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1. 发明申请

WO2008124798A1 SELECTION METHOD FOR CELL INTERNALIZING NUCLEIC ACIDS 审中-公开
标题翻译：细胞内含核酸的选择方法
公开(公告)号：WO2008124798A1
公开(公告)日：2008-10-16
申请号：PCT/US2008/059805
申请日：2008-04-09
申请人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM , ELLINGTON, Andrew, D. , LEVY, Matthew , YAN, Amy , CHU, Chi-tai
发明人： ELLINGTON, Andrew, D. , LEVY, Matthew , YAN, Amy , CHU, Chi-tai
IPC分类号： C12Q1/68
CPC分类号： C12N15/1034 , C12N15/1048
摘要： The present invention includes compositions and methods for contacting one or more cells with a random RNA-containing library, treating the contacted cells and with a denaturing agent or digestion with one or more nucleases, and extracting from the cells one or more internalized nucleic acids resistant to the nucleases or denaturants.
摘要翻译：本发明包括用于使一个或多个细胞与含有随机RNA的文库接触的组合物和方法，用一种或多种核酸酶处理接触的细胞和变性剂或消化，并从细胞中提取一种或多种耐受内化的核酸到核酸酶或变性剂。

2. 发明申请

WO2006074451A9 TARGETED CHIMERIC MOLECULES FOR CANCER THERAPY 审中-公开
标题翻译：针对癌症治疗的靶向分子
公开(公告)号：WO2006074451A9
公开(公告)日：2007-04-26
申请号：PCT/US2006000828
申请日：2006-01-10
申请人： RES DEV FOUNDATION , ROSENBLUM MICHAEL G , ELLINGTON ANDREW D
发明人： ROSENBLUM MICHAEL G , ELLINGTON ANDREW D
IPC分类号： A61K47/48 , A61P35/00 , C07K16/32
CPC分类号： C07K16/32 , A61K41/0038 , A61K47/6849 , A61K47/6859 , C07K16/30 , C07K2317/622 , C07K2317/73 , C07K2317/77 , C07K2319/00
摘要： The present invention concerns chimeric cancer therapeutic molecules comprising a targeting moiety and an anti-cell proliferation moiety. The anti-cell proliferation moiety may comprise a cytotoxic agent or an apoptosis-inducing factor, in specific embodiments. In particular embodiments, the anti-cell proliferation mechanism of the chimeric molecules comprises apoptotic pathways. In additional embodiments, the chimeric molecules of the present invention provide sensitivity to chemotherapy in a cell that is resistant to the chemotherapy.
摘要翻译：本发明涉及包含靶向部分和抗细胞增殖部分的嵌合癌症治疗分子。在特定实施方案中，抗细胞增殖部分可以包含细胞毒性剂或凋亡诱导因子。在具体实施方案中，嵌合分子的抗细胞增殖机制包括凋亡途径。在另外的实施方案中，本发明的嵌合分子对耐化学疗法的细胞中的化学疗法提供敏感性。

3. 发明申请

WO2003075765A1 BIOSPECIFIC CONTRAST AGENTS 审中-公开
标题翻译： BIOSPECIFIC对比代理
公开(公告)号：WO2003075765A1
公开(公告)日：2003-09-18
申请号：PCT/US2003/006730
申请日：2003-03-05
申请人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM , SOKOLOV, Konstantin , KORGEL, Brian, A. , ELLINGTON, Andrew, D. , RICHARDS-KORTUM, Rebecca
发明人： SOKOLOV, Konstantin , KORGEL, Brian, A. , ELLINGTON, Andrew, D. , RICHARDS-KORTUM, Rebecca
IPC分类号： A61B6/00
CPC分类号： A61B5/0059 , A61B5/411 , A61B5/415 , A61B5/416 , A61B5/418 , A61K49/00 , A61K49/0017 , A61K49/0058 , A61K49/0067 , B82Y15/00 , B82Y30/00 , G01N33/587 , G01N33/588
摘要： Methods and apparatuses for detecting a condition of a sample (including, cervical cancers and pre-cancers) through reflectance and/or fluorescence imaging include obtaining a sample and one or more metallic nanoparticles and/or one or more quantum dots (A). The one or more metallic nanoparticles and/or one or more quantum dots are coupled to one or more biomarkers (B) of the sample that are associated with the condition. A reflectance and/or fluorescence image (C) of the sample is then taken. The image(s) exhibit characteristic optical scattering from the one or more metallic nanoparticles and/or characteristic fluorescence excitation from the one or more quantum dots to signal the presence of the one or more biomarkers. In this way, the condition can be readily screened or diagnosed.
摘要翻译：通过反射和/或荧光成像检测样品（包括宫颈癌和癌前病症）的方法和装置包括获得样品和一种或多种金属纳米颗粒和/或一种或多种量子点（A）。一种或多种金属纳米颗粒和/或一个或多个量子点与与该条件相关联的样品的一个或多个生物标志物（B）偶联。然后取样品的反射率和/或荧光图像（C）。该图像表现出来自一种或多种金属纳米颗粒的特征光学散射和/或来自一个或多个量子点的特征荧光激发以发出一个或多个生物标志物的存在。以这种方式，可以容易地筛选或诊断病症。

4. 发明申请

WO0204630A3 METHODS FOR RECOMBINATORIAL NUCLEIC ACID SYNTHESIS 审中-公开
标题翻译：重组核酸合成方法
公开(公告)号：WO0204630A3
公开(公告)日：2002-08-29
申请号：PCT/US0122195
申请日：2001-07-10
申请人： AMBION INC , MURPHY GEORGE L , SETTERQUIST ROBERT A , ELLINGTON ANDREW D
发明人： MURPHY GEORGE L , SETTERQUIST ROBERT A , ELLINGTON ANDREW D
IPC分类号： C12N15/10 , C12P19/34 , C12Q1/68
CPC分类号： C12N15/1027 , C12P19/34
摘要： This invention pertains to a method for generating a pool of nucleic acid fragments useful for in vitro recombination and the creation of novel DNA sequences that encode desirable proteins or enzymes. The invention provides a defined mixture of nucleic acids and methods for use in the synthesis, mutagenesis, and recombination of nucleic acids. Nucleic acids may be synthesized by creating a nucleic acid extension ladder, annealing the extension ladder to template nuclear acids, and further extending the ladder of nucleic acids. The invention also relates to methods for performing repeated cycles of synthesis for the purpose of mutagenesis or recombination, methods for producing mutant peptides and proteins from the mutagenized or recombined nucleic acids, and methods for selecting a peptide, polypeptide or protein having altered biological activities.
摘要翻译：本发明涉及用于产生可用于体外重组的核酸片段库并产生编码所需蛋白质或酶的新型DNA序列的方法。本发明提供了核酸的限定混合物和用于核酸的合成，诱变和重组的核酸的方法。核酸可通过产生核酸延伸梯，将延伸梯退火至模板核酸并进一步延伸核酸的梯子来合成。本发明还涉及用于进行用于诱变或重组目的的重复合成循环的方法，用于从诱变的或重组的核酸产生突变的肽和蛋白质的方法，以及用于选择具有改变的生物学活性的肽，多肽或蛋白质的方法。

5. 发明申请

WO2007027796A3 PROXIMITY LIGATION ASSAYS WITH PEPTIDE CONJUGATE 'BURRS' AND APTAMERS FOR THE SENSITIVE DETECTION OF SPORES AND CANCER CELLS 审中-公开
标题翻译：与PEPTIDE CONJUGATE'BURRS'和APTAMERS的敏感性测定用于敏感检测运动和癌细胞
公开(公告)号：WO2007027796A3
公开(公告)日：2007-09-07
申请号：PCT/US2006033896
申请日：2006-08-30
申请人： UNIV TEXAS , LEVY MATTHEW , ELLINGTON ANDREW D , PAI SUPRIYA
发明人： LEVY MATTHEW , ELLINGTON ANDREW D , PAI SUPRIYA
IPC分类号： C12Q1/68
CPC分类号： G01N33/56983 , G01N33/56911 , G01N33/56966 , G01N2458/10
摘要： The present invention includes compositions and methods for the detection of specific targets on a surface that includes one or more peptides and one or more oligonucleotides connected by a joint to a detectable marker, wherein the joint between the peptides, the oligonucleotides or both the peptides and oligonucleotides are immobilized.
摘要翻译：本发明包括用于检测表面上特异性靶标的组合物和方法，其包括一个或多个肽和一个或多个通过接头与可检测标记连接的寡核苷酸，其中所述肽，寡核苷酸或肽两者之间的连接寡核苷酸被固定化。

6. 发明申请

WO2006074451A3 TARGETED CHIMERIC MOLECULES FOR CANCER THERAPY 审中-公开
公开(公告)号：WO2006074451A3
公开(公告)日：2006-07-13
申请号：PCT/US2006/000828
申请日：2006-01-10
申请人： RESEARCH DEVELOPMENT FOUNDATION , ROSENBLUM, Michael, G. , ELLINGTON, Andrew, D.
发明人： ROSENBLUM, Michael, G. , ELLINGTON, Andrew, D.
IPC分类号： A61K47/48 , A61P35/00 , C07K16/32
摘要： The present invention concerns chimeric cancer therapeutic molecules comprising a targeting moiety and an anti-cell proliferation moiety. The anti-cell proliferation moiety may comprise a cytotoxic agent or an apoptosis-inducing factor, in specific embodiments. In particular embodiments, the anti-cell proliferation mechanism of the chimeric molecules comprises apoptotic pathways. In additional embodiments, the chimeric molecules of the present invention provide sensitivity to chemotherapy in a cell that is resistant to the chemotherapy.

7. 发明申请

WO0022115A9 ASSAYS FOR IDENTIFYING FUNCTIONAL ALTERATIONS IN THE P53 TUMOR SUPPRESSOR 审中-公开
标题翻译：用于鉴别P53肿瘤抑制剂功能改变的测定
公开(公告)号：WO0022115A9
公开(公告)日：2002-08-29
申请号：PCT/US9924072
申请日：1999-10-13
申请人： UNIV TEXAS , ADVANCED RES & TECH INST , ELLINGTON ANDREW D , MATSUMURA ICHIRO
发明人： ELLINGTON ANDREW D , MATSUMURA ICHIRO
IPC分类号： C07K14/47 , C12N15/10 , C12Q1/68
CPC分类号： C12N15/1058 , C07K14/4746 , C12Q1/6886 , C12Q1/6897 , C12Q2600/156 , C12Q2600/158
摘要： The present invention provides for various screening assays which are amenable to high throughput formats and identify a variety of useful mutations in tumor suppressor genes such as p53. Such mutations include those that activate the molecule, increase thermostability, increase transcriptional activity and facilitate resistance to inhibitory molecules. Also provided are methods of screening for accessory proteins that interact with tumor suppressors in both inhibitory and activating fashions, as well as cleavable mutants of p53 that are activated by viral proteases.
摘要翻译：本发明提供适用于高通量格式并鉴定肿瘤抑制基因如p53中的各种有用突变的各种筛选分析。这些突变包括激活分子，增加热稳定性，增加转录活性和促进对抑制性分子的抗性的突变。还提供了筛选与抑制和激活时尚中的肿瘤抑制因子相互作用的辅助蛋白质的方法，以及由病毒蛋白酶激活的可切割的p53突变体。

8. 发明申请

WO2011146514A2 RAPID ISOLATION OF MONOCLONAL ANTIBODIES FROM ANIMALS 审中-公开
标题翻译：从动物快速分离单克隆抗体
公开(公告)号：WO2011146514A2
公开(公告)日：2011-11-24
申请号：PCT/US2011/036852
申请日：2011-05-17
申请人： THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM , REDDY, Sai , GE, Xin , BOUTZ, Danny , ELLINGTON, Andrew, D. , MARCOTTE, Edward, M. , LAVINDER, Jason , GEORGIOU, George
发明人： REDDY, Sai , GE, Xin , BOUTZ, Danny , ELLINGTON, Andrew, D. , MARCOTTE, Edward, M. , LAVINDER, Jason , GEORGIOU, George
CPC分类号： G06F19/24 , C07K16/065 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/92 , C12Q1/6881 , C12Q2600/16 , C40B30/04 , G01N33/6857
摘要： Methods and compositions for identification of candicate antigen-specific variable regions as well as generation of antibodies or antigen-binding fragments that could have desired antigen specificity are provided. For example, in certain aspects methods for determining amino acid sequences of serum antibody CDR and abundancy level are described. In some aspects, methods for determining nucleic acid sequences of antibody variable region sequences and frequency are provided. Furthermore, the invention provides methods for identification and generation of antibody or antigen-binding fragments that comprise highly-represented CDR.
摘要翻译：提供了用于鉴定可以具有希望的抗原特异性的抗原特异性可变区以及产生抗体或抗原结合片段的方法和组合物。例如，在某些方面，描述了确定血清抗体CDR的氨基酸序列和丰度水平的方法。在一些方面，提供了用于确定抗体可变区序列和频率的核酸序列的方法。此外，本发明提供用于鉴定和产生包含高度表示的CDR的抗体或抗原结合片段的方法。

9. 发明申请

WO2007027796A9 PROXIMITY LIGATION ASSAYS WITH PEPTIDE CONJUGATE 'BURRS' AND APTAMERS FOR THE SENSITIVE DETECTION OF SPORES AND CANCER CELLS 审中-公开
标题翻译：与PEPTIDE CONJUGATE'BURRS'和APTAMERS的敏感性测定用于敏感检测运动和癌细胞
公开(公告)号：WO2007027796A9
公开(公告)日：2007-12-06
申请号：PCT/US2006033896
申请日：2006-08-30
申请人： UNIV TEXAS , LEVY MATTHEW , ELLINGTON ANDREW D , PAI SUPRIYA
发明人： LEVY MATTHEW , ELLINGTON ANDREW D , PAI SUPRIYA
IPC分类号： C12Q1/68
CPC分类号： G01N33/56983 , G01N33/56911 , G01N33/56966 , G01N2458/10
摘要： The present invention includes compositions and methods for the detection of specific targ
摘要翻译：本发明包括用于检测特定targ的组合物和方法

10. 发明申请

WO0022115A2 ASSAYS FOR IDENTIFYING FUNCTIONAL ALTERATIONS IN THE P53 TUMOR SUPPRESSOR 审中-公开
标题翻译：用于鉴别P53肿瘤抑制剂功能改变的测定
公开(公告)号：WO0022115A2
公开(公告)日：2000-04-20
申请号：PCT/US9924072
申请日：1999-10-13
申请人： UNIV TEXAS , ADVANCED RES & TECH INST , ELLINGTON ANDREW D , MATSUMURA ICHIRO
发明人： ELLINGTON ANDREW D , MATSUMURA ICHIRO
IPC分类号： C07K14/47 , C12N15/10 , C12Q1/68
CPC分类号： C12N15/1058 , C07K14/4746 , C12Q1/6886 , C12Q1/6897 , C12Q2600/156 , C12Q2600/158
摘要： The present invention provides for various screening assays which are amenable to high throughput formats and identify a variety of useful mutations in tumor suppressor genes such as p53. Such mutations include those that activate the molecule, increase thermostability, increase transcriptional activity and facilitate resistance to inhibitory molecules. Also provided are methods of screening for accessory proteins that interact with tumor suppressors in both inhibitory and activating fashions, as well as cleavable mutants of p53 that are activated by viral proteases.
摘要翻译：本发明提供适用于高通量格式并鉴定肿瘤抑制基因如p53中的各种有用突变的各种筛选分析。这些突变包括激活分子，增加热稳定性，增加转录活性和促进对抑制性分子的抗性的突变。还提供了筛选与抑制和激活时尚中的肿瘤抑制因子相互作用的辅助蛋白质的方法，以及由病毒蛋白酶激活的可切割的p53突变体。

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