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1. 发明申请

WO1990013567A1 NEW HUMAN PARVOVIRUS PEPTIDES WITH DISULFIDE BRIDGE FOR IMMUNIZATION OR DIAGNOSIS 审中-公开
标题翻译：用于免疫或诊断的新型人造血管病毒肽
公开(公告)号：WO1990013567A1
公开(公告)日：1990-11-15
申请号：PCT/SE1990000276
申请日：1990-04-25
申请人： FERRING DIAGNOSTICA AB , TROJNAR, Jerzy , WAHREN, Britta , FRIDELL, Eva
发明人： FERRING DIAGNOSTICA AB
IPC分类号： C07K07/10
CPC分类号： C07K14/005 , A61K39/00 , C12N2750/14222
摘要： An artificial peptide having an amino acid sequence which corresponds to a naturally occurring amino acid sequence of a human parvovirus comprising an epitope and which further has two cysteine residues located on each side of said epitope, and further having a sulphur bridge between said two cysteine residues, which has been formed by a chemical oxidation step, is described. Furthermore, an artificial antigen which reacts with antibodies induced by a human parvovirus is described. Said antigen mainly consists of an artificial peptide according to the invention. Additionally, a method of detecting antibodies induced by a human parvovirus in a sample of body fluid, wherein said sample is subjected to an immunoassay, especially ELISA, and wherein an artificial antigen according to the invention is used as a diagnostic antigen, is described. A diagnostic immunoassay kit for said method is also described. Finally, a vaccine composition comprising, as an immunizing component, at least one antigen according to the invention, is described.
摘要翻译：一种人造肽，其具有对应于包含表位的人细小病毒的天然存在的氨基酸序列的氨基酸序列，并且还具有位于所述表位的每一侧上的两个半胱氨酸残基，并且在所述两个半胱氨酸残基之间还具有硫桥，其通过化学氧化步骤形成。此外，描述了与人细小病毒诱导的抗体反应的人造抗原。所述抗原主要由根据本发明的人造肽组成。另外，本发明描述了检测体液样品中的人细小病毒诱导的抗体的方法，其中对所述样品进行免疫测定，特别是ELISA，其中使用本发明的人造抗原作为诊断抗原。还描述了用于所述方法的诊断免疫测定试剂盒。最后，描述了包含作为免疫组分的至少一种根据本发明的抗原的疫苗组合物。

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