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2. 发明申请

WO2003017127A2 MODELLING OF BIOCHEMICAL PATHWAYS 审中-公开
标题翻译：生物化学途径的建模
公开(公告)号：WO2003017127A2
公开(公告)日：2003-02-27
申请号：PCT/GB2002/003785
申请日：2002-08-15
申请人： FORD, Michael, F. , TAN, Patrick , SELVARAJOO, Kumaran
发明人： TAN, Patrick , SELVARAJOO, Kumaran
IPC分类号： G06F17/00
CPC分类号： G06F19/12 , Y02A90/26
摘要： A method of investigating a biochemical pathway, especially after treating with a potential drug in order to predict its effects, comprises steps of : storing, e.g. in computer memory a set of mathematical expressions to calculate values representing metabolite concentrations in a reference biochemical pathway from an initial value representing measured concentration of one metabolite in that pathway ; assaying concentration of metabolites(s) in a second biochemical pathway containing the same metabolites as the reference pathway, and storing values representing the measured concentrations ; using said mathematical expressions to calculate a predicted value of concentration of at least one metabolite in the second pathway from an initial value representing measured concentration of one metabolite in the second pathway ; comparing predicted values with corresponding values representing measured metabolite concentrations ; and deriving a measure of the match between pathways on the basis of that comparison relationship. The invention includes apparatus for carrying out the method and a computer memory product carrying at least one program for the method.
摘要翻译：调查生物化学途径的方法，特别是用潜在药物治疗以预测其作用之后，包括以下步骤：在计算机存储器中一组数学表达式，从表示该途径中一种代谢物的测量浓度的初始值计算代表参考生物化学途径中的代谢物浓度的值; 测定含有与参照途径相同代谢物的第二生物化学途径中代谢物的浓度，并存储表示测量浓度的值; 使用所述数学表达式从表示第二途径中的一种代谢物的测量浓度的初始值计算第二途径中至少一种代谢物的浓度的预测值; 将预测值与表示测量的代谢物浓度的相应值进行比较; 并基于该比较关系得出路径之间的匹配度量。本发明包括用于执行该方法的装置和携带该方法的至少一个程序的计算机存储器产品。

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