKE, James , KOCH, Kevin
IPC分类号： C07D215/22
CPC分类号： C07D401/14 , C07D215/22 , C07D401/12
摘要： Compounds of Formula I, and stereoisomers, geometric isomers, tautomers, solvates, metabolites, salts and pharmaceutically acceptable prodrugs thereof, are useful for inhibiting receptor tyrosine kinases and for treating hyperproliferative disorders mediated thereby. Methods of using compounds of Formula I, and stereoisomers, geometric isomers, tautomers, solvates and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed. [ Formula I]
摘要翻译：式I化合物和立体异构体，几何异构体，互变异构体，溶剂合物，代谢物，盐和药学上可接受的前药可用于抑制受体酪氨酸激酶和用于治疗由此介导的过度增殖性疾病。使用式I化合物及其立体异构体，几何异构体，互变异构体，溶剂合物及其药学上可接受的盐在哺乳动物细胞或相关病理状况下的体外，原位和体内诊断，预防或治疗这些病症的方法是披露。 [公式I]

6. 发明申请

WO2007103308A2 HETEROBICYCLIC PYRAZOLE COMPOUNDS AND METHODS OF USE 审中-公开
标题翻译：异酞菁化合物及其使用方法
公开(公告)号：WO2007103308A2
公开(公告)日：2007-09-13
申请号：PCT/US2007005583
申请日：2007-03-06
申请人： ARRAY BIOPHARMA INC , GENENTECH INC , BLAKE JAMES F , BOYD STEVEN ARMEN , COHEN FREDERICK , DE MEESE JASON , FONG KIN CHIU , GAUDINO JOHN J , KAPLAN TOMAS , MARLOW ALLISON L , SEO JEONGBEOB , THOMAS ALLEN A , TIAN HONGQI , YOUNG WENDY B
发明人： BLAKE JAMES F , BOYD STEVEN ARMEN , COHEN FREDERICK , DE MEESE JASON , FONG KIN CHIU , GAUDINO JOHN J , KAPLAN TOMAS , MARLOW ALLISON L , SEO JEONGBEOB , THOMAS ALLEN A , TIAN HONGQI , YOUNG WENDY B
CPC分类号： C07D471/04
摘要： Compounds of Formulas (Ia) and (Ib), and stereoisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, are useful for inhibiting receptor tyrosine kinases and for treating disorders mediated thereby. Methods of using compounds of Formula Ia and Ib, and stereoisomers, geometric isomers, tautomers, solvates and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.
摘要翻译：式（Ia）和（Ib）的化合物及其立体异构体，几何异构体，互变异构体，溶剂合物，代谢物和药学上可接受的盐可用于抑制受体酪氨酸激酶和用于治疗由此介导的病症。使用式Ia和Ib化合物及其立体异构体，几何异构体，互变异构体，溶剂化物及其药学上可接受的盐的方法用于体外，原位和体内诊断，预防或治疗哺乳动物细胞中的这种病症或相关病理学条件被公开。

7. 发明申请

WO2006014359A3 COMPOUNDS USEFUL FOR INHIBITING CHK1 审中-公开
公开(公告)号：WO2006014359A3
公开(公告)日：2006-02-09
申请号：PCT/US2005/023554
申请日：2005-07-01
申请人： ICOS CORPORATION , GAUDINO, John, Joseph , COOK, Adam, Wade
发明人： GAUDINO, John, Joseph , COOK, Adam, Wade
IPC分类号： C07D401/12 , A61K31/497 , A61K31/17 , C07D413/12 , C07D417/12
摘要： Substituted urea compounds useful in the treatment of diseases and C 1 - 3 alkyleneOR 3 conditions related to DNA damage or lesions in DNA replication are disclosed formula (I), wherein X 1 is null , - O- , - S - , - CH 2 - , or -N ( R 1 ) - ; X 2 is - O- , . - £>.- , or -N (R 1 ) - ,- . . Y xs 0 or S ; or =y represents two hydrogen atoms attached to a common carbon atom ,- W is selected from the group consisting of heteroaryl , aryl , heterocycloalkyl , cycloalkyl , and C1-6 alkyl substi tuted with a heteroaryl. or aryl group ; R 6 is -C≡C-R 7 or heteroaryl ; R 8 , R 9 , and R 10 , independently, are selected from the group consisting of halo , optionally substituted C 1-6 alkyl , C 2-6 alkenyl , C 2-6 alkynyl , OCP 3 , CF 3 , NO 2 , CN, NC, N (R 3 ) 2 , OR 3 , CO 2 R 3 , C ( O ) N (R 3 ) 2 , C (O) R 3 , N (R 1 )COR 3 , N (R 1 ) C (O) OR 3 , N (R 8 ) C (O) OR 3 , N (R 1 ) C ( O) C 1 -3 alkyleneC (O) R 3 , N ( R 1 ) C (O) C 1 -3 alkyleneC (O) OR 3 , N (R 1 ) C (O) C 1 - 3 alkyleneOR 3 , N (R 1 ) C (O) C 1 -3 alkyleneNHC ( O) OR 3 , N (R 1 ) C (O) C 1-3 alkyleneSO 2 .NR 3 , C 1- 3 alkyleneOR 3 , and SR 3 ; Methods of making the compounds , and their use as therapeutic agents , for example , in treating cancer and other diseases characterized by def ects in DNA repli cation , chromosome segregation , or cell division also are disclosed .

8. 发明申请

WO2006014359A2 COMPOUNDS USEFUL FOR INHIBITING CHK1 审中-公开
标题翻译：化合物可用于抑制CHK1
公开(公告)号：WO2006014359A2
公开(公告)日：2006-02-09
申请号：PCT/US2005023554
申请日：2005-07-01
申请人： ICOS CORP , GAUDINO JOHN JOSEPH , COOK ADAM WADE
发明人： GAUDINO JOHN JOSEPH , COOK ADAM WADE
IPC分类号： C07D401/00
CPC分类号： C07D413/12 , C07D401/12 , C07D417/12
摘要： Substituted urea compounds useful in the treatment of diseases and conditions related to DNA damage or lesions in DNA replication are disclosed. Methods of making the compounds, and their use as therapeutic agents, for example, in treating cancer and other diseases characterized by defects in DNA replication, chromosome segregation, or cell division also are disclosed.
摘要翻译：公开了用于治疗与DNA复制中的DNA损伤或病变相关的疾病和病症的替代的尿素化合物。还公开了制备化合物的方法及其作为治疗剂的用途，例如用于治疗癌症和其它以DNA复制，染色体分离或细胞分裂缺陷为特征的疾病。

9. 发明申请

WO2013020062A1 QUINAZOLINE COMPOUNDS AS SERINE/THREONINE KINASE INHIBITORS 审中-公开
标题翻译：喹喔啉化合物作为丝氨酸/螺旋激酶抑制剂
公开(公告)号：WO2013020062A1
公开(公告)日：2013-02-07
申请号：PCT/US2012/049551
申请日：2012-08-03
申请人： ARRAY BIOPHARMA INC. , GENENTECH, INC. , BLAKE, James, F. , CHEN, Huifen , CHICARELLI, Mark, Joseph , DEMEESE, Jason , GARREY, Rustam, Ferdinand , GAUDINO, John , GAZZARD, Lewis , KAUS, Robert J. , KINTZ, Samuel , MOHR, Peter J. , MORENO, David, A. , SCHWARZ, Jacob , SIEDEM, Christopher, S. , WALLACE, Eli, M.
发明人： BLAKE, James, F. , CHEN, Huifen , CHICARELLI, Mark, Joseph , DEMEESE, Jason , GARREY, Rustam, Ferdinand , GAUDINO, John , GAZZARD, Lewis , KAUS, Robert J. , KINTZ, Samuel , MOHR, Peter J. , MORENO, David, A. , SCHWARZ, Jacob , SIEDEM, Christopher, S. , WALLACE, Eli, M.
IPC分类号： C07D403/12 , A61K31/517 , A61P35/00
CPC分类号： C07D405/14 , C07D403/12
摘要： Compounds having the formula (I) wherein R 1 , R 2 , R 3 and Ar as defined herein are inhibitors of ERK kinase. Also disclosed are compositions and methods for treating hyperproliferative disorders.
摘要翻译：具有式（I）的化合物，其中本文定义的R1，R2，R3和Ar是ERK激酶的抑制剂。还公开了用于治疗过度增殖性疾病的组合物和方法。

10. 发明申请

WO2012118850A1 SERINE/THREONINE KINASE INHIBITORS 审中-公开
标题翻译：丝氨酸/螺旋激酶抑制剂
公开(公告)号：WO2012118850A1
公开(公告)日：2012-09-07
申请号：PCT/US2012/027009
申请日：2012-02-28
申请人： ARRAY BIOPHARMA INC. , GENENTECH, INC. , BLAKE, James F. , CHEN, Huifen , CHICARELLI, Mark Joseph , DEMEESE, Jason , GARREY, Rustam , GAUDINO, John J. , KAUS, Robert J. , KOLAKOWSKI, Gabrielle R. , MARLOW, Allison L. , MOHR, Peter J. , REN, Li , SCHWARZ, Jacob , SIEDEM, Christopher S. , THOMAS, Allen A. , WALLACE, Eli , WENGLOWSKY, Steven Mark
发明人： BLAKE, James F. , CHEN, Huifen , CHICARELLI, Mark Joseph , DEMEESE, Jason , GARREY, Rustam , GAUDINO, John J. , KAUS, Robert J. , KOLAKOWSKI, Gabrielle R. , MARLOW, Allison L. , MOHR, Peter J. , REN, Li , SCHWARZ, Jacob , SIEDEM, Christopher S. , THOMAS, Allen A. , WALLACE, Eli , WENGLOWSKY, Steven Mark
IPC分类号： C07D471/04 , A61K31/519 , A61P35/00
CPC分类号： C07D471/04 , A61K31/519 , A61K45/06 , C07D491/052
摘要： Compounds having the formula I wherein Z, Z 1 Z 2 Z 3 , R 3a , R 3b and R b and as defined herein are inhibitors of ERK kinase. Also disclosed are compositions and methods for treating hyperproliferative disorders.
摘要翻译：具有式I的化合物，其中Z，Z 1 Z 2 Z 3，R 3a，R 3b和R b如本文所定义是ERK激酶的抑制剂。还公开了用于治疗过度增殖性疾病的组合物和方法。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式