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1. 发明申请

WO2002068635A3 METHODS OF INHIBITING EXPRESSION OF A TARGET GENE IN MAMMALIAN CELLS 审中-公开
公开(公告)号：WO2002068635A3
公开(公告)日：2002-09-06
申请号：PCT/EP2002/002098
申请日：2002-02-27
申请人： NOVARTIS FORSCHUNGSSTIFTUNG ZWEIGNIEDERLASSUNG FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH , BILLY, Eric , FILIPOWICZ, Witold , MUELLER, Ulrich
发明人： BILLY, Eric , FILIPOWICZ, Witold , MUELLER, Ulrich
IPC分类号： C12N15/11
摘要： A method is provided for inhibiting gene expression in a mammalian cell based on dsRNA, as well as construct useful for carrying out the invention and resulting cells and transgenic mammals.

2. 发明申请

WO02068635A2 METHODS OF INHIBITING EXPRESSION OF A TARGET GENE IN MAMMALIAN CELLS 审中-公开
标题翻译：抑制MAMMALIAN细胞中目标基因表达的方法
公开(公告)号：WO02068635A2
公开(公告)日：2002-09-06
申请号：PCT/EP0202098
申请日：2002-02-27
申请人： NOVARTIS FORSCHUNGSSTIFTUNG , BILLY ERIC , FILIPOWICZ WITOLD , MUELLER ULRICH
发明人： BILLY ERIC , FILIPOWICZ WITOLD , MUELLER ULRICH
IPC分类号： A01K67/027 , A61K31/7105 , A61K35/12 , A61K35/48 , A61K38/00 , A61K48/00 , A61P3/00 , A61P25/00 , A61P31/00 , A61P35/00 , A61P37/02 , C12N5/10 , C12N15/09 , C12N15/113 , C12Q1/68 , C12N15/11 , A61K31/713
CPC分类号： C12N15/1138 , A61K38/00 , C12N2310/111 , C12N2310/13 , C12N2310/14 , C12N2310/53
摘要： A method is provided for inhibiting gene expression in a mammalian cell based on dsRNA, as well as construct useful for carrying out the invention and resulting cells and transgenic mammals.
摘要翻译：提供了一种用于抑制基于dsRNA的哺乳动物细胞中的基因表达的方法，以及用于实施本发明和所得细胞和转基因哺乳动物的构建体。

3. 发明申请

WO2009130176A1 Antiviral Therapy 审中-公开
标题翻译：抗病毒治疗
公开(公告)号：WO2009130176A1
公开(公告)日：2009-10-29
申请号：PCT/EP2009/054641
申请日：2009-04-20
申请人： NOVARTIS FORSCHUNGSSTIFTUNG ZWEIGNIEDERLASSUNG FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH , UNIVERSITY HOSPITAL BASEL , FILIPOWICZ, Witold , HEIM, Markus , SARASIN-FILIPOWICZ, Magdalena , DUONG, Francois H.T. , OAKELEY, Edward
发明人： FILIPOWICZ, Witold , HEIM, Markus , SARASIN-FILIPOWICZ, Magdalena , DUONG, Francois H.T. , OAKELEY, Edward
IPC分类号： C12Q1/68 , G01N33/50 , G01N33/576
CPC分类号： C12Q1/6883 , C12Q2600/158
摘要： The application relates to treatments for improving antiviral therapies and to method for determining whether or not antiviral therapies wilt be effective. In particular, the present application provides a method for determining the likelihood that a subject having a viral infection of the liver will be responsive to antiviral therapy that includes stimulation of Interferon (IFN) activity, and kits for the performance of said determination.
摘要翻译：本申请涉及用于改善抗病毒疗法的治疗方法以及用于确定抗病毒疗法是否有效的方法。特别地，本申请提供了一种用于确定具有肝病毒感染的受试者对包括刺激干扰素（IFN）活性的抗病毒治疗以及用于进行所述测定的试剂盒的响应的可能性的方法。

4. 发明申请

WO1995000652A1 CHIMERIC PLANT GENES POSSESSING INDEPENDENT REGULATORY SEQUENCES 审中-公开
标题翻译：独立监管序列的重要植物基因
公开(公告)号：WO1995000652A1
公开(公告)日：1995-01-05
申请号：PCT/IB1994000155
申请日：1994-06-15
申请人： CIBA-GEIGY AG , FILIPOWICZ, Witold , CONNELLY, Sheila
发明人： CIBA-GEIGY AG
IPC分类号： C12N15/82
CPC分类号： C12N15/8216
摘要： The present invention relates to chimeric gene constructions comprising snRNA or mRNA promoter elements and 3' termination signals which are independent of the promoter element in functional combination with a structural gene which codes for a polypeptide, which is expressed, in a natural manner, from an mRNA gene, for sense RNA, for anti-sense RNA or for snRNA. In addition to this, the present invention relates to recombinant DNA molecules which encompass such chimeric gene constructs, and, in addition, to microorganisms which harbour these plasmids and to processes for preparing the said chimeric gene constructs and plasmids. Finally, the invention relates to plant cells, to parts of plants which can be regenerated to form entire and preferably fertile plants, and to the plants themselves including their descendants, insofar as they express the chimeric genes according to the invention.
摘要翻译：本发明涉及包含snRNA或mRNA启动子元件的嵌合基因构建体和3个终止信号，其与编码多肽的结构基因的功能组合独立于启动子元件，其以天然的方式从 mRNA基因，用于正义RNA，用于反义RNA或snRNA。除此之外，本发明涉及包含这种嵌合基因构建体的重组DNA分子，另外涉及含有这些质粒的微生物以及制备所述嵌合基因构建体和质粒的方法。最后，本发明涉及可以再生以形成整个和优选可育植物的植物部分，以及包括其后代在内的植物本身，只要它们表达根据本发明的嵌合基因即可。

5. 发明申请

WO2015044890A3 TOOLS AND METHODS USING MIRNA 182, 96 AND/OR 183 FOR TREATING PATHOLOGIES 审中-公开
标题翻译：使用MIRNA 182,96和/或183处理病理学的工具和方法
公开(公告)号：WO2015044890A3
公开(公告)日：2015-06-11
申请号：PCT/IB2014064826
申请日：2014-09-25
申请人： FRIEDRICH MIESCHER INST FOR BIOMEDICAL RES , BUSSKAMP VOLKER , FILIPOWICZ WITOLD , KROL JACEK , ROSKA BOTOND
发明人： BUSSKAMP VOLKER , FILIPOWICZ WITOLD , KROL JACEK , ROSKA BOTOND
IPC分类号： C12N15/113 , A61K31/7088 , A61P27/02
CPC分类号： C12N15/113 , C12N2310/141 , C12N2330/10
摘要： The present inventions relates to isolated nucleic acid molecules comprising a nucleotide sequence coding for mi RNA-182 (uuuggcaaugguagaacucacacu or ugguucuagacuugccaacua), miRNA-96 (uuuggcacuagcacauuuuugcu or aaucaugugcagugccaauaug) and/or mi RNA-183 (uauggcacugguagaauucacu or gugaauuaccgaagggccauaa) for use in treating or ameliorating a ciliopathy and/or a photoreceptor dysfunction.
摘要翻译：本发明涉及分离的核酸分子，其包含编码mi RNA-182（uuuggcaaugguagaacucacacu或ugguucuagacuugccaacua）的核苷酸序列，miRNA-96（uuuggcacuagcacauuuuugcu或aaucaugugcagugccaauaug）和/或mi RNA-183（uauggcacugguagaauucacu或gugaauuacaccgaagggccccauaa），用于治疗或改善皮肤病和/或光感受器功能障碍。

6. 发明申请

WO2009156507A1 PREDICTION OF ANTIVIRAL THERAPY RESPONSE 审中-公开
标题翻译：预防抗病毒治疗反应
公开(公告)号：WO2009156507A1
公开(公告)日：2009-12-30
申请号：PCT/EP2009/058045
申请日：2009-06-26
申请人： NOVARTIS FORSCHUNGSSTIFTUNG ZWEIGNIEDERLASSUNG FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH , UNIVERSITY HOSPITAL BASEL , FILIPOWICZ, Witold , HEIM, Markus , KROL, Jacek , MARKIEWICZ, Ilona , SARASIN-FILIPOWICZ, Magdalena
发明人： FILIPOWICZ, Witold , HEIM, Markus , KROL, Jacek , MARKIEWICZ, Ilona , SARASIN-FILIPOWICZ, Magdalena
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6876 , C12Q1/6883 , C12Q2600/106 , C12Q2600/178
摘要： The application relates to methods for determining whether or not antiviral therapies will be effective. In particular, the present application provides a method using miRNA, e.g. miR-122 or miR-296-5p, for determining the likelihood that a subject having a viral infection of the liver will be responsive to antiviral therapy that includes stimulation of Interferon (IFN) activity, and kits for the performance of said determination.
摘要翻译：本申请涉及用于确定抗病毒疗法是否有效的方法。特别地，本申请提供了使用miRNA的方法，例如， miR-122或miR-296-5p，用于确定具有肝病毒感染的受试者对包括刺激干扰素（IFN）活性的抗病毒治疗有反应的可能性，以及用于执行所述测定的试剂盒。

7. 发明申请

WO2005040419A8 OLIGONUCLEOTIDE MICROARRAY 审中-公开
公开(公告)号：WO2005040419A8
公开(公告)日：2006-05-11
申请号：PCT/EP2004011511
申请日：2004-10-13
申请人： NOVARTIS AG , NOVARTIS PHARMA GMBH , NOVARTIS FORSCHUNGSSTIFTUNG , WEILER JAN , HALL JONATHAN , WANKE CHRISTOPH , LANGE JOERG BERND , FILIPOWICZ WITOLD , KOLB FABRICE
发明人： WEILER JAN , HALL JONATHAN , WANKE CHRISTOPH , LANGE JOERG BERND , FILIPOWICZ WITOLD , KOLB FABRICE
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q1/6886 , C12Q2600/178
摘要： The present invention relates to oligonucleotide microarrays comprising short chemically modified RNA oligonucleotides and uses of such microarrays in genomics applications. More specifically, the invention provides an oligonucleotide array comprising a surface and a plurality of oligonucleotide, wherein at least one oligonucleotide has at least one modified sugar moiety at the 2'OH position. The microarrays of the invention are more specifically useful to detect small RNAs.
摘要翻译：本发明涉及包含短化学修饰的RNA寡核苷酸的寡核苷酸微阵列和在基因组学应用中这种微阵列的用途。更具体地，本发明提供了包含表面和多个寡核苷酸的寡核苷酸阵列，其中至少一个寡核苷酸在2'OH位置具有至少一个修饰的糖部分。本发明的微阵列更具体地用于检测小RNA。

8. 发明申请

WO2009130176A9 ANTIVIRAL THERAPY 审中-公开
标题翻译：抗病毒治疗
公开(公告)号：WO2009130176A9
公开(公告)日：2010-01-07
申请号：PCT/EP2009054641
申请日：2009-04-20
申请人： NOVARTIS FORSCHUNGSSTIFTUNG , UNIV HOSPITAL BASEL , FILIPOWICZ WITOLD , HEIM MARKUS , SARASIN-FILIPOWICZ MAGDALENA , DUONG FRANCOIS H T , OAKELEY EDWARD
发明人： FILIPOWICZ WITOLD , HEIM MARKUS , SARASIN-FILIPOWICZ MAGDALENA , DUONG FRANCOIS H T , OAKELEY EDWARD
IPC分类号： C12Q1/68 , G01N33/50 , G01N33/576
CPC分类号： C12Q1/6883 , C12Q2600/158
摘要： The application relates to treatments for improving antiviral therapies and to method for determining whether or not antiviral therapies wilt be effective. In particular, the present application provides a method for determining the likelihood that a subject having a viral infection of the liver will be responsive to antiviral therapy that includes stimulation of Interferon (IFN) activity, and kits for the performance of said determination.
摘要翻译：本申请涉及用于改善抗病毒疗法的治疗方法以及用于确定抗病毒疗法是否有效的方法。特别地，本申请提供了一种用于确定具有肝病毒感染的受试者对包括刺激干扰素（IFN）活性的抗病毒治疗以及用于进行所述测定的试剂盒的响应的可能性的方法。

9. 发明申请

WO1997045535A1 RECOMBINAT RNA 3'-TERMINAL PHOSPHATE CYCLASES AND PRODUCTION METHODS THEREOF 审中-公开
标题翻译： RECOMBINAT RNA 3'-末端磷酸盐循环及其生产方法
公开(公告)号：WO1997045535A1
公开(公告)日：1997-12-04
申请号：PCT/EP1997002566
申请日：1997-05-20
申请人： NOVARTIS AG , GENSCHIK, Pascal , FILIPOWICZ, Witold
发明人： NOVARTIS AG
IPC分类号： C12N09/00
CPC分类号： C12N9/93
摘要： The invention provides a method for producing RNA 3'-terminal phosphate cyclase comprising expressing a nucleic acid sequence encoding said cyclase, or a derivative thereof in a recombinant host cell. The invention also provides a nucleic acid sequence encoding RNA 3'-terminal phosphate cyclase, or a derivative thereof, as well as vectors and host cells containing such nucleic acids. The RNA 3'-terminal phosphate cyclase of the invention is found to be a conserved enzyme across a wide variety of organisms. The invention accordingly provides RNA 3'-terminal phosphate cyclase polypeptides of eukaryotic as well as prokaryotic origin.
摘要翻译：本发明提供了一种生产RNA 3'末端磷酸环化酶的方法，包括在重组宿主细胞中表达编码所述环化酶或其衍生物的核酸序列。本发明还提供了编码RNA3'-末端磷酸环化酶或其衍生物的核酸序列以及含有这种核酸的载体和宿主细胞。发现本发明的RNA 3'末端磷酸环化酶是多种生物体中的保守酶。因此，本发明提供了真核生物和原核生物来源的RNA 3'末端磷酸环化酶多肽。

10. 发明申请

WO2015044890A2 TOOLS AND METHODS USING MIRNA 182, 96 AND/OR 183 FOR TREATING PATHOLOGIES 审中-公开
标题翻译：使用MIRNA 182,96和/或183处理病理的工具和方法
公开(公告)号：WO2015044890A2
公开(公告)日：2015-04-02
申请号：PCT/IB2014/064826
申请日：2014-09-25
申请人： FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH , BUSSKAMP, Volker , FILIPOWICZ, Witold , KROL, Jacek , ROSKA, Botond
发明人： BUSSKAMP, Volker , FILIPOWICZ, Witold , KROL, Jacek , ROSKA, Botond
IPC分类号： C12N15/113
CPC分类号： C12N15/113 , C12N2310/141 , C12N2330/10
摘要： The present inventions relates to isolated nucleic acid molecules comprising a nucleotide sequence coding for mi RNA-182 (uuuggcaaugguagaacucacacu or ugguucuagacuugccaacua), miRNA-96 (uuuggcacuagcacauuuuugcu or aaucaugugcagugccaauaug) and/or mi RNA-183 (uauggcacugguagaauucacu or gugaauuaccgaagggccauaa) for use in treating or ameliorating a ciliopathy and/or a photoreceptor dysfunction.
摘要翻译：本发明涉及分离的核酸分子，其包含编码mi RNA-182（uuuggcaaugguagaacucacacu或ugguucuagacuugccaacua），miRNA-96（uuuggcacuagcacauuuuugcu或aaucaugugcagugccaauaug）和/或mi RNA-183（uauggcacugguagaauucacu）的核苷酸序列或gugaauuaccgaagggccauaa）用于治疗或改善Ciliopathy和/或光感受器功能障碍。

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