专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO1994011377A2 WATER SOLUBLE CAMPTOTHECIN DERIVATIVES 审中-公开
标题翻译：水溶性胶体衍生物
公开(公告)号：WO1994011377A2
公开(公告)日：1994-05-26
申请号：PCT/US1993010987
申请日：1993-11-10
申请人： GLAXO INC. , BESTERMAN, Jeffrey, Mark , EVANS, Michael, Glenn , LACKEY, Karen, Elizabeth , LUZZIO, Michael, Joseph , PEEL, Michael, Robert , STERNBACH, Daniel, David
发明人： GLAXO INC.
IPC分类号： C07D491/22
CPC分类号： C07D317/66 , C07D319/18
摘要： The present invention relates to water soluble, camptothecin derivatives of formula (I), wherein A represents a moiety of formula (IIA), (IIB) or (IIC), X is selected from the group consisting of alkyl, aryl, (CH2)mOR , (CH2)mSR and (CH2)mNR R wherein m is an integer of 0 to 6, and R and R are hydrogen, lower alkyl, aryl or together with the nitrogen form a 5-7 membered ring; q is an integer of 0 to 2; n represents the integer 1 or 2; p is an integer of 1 to 6; Y and W are selected from the group consisting of alkyl, aryl, alkoxy, aryloxy and amino, Q is oxygen or sulfur; P is phosphorus; J represents the atoms necessary to complete a 5 or 6 membered aromatic ring; and the pharmaceutically acceptable salts thereof; their use as topoisomerase inhibitors, their preparation; and their use in the treatment of cancer.
摘要翻译：本发明涉及式（I）的水溶性喜树碱衍生物，其中A表示式（IIA），（IIB）或（IIC）的部分，X选自烷基，芳基，（CH 2） mOR 1，（CH2）mSR 1和（CH2）mNR 1 R 2其中m是0-6的整数，R 1和R 2是氢，低级烷基，芳基或与氮一起形成5-7元环; q为0〜2的整数; n表示整数1或2; p为1〜6的整数。 Y和W选自烷基，芳基，烷氧基，芳氧基和氨基，Q是氧或硫; 磷是磷; J表示完成5或6元芳环所必需的原子; 及其药学上可接受的盐; 它们用作拓扑异构酶抑制剂，它们的制备; 并用于治疗癌症。

2. 发明申请

WO9411377A3 WATER SOLUBLE CAMPTOTHECIN DERIVATIVES 审中-公开
标题翻译：水溶性胶体衍生物
公开(公告)号：WO9411377A3
公开(公告)日：1994-08-04
申请号：PCT/US9310987
申请日：1993-11-10
申请人： GLAXO INC , BESTERMAN JEFFREY MARK , EVANS MICHAEL GLENN , LACKEY KAREN ELIZABETH , LUZZIO MICHAEL JOSEPH , PEEL MICHAEL ROBERT , STERNBACH DANIEL DAVID
发明人： BESTERMAN JEFFREY MARK , EVANS MICHAEL GLENN , LACKEY KAREN ELIZABETH , LUZZIO MICHAEL JOSEPH , PEEL MICHAEL ROBERT , STERNBACH DANIEL DAVID
IPC分类号： A61K31/47 , A61K31/675 , A61P35/00 , A61P43/00 , C07D317/66 , C07D319/18 , C07D491/22 , C07F9/6561
CPC分类号： C07D317/66 , C07D319/18
摘要： The present invention relates to water soluble, camptothecin derivatives of formula (I), wherein A represents a moiety of formula (IIA), (IIB) or (IIC), X is selected from the group consisting of alkyl, aryl, (CH2)mOR1, (CH2)mSR1 and (CH¿2?)mNR?1R2¿ wherein m is an integer of 0 to 6, and R?1 and R2¿ are hydrogen, lower alkyl, aryl or together with the nitrogen form a 5-7 membered ring; q is an integer of 0 to 2; n represents the integer 1 or 2; p is an integer of 1 to 6; Y and W are selected from the group consisting of alkyl, aryl, alkoxy, aryloxy and amino, Q is oxygen or sulfur; P is phosphorus; J represents the atoms necessary to complete a 5 or 6 membered aromatic ring; and the pharmaceutically acceptable salts thereof; their use as topoisomerase inhibitors, their preparation; and their use in the treatment of cancer.

3. 发明申请

WO1994025466A1 WATER SOLUBLE DERIVATIVES OF CAMPTOTHECIN AND THEIR USE AS ANTITUMOR AGENTS 审中-公开
标题翻译：卡莫司汀的水溶性衍生物及其作为抗菌剂的用途
公开(公告)号：WO1994025466A1
公开(公告)日：1994-11-10
申请号：PCT/US1994004681
申请日：1994-04-28
申请人： GLAXO, INC. , BESTERMAN, Jeffrey, Mark , EVANS, Michael, Glenn , LUZZIO, Michael, Joseph , MYERS, Peter, Leslie
发明人： GLAXO, INC.
IPC分类号： C07D491/22
CPC分类号： C07D317/66 , C07D319/18
摘要： The present invention relates to water soluble, camptothecin derivatives of formula (I), wherein: n represents the integer 1 or 2; and i) R represents: hydrogen, lower alkyl, (C3-7)cycloalkyl, (C3-7)cycloalkyl lower alkyl, lower alkenyl, hydroxy lower alkyl, amino lower alkyl, lower alkylamino lower alkyl, amino lower alkyl, lower alkoxy lower alkyl or (CH2)tAr wherein: t is 0 to 5 and Ar represents phenyl, furyl, pyridyl, N-methylpyrrolyl, imidazolyl; or phenyl, furyl, pyridyl, N-methylpyrrolyl, imidazolyl, with one or more substituents independently selected from hydroxy, methoxy, halogen, and amino; and R represents: diphenylmethyl or (CH2)tAr; or ii) R1 and R2 taken together with the linking nitrogen represent: N-tetrahydroquinolyl or N-tetrahydroisoquinolyl; and the pharmaceutically acceptable salts and solvates thereof, their use in the treatment of tumors and methods of their preparation.
摘要翻译：本发明涉及式（I）的水溶性喜树碱衍生物，其中：n表示整数1或2; 和（i）R 1表示：氢，低级烷基，（C 3-7）环烷基，（C 3-7）环烷基低级烷基，低级烯基，羟基低级烷基，氨基低级烷基，低级烷基氨基低级烷基，氨基低级烷基，低级烷氧基低级烷基或（CH2）tAr其中：t为0至5，Ar表示苯基，呋喃基，吡啶基，N-甲基吡咯基，咪唑基; 或苯基，呋喃基，吡啶基，N-甲基吡咯基，咪唑基，其中一个或多个取代基独立地选自羟基，甲氧基，卤素和氨基; 和R 2代表：二苯基甲基或（CH 2）t Ar; 或ii）R 1和R 2与连接氮一起代表：N-四氢喹啉基或N-四氢异喹啉基; 及其药学上可接受的盐和溶剂合物，它们在治疗肿瘤中的用途及其制备方法。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式