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1. 发明申请

WO2009076227A2 METHODS FOR CONDUCTING A CLINICAL TRIAL 审中-公开
标题翻译：导致临床试验的方法
公开(公告)号：WO2009076227A2
公开(公告)日：2009-06-18
申请号：PCT/US2008/085721
申请日：2008-12-05
申请人： PAIN THERAPEUTICS, INC. , FRIEDMANN, Nadav , BARBIER, Remi
发明人： FRIEDMANN, Nadav , BARBIER, Remi
IPC分类号： G06Q50/00
CPC分类号： G06Q50/22 , G06F19/00 , G16H10/20 , Y02A90/22 , Y02A90/26
摘要： The present disclosure relates generally to methods for selecting subjects for a clinical trial and includes methods for conducting a clinical trial to study the efficacy and/or safety of a drug by selecting subjects, for inclusion in a subsequent double-blind treatment period of the clinical trial, that do not exhibit adverse events to the drug. Methods for conducting a clinical trial may comprise the following: (1) an open-label titration period, (2) an adjustable dose treatment period and (3) a fixed dose treatment period. Optionally, the clinical trial may comprise a washout period prior to the open-label titration period. Also provided are methods for doing business by selecting subjects for a clinical trial for a drug that do not exhibit adverse events to the drug. Such methods may generate, revenue by reducing the length of time required to complete the clinical trial, increasing the likelihood that the drug will obtain regulatory approval and/or reducing the length of time it takes to bring advance the drug to market.
摘要翻译：本公开一般涉及用于选择临床试验的受试者的方法，并且包括用于进行临床试验以通过选择受试者来研究药物的功效和/或安全性的方法，以包括在临床的随后双盲治疗期试验，不会对药物显示不良事件。进行临床试验的方法可包括：（1）开放标签滴定期，（2）可调剂量治疗期和（3）固定剂量治疗期。任选地，临床试验可以包括在开放标签滴定期之前的清除期。还提供了通过选择不对药物显示不良事件的药物的临床试验的对象进行生意的方法。这种方法可以通过减少完成临床试验所需的时间来增加收入，增加药物获得监管批准和/或减少将药物推向市场所需的时间长度的可能性。

2. 发明申请

WO2005107726A2 METHOD FOR THE TREATMENT OF BACK PAIN 审中-公开
标题翻译：用于治疗背痛的方法
公开(公告)号：WO2005107726A2
公开(公告)日：2005-11-17
申请号：PCT/US2005/010043
申请日：2005-03-23
申请人： PAIN THERAPEUTICS, INC. , FRIEDMANN, Nadav , BARBIER, Remi , SCHOENHARD, Grant, L.
发明人： FRIEDMANN, Nadav , BARBIER, Remi , SCHOENHARD, Grant, L.
IPC分类号： A61K31/00
CPC分类号： A61K45/06 , A61K31/485 , A61K2300/00
摘要： Methods and materials, including novel compositions, dosage forms and methods of administration, useful for treating back pain using opioid antagonists, including combinations of opioid antagonists and opioid agonists. Methods and materials comprising opioid antagonists or combinations opioid antagonists and agonists may optionally include one or more additional therapeutic agents.
摘要翻译：方法和材料，包括新型组合物，剂型和给药方法，其可用于使用阿片样物质拮抗剂治疗背部疼痛，包括阿片样物质拮抗剂和阿片激动剂的组合。包含阿片样物质拮抗剂或阿片样物质拮抗剂和激动剂组合的方法和材料可以任选地包括一种或多种另外的治疗剂。

3. 发明申请

WO0067739A2 COMPOSITIONS AND METHODS FOR ENHANCING ANALGESIC POTENCY OF TRAMADOL AND ATTENUATING ITS ADVERSE SIDE EFFECTS 审中-公开
标题翻译：组合物和方法，用于增强TRAMADOL的有效磷酸化和不利影响其副作用
公开(公告)号：WO0067739A2
公开(公告)日：2000-11-16
申请号：PCT/US0012493
申请日：2000-05-05
申请人： PAIN THERAPEUTICS INC , EINSTEIN COLL MED , CRAIN STANLEY M , SHEN KE FEI , SHERMAN BARRY , REMIEN MARY , BARBIER REMI , FRIEDMANN NADAV
发明人： CRAIN STANLEY M , SHEN KE-FEI , SHERMAN BARRY , REMIEN MARY , BARBIER REMI , FRIEDMANN NADAV
IPC分类号： A61K45/00 , A61K31/00 , A61K31/137 , A61K31/485 , A61K38/33 , A61P25/04 , A61P43/00 , G01N33/94
CPC分类号： A61K31/485 , A61K31/00 , A61K38/33 , G01N33/94 , G01N33/9486 , G01N2500/10 , A61K31/135 , A61K2300/00
摘要： The invention generally relates to compositions and methods with tramadol and an opioid antagonist to enhance analgesic potency and/or attenuate one or more adverse effects of tramadol, including adverse side effect(s) in humans such as nausea, vomiting, dizziness, headache, sedation (somnolence) or pruritis. This invention relates to compositions and methods for selectively enhancing the analgesic potency of tramadol and simultaneously attenuating anti-analgesia, hyperalgesia, hyperexcitability, physical dependence and/or tolerance effects associated with the administration of tramadol. The methods of the present invention comprise administering to a subject an analgesic or subanalgesic amount of tramadol and an amount of excitatory opioid receptor antagonist such as naltrexone or nalmefene effective to enhance the analgesic potency of tramadol and attenuate the anti-analgesia, hyperalgesia, hyperexcitability, physical dependence and/or tolerance effects of tramadol.
摘要翻译：本发明一般涉及具有曲马多和阿片样物质拮抗剂以增强镇痛效力和/或减弱曲马多的一种或多种不良反应的组合物和方法，包括人类的不良副作用，例如恶心，呕吐，头晕，头痛，镇静（嗜睡）或瘙痒症。本发明涉及用于选择性增强曲马多镇痛效力的组合物和方法，同时减轻与施用曲马多相关的抗镇痛，痛觉过敏，过度兴奋，身体依赖和/或耐受性作用。本发明的方法包括对受试者施用止痛剂或亚麻痛剂量的曲马多和一定量的兴奋性阿片样物质受体拮抗剂如纳曲酮或纳美芬，其有效地增强曲马多的止痛效力并减弱镇痛，痛觉过敏，兴奋性过高，曲马多的身体依赖和/或耐受性影响。

4. 发明申请

WO2009076227A9 METHODS FOR CONDUCTING A CLINICAL TRIAL 审中-公开
标题翻译：导致临床试验的方法
公开(公告)号：WO2009076227A9
公开(公告)日：2009-10-29
申请号：PCT/US2008085721
申请日：2008-12-05
申请人： PAIN THERAPEUTICS INC , FRIEDMANN NADAV , BARBIER REMI
发明人： FRIEDMANN NADAV , BARBIER REMI
IPC分类号： G06F19/00
CPC分类号： G06Q50/22 , G16H10/20 , Y02A90/22 , Y02A90/26
摘要： The present disclosure relates generally to methods for selecting subjects for a clinical trial and includes methods for conducting a clinical trial to study the efficacy and/or safety of a drug by selecting subjects, for inclusion in a subsequent double-blind treatment period of the clinical trial, that do not exhibit adverse events to the drug. Methods for conducting a clinical trial may comprise the following: (1) an open-label titration period, (2) an adjustable dose treatment period and (3) a fixed dose treatment period. Optionally, the clinical trial may comprise a washout period prior to the open-label titration period. Also provided are methods for doing business by selecting subjects for a clinical trial for a drug that do not exhibit adverse events to the drug. Such methods may generate, revenue by reducing the length of time required to complete the clinical trial, increasing the likelihood that the drug will obtain regulatory approval and/or reducing the length of time it takes to bring advance the drug to market.

5. 发明申请

WO1988006594A1 SYNTHETIC ANTI-CARIES VACCINE 审中-公开
标题翻译：合成抗生素疫苗
公开(公告)号：WO1988006594A1
公开(公告)日：1988-09-07
申请号：PCT/GB1988000137
申请日：1988-02-26
申请人： COUNCIL OF GOVERNORS OF THE UNITED MEDICAL AND ... , JOHNSON & JOHNSON CONSUMER PRODUCTS INC. , LEHNER, Thomas , HARON, Jay , FRIEDMANN, Nadav
发明人： COUNCIL OF GOVERNORS OF THE UNITED MEDICAL AND ... , JOHNSON & JOHNSON CONSUMER PRODUCTS INC.
IPC分类号： C07K07/06
CPC分类号： C07K14/315 , A61K39/00 , A61K39/092
摘要： Synthetic peptides are described, useful in the control of dental caries, and capable of provoking in vivo formation of antibodies that recognise Streptococcus mutans antigens. An 11-mer is described together with larger peptides containing up to 35 amino acid units including the 11-mer and other sequences. These peptides and antibodies produced using the peptides as immunogens can be applied gingivally in primates to control dental caries.
摘要翻译：描述了合成肽，其可用于控制龋齿，并且能够引起体内形成识别变形链球菌抗原的抗体。与含有多达35个氨基酸单元的较大肽（包括11聚体和其它序列）一起描述11聚体。使用肽作为免疫原产生的这些肽和抗体可用牙龈加在灵长类动物中以控制龋齿。

6. 发明申请

WO2005107726A3 METHOD FOR THE TREATMENT OF BACK PAIN 审中-公开
标题翻译：用于治疗背痛的方法
公开(公告)号：WO2005107726A3
公开(公告)日：2006-08-24
申请号：PCT/US2005010043
申请日：2005-03-23
申请人： PAIN THERAPEUTICS INC , FRIEDMANN NADAV , BARBIER REMI , SCHOENHARD GRANT L
发明人： FRIEDMANN NADAV , BARBIER REMI , SCHOENHARD GRANT L
IPC分类号： A61K31/485 , A61K45/06
CPC分类号： A61K45/06 , A61K31/485 , A61K2300/00
摘要： Methods and materials, including novel compositions, dosage forms and methods of administration, useful for treating back pain using opioid antagonists, including combinations of opioid antagonists and opioid agonists. Methods and materials comprising opioid antagonists or combinations opioid antagonists and agonists may optionally include one or more additional therapeutic agents.
摘要翻译：方法和材料，包括新型组合物，剂型和给药方法，其可用于使用阿片样物质拮抗剂治疗背部疼痛，包括阿片样物质拮抗剂和阿片激动剂的组合。包含阿片样物质拮抗剂或阿片样物质拮抗剂和激动剂组合物的方法和材料可任选地包括一种或多种另外的治疗剂。

7. 发明申请

WO2005037318A3 TREATMENT OF ARTHRITIC CONDITIONS, CHRONIC INFLAMMATION OR PAIN 审中-公开
标题翻译：治疗严重条件，慢性炎症或疼痛
公开(公告)号：WO2005037318A3
公开(公告)日：2005-06-09
申请号：PCT/US2004034184
申请日：2004-10-15
申请人： PAIN THERAPEUTICS INC , SCHOENHARD GRANT L , FRIEDMANN NADAV
发明人： SCHOENHARD GRANT L , FRIEDMANN NADAV
IPC分类号： A61K31/485 , A61K45/06 , A61P19/02 , A61P25/00 , A61P29/00 , A61P43/00
CPC分类号： A61K45/06 , A61K31/485 , A61K2300/00
摘要： Methods and materials, including novel compositions, dosage forms and methods of administration, useful for treating arthritic conditions, inflammation associated with a chronic condition, and/or chronic pain, including pain from arthritis and inflammation, using opioid antagonists, including combinations of opioid antagonists and opioid agonists. Methods and materials comprising opioid antagonists or combinations opioid antagonists and agonists may optionally include one or more additional therapeutic agents.
摘要翻译：方法和材料，包括用于治疗关节炎病症，与慢性病症相关的炎症和/或慢性疼痛（包括来自关节炎和炎症的疼痛）的新型组合物，剂型和给药方法，使用阿片样物质拮抗剂，包括阿片样物质拮抗剂的组合和阿片激动剂。包含阿片样物质拮抗剂或阿片样物质拮抗剂和激动剂组合物的方法和材料可任选地包括一种或多种另外的治疗剂。

8. 发明申请

WO2005037318A2 METHODS AND MATERIALS USEFUL FOR THE TREATMENT OF ARTHRITIC CONDITIONS, INFLAMMATION ASSOCIATED WITH A CHRONIC CONDITION OR CHRONIC PAIN 审中-公开
标题翻译：治疗结核病症的方法和材料，与慢性病或慢性疼痛相关的炎症反应
公开(公告)号：WO2005037318A2
公开(公告)日：2005-04-28
申请号：PCT/US2004/034184
申请日：2004-10-15
申请人： PAIN THERAPEUTICS, INC. , SCHOENHARD, Grant, L. , FRIEDMANN, Nadav
发明人： SCHOENHARD, Grant, L. , FRIEDMANN, Nadav
IPC分类号： A61K45/00
CPC分类号： A61K45/06 , A61K31/485 , Y02A50/401 , A61K2300/00
摘要： Methods and materials, including novel compositions, dosage forms and methods of administration, useful for treating arthritic conditions, inflammation associated with a chronic condition, and/or chronic pain, including pain from arthritis and inflammation, using opioid antagonists, including combinations of opioid antagonists and opioid agonists. Methods and materials comprising opioid antagonists or combinations opioid antagonists and agonists may optionally include one or more additional therapeutic agents.
摘要翻译：方法和材料，包括用于治疗关节炎病症，与慢性病症相关的炎症和/或慢性疼痛（包括来自关节炎和炎症的疼痛）的新型组合物，剂型和给药方法，使用阿片样物质拮抗剂，包括阿片样物质拮抗剂的组合和阿片激动剂。包含阿片样物质拮抗剂或阿片样物质拮抗剂和激动剂组合物的方法和材料可任选地包括一种或多种另外的治疗剂。

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