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1. 发明申请

WO2021236578A1 CHROMEN-4-ONE DERIVATIVES, SUCH AS E.G. FLAVONES, FOR USE AS CK2 INHIBITORS FOR THE TREATMENT OF NEUROINFLAMMATION 审中-公开
公开(公告)号：WO2021236578A1
公开(公告)日：2021-11-25
申请号：PCT/US2021/032876
申请日：2021-05-18
申请人： SALK INSTITUTE FOR BIOLOGICAL STUDIES , NITULESCU, Ioana I. , GAGE, Fred H. , TUCKER, James K.
发明人： NITULESCU, Ioana I. , GAGE, Fred H. , TUCKER, James K.
IPC分类号： C07D311/22 , C07D311/28 , C07D405/04 , C07D413/04 , C07D405/12 , C07D413/12 , C07D407/04 , C07D471/04 , C07D498/04 , C07D407/06 , C07D401/10 , C07D417/14 , C07D405/14 , A61K31/352 , A61K31/443
摘要： Chromen-4-one derivatives, such as e.g. flavone derivatives and pharmaceutical compositions thereof are disclosed. In some instances, the compounds have increased aqueous solubility, bioavailability, and ability to cross the blood-brain-barrier. The compounds may be used to inhibit casein kinase 2 (CK2) activity and/or to treat diseases and conditions mediated at least in part by CK2 enzyme, such as e.g. inflammation, in particular neuroinflammation, or other diseases, such as e.g. cancer, cardiac hypertrophy, cystic fibrosis, a neurodegenerative disease, bipolar disorder, depression, a viral infection, obesity, diabetes mellitus, atherosclerosis, epilepsy, or any combination thereof.

2. 发明申请

WO2010111409A3 PLURIPOTENT STEM CELLS 审中-公开
标题翻译： PLURIPOTENT干细胞
公开(公告)号：WO2010111409A3
公开(公告)日：2011-02-24
申请号：PCT/US2010028524
申请日：2010-03-24
申请人： SALK INST FOR BIOLOGICAL STUDI , MUOTRI ALYSSON R , GAGE FRED H , MARCHETTO MARIA C N
发明人： MUOTRI ALYSSON R , GAGE FRED H , MARCHETTO MARIA C N
IPC分类号： C12N5/0797 , C12N5/0735 , C12N5/10 , C12N15/12
CPC分类号： C12N5/0696 , C12N5/0606 , C12N5/0619 , C12N5/0623 , C12N5/0662 , C12N5/0678 , C12N15/79 , C12N15/907 , C12N2501/603 , C12N2501/605 , C12N2502/13 , C12N2506/08 , C12N2510/00 , C12N2800/00 , C12N2800/108
摘要： Methods and compositions for the generation and use of footprint-free human induced pluripotent stem cells are provided.
摘要翻译：提供了用于产生和使用无足迹的人诱导多能干细胞的方法和组合物。

3. 发明申请

WO2010077288A3 METHODS FOR IDENTIFYING DIFFERENCES IN ALTERNATIVE SPLICING BETWEEN TWO RNA SAMPLES 审中-公开
标题翻译：用于识别两种RNA样本之间可变剪接的差异的方法
公开(公告)号：WO2010077288A3
公开(公告)日：2010-11-04
申请号：PCT/US2009006450
申请日：2009-12-08
申请人： SALK INST FOR BIOLOGICAL STUDI , YEO GENE , SCOLNICK JONATHAN , GAGE FRED H
发明人： YEO GENE , SCOLNICK JONATHAN , GAGE FRED H
IPC分类号： C12Q1/68 , C12N15/10
CPC分类号： C12N15/1072 , C12N15/1096 , C12Q1/6809 , C12Q1/6853 , C12Q2521/319 , C12Q2521/107
摘要： Provided are methods of separating one or more alternate isoform of a target gene, which alternate isoform is present in a sample population of RNAs but not in a subtractive population of RNAs. Compositions comprising a subpopulation of RNA:cDNA duplexes and a subpopulation of unhybridized RNA fragments are also provided.
摘要翻译：提供了分离目标基因的一种或多种替代同种型的方法，该替代同种型存在于RNA样品群中但不存在于RNA的消减群中。还提供了包含RNA：cDNA双链体的亚群和未杂交的RNA片段的亚群的组合物。

4. 发明申请

WO2010065776A3 IDENTIFICATION OF NEUROPROTECTIVE AGENTS USING PRO-INFLAMMATORY HUMAN GLIAL CELLS 审中-公开
标题翻译：使用预防性人类神经细胞鉴定神经保护剂
公开(公告)号：WO2010065776A3
公开(公告)日：2010-09-23
申请号：PCT/US2009066641
申请日：2009-12-03
申请人： SALK INST FOR BIOLOGICAL STUDI , MARCHETTO MARIA C N , GAGE FRED H , GLASS CHRISTOPHER K , SAIJO KAORU , WINNER BEATE
发明人： MARCHETTO MARIA C N , GAGE FRED H , GLASS CHRISTOPHER K , SAIJO KAORU , WINNER BEATE
IPC分类号： C12Q1/68 , C12N5/079 , C12Q1/02 , G01N33/15
CPC分类号： G01N33/5058
摘要： Provided herein are methods for, inter alia, identifying new therapeutic agents using human cell-based models.
摘要翻译：本文提供了用于特别地使用基于人细胞的模型鉴定新的治疗剂的方法。

5. 发明申请

WO2010077288A2 METHODS FOR IDENTIFYING DIFFERENCES IN ALTERNATIVE SPLICING BETWEEN TWO RNA SAMPLES 审中-公开
标题翻译：用于鉴定两个RNA样品之间替代分离差异的方法
公开(公告)号：WO2010077288A2
公开(公告)日：2010-07-08
申请号：PCT/US2009/006450
申请日：2009-12-08
申请人： THE SALK INSTITUTE FOR BIOLOGICAL STUDIES , YEO, Gene , SCOLNICK, Jonathan , GAGE, Fred, H.
发明人： YEO, Gene , SCOLNICK, Jonathan , GAGE, Fred, H.
IPC分类号： C12Q1/68 , C12N15/10
CPC分类号： C12N15/1072 , C12N15/1096 , C12Q1/6809 , C12Q1/6853 , C12Q2521/319 , C12Q2521/107
摘要： Provided are methods of separating one or more alternate isoform of a target gene, which alternate isoform is present in a sample population of RNAs but not in a subtractive population of RNAs. Compositions comprising a subpopulation of RNA:cDNA duplexes and a subpopulation of unhybridized RNA fragments are also provided.
摘要翻译：提供分离靶基因的一个或多个替代同种型的方法，其中交替同种型存在于RNA的样品群体中，但不存在于RNA的减法群体中。还提供了包含RNA亚类的cDNA组合物：cDNA双链体和未杂交的RNA片段的亚群。

6. 发明申请

WO2009148617A2 GREPSEQ: AN ALMOST INEXHAUSTIBLE, COST-EFFECTIVE, HIGH-THROUGHPUT PROTOCOL FOR THE GENERATION OF SELECTOR SEQUENCES 审中-公开
标题翻译： GREPSEQ：用于生成选择器序列的可靠，成本有效的高通量协议
公开(公告)号：WO2009148617A2
公开(公告)日：2009-12-10
申请号：PCT/US2009/003417
申请日：2009-06-04
申请人： THE SALK INSTITUTE FOR BIOLOGICAL STUDIES , YEO, Gene , SCOLNICK, Jonathan , GAGE, Fred, H.
发明人： YEO, Gene , SCOLNICK, Jonathan , GAGE, Fred, H.
IPC分类号： C12Q1/68
CPC分类号： C12N15/1096 , B01J2219/00529 , B01J2219/00596 , B01J2219/00608
摘要： Provided are compositions, libraries, and methods for the synthesis of transcripts that can be processed to produce nucleic acid capture probes. Also provided methods for using such nucleic acid capture probes in a variety of downstream applications, including, e.g., determining the sequence of an exon-exon junction.
摘要翻译：提供了用于合成可加工产生核酸捕获探针的转录物的组合物，文库和方法。还提供了在各种下游应用中使用这种核酸捕获探针的方法，包括例如确定外显子 - 外显子连接的序列。

7. 发明申请

WO2005001110A2 TRANSCRIPTIONAL REGULATION OF GENE EXPRESSION BY SMALL DOUBLE-STRANDED MODULATORY RNA 审中-公开
标题翻译：小双链调控RNA对基因表达的转录调控
公开(公告)号：WO2005001110A2
公开(公告)日：2005-01-06
申请号：PCT/US2004017208
申请日：2004-05-28
申请人： SALK INST FOR BIOLOGICAL STUDI , GAGE FRED H , KUWABARA TOMOKO
发明人： GAGE FRED H , KUWABARA TOMOKO
IPC分类号： A61K48/00 , C12N5/0793 , C12N15/867 , C12Q20060101 , C12Q
CPC分类号： C12N5/0619 , C12N2501/60 , C12N2799/027
摘要： The invention provides a method for modulating gene expression by contacting a cellular system with a double-stranded ribonucleic acid molecule capable of associating with a regulatory machinery that controls transcription of one or more genes, wherein the association results in altered expression of the one or more genes. The invention is further directed to a method for directing the differentiation of neuronal stem cells into neurons by contacting a cellular system with a double-stranded ribonucleic acid molecule capable of associating with a regulatory machinery that controls transcription of one or more genes involved in neuronal differentiation and directing the transcription of the one or more genes. In related embodiments, the invention provides particular compositions of double-stranded ribonucleic acid molecules as well as therapeutic and screening applications of the invention.
摘要翻译：本发明提供了通过使细胞系统与双链核糖核酸分子接触来调节基因表达的方法，所述双链核糖核酸分子能够与控制一种或多种基因的转录的调节机制相关联，其中所述结合导致一种或多种基因。本发明还涉及通过使细胞系统与双链核糖核酸分子接触来指导神经元干细胞分化为神经元的方法，所述双链核糖核酸分子能够与控制参与神经元分化的一种或多种基因的转录的调节机制并指导一个或多个基因的转录。在相关的实施方案中，本发明提供了双链核糖核酸分子的特定组合物以及本发明的治疗和筛选应用。

8. 发明申请

WO2003055983A2 TARGETED RETROGRADE GENE DELIVERY TO MOTOR NEURONS 审中-公开
标题翻译：靶向逆行基因传递给运动神经元
公开(公告)号：WO2003055983A2
公开(公告)日：2003-07-10
申请号：PCT/US2002/041194
申请日：2002-12-20
申请人： THE SALK INSTITUTE FOR BIOLOGICAL STUDIES , KASPAR, Brian, K. , GAGE, Fred, H. , PETERSON, Daniel
发明人： KASPAR, Brian, K. , GAGE, Fred, H. , PETERSON, Daniel
IPC分类号： C12N
CPC分类号： C12N15/86 , A61K48/00 , A61K48/0075 , C12N2750/14143
摘要： Methods are disclosed for delivering a heterologous gene to a cell body of a neuron by contacting either the synaptic portion of a neuron, for example or a muscle tissue innervated by the neuron, with a viral vector comprising a heterologous gene, wherein the viral vector enters said neuron and is retrogradely moved to the cell body. Additionally, methods for expressing secreted proteins from a nerve cell body as well as methods for treating neurodegenerative disorders are described.
摘要翻译：公开了用于通过使神经元的突触部分（例如神经元支配的肌肉组织）与包含神经元的病毒载体接触的病毒载体将异源基因递送至神经元的细胞体的方法异源基因，其中病毒载体进入所述神经元并逆行移动至细胞体。另外，描述了从神经细胞体表达分泌蛋白的方法以及治疗神经变性疾病的方法。

9. 发明申请

WO2011017404A2 RETROELEMENTS AND MENTAL DISORDERS AND METHODS OF MEASURING L1 RETROTRANSPOSITION 审中-公开
标题翻译： RETROTRANSPOSITION - 作者：王RET，www.ilib.cn大学学报（医药卫生）
公开(公告)号：WO2011017404A2
公开(公告)日：2011-02-10
申请号：PCT/US2010/044358
申请日：2010-08-04
申请人： THE SALK INSTITUTE FOR BIOLOGICAL STUDIES , GAGE, Fred H. , COUFAL, Nicole , MCCONNELL, Mike , MUOTRI, Alysson , MARCHETTO, Maria, C.N.
发明人： GAGE, Fred H. , COUFAL, Nicole , MCCONNELL, Mike , MUOTRI, Alysson , MARCHETTO, Maria, C.N.
IPC分类号： A61K35/12 , C12N15/85 , A61K48/00 , A61K31/713 , A61P25/00
CPC分类号： C12Q1/6883 , A61K31/713 , A61K48/00 , C12Q2600/106 , C12Q2600/154 , C12Q2600/156 , C12Q2600/158 , C12Q2600/16 , G01N33/5058 , G01N33/6896 , G01N2800/28
摘要： A method of treating increased non-LTR retrotransposition in a cell. The method includes exposing a neural cell to a retrotransposition inhibitor in an amount sufficient to decrease the non-LTR retrotransposition in the neural cell or a progeny of the neural cell. In various embodiments, the non-LTR retrotransposition involves at least one Ll retrotransposon. Also provided is a method of assaying retrotransposition in neural cells. The method includes sorting synchronized neural cells of the same genetic background into single neural cells, and subjecting one or more of the sorted single neural cells to quantitative polymerase chain reaction amplification of at least one retrotransposon. In addition, a method of identifying an inhibitor of retrotransposition and a identifying a neural condition associated with non-LTR retrotransposition are provided.
摘要翻译：治疗细胞中增加的非LTR逆转移的方法。该方法包括使神经细胞暴露于逆转录转染抑制剂，其量足以减少神经细胞或神经细胞后代中的非LTR逆转移。在不同的实施方案中，非LTR逆转录转座涉及至少一个L1逆转录转座子。还提供了测定神经细胞中retrotransposition的方法。该方法包括将具有相同遗传背景的同步神经细胞分选到单个神经细胞中，并对一个或多个分选的单个神经细胞进行至少一个逆转录转座子的定量聚合酶链式反应扩增。此外，还提供了鉴定逆转移的抑制剂和鉴定与非LTR逆转移相关的神经疾病的方法。

10. 发明申请

WO2010083046A3 METHODS FOR USING NEXT GENERATION SEQUENCING TO IDENTIFY 5-METHYL CYTOSINES IN THE GENOME 审中-公开
标题翻译：使用下一代序列鉴定基因组中5-甲基胞苷的方法
公开(公告)号：WO2010083046A3
公开(公告)日：2010-12-02
申请号：PCT/US2010000102
申请日：2010-01-15
申请人： SALK INST FOR BIOLOGICAL STUDI , YEO GENE , SCOLNICK JONATHAN , GAGE FRED H
发明人： YEO GENE , SCOLNICK JONATHAN , GAGE FRED H
IPC分类号： C12Q1/68 , C12N15/11 , G01N33/53
CPC分类号： C12Q1/6827 , C12Q2523/125
摘要： Provided are methods for producing a set of discriminator probes that selectively hybridize to unmethylated sequences in a population of nucleic acids, which sequences have been treated with a methylation state conversion reagent. Also provided are methods of using the discriminator probes to separate methylated subsequences from unmethylated subsequences in a population of nucleic acids. Compositions comprising said discriminator probes are provided. In addition, compositions comprising said discriminator probes hybridized to unmethylated sequences in a population of nucleic acid, which unmethylated sequences have been treated with a methylation state conversion reagent are provided.
摘要翻译：提供了用于产生选择性与核酸群体中的未甲基化序列杂交的鉴定器探针的方法，该序列已经用甲基化状态转化试剂处理。还提供了使用鉴别探针从核酸群体中的甲基化子序列分离甲基化子序列的方法。提供了包括所述鉴别探针的组合物。此外，提供了包含所述鉴别探针的组合物与核酸群体中的未甲基化序列杂交，该非甲基化序列已经用甲基化状态转化试剂处理。

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