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1. 发明申请

WO0234310A3 SELF-FORMING ORTHOPEDIC IMPLANTS 审中-公开
标题翻译：自我形成的骨科植入物
公开(公告)号：WO0234310A3
公开(公告)日：2002-10-17
申请号：PCT/US0145406
申请日：2001-10-23
申请人： SDGI HOLDINGS INC , DICKSON ANDREW M , ESTES BRADLEY T
发明人： DICKSON ANDREW M , ESTES BRADLEY T
IPC分类号： A61L27/00 , A61F2/44 , A61L31/04 , A61L31/14 , A61L27/14 , A61L27/50
CPC分类号： A61L31/14 , A61L31/04 , A61L2400/16 , A61L2430/02
摘要： This invention relates to a self-forming orthopedic implant (10, 40, 60A/B, 100, 140, 200, 250, 280 and 330). The implant is formed a shape memory polymer. The implant can be provided in an original configuration selected to facilitate orthopedic treatment of bone defects, fixation of bone fragments and fractures, or selected to induce bone structures to conform to a desired anatomical configuration. Non-limiting examples of preferred configurations include bone spacers or bone plates, connective tissue replacements (i.e., tendons, ligaments, and/or cartilage). In preferred forms, the implant is deformed to an alternative configuration prior to implantation. Upon application of selected stimuli, for example, heating the implant to a temperature where the shape memory polymeric material becomes elastic induces the implant to revert to its original configuration. In use, when the implant is subjected to the selected stimuli, it conforms to a selected bone tissue or alternatively conforms to a configuration that urgers bone structures into a desired alignment and/or configuration. When used to replace connective tissues, the implant exhibits a tensile strengh to allow the adjacent bone structure to articulate, yet provides sufficient force to urge the bone structures into a desired position and alignment.
摘要翻译：本发明涉及一种自成形整形外科植入物（10,40,60A / B，100,140,200,250,280和330）。植入物形成形状记忆聚合物。植入物可以被提供为原始构型，其被选择为促进骨缺损的整形外科治疗，骨碎片和骨折的固定，或者被选择以诱导骨结构以符合期望的解剖结构。优选构造的非限制性实例包括骨间隔器或骨板，结缔组织替代物（即肌腱，韧带和/或软骨）。在优选的形式中，植入物在植入之前变形为替代构型。例如，在施加选择的刺激时，将植入物加热到形状记忆聚合物材料变得弹性的温度，导致植入物恢复到其原始构造。在使用中，当植入物受到选择的刺激时，其与所选择的骨组织一致或者可选地符合将骨结构促成为期望的对准和/或构造的构造。当用于替代结缔组织时，植入物表现出拉伸强度，以允许相邻骨结构关节连接，但提供足够的力将骨结构推动到期望的位置和对齐。

2. 发明申请

WO0168005A3 VERTEBRAL IMPLANT FOR PROMOTING ARTHRODESIS OF THE SPINE 审中-公开
标题翻译：用于促进脊椎动物的VERTEBRAL植入物
公开(公告)号：WO0168005A3
公开(公告)日：2002-08-29
申请号：PCT/US0108073
申请日：2001-03-14
申请人： SDGI HOLDINGS INC , LIU MINGYAN , FRUH HANS-JOACHIM , EBNER HARALD , ESTES BRADLEY T
发明人： LIU MINGYAN , FRUH HANS-JOACHIM , EBNER HARALD , ESTES BRADLEY T
IPC分类号： A61B17/58 , A61F2/00 , A61F2/28 , A61F2/30 , A61F2/44 , A61F2/46
CPC分类号： A61F2/447 , A61F2/30965 , A61F2/442 , A61F2/4611 , A61F2002/2835 , A61F2002/3008 , A61F2002/30271 , A61F2002/30774 , A61F2002/30785 , A61F2002/30789 , A61F2002/4475 , A61F2230/0082 , A61F2250/0098
摘要： This invention provides a vertebral spacer (1, 80) for impaction in a disc space to restore and/or maintain desired disc space height and spinal orientation. The spacer has an elongated basis body (2, 82) having a generally lens-shape provided by convex upper and lower surfaces (24, 26, 86, and 87). Bearing surfaces (8, 8',9, 9', 98 and 100) are provided on the cross-edge surfaces of the endwalls (6, 7, 94 and 96). Grooves (16, 16' and 104) are provided in the upper and lower surfaces positioned between the bearing surfaces. The spacer (1, 80) can be prepared from a wide variety of materials including metallic materials, synthetic materials, polymeric materials, ceramic materials, and composite materials including reinforced materials i.e. glass, fiber, and/or carbon fiber reinforced materials (CFRP). These preferred materials for fabricating spacers in the present invention reduce costs, increase service life and provide excellent physiological compatibility. The non-metallic material can be selected to be either a substantially permanent material, a biodegradable material or a bioerodable material. Further, the spacer material can be provided to be radio opaque to facilitate monitoring of bone in growth both into the spacer and between the opposing endplates of the adjacent vertebrae.
摘要翻译：本发明提供一种用于在椎间盘空间中撞击以恢复和/或维持期望的椎间盘高度和脊柱取向的椎间隔物（1,80）。间隔件具有由凸形的上表面和下表面（24,26,86和87）提供的具有大致透镜形状的细长基体（2,82）。轴承表面（8,8'，9,9'，98和100）设置在端壁（6,7,94和96）的交叉边缘表面上。沟槽（16,16'和104）设置在位于支承表面之间的上表面和下表面中。间隔物（1,80）可以由各种材料制备，包括金属材料，合成材料，聚合材料，陶瓷材料和复合材料，包括增强材料，例如玻璃，纤维和/或碳纤维增强材料（CFRP）。在本发明中用于制造间隔物的这些优选材料降低成本，延长使用寿命并提供优异的生理相容性。非金属材料可以选择为基本上永久性的材料，可生物降解的材料或生物可蚀塑料。此外，间隔物材料可以设置为无线电不透明的，以便于监测生长中的骨骼，进入间隔物和相邻椎骨的相对端板之间。

3. 发明申请

WO2002058574A2 ANTERIOR LUMBAR PLATE AND METHOD 审中-公开
标题翻译：前腰板及方法
公开(公告)号：WO2002058574A2
公开(公告)日：2002-08-01
申请号：PCT/US2001/049610
申请日：2001-10-24
申请人： SDGI HOLDINGS, INC. , KOZAK, Jeffrey , ESTES, Bradley, T. , BOYD, Lawrence, M.
发明人： KOZAK, Jeffrey , ESTES, Bradley, T. , BOYD, Lawrence, M.
IPC分类号： A61B17/70
CPC分类号： A61B17/8042 , A61B17/7055 , A61B17/7059 , A61B17/8047 , Y10S606/90
摘要： A plate (11) of biocompatible material is provided having curvature in two planes such that it conforms to the curvature of the L5 vertebral body and to the patient's lordotic curve. Holes are provided receiving screws (16, 20) for anchorage in the vertebral body and sacrum. A flange or foot portion on the plate provides a wider base end area (11B) for support in the L5-S1 interspace. The foot portion is also arranged for appropriate entry angle of screws (20) into the sacrum such as to improve anchorage in the sacrum. Anti-backout and low profile features (21, 22) are incorporated. The anterior lumbar plate is situated to maintain the anterior interbody bone graft (31) in compression by resisting tensile forces during extension.
摘要翻译：提供生物相容性材料的板（11），其在两个平面中具有曲率，使得其符合L5椎体的曲率和患者的脊索曲线。孔设置有用于在椎体和骶骨中锚固的接收螺钉（16,20）。板上的凸缘或脚部提供了用于支撑在L5-S1间隙中的更宽的基端部区域（11B）。脚部还布置成适于将螺钉（20）进入骶骨的入口角度，以改善骶骨中的锚固。防止回退和低调特征（21,22）。前腰椎板位于通过阻止拉伸期间的拉伸力来保持前体骨间移植物（31）的压缩。

4. 发明申请

WO0234159A2 NON-METALLIC IMPLANT DEVICES AND INTRA-OPERATIVE METHODS FOR ASSEMBLY AND FIXATION 审中-公开
标题翻译：非金属植入装置和装配和固定的操作方法
公开(公告)号：WO0234159A2
公开(公告)日：2002-05-02
申请号：PCT/US0145608
申请日：2001-10-23
申请人： SDGI HOLDINGS INC , TRIEU HAI H , JUSTIS JEFF R , DREWRY TROY D , SHERMAN MICHAEL C , COATES BRADLEY J , ESTES BRADLEY T
发明人： TRIEU HAI H , JUSTIS JEFF R , DREWRY TROY D , SHERMAN MICHAEL C , COATES BRADLEY J , ESTES BRADLEY T
IPC分类号： A61B17/58 , A61B17/56 , A61B17/70 , A61B17/80 , A61B17/86 , A61F2/08 , A61L24/00 , A61L27/00 , A61F2/00
CPC分类号： A61B17/8042 , A61B17/7059 , A61B17/8052 , A61B17/8085 , A61B17/866 , A61B2017/00004 , A61F2/0811
摘要： This invention relates to orthopedic implants (10, 50, 90, 100, 140, 190, 250, 280, 300, 320, 340, 360, 370, 380, 400 and 440) and to methods of treating bone defects. More specifically, but not exclusively, the present invention is directed to non-metallic implants and to methods for intra-operative assembly and fixation of orthopedic implants to facilitate medical treatment. The non-metallic implant assembly can be secured to underlying tissue by a fastener, such as a bone screw, that is capable of swelling on contact with fluid in the underlying tissue. Alternatively, the non-metallic implant assembly can be assembled intra-operatively using a fastener that is adhesively bonded to a bone plate or the bone plate can be deformed using heat, force or solvents to inhibit withdrawal of the fastener. In preferred embodiments, both the fastener and the bone plate are formed of biodegradable material.
摘要翻译：本发明涉及矫形植入物（10,50,90,100,140,190,250,280,300,340,340,360,370,380,400,440）以及治疗骨缺损的方法。更具体地但非唯一地，本发明涉及非金属植入物以及用于手术中组装和固定矫形植入物以方便医疗的方法。非金属植入物组件可以通过紧固件（例如骨螺钉）固定到下面的组织上，该紧固件能够在与下面的组织中的流体接触时膨胀。或者，非金属植入物组件可以使用粘合剂粘合到骨板上的紧固件在手术中组装，或者骨板可以使用热，力或溶剂变形以阻止紧固件的拉出。在优选实施例中，紧固件和骨板都是由可生物降解的材料形成的。

5. 发明申请

WO0041654B1 TRUNCATED OPEN INTERVERTEBRAL SPACERS 审中-公开
标题翻译：闭合开放的椎间隙
公开(公告)号：WO0041654B1
公开(公告)日：2002-02-07
申请号：PCT/US0000590
申请日：2000-01-11
申请人： SDGI HOLDINGS INC , BOYD LAWRENCE M , BURKUS J KENNETH , DORCHAK JOHN D , ESTES BRADLEY T , RAY EDDIE F III
发明人： BOYD LAWRENCE M , BURKUS J KENNETH , DORCHAK JOHN D , ESTES BRADLEY T , RAY EDDIE F III
IPC分类号： A61F2/00 , A61F2/28 , A61F2/30 , A61F2/44 , A61F2/46
CPC分类号： A61F2/4611 , A61F2/28 , A61F2/442 , A61F2/446 , A61F2002/2817 , A61F2002/2835 , A61F2002/2839 , A61F2002/30131 , A61F2002/30611 , A61F2002/30677 , A61F2002/30772 , A61F2002/30777 , A61F2002/30787 , A61F2002/3082 , A61F2002/30858 , A61F2002/30871 , A61F2002/4475 , A61F2002/448 , A61F2002/4627 , A61F2002/4649 , A61F2230/0013 , A61F2250/0063 , A61F2310/00017 , A61F2310/00023 , A61F2310/00293
摘要： Open chambered spacers, implanting tools and methods are provided. The spacers (100) include a body (105) having a wall (106) which defines a chamber (130) and an opening (131) in communication with the chamber (130). In one embodiment the wall (106) includes a pair of arms (120, 121) facing one another and forming a mouth (110) to the chamber (130). Each of the arms has an end configured to form a region within which an adjacent spacer can nest. In one aspect the body (105) is a bone dowel comprising an off-center plug from the diaphysis of a long bone. The tool (300) includes spacer engaging means for engaging a spacer and occlusion means for blocking an opening defined in the spacer. In some embodiments, the occlusion means (320) includes a plate (321) extendible from the housing (305). In one specific embodiment the plate (321) defines a groove (322) which is disposed around a fastener (330) attached to the housing (305) so that the plate (321) is slideable relative to the housing (305).
摘要翻译：提供开放式隔板，植入工具和方法。间隔件（100）包括具有限定腔室（130）的壁（106）和与腔室（130）连通的开口（131）的本体（105）。在一个实施例中，壁（106）包括彼此面对并且形成到腔室（130）的口（110）的一对臂（120,121）。每个臂具有构造成形成相邻间隔物可嵌套在其中的区域的端部。在一个方面，主体（105）是包括来自长骨骨干的偏心塞的骨榫。工具（300）包括用于接合间隔件的间隔件接合装置和用于阻挡限定在间隔件中的开口的闭塞装置。在一些实施例中，闭塞装置（320）包括可从壳体（305）延伸的板（321）。在一个具体实施例中，板（321）限定了一个设置在附接到壳体（305）的紧固件（330）周围的凹槽（322），使得板（321）相对于壳体（305）可滑动。

6. 发明申请

WO9952446B1 METHOD AND INSTRUMENTATION FOR POSTERIOR INTERBODY FUSION 审中-公开
标题翻译：用于后置融合的方法和仪器
公开(公告)号：WO9952446B1
公开(公告)日：2000-03-02
申请号：PCT/US9907805
申请日：1999-04-09
申请人： SDGI HOLDINGS INC , ESTES BRADLEY T , HAID REGIS W JR , RAY EDDIE F III , MOORE JEFFREY D , RODTS GERALD E JR
发明人： ESTES BRADLEY T , HAID REGIS W JR , RAY EDDIE F III , MOORE JEFFREY D , RODTS GERALD E JR
IPC分类号： A61B17/02 , A61B17/17 , A61B19/00 , A61F2/46
CPC分类号： A61B17/1757 , A61B17/025 , A61B2017/0256 , A61B2090/062 , A61F2/4611 , A61F2002/4627 , A61F2002/4687
摘要： A method and instrumentation for spinal interbody fusion is disclosed. The instruments and methods are particularly adapted for interbody fusion from a posterior approach to the spine. One instrument is a retractor (10) having a lockable pivotally mounted handle (12). Another instrument is a template (100) for straddling the dura. A modular distractor (150) is also provided and preferably includes a tapered shaft (160) with a visualization window (168) disposed therein. Yet another instrument is a depth gauge (360) to verify bone opening depth and dimension, preferably including a radiopaque portion (370). A method contemplates the use of these instruments to prepare a disc space to receive an implant.
摘要翻译：公开了一种脊柱体内融合的方法和仪器。仪器和方法特别适用于从后路到脊柱的椎间融合。一个乐器是具有可锁定的可枢转地安装的手柄（12）的牵开器（10）。另一种仪器是跨越硬脑膜的模板（100）。还提供了模块化牵引器（150），并且优选地包括具有设置在其中的可视化窗口（168）的锥形轴（160）。另一种仪器是用于验证骨骼开口深度和尺寸的深度计（360），优选地包括不透射线部分（370）。一种方法考虑使用这些器械来准备椎间盘以接收植入物。

7. 发明申请

WO9952453A3 METHOD AND INSTRUMENTATION FOR VERTEBRAL INTERBODY FUSION 审中-公开
标题翻译： VERTEBRAL INTERBODY FUSION的方法与仪器
公开(公告)号：WO9952453A3
公开(公告)日：2000-01-13
申请号：PCT/US9907868
申请日：1999-04-09
申请人： SDGI HOLDINGS INC , BOYD LAWRENCE M , RAY EDDIE F III , ESTES BRADLEY T , LIU MINGYAN
发明人： BOYD LAWRENCE M , RAY EDDIE F III , ESTES BRADLEY T , LIU MINGYAN
IPC分类号： A61B17/56 , A61B17/00 , A61B17/02 , A61B17/16 , A61B17/17 , A61B17/34 , A61B19/00 , A61F2/46 , B23D77/00
CPC分类号： A61B17/025 , A61B17/1615 , A61B17/1617 , A61B17/1637 , A61B17/1655 , A61B17/1671 , A61B17/1757 , A61B2017/0256 , A61B2017/3445 , A61B2090/034 , A61B2090/062 , A61F2/4611 , A61F2002/4627 , A61F2002/4687
摘要： A method and instrumentation particularly adapted for disc space preparation from an anterior approach to the spine. In one aspect, an expandable template (10) is provided having guides (26 and 24) to guide a cutting device (601) for bilateral formation of openings in the disc space. In another aspect, an improved guide member (450) is provided for guiding a cutting tool. Still further, the invention provides an improved double barrel guide sleeve (100) with a central distraction extension (116) and lateral non-distracting extensions (118 and 120). Optionally, the guide sleeve (100) includes windows (110 and 112) and a cover (160) to selectively cover the windows. An improved reamer (200) with an internal chamber (209) and optional modular coupling (254) is also provided. A depth stop (326) is provided to selectively engage a tool shaft (360) and a guide sleeve (370) to control tool penetration into the disc space. A method of using the disclosed instruments is also provided.
摘要翻译：一种方法和仪器，特别适用于从脊椎前路进入椎间盘的准备。在一个方面，提供了一种可扩张模板（10），其具有引导件（26和24）以引导用于在盘片空间中双边形成开口的切割装置（601）。另一方面，提供了一种用于引导切割工具的改进的引导构件（450）。此外，本发明提供了一种具有中心牵引延伸部（116）和横向非分散延伸部（118和120）的改进的双筒引导套筒（100）。可选地，导向套筒（100）包括窗口（110和112）以及用于选择性地覆盖窗户的盖子（160）。还提供了具有内部腔室（209）和可选的模块联接件（254）的改进的铰刀（200）。提供深度限位器（326）以选择性地接合工具轴（360）和引导套筒（370），以控制工具穿入盘片空间。还提供了使用所公开的仪器的方法。

8. 发明申请

WO2007030811A3 TISSUE ENGINEERING METHODS AND COMPOSITIONS 审中-公开
标题翻译：组织工程方法与组成
公开(公告)号：WO2007030811A3
公开(公告)日：2009-04-16
申请号：PCT/US2006035243
申请日：2006-09-11
申请人： UNIV DUKE , GUILAK FARSHID , ESTES BRADLEY T , WU ARTHUR W
发明人： GUILAK FARSHID , ESTES BRADLEY T , WU ARTHUR W
IPC分类号： C12N5/0775
CPC分类号： A61L27/54 , A61K35/12 , A61K35/28 , A61K35/32 , A61K35/33 , A61K38/1841 , A61K38/1875 , A61K38/30 , C12N5/0667 , C12N2501/105 , C12N2501/11 , C12N2501/115 , C12N2501/135 , C12N2501/15 , C12N2501/155 , C12N2501/23 , C12N2501/37 , C12N2501/39 , C12N2533/30 , C12N2533/40
摘要： The presently disclosed subject matter generally relates to methods and systems for facilitating the growth and differentiation of adipose-derived stem cells for laboratory and therapeutic applications. The cells can be employed alone or in conjunction with unique biologically-compatible scaffold structures to generate differentiated tissues and structures, both in vitro and in vivo. The presently disclosed subject matter further relates to methods of forming and using improved tissue engineered scaffolds that can be used as substrates to facilitate the growth and differentiation of cells.
摘要翻译：目前公开的主题一般涉及促进脂肪来源的干细胞在实验室和治疗应用中的生长和分化的方法和系统。细胞可以单独使用或与独特的生物相容性支架结构结合使用，以在体外和体内产生分化的组织和结构。目前公开的主题还涉及形成和使用改进的组织工程化支架的方法，其可以用作底物以促进细胞的生长和分化。

9. 发明申请

WO0234144A9 METHODS AND INSTRUMENTS FOR INTERBODY SURGICAL TECHNIQUES 审中-公开
标题翻译：方法和仪器的内部手术技术
公开(公告)号：WO0234144A9
公开(公告)日：2002-07-18
申请号：PCT/US0142457
申请日：2001-10-02
申请人： SDGI HOLDINGS INC , FOLEY KEVIN T , MOORE JEFFREY D , ESTES BRADLEY T , LIU MINGYAN , JOSSE LOIC
发明人： FOLEY KEVIN T , MOORE JEFFREY D , ESTES BRADLEY T , LIU MINGYAN , JOSSE LOIC
IPC分类号： A61B17/56 , A61B17/00 , A61B17/02 , A61B17/16 , A61B17/17 , A61B17/32
CPC分类号： A61B17/1757 , A61B17/1604 , A61B17/1671 , A61B17/320016 , A61B2017/00261 , A61B2017/0256
摘要： This invention relates to methods and instruments for performing a surgical procedure in a disc space between adjacent vertebrae. The instruments include a distractor (18) and a cutting instrument (52). In one embodiment the distractor includes a body portion (20) and a pair of flanges (26, 28) extending along opposite sides of the body portion (20) such that a slot (42, 44) is formed between the flanges (26, 28) and the body portion (20). The cutting instrument (52) is positionable over the body portion (20) and into the slots (42, 44) of the distractor (18) so that the flanges (26, 28) are positioned between the cutting instrument (52) and the adjacent tissue.
摘要翻译：本发明涉及用于在相邻椎骨之间的椎间盘空间中执行外科手术的方法和装置。仪器包括牵引器（18）和切割仪器（52）。在一个实施例中，牵引器包括主体部分（20）和沿主体部分（20）的相对侧延伸的一对凸缘（26,28），使得在凸缘（26， 28）和主体部分（20）。切割工具（52）可定位在主体部分（20）上并进入牵引机（18）的槽（42,44）中，使得凸缘（26,28）位于切割仪器（52）和相邻组织。

10. 发明申请

WO0128461A3 IMPACTED ORTHOPEDIC BONE SUPPORT IMPLANT 审中-公开
标题翻译：影响骨性支持植入物
公开(公告)号：WO0128461A3
公开(公告)日：2002-01-03
申请号：PCT/US0041392
申请日：2000-10-20
申请人： SDGI HOLDINGS INC , BRANCH CHARLES L , WHITE JOHN L , ESTES BRADLEY T , RAY EDDIE F III
发明人： BRANCH CHARLES L , WHITE JOHN L , ESTES BRADLEY T , RAY EDDIE F III
IPC分类号： A61B17/14 , A61B17/16 , A61F2/00 , A61F2/28 , A61F2/30 , A61F2/44 , A61F2/46
CPC分类号： A61F2/446 , A61B17/14 , A61B17/1604 , A61F2/28 , A61F2/2846 , A61F2/30965 , A61F2/442 , A61F2/4455 , A61F2/4603 , A61F2/4611 , A61F2002/2835 , A61F2002/2839 , A61F2002/30112 , A61F2002/30138 , A61F2002/30153 , A61F2002/30154 , A61F2002/30156 , A61F2002/30235 , A61F2002/30271 , A61F2002/30324 , A61F2002/30593 , A61F2002/30616 , A61F2002/30774 , A61F2002/30777 , A61F2002/30785 , A61F2002/30787 , A61F2002/30789 , A61F2002/3082 , A61F2002/30836 , A61F2002/30879 , A61F2002/30912 , A61F2002/3097 , A61F2002/4475 , A61F2002/4623 , A61F2002/4649 , A61F2002/4681 , A61F2230/0004 , A61F2230/0017 , A61F2230/0019 , A61F2230/0021 , A61F2230/0023 , A61F2230/0069 , A61F2230/0082 , A61F2250/0036 , A61F2310/00017 , A61F2310/00023 , A61F2310/00179
摘要： This invention relates to a porous bone implant (10, 110, and 210), a method of manufacturing the implant and a method of orthopedic treatment. The mesh implant can be manufactured using extrusion techniques and a variety of cutting and machining processes to provide the implant with the desired structural features and in the required dimensions to be matingly received within the bone defect or cavity. The implant can be used to strengthen bone structures and support bone tissue adjacent to a defect of cavity. Thus, the implant can be used to provide improved treatment of patients having bone defects or diseases with decreased postoperative pain and a shorter recovery time.
摘要翻译：本发明涉及多孔骨植入物（10,110和210），制造植入物的方法和矫形治疗方法。网状植入物可以使用挤出技术和各种切割和机械加工工艺制造，以使植入物具有期望的结构特征，并且在所需的尺寸内被配合地接纳在骨缺损或空腔内。植入物可用于加强骨结构并支持与腔的缺损相邻的骨组织。因此，可以使用植入物来提供具有骨缺损的患者或具有降低的术后疼痛的疾病和更短的恢复时间的改善的治疗。

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