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1. 发明申请

WO2017103678A2 CHROMOGENIC PEROXIDASE SUBSTRATES 审中-公开
公开(公告)号：WO2017103678A2
公开(公告)日：2017-06-22
申请号：PCT/IB2016/001920
申请日：2016-12-19
申请人： DAKO DENMARK A/S
发明人： HANSEN, Mike Paw, Maischnack , LOHSE, Jesper
IPC分类号： G01N33/58
CPC分类号： C12Q1/6841 , C07D311/82 , C07D311/90 , C07D493/10 , C12N9/0065 , C12N9/96 , C12Q1/28 , G01N33/581
摘要： Chromogenic conjugates for color-based detection of targets are described. The conjugates comprise a chromogenic moiety such as a rhodamine, rhodol or fluorescein. The chromogenic moiety is linked to a peroxidase substrate. The chromogenic conjugates can be used in immunohistochemical analysis and in situ hybridization. The conjugates can be used to detect 1 2, 3 or more targets in a sample by color.

2. 发明申请

WO2013167139A1 METHOD AND APPARATUS FOR IMAGE SCORING AND ANALYSIS 审中-公开
标题翻译：用于图像分割和分析的方法和装置
公开(公告)号：WO2013167139A1
公开(公告)日：2013-11-14
申请号：PCT/DK2013/050136
申请日：2013-05-10
申请人： DAKO DENMARK A/S
发明人： JAIN, Rohit , SCHMID, Joachim Helmut , VERARDO, Mark , CARON, Jeffery
IPC分类号： G06T7/00 , G06K9/46
CPC分类号： G06T7/0012 , G06K9/0014 , G06T7/11 , G06T7/136 , G06T7/194 , G06T7/60 , G06T2207/10024 , G06T2207/10056 , G06T2207/30024 , G06T2207/30068
摘要： Methods and systems for image scoring and analysis are provided. Scored and analyzed images may include digital pathology images, image scoring and analysis methods may include techniques to identify nuclei and determine membrane staining extent through the use of a priori models. Image scoring and analysis methods may include techniques for membrane intensity determination. Images may he scored based on an extent of membrane staining and membrane intensity.
摘要翻译：提供了图像评分和分析的方法和系统。评分和分析的图像可以包括数字病理图像，图像评分和分析方法可以包括通过使用先验模型来识别细胞核并确定膜染色程度的技术。图像评分和分析方法可以包括用于膜强度测定的技术。他可以根据膜染色和膜强度的程度进行图像评分。

3. 发明申请

WO2013068011A1 NEW METHOD FOR EVALUATION OF TARGET IN HISTOLOGICAL SAMPLE 审中-公开
标题翻译：用于评估血液样本中目标的新方法
公开(公告)号：WO2013068011A1
公开(公告)日：2013-05-16
申请号：PCT/DK2012/000119
申请日：2012-11-08
申请人： DAKO DENMARK A/S
发明人： LOHSE, Jesper , JENSEN, Kristian , JØRGENSEN, Rikke, Malene , HOFF, Kirsten, Damgaard , JACOBSEN, Lars, Christian
IPC分类号： G01N33/53 , G01N33/58 , G01N33/68
CPC分类号： G01N33/5308 , G01N33/58 , G01N33/6854
摘要： The present invention lies in the field of visualization and quantification of immobilized targets in samples using immunochemical means. In particular, the invention relates to a method and reagents for detection, visualization and quantification of a molecular target in immunostained histological samples using particular compositions of the target specific binding agent. Methods and compositions of the invention are suitable for any assay that uses a target visualization system in histological samples based on detection of the target by the target specific binding agent. The methods and compositions are useful for evaluation of targets that are biomarkers of diseases in medical diagnostic.
摘要翻译：本发明在于使用免疫化学方法在样品中固定化靶标的可视化和定量的领域。特别地，本发明涉及使用特定目标特异性结合剂的组合物在免疫染色组织学样品中检测，可视化和定量分子靶标的方法和试剂。本发明的方法和组合物适用于基于目标特异性结合剂检测靶标的组织学样品中使用目标可视化系统的任何测定法。所述方法和组合物可用于评估作为医学诊断中的疾病的生物标志物的靶标。

4. 发明申请

WO2013057310A2 HYBRIDIZATION COMPOSITIONS AND METHODS 审中-公开
标题翻译：杂化组合物和方法
公开(公告)号：WO2013057310A2
公开(公告)日：2013-04-25
申请号：PCT/EP2012/070877
申请日：2012-10-22
申请人： DAKO DENMARK A/S
发明人： MATTHIESEN, Steen Hauge
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6881 , C12Q1/6832 , C12Q1/6841 , C12Q2523/113
摘要： The invention provides methods and compositions for hybridizing at least one molecule to a target. The invention may, for example, utilize a of cyclic and/or non-cyclic solvent that is non-toxic and may eliminate or reduce the amount of formamide in the hybridization composition.
摘要翻译：本发明提供用于将至少一种分子与目标物杂交的方法和组合物。本发明可以例如利用无毒的环状和/或非环状溶剂，并且可以消除或减少杂交组合物中甲酰胺的量。

5. 发明申请

WO2013046033A1 HYBRIDIZATION COMPOSITIONS AND METHODS USING FORMAMIDE 审中-公开
标题翻译：杂化组合物和使用甲酰胺的方法
公开(公告)号：WO2013046033A1
公开(公告)日：2013-04-04
申请号：PCT/IB2012/002359
申请日：2012-09-28
申请人： DAKO DENMARK A/S
发明人： MATTHIESEN, Steen Hauge
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6832 , C12Q1/6841 , C12Q1/6876 , C12Q2523/113 , C12Q2527/125 , C12Q2527/137
摘要： The invention provides methods and compositions for hybridizing at least one molecule to a target. The composition comprises at least one nucleic acid sequence, formamide, and a hybridization solution, wherein the concentration of formamide is less than or equal to 25%.
摘要翻译：本发明提供了用于将至少一种分子与目标物杂交的方法和组合物。组合物包含至少一种核酸序列，甲酰胺和杂交溶液，其中甲酰胺的浓度小于或等于25％。

6. 发明申请

WO2011069507A1 AN APPARATUS AND METHOD FOR PROCESSING BIOLOGICAL SAMPLES 审中-公开
标题翻译：一种处理生物样本的装置和方法
公开(公告)号：WO2011069507A1
公开(公告)日：2011-06-16
申请号：PCT/DK2010/000169
申请日：2010-12-09
申请人： DAKO DENMARK A/S , LARSEN, Søren Damgaard , VALBJØRN, Peter Axel
发明人： LARSEN, Søren Damgaard , VALBJØRN, Peter Axel
IPC分类号： G01N1/28
CPC分类号： G01N1/312 , G01N1/2813 , G01N35/00029 , G01N2035/00079 , G01N2035/00138
摘要： A method and an automated apparatus for processing at least one biological sample arranged on a slide. At least one capillary staining module has a slide rack holder configured to detachably hold a slide rack configured to hold slides, and a capillary lid rack holder configured to detachably hold a capillary lid rack configured to hold capillary lids, wherein the slide rack can be removed independently of removing the capillary lid rack. A first fluid container has a first fluid. The apparatus being configured to automatically rotate the one or more slides, and to move the lids towards the slides to automatically form a capillary gap between each slide and each capillary lid, said capillary gap functioning as a capillary chamber; and to supply an amount of the first fluid to the slide.
摘要翻译：一种用于处理布置在载玻片上的至少一个生物样品的方法和自动化装置。至少一个毛细管染色模块具有滑动架保持器，其被配置为可拆卸地保持构造成保持滑块的滑动架，以及毛细管盖架架保持器，其构造成可拆卸地保持构造成保持毛细管盖的毛细管盖架，其中可以移除滑架独立于去除毛细管盖架。第一流体容器具有第一流体。所述设备被配置为自动旋转所述一个或多个滑块，并且将所述盖子朝向所述滑块移动，以在每个滑块和每个毛细管盖之间自动形成毛细管间隙，所述毛细管间隙用作毛细管腔室; 并且将一定量的第一流体供应到载玻片。

7. 发明申请

WO2010097707A1 COMPOSITIONS AND METHODS FOR PERFORMING HYBRIDIZATIONS WITH SEPARATE DENATURATION OF THE SAMPLE AND PROBE 审中-公开
标题翻译：用于对样品和探针进行单独测定进行杂交的组合物和方法
公开(公告)号：WO2010097707A1
公开(公告)日：2010-09-02
申请号：PCT/IB2010/000659
申请日：2010-02-26
申请人： DAKO DENMARK A/S , MATTHIESEN, Steen, Hauge
发明人： MATTHIESEN, Steen, Hauge
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6841 , C12Q1/6832 , C12Q2527/125 , C12Q2527/137
摘要： The invention provides methods and compositions for separately denaturing a probe and target in hybridization applications. The invention may, for example, eliminate the use of, or reduce the dependence on formamide in hybridization applications. Compositions for use in the invention include an aqueous composition comprising at least one polar aprotic solvent in an amount effective to denature double-stranded nucleotide sequences.
摘要翻译：本发明提供用于在杂交应用中单独变性探针和靶的方法和组合物。本发明可以例如在杂交应用中消除对甲酰胺的使用或降低对甲酰胺的依赖性。用于本发明的组合物包括含有至少一种极性非质子溶剂的含水组合物，其量有效地使双链核苷酸序列变性。

8. 发明申请

WO2009106081A1 SYSTEMS AND METHODS FOR TRACKING AND PROVIDING WORKFLOW INFORMATION 审中-公开
标题翻译：跟踪和提供工作流信息的系统和方法
公开(公告)号：WO2009106081A1
公开(公告)日：2009-09-03
申请号：PCT/DK2009/000055
申请日：2009-02-27
申请人： DAKO DENMARK A/S , CHIRICA, Laura , GRAHN, Mats , JONES, Stephen
发明人： CHIRICA, Laura , GRAHN, Mats , JONES, Stephen
IPC分类号： G06F19/00
CPC分类号： G06Q10/0633 , G06F19/00 , G06Q10/06 , G16H10/40 , G16H40/20 , G16H40/67
摘要： A tangible computer-readable storage device storing computer-executable program instructions that generate a user interface for displaying workflow information associated with a tissue specimen in a pathology laboratory. The program instructions may be configured to perform a method including displaying a virtual laboratory component representing a physical pathology laboratory having one or more laboratory stations for processing the tissue specimen, wherein the tissue specimen is processed by the one or more laboratory stations according to a workflow, and displaying a specimen indicator that indicates a current specimen state based on a current relationship of the tissue specimen to the workflow. The method may further include enabling a first active component associated with the virtual laboratory component, wherein the first active component is configured to receive a user selection of a laboratory station and generating a supplemental view component of the selected laboratory station in response to the user selection, wherein the supplemental view provides supplemental information on processing by the selected laboratory station of the tissue specimen.
摘要翻译：存储计算机可执行程序指令的有形计算机可读存储设备，其生成用于在病理学实验室中显示与组织标本相关联的工作流信息的用户界面。程序指令可以被配置为执行一种方法，包括显示代表具有用于处理组织样本的一个或多个实验室的物理病理学实验室的虚拟实验室部件，其中根据工作流程由所述一个或多个实验室站处理所述组织标本并且基于组织样本与工作流的当前关系，显示指示当前样本状态的样本指示符。该方法还可以包括启用与虚拟实验室组件相关联的第一活动组件，其中第一活动组件被配置为接收实验室的用户选择并响应于用户选择生成所选实验室的补充视图组件其中补充视图提供了所选实验室对组织标本进行加工的补充信息。

9. 发明申请

WO2009039854A3 MHC MULTIMERS IN TUBERCULOSIS DIAGNOSTICS, VACCINE AND THERAPEUTICS 审中-公开
公开(公告)号：WO2009039854A3
公开(公告)日：2009-04-02
申请号：PCT/DK2008/000339
申请日：2008-09-29
申请人： DAKO DENMARK A/S , SCHOLLER, Jorgen , BRIX, Liselotte , PEDERSEN, Henrik , JAKOBSEN, Tina
发明人： SCHOLLER, Jorgen , BRIX, Liselotte , PEDERSEN, Henrik , JAKOBSEN, Tina
IPC分类号： C07K14/705 , A61K47/48 , A61K39/00 , A61K38/17 , G01N33/50 , A61P31/00
摘要： The present invention relates to MHC-peptide complexes and uses thereof in the diagnosis of, treatment of or vaccination against a disease in an individual. More specifically the invention discloses MHC complexes comprising Mycobacterium tuberculosis antigenic peptides and uses there of.

10. 发明申请

WO2009026919A2 ON-SITE LIQUID PRODUCTION 审中-公开
标题翻译：现场液体生产
公开(公告)号：WO2009026919A2
公开(公告)日：2009-03-05
申请号：PCT/DK2008/000300
申请日：2008-08-25
申请人： DAKO DENMARK A/S , LINDBERG, Martin , WINTHER, Lars
发明人： LINDBERG, Martin , WINTHER, Lars
IPC分类号： G01N35/00
CPC分类号： G01N35/00029 , G01N2035/00138 , G01N2035/00217 , G01N2035/00544
摘要： A biological sample processing system (100) for on-site liquid production comprises a processing apparatus (102) for processing of biological samples arranged on microscope slides, and a production unit (110) connected to the apparatus (102). The production unit (110) comprises a first ingredient source (112), a second ingredient source (114), and a mixer station (120). The mixer station (120) is configured to mix ingredients to produce a liquid product (123). Supply conduits (128, 130) are arranged to supply an amount of a first ingredient (113) and an amount of a second ingredient (115) from the first and second ingredient sources to the mixer station (120). A delivery conduit (132) is provided for transportation of an amount of the liquid product (123) from the mixer station (120). A production controller (134) is arranged in communication with the production unit (110), and is configured to control the operation of the production unit (110).
摘要翻译：用于现场液体生产的生物样品处理系统（100）包括用于处理布置在显微镜载片上的生物样品的处理设备（102）和连接到设备（102）的生产单元（110）。生产单元（110）包括第一成分源（112），第二成分源（114）和混合站（120）。搅拌站（120）被配置成混合成分以产生液体产物（123）。供应管道（128,130）被布置成将一定量的第一成分（113）和第二成分（115）的量从第一和第二成分源提供给混合器站（120）。输送管道（132）用于从混合站（120）输送一定量的液体产品（123）。生产控制器（134）被布置成与生产单元（110）通信，并且被配置为控制生产单元（110）的操作。

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