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1. 发明申请

WO2012177258A1 DOORWAY WIDTH RESTRICTION SYSTEM 审中-公开
标题翻译：门禁宽限制系统
公开(公告)号：WO2012177258A1
公开(公告)日：2012-12-27
申请号：PCT/US2011/041695
申请日：2011-06-23
申请人： THE BOEING COMPANY , ECKERT, David Wayne , LENABURG, Robert J. , DRAKE, Michael Lane , FLEMING, Michael Anthony
发明人： ECKERT, David Wayne , LENABURG, Robert J. , DRAKE, Michael Lane , FLEMING, Michael Anthony
IPC分类号： B64C1/14
CPC分类号： B64C1/143 , B64C1/1407
摘要： A method and apparatus comprising a structure (330) and an extended portion (332) in the structure (330). The structure (330) is configured for connection to a hinge (328) for a door (308) in an aircraft (200). The extended portion (332) in the structure (330) is configured to reduce a width (324) of a doorway (302) in which the door (308) is located when the door (308) is in a substantially open position (334).
摘要翻译：一种在结构（330）中包括结构（330）和延伸部分（332）的方法和装置。结构（330）构造成用于连接到飞行器（200）中的门（308）的铰链（328）。结构（330）中的延伸部分（332）构造成当门（308）处于基本打开位置（334）时，减小门（308）位于其中的门口（302）的宽度（324））。

2. 发明申请

WO2002041987A3 POLYMERIC MICROSPHERES 审中-公开
公开(公告)号：WO2002041987A3
公开(公告)日：2002-05-30
申请号：PCT/US2001/051278
申请日：2001-10-25
申请人： TUFTS UNIVERSITY , WALT, David, R. , MANDAL, Tarun, K. , FLEMING, Michael, S.
发明人： WALT, David, R. , MANDAL, Tarun, K. , FLEMING, Michael, S.
IPC分类号： B01J13/02
摘要： The invention features core-shell microsphere compositions, hollow polymeric microspheres, and methods for making the microspheres. The microspheres are characterized as having a polymeric shell with consistent shell thickness.

3. 发明申请

WO2010115916A1 PROCESS FOR ISOLATING THERAPEUTIC PEPTIDE 审中-公开
标题翻译：分离治疗肽的方法
公开(公告)号：WO2010115916A1
公开(公告)日：2010-10-14
申请号：PCT/EP2010/054577
申请日：2010-04-07
申请人： F. HOFFMANN-LA ROCHE AG , FLEMING, Michael Paul , PETERSEN, Raymond Dennis
发明人： FLEMING, Michael Paul , PETERSEN, Raymond Dennis
IPC分类号： C07K7/08 , C07K14/245
CPC分类号： C07K14/245 , C07K7/08
摘要： Disclosed are methods of isolating linaclotide, a cyclized 14-amino-acid peptide with three disulfide bonds. The sequence consists of Cys-Cys-Glu-Tyr-Cys-Cys-Asn-Pro-Ala-Cys-Thr-Gly-Cys-Tyr (SEQ ID NO 1) with disulfide bridges between the cysteine residues at positions 1 and 6, 2 and 10, and 5 and 13. The drug acts as a GCC superagonist, elevating intracellular cGMP composition for treating various disorders, including gastrointestinal disorders, obesity, congestive heart failure and benign prostatic hyperplasia.
摘要翻译：公开了分离具有三个二硫键的环化的14-氨基酸肽的利那洛肽的方法。序列由Cys-Cys-Glu-Tyr-Cys-Cys-Asn-Pro-Ala-Cys-Thr-Gly-Cys-Tyr（SEQ ID NO 1）与位置1和6之间的半胱氨酸残基之间的二硫键组成， 2和10和5和13.该药物作为GCC增强剂，提高用于治疗各种疾病，包括胃肠道疾病，肥胖，充血性心力衰竭和良性前列腺增生的细胞内cGMP组合物。

4. 发明申请

WO2007123482A1 A THREADING TOOL, A THREADING INSERT WITH A FACE OF PCBN AND A METHOD OF FORMING A THREAD 审中-公开
标题翻译：螺纹工具，具有PCBN面的螺纹插件和形成螺纹的方法
公开(公告)号：WO2007123482A1
公开(公告)日：2007-11-01
申请号：PCT/SE2007/050255
申请日：2007-04-19
申请人： SECO TOOLS AB , WICKMAN, Anders , FLEMING, Michael
发明人： WICKMAN, Anders , FLEMING, Michael
IPC分类号： B23G5/00 , B23B27/16 , B23G5/18
CPC分类号： B23B27/065 , B23B27/1614 , B23B27/1625 , B23B2200/0485 , B23B2200/167 , B23B2205/02 , B23B2226/125 , Y10T82/10 , Y10T407/23 , Y10T407/27
摘要： The present invention relates to a threading tool, a threading insert, and a method of forming a thread. The threading insert (21) comprises a cutting edge (23). The insert comprises an insert supporting surface (25) and a clamping surface (27') for clamping the 5 insert relative to a toolholder (29) such that the insert supporting surface supports the insert against an abutment surface (31) of the toolholder. At least one layer (33) of PCBN forms a face (35) of the insert. The cutting edge (23) extends at least partially around a periphery of the insert and is formed in the PCBN layer.
摘要翻译：本发明涉及一种穿线工具，穿线刀片及其形成方法。穿线刀片（21）包括切削刃（23）。插入件包括插入件支撑表面（25）和用于相对于刀架（29）夹紧5刀片的夹紧表面（27'），使得刀片支撑表面将刀片支撑在刀架的邻接表面（31）上。 PCBN的至少一层（33）形成插入物的面（35）。切割刃（23）至少部分地围绕插入件的周边延伸并形成在PCBN层中。

5. 发明申请

WO2006007499A1 PROTECTIVE HELMET FOR CHILDREN IN AUTOMOBILES 审中-公开
标题翻译：儿童汽车保护措施
公开(公告)号：WO2006007499A1
公开(公告)日：2006-01-19
申请号：PCT/US2005/022942
申请日：2005-06-27
申请人： FLEMING, Michael, P.
发明人： FLEMING, Michael, P.
IPC分类号： A42B3/00
CPC分类号： A42B3/00 , A42B3/06 , A42B3/30
摘要： A children's protective helmet for use by children riding in automobiles, includes an impact absorbing structure having a soft outer wall surface which a child may wear while in an automobile to diminish the amount of force applied to the head of the child when an impact force is applied to the impact absorbing structure of the protective helmet.
摘要翻译：一种儿童乘坐汽车的儿童防护用头盔，包括一个冲击吸收结构，该冲击吸收结构具有软的外壁表面，儿童在汽车中可能会磨损，以减少施加到儿童头部的力量，当冲击力为适用于防护头盔的冲击吸收结构。

6. 发明申请

WO2004110498A3 DRUG CONJUGATE COMPOSITION 审中-公开
公开(公告)号：WO2004110498A3
公开(公告)日：2004-12-23
申请号：PCT/US2004/015376
申请日：2004-05-14
申请人： IMMUNOGEN, INC. , AMPHLETT, Godfrey , ZHANG, Wei , FLEMING, Michael , CHIH, Hung-Wei
发明人： AMPHLETT, Godfrey , ZHANG, Wei , FLEMING, Michael , CHIH, Hung-Wei
IPC分类号： A61K47/48
摘要： The invention provides a liquid composition and a Iyophilized composition comprising a therapeutically effective amount of a conjugate comprising an antibody chemically coupled to a maytansinoid. The invention further provides a method for killing a cell in a human comprising administering to the human either of the compositions such that the antibody binds to the surface of the cell and the cytotoxicity of the maytansinoid is activated, whereby the cell is killed.

7. 发明申请

WO0241987A2 POLYMERIC MICROSPHERES 审中-公开
标题翻译：聚合微球
公开(公告)号：WO0241987A2
公开(公告)日：2002-05-30
申请号：PCT/US0151278
申请日：2001-10-25
申请人： UNIV TUFTS , WALT DAVID R , MANDAL TARUN K , FLEMING MICHAEL S
发明人： WALT DAVID R , MANDAL TARUN K , FLEMING MICHAEL S
IPC分类号： A61K9/50 , A61K9/51 , B01J13/02 , B01J13/14
CPC分类号： A61K9/5138 , A61K9/5089 , A61K9/5146 , B01J13/02 , B01J13/14 , Y10T428/2982
摘要： The invention features core-shell microsphere compositions, hollow polymeric microspheres, and methods for making the microspheres. The microspheres are characterized as having a polymeric shell with consistent shell thickness.
摘要翻译：本发明的特征在于核 - 壳微球组合物，中空聚合物微球和制备微球的方法。微球的特征在于具有一致的壳厚度的聚合物壳。

8. 发明申请

WO2011013113A1 A VEHICLE SAFETY APPARATUS 审中-公开
标题翻译：一种车辆安全装置
公开(公告)号：WO2011013113A1
公开(公告)日：2011-02-03
申请号：PCT/IE2010/000043
申请日：2010-07-29
申请人： AMIRI LIMITED , O'FLYNN, John , FLEMING, Michael , FOLEY, Anthony , O'FLYNN, Michael
发明人： O'FLYNN, John , FLEMING, Michael , FOLEY, Anthony , O'FLYNN, Michael
IPC分类号： B60Q1/52
CPC分类号： B60Q1/52
摘要： A vehicle safety apparatus (1, 2) comprises an electronic sign (11), a registration plate support (21) covering the sign (11), a controller (2), and a mechanism (30) to, in response to an event, move the registration plate support (21) in a direction away from the sign (11) and up or down to expose the sign (11) and leave a registration plate (P) on the registration plate support (21) visible. The mechanism (30) has a rotating link (17, 18) at each lateral end of the registration plate support (21). The sign (11) is adapted to display any of a number of options and the controller (2) provides a default option. An in-car controller (2) comprises a radiation receiver and is adapted to respond to a remotely-transmitted signal to activate the warning sign. Also, the in-car controller (2) regularly polls the sign (11) and in absence of a response it generates a tampering output alarm.
摘要翻译：车辆安全装置（1,2）包括电子标志（11），覆盖符号（11）的登记板支撑（21），控制器（2）和响应于事件的机构（30），沿着远离标志（11）的方向上移动对准板支撑件（21）并向上或向下移动以露出标志（11）并且在对准板支撑件（21）上留下对准板（P）可见。机构（30）在对齐板支撑件（21）的每个侧端具有旋转连杆（17,18）。符号（11）适于显示多个选项中的任何一个，并且控制器（2）提供默认选项。车载控制器（2）包括辐射接收器，并且适于响应远程发送的信号以激活警告信号。此外，车载控制器（2）定期轮询符号（11），并且在没有响应的情况下，其产生篡改输出警报。

9. 发明申请

WO2007060379A1 SEWAGE SLUDGE TREATMENT METHOD 审中-公开
标题翻译：污水处理方法
公开(公告)号：WO2007060379A1
公开(公告)日：2007-05-31
申请号：PCT/GB2005/004544
申请日：2005-11-28
申请人： FLEMING, Gilbert , FLEMING, Michael
发明人： FLEMING, Gilbert , FLEMING, Michael
IPC分类号： C02F11/12 , C10L5/46
CPC分类号： C10L5/44 , C02F11/12 , C02F11/14 , C10L5/46 , Y02E50/10 , Y02E50/30
摘要： The present invention concerns an improved method for dewatering industrial or sewage sludge, in particular a method for dewatering to give a high solids content sludge concentrate more suitable, where appropriate, for subsequent incineration. The invention comprises a process in which to a sewage sludge there is added a fibrous additive, an optional coagulant, a dewetting additive and a flocculant polymer which is followed by mechanical de-watering. The end product may have useable calorific content which can be used as fuel for incineration.
摘要翻译：本发明涉及一种用于脱水工业或污水污泥的改进方法，特别是一种脱水方法，以在适当情况下给予更适合于后续焚烧的高固含量污泥浓缩物。本发明包括一种方法，其中对污水污泥添加纤维添加剂，任选的絮凝剂，去湿添加剂和絮凝剂聚合物，随后机械脱水。最终产品可能具有可用的热量，可用作焚化燃料。

10. 发明申请

WO2004110498A2 DRUG CONJUGATE COMPOSITION 审中-公开
标题翻译：药物组合物
公开(公告)号：WO2004110498A2
公开(公告)日：2004-12-23
申请号：PCT/US2004015376
申请日：2004-05-14
申请人： IMMUNOGEN INC , AMPHLETT GODFREY , ZHANG WEI , FLEMING MICHAEL , CHIH HUNG-WEI
发明人： AMPHLETT GODFREY , ZHANG WEI , FLEMING MICHAEL , CHIH HUNG-WEI
IPC分类号： A61K47/48
CPC分类号： A61K47/48384 , A61K9/19 , A61K47/12 , A61K47/183 , A61K47/26 , A61K47/6803 , A61K47/6817 , A61K47/6851 , A61K47/6857 , C07K16/2803 , C07K2317/24
摘要： The invention provides a liquid composition and a Iyophilized composition comprising a therapeutically effective amount of a conjugate comprising an antibody chemically coupled to a maytansinoid. The invention further provides a method for killing a cell in a human comprising administering to the human either of the compositions such that the antibody binds to the surface of the cell and the cytotoxicity of the maytansinoid is activated, whereby the cell is killed.
摘要翻译：本发明提供液体组合物和含有治疗有效量的缀合物的离子化组合物，所述缀合物包含与美登木素生物素化学偶联的抗体。本发明进一步提供了一种杀死人体细胞的方法，包括对人体施用组合物使得抗体结合细胞表面，并且美登木素生物碱的细胞毒性被激活，由此细胞被杀死。

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