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1. 发明申请

WO2014004365A2 MAGNETIC IMAGING DEVICE TO INVENTORY HUMAN BRAIN CORTICAL FUNCTION 审中-公开
标题翻译：磁性成像装置存储人脑神经功能
公开(公告)号：WO2014004365A2
公开(公告)日：2014-01-03
申请号：PCT/US2013047289
申请日：2013-06-24
申请人： FORD JOHN P
发明人： FORD JOHN P
IPC分类号： A61B5/055
CPC分类号： A61B5/04008 , A61B5/0042 , A61B5/04009 , A61B5/05 , A61B5/162 , A61B5/4064 , A61B5/4088 , A61B5/6803 , A61B5/7282 , A61B6/04 , A61B2562/0223 , A61B2576/026 , A61G13/12
摘要： Systems and methods detect electrical activity in the human brain in the form of the generated magnetic fields and map the magnetic field strength to the surface of the cerebral cortex. By mapping the measured magnetic fields to the sulcal-defined gyrus of the cerebral cortex rather than to its three-dimensional volume, the data complexity and the resulting image are dramatically reduced. The device allows an inventory of brain function, including, but not limited to, vision, sound, sensory, and cognition, with the sensors placed over the corresponding region or regions of interest of the brain.
摘要翻译：系统和方法以产生的磁场的形式检测人类大脑中的电活动，并将磁场强度映射到大脑皮质的表面。通过将测量的磁场映射到大脑皮质的定义的回脑而不是其三维体积，数据复杂性和所得到的图像被显着降低。该装置允许脑功能的清单，包括但不限于视觉，声音，感觉和认知，其中传感器放置在脑的相关区域或区域上。

2. 发明申请

WO2010023448A1 NOVEL POTASSIUM CHANNEL BLOCKERS 审中-公开
标题翻译：新型钾通道阻塞剂
公开(公告)号：WO2010023448A1
公开(公告)日：2010-03-04
申请号：PCT/GB2009/002078
申请日：2009-08-27
申请人： XENTION LIMITED , JOHN, Derek, Edward , MULLA, Mushtaq , HAMLYN, Richard, John , GARRETT, Sarah, Louise , HARTZOULAKIS, Basil , MADGE, David , FORD, John
发明人： JOHN, Derek, Edward , MULLA, Mushtaq , HAMLYN, Richard, John , GARRETT, Sarah, Louise , HARTZOULAKIS, Basil , MADGE, David , FORD, John
IPC分类号： C07C311/21 , C07D205/04 , C07D211/08 , C07D213/04 , C07D231/00 , C07D233/54 , C07D265/28 , C07D271/12 , C07D277/32 , C07D307/79 , C07D311/70 , C07D317/62 , C07D319/18 , A61K31/18 , A61P29/00
CPC分类号： C07C311/21 , C07C311/46 , C07C317/32 , C07C317/40 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07D207/12 , C07D209/08 , C07D211/16 , C07D211/34 , C07D211/44 , C07D213/36 , C07D213/40 , C07D213/71 , C07D231/12 , C07D231/18 , C07D231/56 , C07D233/61 , C07D233/64 , C07D233/84 , C07D265/30 , C07D265/36 , C07D271/08 , C07D277/28 , C07D277/36 , C07D277/46 , C07D285/12 , C07D285/135 , C07D307/79 , C07D311/70 , C07D317/62 , C07D319/18 , C07D401/12 , C07D403/12 , C07D413/12
摘要： The present invention provides a compound of formula (I) or its salts or pharmaceutically acceptable derivatives thereof wherein; X 1 is selected from a group consisting of CH 2 , C(=O), C(=NH), NC(=O), R 1 is selected from the group consisting of optionally substituted arylalkyl, and optionally substituted heteroarylalkyl R 2 is selected from the group consisting of optionally substituted alkyl, optionally substituted aryl or heteroaryl or NR 24 R 25 , R 3 is selected from the group consisting of hydrogen, halogen, hydroxyl, alkoxy, aryloxy, optionally substituted alkyl, optionally substituted amino, optionally substituted amino sulfonyl or nitrile; R 4 is selected from the group consisting of optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted heterocycloalkyl, optionally substituted acyl, optionally substituted sulfonyl, optionally substituted sulfamoyl, optionally substituted aryl, optionally substituted arylalkyl, and optionally substituted heteroaryl R 5 may be hydrogen, an optionally substituted alkyl, preferably CH 3 or, NR 4 R 5 may form an optionally substituted saturated or partially saturated 4-7 membered ring with the general formula (II). Wherein; X 2 is C(=O), CH 2 , CH(R 6 ) or C(R 6 )(R 6 ), X 3 is CH 2 , CH(R 7 ), C(R 7 )(R 7 ), NH, N(R 8 ), O or S Each R 6 independently represents optionally substituted amino, optionally substituted amino carbonyl, hydroxyl, optionally substituted acyl, optionally substituted alkoxy, optionally substituted aryloxy, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted arylalky, optionally substituted aryl or optionally substituted heteroaryl; Each R 7 independently represents optionally substituted amino, optionally substituted amino carbonyl, hydroxyl, optionally substituted acyl, optionally substituted alkoxy, optionally substituted aryloxy, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted arylalky, optionally substituted aryl or optionally substituted heteroaryl R 8 is optionally substituted acyl, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted arylalkyl, optionally substituted aryl or optionally substituted heteroaryl; R 24 and R 25 are the same or different and each represents hydrogen, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted arylalkyl, optionally substituted aryl or optionally substituted heteroaryl, n = 1 or 2 m = 1, 2 or 3 With the proviso that when X 1 is C=O and R 5 is H then R 4 is not (a) or (b) or (c). Where R 4 a, R 5 a and R 6 a are each independently H, C 1-6 alkyl, aryl, heteroaryl, cycloalkyl, or aryl-C 1-6 alkyl; R 10 a is H or C 1-6 alkyl; and R 11 a is C 1-6 alkyl or aryl-C 1-6 alkyl and when X 1 is C=O or CH 2 and R 5 is H then R 4 is not (d) Where q is 0 to 5, R 3 b is H, OH or alkoxy and R 4 b is NH 2 , phenyl or a C 3-10 heterocycle. The compounds are useful as potassium ion channel inhibitors.
摘要翻译：本发明提供式（I）化合物或其盐或其药学上可接受的衍生物，其中： X 1选自CH 2，C（= O），C（= NH），NC（= O），R 1选自任选取代的芳烷基和任选取代的杂芳基烷基R 2选自基团由任选取代的烷基，任选取代的芳基或杂芳基或NR 24 R 25组成，R 3选自氢，卤素，羟基，烷氧基，芳氧基，任选取代的烷基，任选取代的氨基，任选取代的氨基磺酰基或腈; R 4选自任选取代的烷基，任选取代的环烷基，任选取代的杂环烷基，任选取代的酰基，任选取代的磺酰基，任选取代的氨磺酰基，任选取代的芳基，任选取代的芳基烷基和任选取代的杂芳基R 5可以是氢，任选取代的烷基，优选CH 3或NR 4 R 5可以形成具有通式（II）的任选取代的饱和或部分饱和的4-7元环。其中： X2是C（= O），CH2，CH（R6）或C（R6）（R6），X3是CH2，CH（R7），C（R7）（R7），NH，N（R8）每个R 6独立地表示任选取代的氨基，任选取代的氨基羰基，羟基，任选取代的酰基，任选取代的烷氧基，任选取代的芳氧基，任选取代的烷基，任选取代的环烷基，任选取代的芳基烷基，任选取代的芳基或任选取代的杂芳基; 每个R 7独立地表示任选取代的氨基，任选取代的氨基羰基，羟基，任选取代的酰基，任选取代的烷氧基，任选取代的芳氧基，任选取代的烷基，任选取代的环烷基，任选取代的芳基烷基，任选取代的芳基或任选取代的杂芳基R 8是任选取代的酰基，任选取代的烷基，任选取代的环烷基，任选取代的芳基烷基，任选取代的芳基或任选取代的杂芳基; R 24和R 25相同或不同，各自表示氢，任选取代的烷基，任选取代的环烷基，任选取代的芳基烷基，任选取代的芳基或任选取代的杂芳基，n = 1或2 m = 1,2或3，条件是当 X1为C = O，R5为H，R4不为（a）或（b）或（c）。其中R 4a，R 5a和R 6a各自独立地为H，C 1-6烷基，芳基，杂芳基，环烷基或芳基-C 1-6烷基; R10a是H或C1-6烷基; R 11a为C 1-6烷基或芳基-C 1-6烷基，当X 1为C = O或CH 2且R 5为H时，R 4不为（d）其中q为0至5，R 3b为H，OH或烷氧基，R 4b为NH 2 ，苯基或C 3-10杂环。该化合物可用作钾离子通道抑制剂。

3. 发明申请

WO2007053369A2 SYSTEM AND METHOD FOR DELIVERING INFORMATION TO OPTIMIZE INFORMATION RETENTION 审中-公开
标题翻译：用于传递信息以优化信息保留的系统和方法
公开(公告)号：WO2007053369A2
公开(公告)日：2007-05-10
申请号：PCT/US2006/041433
申请日：2006-10-23
申请人： BALANCED FITNESS, INC. , FORD, John, Hajime
发明人： FORD, John, Hajime
IPC分类号： G09B3/00
CPC分类号： G09B5/00 , A63B24/00 , A63B71/0622 , A63B2024/0078 , A63B2225/20 , A63B2230/00 , A63B2230/065
摘要： The invention teaches a system for use at a location, such as a health club, home or school. The system manages all or some of course scheduling, course delivery, instructor scheduling, participant information, course information, registration, and fee payment. Analysis of course selections to demographics and/or survey information can also be provided by the system. The system also provides a mechanism for providing target variable parameter information for participants in either a generic value or a participant specific value.
摘要翻译：本发明教导了在诸如健身俱乐部，家庭或学校的位置使用的系统。系统管理课程安排，课程交付，指导者安排，参与者信息，课程信息，注册和费用支付的全部或一些。课程选择对人口统计学和/或调查信息的分析也可以由系统提供。该系统还提供用于为参与者提供目标可变参数信息的机制，该参与者具有通用值或参与者特定值。

4. 发明申请

WO2007041082A1 IMPROVEMENTS TO WET MARINE EXHAUST SYSTEM CONTAINING A WATER SEPARATION DEVICE AND A FILTER TO REMOVE IMPURITIES FROM THE COOLING WATER 审中-公开
标题翻译：改善包含水分离装置的海洋废气系统和过滤器从冷却水中除去污染物
公开(公告)号：WO2007041082A1
公开(公告)日：2007-04-12
申请号：PCT/US2006/037340
申请日：2006-09-25
申请人： CENTEK INDUSTRIES, INC. , HARSTEL, Ken , BECKWITH, Ernie , FORD, John, R.
发明人： HARSTEL, Ken , BECKWITH, Ernie , FORD, John, R.
IPC分类号： F01N7/00 , F01N3/02
CPC分类号： F01N3/02 , F01N13/004 , F01N2260/00 , F01N2260/02 , F01N2590/02 , Y02T10/20
摘要： A marine wet exhaust system includes an exhaust gas/cooling water separator (24) for receiving an exhaust gas and waste cooling water mixture through a cooling water/exhaust gas inlet (66) . The exhaust system also includes a reservoir for collecting the waste cooling water separated from the exhaust gas and a de- watered exhaust gas discharge conduit (38) . The exhaust system also includes a cooling water discharge conduit (34) and a reservoir discharge pump (50) in the cooling water discharge conduit (34) configured to pump cooling water collected in the reservoir, the cooling water discharge conduit (34) and reservoir discharge pump (50) fluidically connected to the reservoir through a water outlet (32) having a first vertical height in the reservoir. The marine wet exhaust system also includes a pump controller (56) for controlling the reservoir discharge pump (50) and a water level sensing system (70) configured to provide a signal to the pump controller (55) based on the water level in the reservoir. The water level sensing system (70) is configured to function without the need for the reservoir to be vented to atmosphere .
摘要翻译：海洋湿式排气系统包括用于通过冷却水/排气入口（66）接收废气和废弃冷却水混合物的废气/冷却水分离器（24）。排气系统还包括用于收集从排气分离的废弃冷却水的储存器和排出的废气排出管道（38）。排气系统还包括冷却水排放管道（34）中的冷却水排出管道（34）和储存器排放泵（50），该冷却水排出管道构造成泵送收集在储存器中的冷却水，冷却水排出管道（34）和储存器排出泵（50）通过在储存器中具有第一垂直高度的出水口（32）与储存器流体连接。海洋湿式排气系统还包括一个用于控制储存器排放泵（50）的泵控制器（56）和一个水位检测系统（70），该水位检测系统（70）被配置为基于水位检测系统水库。水位感测系统（70）被配置为在不需要将储存器排放到大气中的情况下起作用。

5. 发明申请

WO2006057851A1 WET MARINE EXHAUST SYSTEM WITH CONTROLLED EVACUATION OF COOLING WATER 审中-公开
标题翻译：具有控制冷却水排放的海洋排气系统
公开(公告)号：WO2006057851A1
公开(公告)日：2006-06-01
申请号：PCT/US2005/041235
申请日：2005-11-15
申请人： CENTEK INDUSTRIES, INC. , FORD, John, R. , HARSTEL, Ken , BECKWITH, Ernie, Sr.
发明人： FORD, John, R. , HARSTEL, Ken , BECKWITH, Ernie, Sr.
IPC分类号： B63H21/32 , F01N7/00
CPC分类号： F01N13/004 , B63H21/32 , F01N2590/02
摘要： A wet exhaust system (20) is configured to direct exhaust gas generated by an engine (12) on a water craft (10) to an overboard discharge (44). The exhaust system (20) includes an exhaust conduit (22) connected to an exhaust manifold (24) of the engine (12), wherein cooling water from a cooling water supply (36, 38) is injected into the exhaust conduit (22). The exhaust system (20) also includes a wet marine exhaust muffler (30) connected to the exhaust conduit (22), the muffler (30) having a sump (60), and an exhaust pipe (42) connecting the muffler (30) to the overboard discharge (44). A drain assembly (68) having a drain line (48) that extends from the sump (60) to a drain terminus (50) and a motor-driven pump (70) evacuates cooling water collected in the sump (60). A pressure sensor (32) is configured to measure the pressure in the exhaust conduit (22) and generate a pressure signal related to the pressure. A pump controller (72) receives the pressure signal and controls the speed of the motor (80) of the pump (70) based on the pressure in the exhaust conduit (22).
摘要翻译：湿排气系统（20）构造成将由发动机（12）产生的废气引导到水上工具（10）到舷外排放口（44）。排气系统（20）包括连接到发动机（12）的排气歧管（24）的排气管道（22），其中来自冷却水供应源（36,38）的冷却水被注入排气管道（22）。排气系统（20）还包括连接到排气管道（22）的湿式船用排气消声器（30），具有贮槽（60）的消音器（30）和连接消声器（30）的排气管（42）到舷外放电（44）。排水组件（68）具有从贮槽（60）延伸到排水终端（50）的排水管线（48）和排出集水槽（60）中的冷却水的电机驱动泵（70）。压力传感器（32）构造成测量排气管道（22）中的压力并产生与压力相关的压力信号。泵控制器（72）基于排气管道（22）中的压力接收压力信号并控制泵（70）的马达（80）的速度。

6. 发明申请

WO2006026660A3 RADIO FREQUENCY IDENTIFICATION (RFID) LABEL APPLICATOR 审中-公开
标题翻译：无线电频率识别（RFID）标签应用
公开(公告)号：WO2006026660A3
公开(公告)日：2006-05-26
申请号：PCT/US2005030957
申请日：2005-08-29
申请人： SENSORMATIC ELECTRONICS CORP , FORD JOHN C , MARCUS CHRISTOPHER
发明人： FORD JOHN C , MARCUS CHRISTOPHER
IPC分类号： B65C9/18 , B65C9/40
CPC分类号： B65C9/1884 , B65C2009/0003 , B65C2009/0093 , B65C2009/405 , G06K2017/0041 , Y10T156/1707
摘要： The invention relates to an RFID label applicator (100) that may include a peeler body portion (140) having a peel end (142), the body portion being configured to cause an RFID label (102) to peel away from a web (110) when the web passes around the peel end. The body portion may define a cavity (302) having an RFID programming antenna (132) located therein that is configured to transmit programming signals to the RFID label prior to its passing around the peel end. The system may also include an extendable path (162) altering mechanism (164) configured to advance from a retracted position to an extended position to alter a path of the web around said peel end, and wherein the extendable path altering mechanism is positioned and dimensioned to inhibit a RFID label from peeling away from the web when in the extended position.
摘要翻译：本发明涉及RFID标签施加器（100），其可以包括具有剥离端（142）的剥离器主体部分（140），所述主体部分被配置为使得RFID标签（102）从网（110）剥离）当纸幅绕剥皮端部时。身体部分可以限定具有位于其中的RFID编程天线（132）的空腔（302），其被配置成在RFID标签通过剥离端之前将编程信号发送到RFID标签。系统还可以包括可延伸路径（162）改变机构（164），其被配置为从缩回位置前进到延伸位置以改变幅材围绕所述剥离端的路径，并且其中可延伸路径改变机构被定位和确定尺寸以防止RFID标签在伸展位置从纸幅剥离。

7. 发明申请

WO2006031423A1 RADIO FREQUENCY IDENTIFICATION (RFID) LABEL APPLICATOR 审中-公开
标题翻译：无线电频率识别（RFID）标签应用
公开(公告)号：WO2006031423A1
公开(公告)日：2006-03-23
申请号：PCT/US2005/030676
申请日：2005-08-29
申请人： SENSORMATIC ELECTRONICS CORPORATION , FORD, John, C. , MARCUS, Christopher
发明人： FORD, John, C. , MARCUS, Christopher
IPC分类号： B65C9/18
CPC分类号： B65C9/1884 , B65C2009/0003 , B65C2009/0093 , B65C2009/405 , G06K2017/0041 , G08B13/2417 , Y10T156/1707
摘要： The invention relates to an RFID label applicator (100) may include a peeler member (140) having a peel end (142), the peeler member being configured to cause an RFID label (102) to peel away from a web (110) when the web passes around the peel end; and a label tamp assembly (150) having a receiving surface (612) configured to receive the RFID label and to move it into contact with an item (104) on which the RFID label is to be applied, the label tamp assembly having at least one forward opening in a portion of the receiving surface away from the peeler member and a plurality of rearward openings in a portion of the receiving surface proximate the peeler member, wherein at least one of the forward or rearward openings is configured to draw in air such that a leading portion of the RFID label is substantially secured.
摘要翻译：本发明涉及RFID标签施加器（100）可以包括具有剥离端（142）的剥离器构件（140），所述剥离器构件被配置为使RFID标签（102）从网（110）剥离，当纸卷绕剥皮端; 以及具有接收表面（612）的标签捣固组件（150），所述接收表面被配置为接收RFID标签并使其移动与要在其上施加RFID标签的物品（104）接触，所述标签夯组件至少具有所述接收表面远离所述剥离器部件的一部分中的一个前部开口以及靠近所述剥离器部件的所述接收表面的一部分中的多个向后开口，其中，所述前部或后部开口中的至少一个构造成在空气中抽吸 RFID标签的引导部分基本上是固定的。

8. 发明申请

WO2006026660A2 RADIO FREQUENCY IDENTIFICATION (RFID) LABEL APPLICATOR 审中-公开
标题翻译：无线电频率识别（RFID）标签应用
公开(公告)号：WO2006026660A2
公开(公告)日：2006-03-09
申请号：PCT/US2005/030957
申请日：2005-08-29
申请人： SENSORMATIC ELECTRONICS CORPORATION , FORD, John, C. , MARCUS, Christopher
发明人： FORD, John, C. , MARCUS, Christopher
IPC分类号： B65C9/18 , B65C9/40
CPC分类号： B65C9/1884 , B65C2009/0003 , B65C2009/0093 , B65C2009/405 , G06K2017/0041 , G08B13/2417 , Y10T156/1707
摘要： The invention relates to an RFID label applicator that may include a peeler body portion having a peel end, the body portion being configured to cause an RFID label to peel away from a web when the web passes around the peel end. The body portion may define a cavity having an RFID programming antenna located therein that is configured to transmit programming signals to the RFID label prior to its passing around the peel end. The system may also include an extendable path altering mechanism configured to advance from a retracted position to an extended position to alter a path of the web around said peel end, and wherein the extendable path altering mechanism is positioned and dimensioned to inhibit a RFID label from peeling away from the web when in the extended position.
摘要翻译：本发明涉及一种RFID标签施加器，其可以包括具有剥离端部的剥离器主体部分，该主体部分被配置成当纸幅绕剥离端部通过时使RFID标签从纸幅剥离。主体部分可以限定具有位于其中的RFID编程天线的空腔，其被配置成在RFID标签通过剥离端之前将编程信号发送到RFID标签。该系统还可以包括可延伸的路径改变机构，其构造成从缩回位置前进到延伸位置以改变幅材围绕所述剥离端的路径，并且其中所述可延伸路径改变机构被定位和设定尺寸以阻止RFID标签从当处于延伸位置时，从纸幅上剥离。

9. 发明申请

WO2005039585A1 METHODS, COMPOSITIONS, AND KITS FOR ORGAN PROTECTION DURING SYSTEMIC ANTICANCER THERAPY 审中-公开
标题翻译：系统反应治疗期间组织保护的方法，组合物和试剂盒
公开(公告)号：WO2005039585A1
公开(公告)日：2005-05-06
申请号：PCT/US2004/026352
申请日：2004-08-13
申请人： FORD, John, P.
发明人： FORD, John, P.
IPC分类号： A61K31/505
CPC分类号： A61K31/00 , A61K31/337 , A61K31/505 , A61K31/513 , A61K31/555 , A61K31/704 , A61K31/7072 , A61K2300/00
摘要： Methods, compositions, and kits are presented for local tissue protection during systemic administration of anticancer therapeutic agents.
摘要翻译：在抗癌治疗剂的全身给药期间，提供了用于局部组织保护的方法，组合物和试剂盒。

10. 发明申请

WO1993010465A1 APPARATUS FOR TESTING WOUND COMPONENTS 审中-公开
标题翻译：用于测试创伤组件的装置
公开(公告)号：WO1993010465A1
公开(公告)日：1993-05-27
申请号：PCT/GB1992002104
申请日：1992-11-13
申请人： VOLTECH INSTRUMENTS LIMITED , FORD, John, Stewart
发明人： VOLTECH INSTRUMENTS LIMITED
IPC分类号： G01R31/06
CPC分类号： G01R31/027 , G01R31/06 , G01R31/346
摘要： The apparatus comprises a plurality of connectors (9, 10, 11, 12...) for connecting to the component to be tested (e.g. a transformer), a signal generator (19), a measuring system (23) and control means (22) which is arranged to control which of the connectors (9, 10, 11, 12...) are connected to the signal generator (19) and the measuring system (23) and arranged to control the function of the signal generator (19) and the measuring system (23) so that the same signal generator (19) and measuring system (23) can be used to carry out a variety of different tests on the component, the signal generator (19) also being arranged to provide a synchronising signal (28) to the measuring system (23) so that the phase relationship between measurements at different times can be calculated by comparing the phase relationships of those measurements with the synchronising signal (28).

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