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    • 3. 发明申请
    • ALKYLTHIOBENZYLPIPERIDINE COMPOUNDS
    • 烷基二苯基哌啶化合物
    • WO2007114902A2
    • 2007-10-11
    • PCT/US2007008142
    • 2007-04-02
    • LUNDBECK & CO AS HMARZABADI MOHAMMADANDERSEN KIMCHEN BINREITMAN MICHAELJIANG YUELDEMENKY EMAN
    • MARZABADI MOHAMMADANDERSEN KIMCHEN BINREITMAN MICHAELJIANG YUELDEMENKY EMAN
    • C02F1/00
    • C07D211/26C07D405/12
    • This invention is directed to alkylthiobenzylpiperidine compounds which are ligands at the MCHl receptor. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. This invention also provides a method of treating a subject suffering from depression comprising administering to the subject a therapeutically effective amount of a compound of the subject invention. This invention further provides a method of treating a subject suffering from anxiety comprising administering to the subject a therapeutically effective amount of a compound of the subject invention. This invention also provides a method of treating a subject suffering from obesity comprising administering to the subject a therapeutically effective amount of a compound of the subject invention. Furthermore, the present invention is directed to the use of a compound of the subject invention for the manufacture of a medicament for treating a subject suffering from depression, anxiety or obesity.
    • 本发明涉及作为MCH1受体的配体的烷硫基苄基哌啶化合物。 本发明提供了包含治疗有效量的本发明化合物和药学上可接受的载体的药物组合物。 本发明还提供了治疗患有抑郁症的受试者的方法,包括向受试者施用治疗有效量的本发明化合物。 本发明还提供了治疗患有焦虑症的受试者的方法,其包括向受试者施用治疗有效量的本发明化合物。 本发明还提供了治疗患有肥胖症的受试者的方法,包括向受试者施用治疗有效量的本发明化合物。 此外,本发明涉及本发明化合物在制备用于治疗患有抑郁,焦虑或肥胖的受试者的药物中的用途。