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1. 发明申请

WO2009120655A1 INDOLE DERIVATIVES 审中-公开
标题翻译： INDOLE DORIVATIVES
公开(公告)号：WO2009120655A1
公开(公告)日：2009-10-01
申请号：PCT/US2009/038022
申请日：2009-03-24
申请人： H. LUNDBECK A/S , JIANG, Yu , HONG, Sang-Phyo , CHEN, Bin , ELDEMENKY, Eman , HUSAIN, Arifa , WU, Lingyun , LU, Kai , MA, Gil , LABELLE, Marc , MARZABADI, Mohammad , SABIO, Michael , WHITE, Andrew , MAZZA, Christine , PACKIARAJAN, Mathivanan
发明人： JIANG, Yu , HONG, Sang-Phyo , CHEN, Bin , ELDEMENKY, Eman , HUSAIN, Arifa , WU, Lingyun , LU, Kai , MA, Gil , LABELLE, Marc , MARZABADI, Mohammad , SABIO, Michael , WHITE, Andrew , MAZZA, Christine , PACKIARAJAN, Mathivanan
IPC分类号： C07D403/02 , C07D209/04
CPC分类号： C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14
摘要： The present invention relates to indole derivatives which bind to the MCHl receptor. In separate aspects, the subject invention is directed to uses of said compounds in the preparation of a pharmaceutical composition for the treatment of obesity and CNS related disorders and to methods of treating said disorders comprising administering a therapeutically effective amount of a compound of the invention.
摘要翻译：本发明涉及与MCH1受体结合的吲哚衍生物。在单独的方面，本发明涉及所述化合物在制备用于治疗肥胖症和CNS相关疾病的药物组合物中的用途以及治疗所述病症的方法，包括施用治疗有效量的本发明化合物。

2. 发明申请

WO2007114902A3 ALKYLTHIOBENZYLPIPERIDINE COMPOUNDS 审中-公开
公开(公告)号：WO2007114902A3
公开(公告)日：2007-10-11
申请号：PCT/US2007/008142
申请日：2007-04-02
申请人： H.LUNDBECK A/S , MARZABADI, Mohammad , ANDERSEN, Kim , CHEN, Bin , REITMAN, Michael , JIANG, Yu , ELDEMENKY, Eman
发明人： MARZABADI, Mohammad , ANDERSEN, Kim , CHEN, Bin , REITMAN, Michael , JIANG, Yu , ELDEMENKY, Eman
IPC分类号： A61K31/445 , C07D211/30 , C07D401/06
摘要： This invention is directed to alkylthiobenzylpiperidine compounds which are ligands at the MCHl receptor. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. This invention also provides a method of treating a subject suffering from depression comprising administering to the subject a therapeutically effective amount of a compound of the subject invention. This invention further provides a method of treating a subject suffering from anxiety comprising administering to the subject a therapeutically effective amount of a compound of the subject invention. This invention also provides a method of treating a subject suffering from obesity comprising administering to the subject a therapeutically effective amount of a compound of the subject invention. Furthermore, the present invention is directed to the use of a compound of the subject invention for the manufacture of a medicament for treating a subject suffering from depression, anxiety or obesity.

3. 发明申请

WO2007114902A2 ALKYLTHIOBENZYLPIPERIDINE COMPOUNDS 审中-公开
标题翻译：烷基二苯基哌啶化合物
公开(公告)号：WO2007114902A2
公开(公告)日：2007-10-11
申请号：PCT/US2007008142
申请日：2007-04-02
申请人： LUNDBECK & CO AS H , MARZABADI MOHAMMAD , ANDERSEN KIM , CHEN BIN , REITMAN MICHAEL , JIANG YU , ELDEMENKY EMAN
发明人： MARZABADI MOHAMMAD , ANDERSEN KIM , CHEN BIN , REITMAN MICHAEL , JIANG YU , ELDEMENKY EMAN
IPC分类号： C02F1/00
CPC分类号： C07D211/26 , C07D405/12
摘要： This invention is directed to alkylthiobenzylpiperidine compounds which are ligands at the MCHl receptor. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. This invention also provides a method of treating a subject suffering from depression comprising administering to the subject a therapeutically effective amount of a compound of the subject invention. This invention further provides a method of treating a subject suffering from anxiety comprising administering to the subject a therapeutically effective amount of a compound of the subject invention. This invention also provides a method of treating a subject suffering from obesity comprising administering to the subject a therapeutically effective amount of a compound of the subject invention. Furthermore, the present invention is directed to the use of a compound of the subject invention for the manufacture of a medicament for treating a subject suffering from depression, anxiety or obesity.
摘要翻译：本发明涉及作为MCH1受体的配体的烷硫基苄基哌啶化合物。本发明提供了包含治疗有效量的本发明化合物和药学上可接受的载体的药物组合物。本发明还提供了治疗患有抑郁症的受试者的方法，包括向受试者施用治疗有效量的本发明化合物。本发明还提供了治疗患有焦虑症的受试者的方法，其包括向受试者施用治疗有效量的本发明化合物。本发明还提供了治疗患有肥胖症的受试者的方法，包括向受试者施用治疗有效量的本发明化合物。此外，本发明涉及本发明化合物在制备用于治疗患有抑郁，焦虑或肥胖的受试者的药物中的用途。

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