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1. 发明申请

WO2010138862A3 COMPOSITIONS FOR RESPIRATORY DELIVERY OF ACTIVE AGENTS AND ASSOCIATED METHODS AND SYSTEMS 审中-公开
公开(公告)号：WO2010138862A3
公开(公告)日：2010-12-02
申请号：PCT/US2010/036650
申请日：2010-05-28
申请人： PEARL THERAPEUTICS, INC. , VEHRING, Reinhard , HARTMAN, Michael, Steven , SMITH, Adrian, Edward , JOSHI, Vidya, B. , DWIVEDI, Sarvajna, Kumar
发明人： VEHRING, Reinhard , HARTMAN, Michael, Steven , SMITH, Adrian, Edward , JOSHI, Vidya, B. , DWIVEDI, Sarvajna, Kumar
IPC分类号： A61K9/12 , A61P11/00
摘要： Compositions, methods and systems are provided for pulmonary or nasal delivery of active agents via a metered dose inhaler. In one embodiment, the compositions include a suspension medium, active agent particles, and suspending particles, in which the active agent particles and suspending particles form a co-suspension within the suspension medium.

2. 发明申请

WO2012158166A1 COMPOSITIONS, METHODS & SYSTEMS FOR RESPIRATORY DELIVERY OF TWO OR MORE ACTIVE AGENTS 审中-公开
标题翻译：组合物，两种或更多活性剂的呼吸输送方法和系统
公开(公告)号：WO2012158166A1
公开(公告)日：2012-11-22
申请号：PCT/US2011/036868
申请日：2011-05-17
申请人： PEARL THERAPEUTICS, INC. , VEHRING, Reinhard , HARTMAN, Michael Steven , LECHUGA-BALLESTEROS, David , SMITH, Adrian Edward , JOSHI, Vidya B. , DWIVEDI, Sarvajna Kumar
发明人： VEHRING, Reinhard , HARTMAN, Michael Steven , LECHUGA-BALLESTEROS, David , SMITH, Adrian Edward , JOSHI, Vidya B. , DWIVEDI, Sarvajna Kumar
IPC分类号： A01N25/00 , A61K9/72 , A61L9/02
CPC分类号： A61K9/008 , A61K9/10 , A61K31/00 , A61K31/167 , A61K31/40 , A61K2300/00
摘要： Compositions, methods and systems are provided for pulmonary or nasal delivery of two or more active agents via a metered dose inhaler. In one embodiment, the compositions include a suspension medium, active agent particles, and suspending particles, in which the active agent particles and suspending particles form a co-suspension within the suspension medium.
摘要翻译：提供组合物，方法和系统用于通过计量剂量吸入器肺或鼻递送两种或多种活性剂。在一个实施方案中，组合物包括悬浮介质，活性剂颗粒和悬浮颗粒，其中活性剂颗粒和悬浮颗粒在悬浮介质中形成共悬浮液。

3. 发明申请

WO2010138884A3 RESPIRATORY DELIVERY OF ACTIVE AGENTS 审中-公开
公开(公告)号：WO2010138884A3
公开(公告)日：2010-12-02
申请号：PCT/US2010/036676
申请日：2010-05-28
申请人： PEARL THERAPEUTICS, INC. , VEHRING, Reinhard , HARTMAN, Michael, Steven , SMITH, Adrian, Edward , JOSHI, Vidya, B. , DWIVEDI, Sarvajna, Kumar , LECHUGA-BALLESTEROS, David
发明人： VEHRING, Reinhard , HARTMAN, Michael, Steven , SMITH, Adrian, Edward , JOSHI, Vidya, B. , DWIVEDI, Sarvajna, Kumar , LECHUGA-BALLESTEROS, David
IPC分类号： A61K9/12 , A61P11/00
摘要： Compositions, methods and systems are provided for pulmonary or nasal delivery of two or more active agents via a metered dose inhaler. In one embodiment, the compositions include a suspension medium, active agent particles, and suspending particles, in which the active agent particles and suspending particles form a co-suspension within the suspension medium.

4. 发明申请

WO2010138862A2 COMPOSITIONS FOR RESPIRATORY DELIVERY OF ACTIVE AGENTS AND ASSOCIATED METHODS AND SYSTEMS 审中-公开
标题翻译：用于呼吸传递活性药剂和相关方法和系统的组合物
公开(公告)号：WO2010138862A2
公开(公告)日：2010-12-02
申请号：PCT/US2010036650
申请日：2010-05-28
申请人： PEARL THERAPEUTICS INC , VEHRING REINHARD , HARTMAN MICHAEL STEVEN , SMITH ADRIAN EDWARD , JOSHI VIDYA B , DWIVEDI SARVAJNA KUMAR
发明人： VEHRING REINHARD , HARTMAN MICHAEL STEVEN , SMITH ADRIAN EDWARD , JOSHI VIDYA B , DWIVEDI SARVAJNA KUMAR
IPC分类号： A61K9/12
CPC分类号： A61K9/008 , A61K9/1611 , A61K9/1617 , A61K31/135 , A61K31/137 , A61K31/16 , A61K31/167 , A61K31/192 , A61K31/194 , A61K31/40 , A61K31/46 , A61K31/56 , A61K31/573 , A61K31/58 , A61M15/0065 , A61K2300/00
摘要： Compositions, methods and systems are provided for pulmonary or nasal delivery of active agents via a metered dose inhaler. In one embodiment, the compositions include a suspension medium, active agent particles, and suspending particles, in which the active agent particles and suspending particles form a co-suspension within the suspension medium.
摘要翻译：提供组合物，方法和系统用于通过计量剂量吸入器肺或鼻递送活性剂。在一个实施方案中，组合物包括悬浮介质，活性剂颗粒和悬浮颗粒，其中活性剂颗粒和悬浮颗粒在悬浮介质中形成共悬浮液。

5. 发明申请

WO1997044080A1 METERING APPARATUS 审中-公开
标题翻译：计量装置
公开(公告)号：WO1997044080A1
公开(公告)日：1997-11-27
申请号：PCT/EP1997002594
申请日：1997-05-22
申请人： GLAXO GROUP LIMITED , SACCHETTI, Mark, Joseph , VAN OORT, Michiel, Mary , ROBERTS, William, Leroy, II , DWIVEDI, Sarvajna, Kumar
发明人： GLAXO GROUP LIMITED
IPC分类号： A61M15/00
CPC分类号： A61J3/00 , A61M15/0028 , A61M2202/064
摘要： An apparatus (100) adapted for applying to a carrier (C) a suspension (S) comprising a suspending agent and a powdered medicament. The apparatus (110) includes a reservoir (110), a junction container (120) adapted to contain a liquid, an outlet line (130) extending from the reservoir (110) and through the junction container (120) to a pump (P), a nozzle (160) connected to the pump (P) and a sonicator (150) operatively connected to the junction container (120). The reservoir (110) is adapted to maintain the agent and the medicament admixed in suspension. The nozzle (160) is formed from an inner cylinder (161) disposed within an outer cylinder (162), thereby defining a space (X) therebetween, and includes a purge line (165) fluidly connected with the outer cylinder (162) for providing a gas jet to the space (X). The sonicator (150) creates waves in the liquid in the container (110) to help prevent the suspension (S) from flocculating as it travels through the outlet line (130) from the reservoir (110) and to the pump (P). The pump (P) expels the suspension (S) through the nozzle (160) to the carrier (C), and a gas jet (GJ) from the purge line (165) prevents capillary forces from allowing the suspension (S) to collect around the tip (T) of the inner cylinder (161) of the nozzle (160).
摘要翻译：适于向载体（C）施加包含悬浮剂和粉末状药物的悬浮液（S）的装置（100）。装置（110）包括容器（110），适于容纳液体的接合容器（120），从贮存器（110）延伸并通过接合容器（120）延伸到泵（P）的出口管线），连接到泵（P）的喷嘴（160）和可操作地连接到接合容器（120）的超声波器（150）。储存器（110）适于将试剂和药剂混合在悬浮液中。喷嘴（160）由设置在外筒（162）内的内筒（161）形成，从而在其间限定空间（X），并且包括与外筒（162）流体连接的吹扫管线（165），用于向空间（X）提供气体射流。超声波发生器（150）在容器（110）中的液体中产生波浪，以帮助防止悬浮液（S）在从储存器（110）和泵（P）通过出口管线（130）时絮凝。泵（P）通过喷嘴（160）将悬浮液（S）排出到载体（C），并且来自吹扫管线（165）的气体喷射（GJ）防止毛细管力使悬浮液（S）收集围绕喷嘴（160）的内筒（161）的尖端（T）。

6. 发明申请

WO2010138868A3 COMPOSITIONS FOR PULMONARY DELIVERY OF LONG-ACTING MUSCARINIC ANTAGONISTS AND LONG-ACTING B2 ADRENERGIC RECEPTOR AGONISTS AND ASSOCIATED METHODS AND SYSTEMS 审中-公开
标题翻译：用于长期给药的肌肉酸痛拮抗剂和长效B2受体激动剂的组合物及相关方法和系统
公开(公告)号：WO2010138868A3
公开(公告)日：2011-04-28
申请号：PCT/US2010036659
申请日：2010-05-28
申请人： PEARL THERAPEUTICS INC , VEHRING REINHARD , HARTMAN MICHAEL STEVEN , SMITH ADRIAN EDWARD , JOSHI VIDYA B , DWIVEDI SARVAJNA KUMAR
发明人： VEHRING REINHARD , HARTMAN MICHAEL STEVEN , SMITH ADRIAN EDWARD , JOSHI VIDYA B , DWIVEDI SARVAJNA KUMAR
IPC分类号： A61K9/12 , A61K9/00 , A61K31/40 , A61P11/00
CPC分类号： A61K9/008 , A61K9/1611 , A61K9/1617 , A61K31/135 , A61K31/137 , A61K31/16 , A61K31/167 , A61K31/192 , A61K31/194 , A61K31/40 , A61K31/46 , A61K31/56 , A61K31/573 , A61K31/58 , A61M15/0065 , A61K2300/00
摘要： Compositions, methods and systems are provided for pulmonary delivery of long-acting muscarinic antagonists and long-acting ß2 adrenergic receptor agonists via a metered dose inhaler. In particular embodiments, the compositions include a suspension medium, active agent particles, and suspending particles, in which the active agent particles and suspending particles form a co-suspension within the suspension medium.
摘要翻译：提供组合物，方法和系统用于经由计量吸入器肺部递送长效毒蕈碱性拮抗剂和长效β2肾上腺素能受体激动剂。在具体实施方案中，组合物包括悬浮介质，活性剂颗粒和悬浮颗粒，其中活性剂颗粒和悬浮颗粒在悬浮介质中形成共悬浮液。

7. 发明申请

WO2010138884A2 COMPOSITIONS, METHODS & SYSTEMS FOR RESPIRATORY DELIVERY OF TWO OR MORE ACTIVE AGENTS 审中-公开
标题翻译：组合物，两种或更多活性剂的呼吸输送方法和系统
公开(公告)号：WO2010138884A2
公开(公告)日：2010-12-02
申请号：PCT/US2010036676
申请日：2010-05-28
申请人： PEARL THERAPEUTICS INC , VEHRING REINHARD , HARTMAN MICHAEL STEVEN , SMITH ADRIAN EDWARD , JOSHI VIDYA B , DWIVEDI SARVAJNA KUMAR , LECHUGA-BALLESTEROS DAVID
发明人： VEHRING REINHARD , HARTMAN MICHAEL STEVEN , SMITH ADRIAN EDWARD , JOSHI VIDYA B , DWIVEDI SARVAJNA KUMAR , LECHUGA-BALLESTEROS DAVID
IPC分类号： A61K9/12
CPC分类号： A61K9/008 , A61K9/1611 , A61K9/1617 , A61K31/135 , A61K31/137 , A61K31/16 , A61K31/167 , A61K31/192 , A61K31/194 , A61K31/40 , A61K31/46 , A61K31/56 , A61K31/573 , A61K31/58 , A61M15/0065 , A61K2300/00
摘要： Compositions, methods and systems are provided for pulmonary or nasal delivery of two or more active agents via a metered dose inhaler. In one embodiment, the compositions include a suspension medium, active agent particles, and suspending particles, in which the active agent particles and suspending particles form a co-suspension within the suspension medium.
摘要翻译：提供组合物，方法和系统用于通过计量剂量吸入器肺或鼻递送两种或多种活性剂。在一个实施方案中，组合物包括悬浮介质，活性剂颗粒和悬浮颗粒，其中活性剂颗粒和悬浮颗粒在悬浮介质中形成共悬浮液。

8. 发明申请

WO2004073681A1 MEDICAMENTS 审中-公开
标题翻译：药物
公开(公告)号：WO2004073681A1
公开(公告)日：2004-09-02
申请号：PCT/GB1996/003154
申请日：1996-12-19
申请人： RIEBE, Michael, Thomas , DWIVEDI, Sarvajna, Kumar , LI-BOVET, Li
发明人： RIEBE, Michael, Thomas , DWIVEDI, Sarvajna, Kumar , LI-BOVET, Li
IPC分类号： A61K9/12
CPC分类号： A61K9/008 , A61K9/14
摘要： This invention relates to aerosol formulations of use for the administration of medicaments by inhalation. More particularly, the invention relates to a pharmaceutical aerosol formulation which comprises particulate salbutamol sulphate having a crystalline form in which the outer layer of the crystals is substantially non-amorphous; and 1,1,1,2-tetrafluoroethane. A method of treating respiratory disorders which comprises administration by inhalation of an effective amount of a pharmaceutical aerosol formulation as defined is also described.
摘要翻译：本发明涉及用于通过吸入给药药物的气溶胶制剂。更具体地，本发明涉及一种药物气溶胶制剂，其包含具有结晶形式的颗粒状沙丁胺醇硫酸盐，其中所述晶体的外层基本上是非无定形的; 和1,1,1,2-四氟乙烷。还描述了一种治疗呼吸系统疾病的方法，其包括通过吸入有效量的如所定义的药物气雾剂制剂给药。

9. 发明申请

WO2010138868A2 COMPOSITIONS FOR PULMONARY DELIVERY OF LONG-ACTING MUSCARINIC ANTAGONISTS AND LONG-ACTING B2 ADRENERGIC RECEPTOR AGONISTS AND ASSOCIATED METHODS AND SYSTEMS 审中-公开
标题翻译：用于长期给药的肌肉酸痛拮抗剂和长效B2受体激动剂的组合物及相关方法和系统
公开(公告)号：WO2010138868A2
公开(公告)日：2010-12-02
申请号：PCT/US2010/036659
申请日：2010-05-28
申请人： PEARL THERAPEUTICS, INC. , VEHRING, Reinhard , HARTMAN, Michael Steven , SMITH, Adrian Edward , JOSHI, Vidya B. , DWIVEDI, Sarvajna Kumar
发明人： VEHRING, Reinhard , HARTMAN, Michael Steven , SMITH, Adrian Edward , JOSHI, Vidya B. , DWIVEDI, Sarvajna Kumar
IPC分类号： A61K9/12
CPC分类号： A61K9/008 , A61K9/1611 , A61K9/1617 , A61K31/135 , A61K31/137 , A61K31/16 , A61K31/167 , A61K31/192 , A61K31/194 , A61K31/40 , A61K31/46 , A61K31/56 , A61K31/573 , A61K31/58 , A61M15/0065 , A61K2300/00
摘要： Compositions, methods and systems are provided for pulmonary delivery of long-acting muscarinic antagonists and long-acting β 2 adrenergic receptor agonists via a metered dose inhaler. In particular embodiments, the compositions include a suspension medium, active agent particles, and suspending particles, in which the active agent particles and suspending particles form a co-suspension within the suspension medium.
摘要翻译：提供组合物，方法和系统用于经由计量吸入器肺部递送长效毒蕈碱性拮抗剂和长效β2肾上腺素能受体激动剂。在具体实施方案中，组合物包括悬浮介质，活性剂颗粒和悬浮颗粒，其中活性剂颗粒和悬浮颗粒在悬浮介质中形成共悬浮液。

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