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1. 发明申请

WO2008055206A2 HUMANIZED ANTI-FACTOR D ANTIBODIES AND USES THEREOF 审中-公开
标题翻译：人类抗因子D抗体及其用途
公开(公告)号：WO2008055206A2
公开(公告)日：2008-05-08
申请号：PCT/US2007/083172
申请日：2007-10-31
申请人： GENENTECH, INC. , WU, Herren , SINGH, Sanjaya , FUNG, Sek, Chung , AN, Ling-ling , LOWMAN, Henry, B. , KELLEY, Robert, F.
发明人： WU, Herren , SINGH, Sanjaya , FUNG, Sek, Chung , AN, Ling-ling , LOWMAN, Henry, B. , KELLEY, Robert, F.
IPC分类号： C07K16/36 , A61P37/00 , A61P27/02
CPC分类号： C07K16/18 , A61K2039/505 , C07K16/40 , C07K2317/24 , C07K2317/50 , C07K2317/54 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： The invention relates to humanized anti-human Factor D monoclonal antibodies, their nucleic acid and amino acid sequences, the cells and vectors that harbor these antibodies and their use in the preparation of compositions and medicaments for treatment of diseases and disorders associated with excessive or uncontrolled complement activation. These antibodies are useful for diagnostics, prophylaxis and treatment of disease.
摘要翻译：本发明涉及人源化抗人因子D单克隆抗体，其核酸和氨基酸序列，携带这些抗体的细胞和载体及其在制备用于治疗与过度或不受控制的疾病和病症的组合物和药物中的用途补体激活。这些抗体可用于疾病的诊断，预防和治疗。

2. 发明申请

WO2007076091A2 TREATMENT OF VIRAL INFECTIONS USING A TISSUE FACTOR INHIBITOR 审中-公开
标题翻译：使用组织因子抑制剂治疗病毒感染
公开(公告)号：WO2007076091A2
公开(公告)日：2007-07-05
申请号：PCT/US2006049185
申请日：2006-12-21
申请人： TANOX INC , FUNG SEK CHUNG MICHAEL
发明人： FUNG SEK CHUNG MICHAEL
IPC分类号： A61K39/42
CPC分类号： C07K16/36 , A61K31/13 , A61K31/196 , A61K31/351 , A61K31/66 , A61K39/39541 , A61K45/06 , A61K2300/00
摘要： The present invention provides novel methods for the treatment of viral infections, such as influenza virus both human and avian, by administering a tissue factor inhibitor.
摘要翻译：本发明通过施用组织因子抑制剂来提供用于治疗病毒感染的新方法，例如人类和禽类的流感病毒。

3. 发明申请

WO2004028473A3 SYNERGISTIC COMPOSITIONS FOR THE PREVENTION AND TREATMENT OF ACQUIRED IMMUNODEFICIENCY SYNDROME 审中-公开
标题翻译：用于预防和治疗获得性免疫缺陷综合征的协同组合物
公开(公告)号：WO2004028473A3
公开(公告)日：2004-12-09
申请号：PCT/US0330538
申请日：2003-09-26
申请人： TANOX INC , FUNG SEK CHUNG
发明人： FUNG SEK CHUNG
IPC分类号： A61K20060101 , A61K38/00 , A61K39/21 , A61K39/395 , A61K39/42 , A61K45/06 , C07K20060101 , C07K5/00 , C07K7/00 , C07K16/00 , C07K17/00 , C12Q20060101 , C12Q1/70
CPC分类号： A61K45/06 , A61K39/39541 , A61K2300/00
摘要： A method for preventing infection of helper T and other target cells by human immunodeficiency virus type 1 ("HIV-1") and for preventing or treating acquired immunodeficiency syndrome ("AIDS") by exposing target cells to a synergistic combination of at least one attachment inhibitor and at least one fusion inhibitor. The attachment inhibitors are compounds that bind to the CD4 receptor on target cells or that bind to gp120 on HIV-1, e.g., antibodies, and the fusion inhibitors compounds that interact with gp4l to inhibit or prevent its interaction with target cells, e.g., pentafuside.
摘要翻译：一种通过人类免疫缺陷病毒1型（“HIV-1”）预防辅助T和其他靶细胞的感染并通过将靶细胞暴露于至少一种的协同组合来预防或治疗获得性免疫缺陷综合征（“AIDS”）的方法附着抑制剂和至少一种融合抑制剂。附着抑制剂是结合靶细胞上的CD4受体或结合HIV-1上的gp120的化合物，例如抗体，以及与gp4I相互作用以抑制或阻止其与靶细胞相互作用的融合抑制剂化合物，例如五。

4. 发明申请

WO2004075837A2 METHODS FOR PREVENTING AND TREATING TISSUE DAMAGE ASSOCIATED WITH ISCHEMIA-REPERFUSION INJURY 审中-公开
标题翻译：预防和治疗与间质损伤相关的组织损伤的方法
公开(公告)号：WO2004075837A2
公开(公告)日：2004-09-10
申请号：PCT/US2004005136
申请日：2004-02-20
申请人： TANOX INC , FUNG SEK CHUNG
发明人： FUNG SEK CHUNG
IPC分类号： A61K38/00 , C07K16/18 , A61K
CPC分类号： C07K16/18 , A61K38/00 , A61K2039/505
摘要： A method for preventing or treating tissue damage associated with ischemia-reperfusion injury and thoraco-abdominal aortic aneurysm (TAAA) repair by administering a tissue damage preventing or treating amount of a complement inhibitor to a patient likely to suffer from or suffering from tissue damage associated with ischemia-reperfusion injury or TAAA repair. The complement inhibitors are preferably antibodies that bind to and inhibit complement proteins involved in the formation of the membrane attach complex, preferably antibodies that inhibit MBL, MASP1, MASP2, and MASP3 in the lectin pathway. The complement inhibitors can be used alone or in combination to decrease the morbidity and mortality caused by tissue damage associated with ischemia-reperfusion injury or TAAA repair.
摘要翻译：一种用于预防或治疗与缺血 - 再灌注损伤和胸腹主动脉瘤（TAAA）修复相关的组织损伤的方法，其通过对可能患有或遭受组织损伤的患者施用组织损伤来预防或治疗补体抑制剂的量缺血再灌注损伤或TAAA修复。补体抑制剂优选结合并抑制参与膜附着复合物形成的补体蛋白的抗体，优选抗体在凝集素途径中抑制MBL，MASP1，MASP2和MASP3。补体抑制剂可以单独使用或组合使用以降低与缺血再灌注损伤或TAAA修复相关的组织损伤引起的发病率和死亡率。

5. 发明申请

WO2004028473A2 SYNERGISTIC COMPOSITIONS FOR THE PREVENTION AND TREATMENT OF ACQUIRED IMMUNODEFICIENCY SYNDROME 审中-公开
标题翻译：用于预防和治疗获得性免疫缺陷综合征的协同组合物
公开(公告)号：WO2004028473A2
公开(公告)日：2004-04-08
申请号：PCT/US2003/030538
申请日：2003-09-26
申请人： TANOX, INC. , FUNG, Sek, Chung
发明人： FUNG, Sek, Chung
IPC分类号： A61K
CPC分类号： A61K45/06 , A61K39/39541 , A61K2300/00
摘要： A method for preventing infection of helper T and other target cells by human immunodeficiency virus type 1 ("HIV-1") and for preventing or treating acquired immunodeficiency syndrome ("AIDS") by exposing target cells to a synergistic combination of at least one attachment inhibitor and at least one fusion inhibitor. The attachment inhibitors are compounds that bind to the CD4 receptor on target cells or that bind to gp120 on HIV-1, e.g., antibodies, and the fusion inhibitors compounds that interact with gp4l to inhibit or prevent its interaction with target cells, e.g., pentafuside.
摘要翻译：一种预防1型人免疫缺陷病毒（“HIV-1”）对辅助T和其他靶细胞的感染以及通过暴露来预防或治疗获得性免疫缺陷综合征（“AIDS”）的方法将靶细胞转化为至少一种附着抑制剂和至少一种融合抑制剂的协同组合。附着抑制剂是与靶细胞上的CD4受体结合或与HIV-1上的gp120结合的化合物，例如抗体，以及与gp41相互作用以抑制或防止其与靶细胞例如五氟化磷相互作用的融合抑制剂化合物

6. 发明申请

WO2008140455A1 TREATMENT OF RADIATION AND CHEMO-THERAPY INDUCED FIBROSIS USING NOVEL ANTI-IL 13 MONOCLONAL ANTIBODIES 审中-公开
标题翻译：使用新型抗IL 13单克隆抗体治疗放射治疗和化疗疗法诱导性纤维化
公开(公告)号：WO2008140455A1
公开(公告)日：2008-11-20
申请号：PCT/US2007/011559
申请日：2007-05-15
申请人： TANOX, INC. , FUNG, Sek, Chung , MOYLE, Matthew
发明人： FUNG, Sek, Chung , MOYLE, Matthew
IPC分类号： C12N5/06 , C12N5/16
CPC分类号： C07K16/244 , A61K2039/505 , C07K2317/24
摘要： The present application relates to the treatment of fibrosis using novel anti-IL13 monoclonal antibodies. The antibodies useful in the present invention comprise anti-ILl 3 antibodies that bind specifically and with high affinity to ILl 3. In particular, such treatment may be in subjects undergoing radiotherapy and/or chemotherapy. Examples of anti-IL13 antibodies are 228B/C-1, 228A-4, 227-26, and 227-43.
摘要翻译：本申请涉及使用新的抗IL13单克隆抗体治疗纤维化。可用于本发明的抗体包含特异性结合并以高亲和力结合IL11的抗IL11抗体。特别地，这种治疗可以是进行放射治疗和/或化疗的受试者。抗IL13抗体的实例是228B / C-1,228A-4,227-26和227-43。

7. 发明申请

WO2008076960A3 ANTAGONIST ANTI-NOTCH3 ANTIBODIES AND THEIR USE IN THE PREVENTION AND TREATMENT OF NOTCH3-RELATED DISEASES 审中-公开
公开(公告)号：WO2008076960A3
公开(公告)日：2008-06-26
申请号：PCT/US2007/087723
申请日：2007-12-17
申请人： GENENTECH, INC. , LI, Kang , ZHOU, Bin-bing Stephen , LI, Yucheng , FUNG, Sek Chung , SINGH, Sanjaya
发明人： LI, Kang , ZHOU, Bin-bing Stephen , LI, Yucheng , FUNG, Sek Chung , SINGH, Sanjaya
IPC分类号： C07K16/28 , C12N15/13 , C12N5/12 , A61K39/395 , A61P35/00
摘要： The present invention relates to antagonist antibodies that specifically bind to Notch 3 and inhibit its activation. The present invention includes antibodies binding to a conformational epitope comprising the first Lin12 domain and the second dimerization domain. The present invention also includes uses of these antibodies to treat or prevent Notch 3 related diseases or disorders.

8. 发明申请

WO2008076960A2 ANTAGONIST ANTI-NOTCH3 ANTIBODIES AND THEIR USE IN THE PREVENTION AND TREATMENT OF NOTCH3-RELATED DISEASES 审中-公开
标题翻译：拮抗剂抗NOTCH3抗体及其在预防和治疗NOTCH3相关疾病中的用途
公开(公告)号：WO2008076960A2
公开(公告)日：2008-06-26
申请号：PCT/US2007087723
申请日：2007-12-17
申请人： GENENTECH INC , LI KANG , ZHOU BIN-BING STEPHEN , LI YUCHENG , FUNG SEK CHUNG , SINGH SANJAYA
发明人： LI KANG , ZHOU BIN-BING STEPHEN , LI YUCHENG , FUNG SEK CHUNG , SINGH SANJAYA
IPC分类号： C07K16/28 , A61K39/395 , A61P35/00 , C12N5/12 , C12N15/13
CPC分类号： C07K16/18 , A61K2039/505 , C07K14/705 , C07K16/28 , C07K2317/56 , C07K2317/76 , C07K2319/30
摘要： The present invention relates to antagonist antibodies that specifically bind to Notch 3 and inhibit its activation. The present invention includes antibodies binding to a conformational epitope comprising the first Lin12 domain and the second dimerization domain. The present invention also includes uses of these antibodies to treat or prevent Notch 3 related diseases or disorders.
摘要翻译：本发明涉及与Notch3特异性结合并抑制其活化的拮抗剂抗体。本发明包括与包含第一Lin12结构域和第二二聚化结构域的构象表位结合的抗体。本发明还包括这些抗体用于治疗或预防Notch3相关疾病或病症的用途。

9. 发明申请

WO2008030260A2 TREATMENT OF VARIOLA VIRAL INFECTIONS USING A TISSUE FACTOR INHIBITOR 审中-公开
标题翻译：用组织因子抑制剂治疗变异型病毒感染
公开(公告)号：WO2008030260A2
公开(公告)日：2008-03-13
申请号：PCT/US2006049186
申请日：2006-12-21
申请人： TANOX INC , FUNG SEK CHUNG MICHAEL
发明人： FUNG SEK CHUNG MICHAEL
IPC分类号： A61K39/395
CPC分类号： C07K16/36 , A61K31/13 , A61K31/196 , A61K31/351 , A61K31/66 , A61K39/39541 , A61K45/06 , A61K2300/00
摘要： The present invention provides novel methods for the treatment of variola viral infections, such as smallpox and monkeypox, by administering a tissue factor inhibitor.
摘要翻译：本发明提供了通过施用组织因子抑制剂来治疗天花病毒和猴痘等天花病毒感染的新方法。

10. 发明申请

WO2007056227A2 USE OF COMPLEMENT PATHWAY INHIBITORS TO TREAT OCULAR DISEASES 审中-公开
标题翻译：补充途径抑制剂治疗眼部疾病的使用
公开(公告)号：WO2007056227A2
公开(公告)日：2007-05-18
申请号：PCT/US2006/043103
申请日：2006-11-04
申请人： TANOX, INC. , FUNG, Sek, Chung , YAO, Zhengbin
发明人： FUNG, Sek, Chung , YAO, Zhengbin
IPC分类号： A61K39/395
CPC分类号： C07K16/18 , A61K38/00 , A61K38/1709 , A61K39/395 , A61K39/3955 , A61K45/06 , A61K2039/505 , A61K2300/00 , C12N15/113
摘要： The present invention relates to the treatment of ocular diseases and conditions by administering a complement pathway inhibitor, particularly an alternative pathway inhibitor. Ocular diseases include age-related macular degeneration, diabetic retinopathy, and ocular angiogenesis. One embodiment comprises the administration of an anti-Factor D antibody in the form of a whole antibody, a Fab fragment or a single domain antibody. Other complement component inhibitors that may be useful in the present method include Factor H or inhibitors that block the action of properdin, factor B, factor Ba, factor Bb, C2, C2a, C3a, C5, C5a, C5b, C6, C7, C8, C9, or C5b-9.
摘要翻译：本发明涉及通过施用补体途径抑制剂，特别是替代途径抑制剂来治疗眼部疾病和病症。眼部疾病包括年龄相关性黄斑变性，糖尿病性视网膜病变和眼血管发生。一个实施方案包括以全抗体，Fab片段或单结构域抗体的形式施用抗因子D抗体。可用于本发明方法的其它补体成分抑制剂包括因子H或阻断适当素，因子B，因子Ba，因子Bb，C2，C2a，C3a，C5，C5a，C5b，C6，C7，C8的作用的抑制剂，C9或C5b-9。

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