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1. 发明申请

WO2005009371A3 ULTRA THIN FILM TRANSDERMAL/DERMAL OR TRANSMUCOSAL/MUCOSAL DELIVERY SYSTEM 审中-公开
标题翻译：超薄膜透皮/皮肤或透皮/粘膜输送系统
公开(公告)号：WO2005009371A3
公开(公告)日：2005-12-15
申请号：PCT/US2004023422
申请日：2004-07-20
申请人： CORIUM INT INC , CLEARY GARY W , FAASSE ADRIAN L JR
发明人： CLEARY GARY W , FAASSE ADRIAN L JR
IPC分类号： A61F13/00 , A61F13/02 , A61F15/00 , A61K20060101 , A61K9/70 , A61L15/44 , A61L15/48
CPC分类号： A61L15/48 , A61F13/0213 , A61F13/0226 , A61F13/023 , A61F13/0259 , A61F2013/00804 , A61F2013/00817 , A61K9/703 , A61K9/7084 , A61L15/44 , A61L2300/602
摘要： An ultra thin film transdermal, dermal, transmucosal, mucosal pharmaceutical delivery system is disclosed, which has a handle adhered by a first adhesive to an ultra thin film layer. The opposite side of the ultra thin film is coated with a second adhesive layer, and carries an active ingredient. The handle adheres firmly to the ultra thin film layer, but does not adhere to skin, mucosa, or the silicone coated surface of a release liner. A portion of the handle extends beyond an edge of the ultra thin film to facilitate separation of the film from the release liner, and handling thereof. The second adhesive is more aggressive with respect to the patient's skin than the first adhesive is with respect to the surface of the ultra thin film, whereby the handle can be peeled away from the ultra thin film after the film has been applied to the patient.
摘要翻译：公开了一种超薄膜透皮，皮肤，透粘膜，粘膜药物递送系统，其具有通过第一粘合剂附着到超薄膜层上的手柄。超薄膜的另一面涂有第二粘合剂层，并带有活性成分。手柄牢固粘附在超薄膜层上，但不粘附在剥离衬垫的皮肤，粘膜或有机硅涂层表面。手柄的一部分延伸超过超薄膜的边缘以促进膜与剥离衬垫的分离和处理。第二粘合剂相对于患者皮肤比第一粘合剂相对于超薄膜的表面更具侵蚀性，由此在将薄膜施用于患者之后可以将手柄从超薄膜剥离。

2. 发明申请

WO2005009371A2 ULTRA THIN FILM TRANSDERMAL/DERMAL OR TRANSMUCOSAL/MUCOSAL DELIVERY SYSTEM 审中-公开
标题翻译：超薄薄膜超薄/透光/胶体输送系统
公开(公告)号：WO2005009371A2
公开(公告)日：2005-02-03
申请号：PCT/US2004/023422
申请日：2004-07-20
申请人： CORIUM INTERNATIONAL, INC. , CLEARY, Gary W. , FAASSE, Adrian L., Jr.
发明人： CLEARY, Gary W. , FAASSE, Adrian L., Jr.
IPC分类号： A61K
CPC分类号： A61L15/48 , A61F13/0213 , A61F13/0226 , A61F13/023 , A61F13/0259 , A61F2013/00804 , A61F2013/00817 , A61K9/703 , A61K9/7084 , A61L15/44 , A61L2300/602
摘要： An ultra thin film transdermal, dermal, transmucosal, mucosal pharmaceutical delivery system is disclosed, which has a handle adhered by a first adhesive to an ultra thin film layer. The opposite side of the ultra thin film is coated with a second adhesive layer, and carries an active ingredient. The handle adheres firmly to the ultra thin film layer, but does not adhere to skin, mucosa, or the silicone coated surface of a release liner. A portion of the handle extends beyond an edge of the ultra thin film to facilitate separation of the film from the release liner, and handling thereof. The second adhesive is more aggressive with respect to the patient's skin than the first adhesive is with respect to the surface of the ultra thin film, whereby the handle can be peeled away from the ultra thin film after the film has been applied to the patient.
摘要翻译：公开了一种超薄膜透皮，真皮，经粘膜，粘膜药物递送系统，其具有通过第一粘合剂粘附到超薄膜层的手柄。超薄膜的相反侧涂有第二粘合剂层，并带有活性成分。手柄牢固地粘附到超薄膜层，但不粘附到皮肤，粘膜或剥离衬垫的硅氧烷涂覆的表面上。手柄的一部分延伸超出超薄膜的边缘，以便于膜与剥离衬垫的分离及其处理。相对于第一粘合剂相对于超薄膜的表面，第二粘合剂相对于患者的皮肤更具攻击性，从而在膜施加到患者之后手柄可以从超薄膜剥离。

3. 发明申请

WO2005027768A3 HYDROGEL COMPOSITIONS WITH AN ERODIBLE BACKING MEMBER 审中-公开
标题翻译：具有可防止背部构件的水凝胶组合物
公开(公告)号：WO2005027768A3
公开(公告)日：2005-07-07
申请号：PCT/US2004029620
申请日：2004-09-09
申请人： CORIUM INT , AV TOPCHIEV INST PETROCHEMICAL , SINGH PARMINDER , FAASSE ADRIAN , CLEARY GARY W , MUDUMBA SRI , FELDSTEIN MIKHAIL , BAIRAMOV DANIR
发明人： SINGH PARMINDER , FAASSE ADRIAN , CLEARY GARY W , MUDUMBA SRI , FELDSTEIN MIKHAIL , BAIRAMOV DANIR
IPC分类号： A61C20060101 , A61C19/06 , A61K6/00 , A61K8/02 , A61K8/04 , A61K8/22 , A61K8/42 , A61K8/73 , A61K8/81 , A61K8/86 , A61K9/14 , A61K9/70 , A61L15/60 , A61Q11/00
CPC分类号： A61K8/0204 , A61C19/066 , A61K8/0208 , A61K8/042 , A61K8/22 , A61K8/42 , A61K8/731 , A61K8/733 , A61K8/8147 , A61K8/8152 , A61K8/817 , A61K8/8176 , A61K8/86 , A61K2800/262 , A61K2800/54 , A61K2800/5422 , A61L15/60 , A61L15/64 , A61Q11/00 , C08L2312/00
摘要： A composition is provided, wherein the composition comprises a water-swellable, water-insoluble polymer and a blend of a hydrophilic polymer with a complementary oligomer capable of hydrogen or electrostatic bonding to the hydrophilic polymer. The composition also includes a backing member. Active ingredients, such as a whitening agent, may be included. The composition finds utility as an oral dressing, for example, a tooth whitening composition that is applied to the teeth in need of whitening. The composition can be designed to be removed when the degree of whitening has been achieved or left in place and allowed to erode entirely. In certain embodiments, the composition is translucent. Methods for preparing and using the compositions are also disclosed.
摘要翻译：提供了一种组合物，其中所述组合物包含水溶胀性水不溶性聚合物和亲水性聚合物与能够与亲水性聚合物氢键或静电键合的互补低聚物的共混物。该组合物还包括背衬构件。可以包括活性成分，例如增白剂。该组合物可用作口腔敷料，例如应用于需要美白的牙齿的牙齿美白组合物。可以将成分设计成当已经达到或保持白化程度并被完全侵蚀时除去。在某些实施方案中，组合物是半透明的。还公开了制备和使用组合物的方法。

4. 发明申请

WO2005027768A2 HYDROGEL COMPOSITIONS WITH AN ERODIBLE BACKING MEMBER 审中-公开
标题翻译：具有侵蚀性背衬构件的水凝胶组合物
公开(公告)号：WO2005027768A2
公开(公告)日：2005-03-31
申请号：PCT/US2004/029620
申请日：2004-09-09
申请人： CORIUM INTERNATIONAL , A.V. TOPCHIEV INSTITUTE OF PETROCHEMICAL SYNTHESIS , SINGH, Parminder , FAASSE, Adrian , CLEARY, Gary, W. , MUDUMBA, Sri , FELDSTEIN, Mikhail , BAIRAMOV, Danir
发明人： SINGH, Parminder , FAASSE, Adrian , CLEARY, Gary, W. , MUDUMBA, Sri , FELDSTEIN, Mikhail , BAIRAMOV, Danir
IPC分类号： A61C
CPC分类号： A61K8/0204 , A61C19/066 , A61K8/0208 , A61K8/042 , A61K8/22 , A61K8/42 , A61K8/731 , A61K8/733 , A61K8/8147 , A61K8/8152 , A61K8/817 , A61K8/8176 , A61K8/86 , A61K2800/262 , A61K2800/54 , A61K2800/5422 , A61L15/60 , A61L15/64 , A61Q11/00 , C08L2312/00
摘要： A composition is provided, wherein the composition comprises a water-swellable, water-insoluble polymer and a blend of a hydrophilic polymer with a complementary oligomer capable of hydrogen or electrostatic bonding to the hydrophilic polymer. The composition also includes a backing member. Active ingredients, such as a whitening agent, may be included. The composition finds utility as an oral dressing, for example, a tooth whitening composition that is applied to the teeth in need of whitening. The composition can be designed to be removed when the degree of whitening has been achieved or left in place and allowed to erode entirely. In certain embodiments, the composition is translucent. Methods for preparing and using the compositions are also disclosed.
摘要翻译：提供了一种组合物，其中所述组合物包含水溶胀性，水不溶性聚合物和亲水性聚合物与能够氢的互补性低聚物或静电结合至亲水性聚合物的共混物。该组合物还包含背衬成分。可以包括活性成分，例如增白剂。该组合物可用作口腔敷料，例如应用于需要增白的牙齿的牙齿增白组合物。当白化已达到或留在原地并完全侵蚀时，组合物可被设计为可去除。在某些实施方案中，组合物是半透明的。还公开了制备和使用该组合物的方法。

5. 发明申请

WO2004054638A3 DERMAL, TRANSDERMAL, MUCOSAL OR TRANSMUCOSAL INGREDIENT DELIVERY DEVICES 审中-公开
标题翻译：皮肤，经皮，粘膜或透肌成分递送装置
公开(公告)号：WO2004054638A3
公开(公告)日：2004-08-12
申请号：PCT/US0339717
申请日：2003-12-12
申请人： CORIUM INT INC , FAASSE ADRIAN L JR , MARCOUX MICHAEL G , CLEARY GARY W , MUDUMBA SREENIVASU
发明人： FAASSE ADRIAN L JR , MARCOUX MICHAEL G , CLEARY GARY W , MUDUMBA SREENIVASU
IPC分类号： A61F13/00 , A61K9/70 , A61K31/60 , A61M20060101 , A61M37/00
CPC分类号： A61K9/703 , A61K9/7084 , A61K31/60
摘要： A dermal, transdermal, mucosal or transmucosal delivery device is provided. The device includes a backing layer, defining an ingredient containing reservoir, a cover for the reservoir having at least one opening therethrough, an adhesive layer and a liner layer. Upon removal of the liner layer, the device may be placed over the desired area of the skin or mucosa and adhesively applied thereto allowing the ingredients to flow from the reservoir through the at least one opening to the dermis or mucosa.
摘要翻译：提供了真皮，透皮，粘膜或透粘膜递送装置。该装置包括背衬层，该背衬层限定含有容器的成分，用于容器的盖具有至少一个穿过其中的开口，粘合剂层和衬垫层。在移除衬垫层时，可以将装置放置在皮肤或粘膜的所需区域上并粘贴到其上，从而允许成分从贮存器通过至少一个开口流到真皮或粘膜。

6. 发明申请

WO2006052593A3 DEVICE AND METHOD FOR DELIVERING AN ORAL CARE AGENT 审中-公开
标题翻译：用于输送口服护理剂的装置和方法
公开(公告)号：WO2006052593A3
公开(公告)日：2007-01-04
申请号：PCT/US2005039632
申请日：2005-11-02
申请人： RANIR LLC , FAASSE ADRIAN L , KLEMM STEVEN RICHARD , GROENEWEG GLEN EDWARD , THELEN ALAN GENE
发明人： FAASSE ADRIAN L , KLEMM STEVEN RICHARD , GROENEWEG GLEN EDWARD , THELEN ALAN GENE
IPC分类号： A61C9/00 , A61C5/00 , A61C15/00 , A61L27/32
CPC分类号： A61C19/063
摘要： An oral care agent delivery device is provided which comprises a permanently deformable backing layer, an oral care layer, and a non-woven binding material with a first part that is substantially invested in the oral care layer and a second part that is substantially invested in the backing layer. The device is sized to fit over a plurality of teeth in an upper or lower dental arch of a subject. The oral care layer comprises at least one oral care agent and at least one hydrophilic polymer. When hydrated, the oral care layer has an adhesiveness relative to the surface of a user's teeth that is sufficient to retain the device on the user's teeth when placed thereon. The device can also have an oral care agent which is activated on hydration of the oral care layer, or an oral care layer which releases the oral care agent over time.
摘要翻译：提供一种口腔护理剂递送装置，其包括永久可变形的背衬层，口腔护理层和非织造粘合材料，其具有基本上投入到口腔护理层中的第一部分和基本上投入在口腔护理层中的第二部分背衬层。该装置的尺寸适于装配在受试者的上部或下部牙弓中的多个牙齿上。口腔护理层包含至少一种口腔护理剂和至少一种亲水性聚合物。当水合时，口腔护理层相对于使用者牙齿的表面具有足够的粘附性，足以在放置在使用者的牙齿上时将该装置保持在使用者的牙齿上。该装置还可以具有在口腔护理层的水合时活化的口腔护理剂，或随着时间释放口腔护理剂的口腔护理层。

7. 发明申请

WO2006052593A2 DEVICE AND METHOD FOR DELIVERING AN ORAL CARE AGENT 审中-公开
标题翻译：用于输送口服护理剂的装置和方法
公开(公告)号：WO2006052593A2
公开(公告)日：2006-05-18
申请号：PCT/US2005/039632
申请日：2005-11-02
申请人： RANIR LLC , FAASSE, Adrian, L. , KLEMM, Steven, Richard , GROENEWEG, Glen, Edward , THELEN, Alan, Gene
发明人： FAASSE, Adrian, L. , KLEMM, Steven, Richard , GROENEWEG, Glen, Edward , THELEN, Alan, Gene
IPC分类号： A61C5/00
CPC分类号： A61C19/063
摘要： An oral care agent delivery device is provided which comprises a permanently deformable backing layer, an oral care layer, and a non-woven binding material with a first part that is substantially invested in the oral care layer and a second part that is substantially invested in the backing layer. The device is sized to fit over a plurality of teeth in an upper or lower dental arch of a subject. The oral care layer comprises at least one oral care agent and at least one hydrophilic polymer. When hydrated, the oral care layer has an adhesiveness relative to the surface of a user's teeth that is sufficient to retain the device on the user's teeth when placed thereon. The device can also have an oral care agent which is activated on hydration of the oral care layer, or an oral care layer which releases the oral care agent over time.
摘要翻译：提供一种口腔护理剂递送装置，其包括永久可变形的背衬层，口腔护理层和非织造粘合材料，其具有基本上投入到口腔护理层中的第一部分和基本上投入在口腔护理层中的第二部分背衬层。该装置的尺寸适于装配在受试者的上部或下部牙弓中的多个牙齿上。口腔护理层包含至少一种口腔护理剂和至少一种亲水性聚合物。当水合时，口腔护理层相对于使用者牙齿的表面具有足够的粘附性，足以在放置在使用者的牙齿上时将该装置保持在使用者的牙齿上。该装置还可以具有在口腔护理层的水合时活化的口腔护理剂，或随着时间释放口腔护理剂的口腔护理层。

8. 发明申请

WO2004054638A2 DERMAL, TRANSDERMAL, MUCOSAL OR TRANSMUCOSAL INGREDIENT DELIVERY DEVICES 审中-公开
标题翻译： DERMAL，TRANSDERMAL，MUCOSAL或TRANSMUCOS成分递送装置
公开(公告)号：WO2004054638A2
公开(公告)日：2004-07-01
申请号：PCT/US2003/039717
申请日：2003-12-12
申请人： CORIUM INTERNATIONAL, INC. , FAASSE, Adrian, L., Jr. , MARCOUX, Michael, G.
发明人： FAASSE, Adrian, L., Jr. , MARCOUX, Michael, G.
IPC分类号： A61M
CPC分类号： A61K9/703 , A61K9/7084 , A61K31/60
摘要： A dermal, transdermal, mucosal or transmucosal delivery device is provided. The device includes a backing layer, defining an ingredient containing reservoir, a cover for the reservoir having at least one opening therethrough, an adhesive layer and a liner layer. Upon removal of the liner layer, the device may be placed over the desired area of the skin or mucosa and adhesively applied thereto allowing the ingredients to flow from the reservoir through the at least one opening to the dermis or mucosa.
摘要翻译：提供了皮肤，透皮，粘膜或经粘膜递送装置。该装置包括背衬层，限定含有成分的储存器，用于储存器的盖具有穿过其中的至少一个开口，粘合剂层和衬垫层。在去除衬里层时，可以将装置放置在皮肤或粘膜的期望区域上并粘附施加于其上，从而允许成分从储存器流过至少一个开口至真皮或粘膜。

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