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1. 发明申请

WO2004084789B1 MASSAGE MACHINE 审中-公开
标题翻译：按摩机
公开(公告)号：WO2004084789B1
公开(公告)日：2004-12-29
申请号：PCT/JP2004004389
申请日：2004-03-26
申请人： MATSUSHITA ELECTRIC WORKS LTD , FUJIWARA SHIGEKI
发明人： FUJIWARA SHIGEKI
IPC分类号： A61H1/00 , A61H7/00 , A61H37/00
CPC分类号： A61H7/004 , A61H7/007 , A61H15/0078 , A61H2015/0028 , A61H2201/0138 , A61H2201/0149 , A61H2201/1623 , A61H2201/1654 , A61H2201/1669 , A61H2201/1678 , A61H2205/081
摘要： In a massage machine, a massage mechanism portion (100) has a first up/down motion mechanism portion for converting the rotation of a drive motor (M11) into motion in the up/down directions to cause a rear portion of a treatment-member tie (5) to move up and down, a second up/down motion mechanism portion for converting the rotation of a drive motor (M12) into motion in the up/down directions to cause portion between a front and a rear portion of the treatment-member tie (5) to move up and down, and a left/right motion mechanism for converting the rotation of a drive motor (M13) into motion in the left/right directions to cause the treatment-member tie (5) to move in the left/right directions. Forward and backward pushing motion by a treatment member (4) is performed by repeating the motion of the treatment-member tie (5) in the up/down directions performed by the drive motors (M11, M12) and the first or the second up/down motion mechanism portion. Further, sandwiching motion is performed by repeating the motion of the treatment-member tie (5) in the left/right directions performed by the drive motor (M13) and the left/right motion mechanism portion. Operation of changing a treatment position in the up/down directions is made by the cooperative rotation of the drive motors (M11, M12).
摘要翻译：在按摩机中，按摩机构部（100）具有第一升降机构部，该第一升降机构部用于将驱动马达（M11）的旋转变换为上下方向的动作而使处置部件（5）上下移动;第二升降机构部分，用于将驱动马达（M12）的旋转转换为向上/下方向的运动，以使处理的前部和后部之间的部分（5）上下移动，以及左右移动机构，用于将驱动马达（M13）的旋转转换成左/右方向的运动，以使治疗部件绑带（5）移动在左/右方向。通过重复由驱动电动机（M11，M12）以及第一或第二向上方向施加的治疗部件接合部（5）在上/下方向上的运动来执行通过治疗部件（4）的向前和向后推动运动 /向下运动机构部分。此外，通过重复由驱动马达（M13）和左/右运动机构部分执行的治疗部件绑带（5）在左/右方向上的运动来执行夹心动作。通过驱动马达（M11，M12）的协同旋转来进行沿上/下方向改变治疗位置的操作。

2. 发明申请

WO0216361A2 NITROGENOUS HETEROCYCLIC COMPOUNDS 审中-公开
标题翻译：非活性杂环化合物
公开(公告)号：WO0216361A2
公开(公告)日：2002-02-28
申请号：PCT/US0141750
申请日：2001-08-17
申请人： COR THERAPEUTICS INC , KYOWA HAKKO KOGYO KK , PANDEY ANJALI , SCARBOROUGH ROBERT M , MATSUNO KENJI , ICHIMURA MICHIO , NOMOTO YUGI , FUJIWARA SHIGEKI , IDE SHINICHI , TSUKIDA EIJI , IRIE JUNKO , ODA SHOJI
发明人： PANDEY ANJALI , SCARBOROUGH ROBERT M , MATSUNO KENJI , ICHIMURA MICHIO , NOMOTO YUGI , FUJIWARA SHIGEKI , IDE SHINICHI , TSUKIDA EIJI , IRIE JUNKO , ODA SHOJI
IPC分类号： A61P35/00 , C07D239/94 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D417/12 , C07D487/00
CPC分类号： C07D401/12 , C07D239/94 , C07D403/12 , C07D405/12 , C07D409/12 , C07D417/12
摘要： The present invention relates to nitrogen-containing heterocyclic compounds and pharmaceutically acceptable salts thereof which have inhibitory activity on the phosphorylation of kinases, which inhibits the activity of such kinases. The invention is also related to a method of inhibitng kinases and treating disease states in a mammal by inhibiting the phosphorylation of kinases. In a particular aspect the present invention provides nitrogen-containing heterocyclic compounds and pharmaceutically acceptable salts thereof which inhibit phosphorylation of a PDGF receptor to hinder abnormal cell growth and cell wandering, and a method for preventing or treating cell-proliferative diseases such as arteriosclerosis, vascular reobstruction, cancer and glomerulosclerosis.
摘要翻译：本发明涉及对激酶的磷酸化具有抑制活性的含氮杂环化合物及其药学上可接受的盐，其抑制这些激酶的活性。本发明还涉及抑制激酶和通过抑制激酶的磷酸化来治疗哺乳动物的疾病状态的方法。本发明的一个特定方面提供了抑制PDGF受体的磷酸化以阻碍异常细胞生长和细胞游动的含氮杂环化合物及其药学上可接受的盐，以及预防或治疗细胞增殖性疾病如动脉硬化，血管性重建，癌症和肾小球硬化。

3. 发明申请

WO1994019342A1 ADENOSINE INCORPORATION INHIBITOR 审中-公开
标题翻译：腺苷合成抑制剂
公开(公告)号：WO1994019342A1
公开(公告)日：1994-09-01
申请号：PCT/JP1994000229
申请日：1994-02-16
申请人： KYOWA HAKKO KOGYO CO., LTD. , FUJIWARA, Shigeki , MACHII, Daisuke , TAKAI, Haruki , NONAKA, Hiromi , KASE, Hiroshi , YAO, Kozo , KAWAKAGE, Michiyo , KUSAKA, Hideaki , KARASAWA, Akira
发明人： KYOWA HAKKO KOGYO CO., LTD.
IPC分类号： C07D401/14
CPC分类号： C07D401/14 , C07D491/04
摘要： An adenosine incorporation inhibitor and a drug for protecting cardiac muscles or preventing or treating inflammatory edema, each containing as the active ingredient a 1,2,3,4-tetrahydro-2,4-dioxoquinazoline derivative represented by general formula (I) or a pharmacologically acceptable salt thereof, wherein R represents hydrogen, (un)substituted lower alkyl, alkenyl or (un)substituted aralkyl; R , R , R and R represent each independently hydrogen, halogen, amino, mono- or di(lower alkyl) amino, lower alkanoyl amino, nitro, cyano, (un)substituted lower alkyl, hydroxy, lower alkoxy, lower alkylthio, carboxy, lower alkoxycarbonyl, lower alkanoyl, aralkyloxy or lower alkanoyloxy; R , R , R and R represent each independently hydrogen, hydroxy, (un)substituted lower alkoxy or aralkyloxy, or alternatively the two adjacent groups among them may be combined together to represent methylenedioxy; R represents hydrogen or lower alkyl; and Y and Z represent each independently N or C-R'', wherein R'' represents hydrogen, (un)substituted lower alkyl or halogen.
摘要翻译：一种腺苷并入抑制剂和用于保护心肌或预防或治疗炎症性水肿的药物，每种含有作为活性成分的通式（I）表示的1,2,3,4-四氢-2,4-二氧代喹唑啉衍生物或其中R 1表示氢，（取代的）取代的低级烷基，烯基或（未）取代的芳烷基; R 2，R 3，R 4和R 5各自独立地表示氢，卤素，氨基，一或二（低级烷基）氨基，低级烷酰氨基，硝基，氰基，（取代）低级烷基，羟基，低级烷氧基，低级烷硫基，羧基，低级烷氧基羰基，低级烷酰基，芳烷氧基或低级烷酰氧基; R 6，R 7，R 8和R 9各自独立地表示氢，羟基，（未）取代的低级烷氧基或芳烷氧基，或者它们中的两个相邻基团可以组合在一起代表亚甲二氧基 ; R 10代表氢或低级烷基; 并且Y和Z各自独立地表示N或C-R“，其中R”表示氢，（un）取代的低级烷基或卤素。

4. 发明申请

WO1997014672A1 TRICICLIC COMPOUNDS 审中-公开
标题翻译： TRICICLIC化合物
公开(公告)号：WO1997014672A1
公开(公告)日：1997-04-24
申请号：PCT/JP1996002997
申请日：1996-10-16
申请人： KYOWA HAKKO KOGYO CO. LTD. , YOSHIDA, Makoto , SASAKI, Shin-ichi , AONO, Shigeru , FUJIWARA, Shigeki , TAKAI, Haruki , YAMAGATA, Tsuyoshi , NAGASAHIMA, Ken , KARASAWA, Akira
发明人： KYOWA HAKKO KOGYO CO. LTD.
IPC分类号： C07C235/16
CPC分类号： C07D491/04 , C07C235/16 , C07C2603/16 , C07C2603/18 , C07C2603/32 , C07D221/16 , C07D307/93 , C07D313/12 , C07D333/80 , C07D337/12 , C07D493/04 , C07D495/04
摘要： Triciclic compounds represented by general formula (I) which are useful as a remedy for urinary incontinence, wherein R represents hydrogen, etc.; and -X -X -X - represents -CR =CR -CR =CR - (wherein R , R , R and R represent each hydrogen, etc.); and Y represents -CH2O- etc.
摘要翻译：由通式（I）表示的三联化合物可用作尿失禁的治疗剂，其中R 1表示氢等; 和-X 1 -X 2 -X 3表示-CR 2 = CR 3 -CR 4 = CR 5 - （其中R 2，R 3， R 4和R 5代表每个氢等）; Y表示-CH 2 O-等

5. 发明申请

WO0216362A3 NITROGENOUS HETEROCYCLIC COMPOUNDS 审中-公开
标题翻译：非活性杂环化合物
公开(公告)号：WO0216362A3
公开(公告)日：2002-06-13
申请号：PCT/US0141751
申请日：2001-08-17
申请人： COR THERAPEUTICS INC , KYOWA HAKKO KOGYO KK , PANDEY ANJALI , SCARBOROUGH ROBERT M , MATSUNO KENJI , ICHIMURA MICHIO , NOMOTO YUJI , FUJIWARA SHIGEKI , IDE SHINICHI , TSUKUDA EIJI , IRIE JUNKO , ODA SHOJI
发明人： PANDEY ANJALI , SCARBOROUGH ROBERT M , MATSUNO KENJI , ICHIMURA MICHIO , NOMOTO YUJI , FUJIWARA SHIGEKI , IDE SHINICHI , TSUKUDA EIJI , IRIE JUNKO , ODA SHOJI
IPC分类号： A61P35/00 , C07D239/94 , C07D401/12 , C07D403/12 , A61K31/517
CPC分类号： C07D401/12 , C07D239/94 , C07D403/12
摘要： The present invention relates to nitrogen-containing heterocyclic compounds and pharmaceutically acceptable salts thereof which have inhibitory activity on the phosphorylation of kinases, which inhibits the activity of such kinases. The invention is also related to a method of inhibiting kinases and treating disease states in a mammal by inhibiting the phosphorylation of kinases. In a particular aspect the present invention provides nitrogen-containing heterocyclic compounds and pharmaceutically acceptable salts thereof which inhibit phosphorylation of a PDGF receptor to hinder abnormal cell growth and cell wandering, and a method for preventing or treating cell-proliferative diseases such as arteriosclerosis, vascular reobstruction, cancer and glomerulosclerosis.
摘要翻译：本发明涉及对激酶的磷酸化具有抑制活性的含氮杂环化合物及其药学上可接受的盐，其抑制这些激酶的活性。本发明还涉及抑制激酶并通过抑制激酶的磷酸化来治疗哺乳动物的疾病状态的方法。本发明的一个特定方面提供了抑制PDGF受体的磷酸化以阻碍异常细胞生长和细胞游动的含氮杂环化合物及其药学上可接受的盐，以及预防或治疗细胞增殖性疾病如动脉硬化，血管性重建，癌症和肾小球硬化。

6. 发明申请

WO1998014431A1 NITROGENOUS HETEROCYCLIC COMPOUNDS 审中-公开
标题翻译：硝基杂环化合物
公开(公告)号：WO1998014431A1
公开(公告)日：1998-04-09
申请号：PCT/JP1997003510
申请日：1997-10-01
申请人： KYOWA HAKKO KOGYO CO., LTD. , MATSUNO, Kenji , ICHIMURA, Michio , NOMOTO, Yuji , FUJIWARA, Shigeki , IDE, Shinichi , TSUKUDA, Eiji , IRIE, Junko , ODA, Shoji
发明人： KYOWA HAKKO KOGYO CO., LTD.
IPC分类号： C07D215/46
CPC分类号： C07D401/12 , A61K31/496 , A61K31/502 , A61K31/517 , C07D215/46 , C07D217/22 , C07D237/34 , C07D239/94 , C07D403/12 , C07D405/12 , C07D409/12 , C07D417/12 , C07D487/04
摘要： Nitrogenous heterocyclic compounds of general formula (I) and pharmacologically acceptable salts thereof, which hinder the phosphorylation of PDGF acceptors and the abnormal proliferation or migration of cells and so are effective in preventing or treating cell proliferative diseases such as arterial sclerosis, vascular reocclusion diseases, cancer and glomerulosclerosis, wherein V is oxygen or sulfur; W is 1,4-piperazinediyl or 1,4-homopiperazinediyl which may be substituted with unsubstituted alkyl on the ring; X is nitrogen or C-R , Y is nitrogen or C-R and Z is nitrogen or C-R , with at least one of X, Y and Z being nitrogen; R is hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl or the like; R is substituted alkyl, substituted or unsubstituted cycloalkyl or the like; R , R , R and R are each independently hydrogen, halogeno, substituted or unsubstituted alkyl, nitro, cyano, -OR , -NR R or the like; R is halogeno or the like; R is the same as defined above for R ; and R is hydrogen or -COR .
摘要翻译：通式（I）的氮杂环化合物及其药理学上可接受的盐阻碍PDGF受体的磷酸化和细胞的异常增殖或迁移等，有效预防或治疗细胞增殖性疾病如动脉硬化，血管再闭塞疾病，癌症和肾小球硬化，其中V是氧或硫; W是可以在环上被未取代的烷基取代的1,4-哌嗪二基或1,4-高哌嗪二基; X是氮或C-R 9，Y是氮或C-R 8，Z是氮或C-R 7，X，Y和Z中的至少一个是氮; R 1是氢，取代或未取代的烷基，取代或未取代的环烷基等; R 2是取代的烷基，取代或未取代的环烷基等; R 3，R 4，R 5和R 6各自独立地为氢，卤素，取代或未取代的烷基，硝基，氰基，-OR 12，-NR 15 R 16，或类似物; R 7是卤代等; R 8与上述R 7相同; R 9为氢或-COR 41。

7. 发明申请

WO1996006841A1 QUINAZOLINE DERIVATIVE 审中-公开
标题翻译：喹诺酮衍生物
公开(公告)号：WO1996006841A1
公开(公告)日：1996-03-07
申请号：PCT/JP1995001694
申请日：1995-08-25
申请人： KYOWA HAKKO KOGYO CO., LTD. , FUJIWARA, Shigeki , OKAMURA, Yuko , TAKAI, Haruki , NONAKA, Hiromi , MORIYAMA, Takahiro , YAO, Kozo , KARASAWA, Akira
发明人： KYOWA HAKKO KOGYO CO., LTD.
IPC分类号： C07D401/14
CPC分类号： C07D401/14
摘要： A quinazoline derivative represented by general formula (I) or a pharmacologically acceptable salt thereof (wherein R represents hydrogen, lower alkyl, alkenyl or aralkyl; R , R , R and R represent each hydrogen, lower alkyl, lower alkoxy, lower alkanolyl, etc.; R , R , R and R represent each hydrogen, lower alkyl, lower alkoxy, aralkyloxy, etc., or two adjacent members thereof are combined together to represent methylenedioxy, etc; R represents hydrogen, lower alkyl, etc.; R and R either represent each hydrogen, lower alkyl, cycloalkyl, phenyl or aralkyl, or are combined together with the nitrogen atom to which they are bonded to represent a heterocyclic group; and n represents 0, 1 or 2). The compound has the effect of inhibiting adenosine incorporation and is useful for protecting cardiac muscles and preventing or treating inflammations such as podedema.
摘要翻译：由通式（I）表示的喹唑啉衍生物或其药理学上可接受的盐（其中R 1表示氢，低级烷基，烯基或芳烷基; R 2，R 3，R 4和R 5 代表每个氢，低级烷基，低级烷氧基，低级链烷酰基等; R 6，R 7，R 8和R 9分别表示氢，低级烷基，低级烷氧基，芳烷氧基等。或其两个相邻的成员结合在一起代表亚甲二氧基等; R 10代表氢，低级烷基等; R 11和R 12分别表示氢，低级烷基，环烷基，苯基或芳烷基，或与它们所键合的氮原子一起表示杂环基; n表示0,1或2）。该化合物具有抑制腺苷掺入的作用，并且可用于保护心肌和预防或治疗诸如肝硬化的炎症。

8. 发明申请

WO0216360A3 NITROGENOUS HETEROCYCLIC COMPOUNDS 审中-公开
标题翻译：硝基杂环化合物
公开(公告)号：WO0216360A3
公开(公告)日：2002-06-13
申请号：PCT/US0141749
申请日：2001-08-17
申请人： COR THERAPEUTICS INC , KYOWA HAKKO KOGYO KK , PANDEY ANJALI , SCARBOROUGH ROBERT M , MATSUNO KENJI , ICHIMURA MICHIO , NOMOTO YUJI , FUJIWARA SHIGEKI , IDE SHINICHI , TSUKUDA EIJI , IRIE JUNKO , ODA SHOJI
发明人： PANDEY ANJALI , SCARBOROUGH ROBERT M , MATSUNO KENJI , ICHIMURA MICHIO , NOMOTO YUJI , FUJIWARA SHIGEKI , IDE SHINICHI , TSUKUDA EIJI , IRIE JUNKO , ODA SHOJI
IPC分类号： A61P35/00 , C07D239/94 , C07D401/12 , C07D403/12 , A61K31/517 , C07D405/12 , C07D409/12 , C07D417/12
CPC分类号： C07D401/12 , C07D239/94 , C07D403/12
摘要： The present invention relates to nitrogen-containing heterocyclic compounds and pharmaceutically acceptable salts thereof which have inhibitory activity on the phosphorylation of kinases, which inhibits the activity of such kinases. The invention is also related to a method of inhibiting kinases and treating disease states in a mammal by inhibiting the phosphorylation of kinases. In a particular aspect the present invention provides nitrogen-containing heterocyclic compounds and pharmaceutically acceptable salts thereof which inhibit phosphorylation of a PDGF receptor to hinder abnormal cell growth and cell wandering, and a method for preventing or treating cell-proliferative diseases such as arteriosclerosis, vascular reobstruction, cancer and glomerulosclerosis.
摘要翻译：本发明涉及对抑制这种激酶活性的激酶磷酸化具有抑制活性的含氮杂环化合物及其药学上可接受的盐。本发明还涉及通过抑制激酶的磷酸化来抑制哺乳动物的激酶和治疗疾病状态的方法。在一个特定方面，本发明提供了抑制PDGF受体的磷酸化以阻止异常细胞生长和细胞游动的含氮杂环化合物及其药学上可接受的盐，以及预防或治疗细胞增殖性疾病如动脉硬化，血管重建，癌症和肾小球硬化症。

9. 发明申请

WO1997029749A1 THERAPEUTIC AGENT FOR KIDNEY DISEASES 审中-公开
标题翻译：用于治疗疾病的治疗剂
公开(公告)号：WO1997029749A1
公开(公告)日：1997-08-21
申请号：PCT/JP1997000439
申请日：1997-02-19
申请人： KYOWA HAKKO KOGYO CO., LTD. , FUJIWARA, Shigeki , OKAMURA, Yuko , TAKAI, Haruki , NONAKA, Hiromi , MORIYAMA, Takahiro , YAO, Kozo , KARASAWA, Akira
发明人： KYOWA HAKKO KOGYO CO., LTD.
IPC分类号： A61K31/505
CPC分类号： C07D401/14 , A61K31/517 , A61K31/5377 , A61K31/541 , A61K31/55
摘要： A therapeutic agent for kidney diseases which comprises as the active ingredient a quinazoline derivative represented by general formula (I) or a pharmacologically acceptable salt thereof, wherein R represents hydrogen, lower alkyl, alkenyl, aralkyl, etc.; R , R , R , and R may be the same or different and each represents hydrogen, lower alkyl, lower alkoxy, lower alkanoyl, etc.; R , R , R , and R may be the same or different and each represents hydrogen, lower alkyl, lower alkoxy, aralkyloxy, lower alkanoyloxy, etc., or adjacent two of these may be bonded to each other to thereby form methylenedioxy, etc.; R represents hydrogen, lower alkyl, etc.; R and R may be the same or different and each represents hydrogen, lower alkyl, cycloalkyl, phenyl, aralkyl, etc., or R and R may be bonded to each other to thereby form a heterocycle with the nitrogen atom; and n is 0, 1, or 2. The therapeutic agent is useful for the prevention or treatment of kidney diseases such as nephritis and diabetic nephropathy.
摘要翻译：作为肾脏疾病的治疗剂，其含有作为活性成分的通式（I）表示的喹唑啉衍生物或其药理学上可接受的盐，其中R 1表示氢，低级烷基，烯基，芳烷基等; R 2，R 3，R 4和R 5可以相同或不同，各自代表氢，低级烷基，低级烷氧基，低级烷酰基等; R 6，R 7，R 8和R 9可以相同或不同，各自表示氢，低级烷基，低级烷氧基，芳烷氧基，低级烷酰氧基等，或相邻的两个可以彼此键合从而形成亚甲二氧基等; R 10代表氢，低级烷基等; R 11和R 12可以相同或不同，各自表示氢，低级烷基，环烷基，苯基，芳烷基等，或者R 11和R 12可以彼此键合，从而与氮原子形成杂环; 并且n为0,1或2.治疗剂可用于预防或治疗肾脏疾病如肾炎和糖尿病性肾病。

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