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1. 发明申请

WO2005116065A1 LABELLED ADRENOMEDULLIN DERIVATIVES AND THEIR USE FOR IMAGING AND THERAPY 审中-公开
标题翻译：标记的ADRENOMEDULLIN衍生物及其用于成像和治疗的用途
公开(公告)号：WO2005116065A1
公开(公告)日：2005-12-08
申请号：PCT/CA2005/000791
申请日：2005-05-24
申请人： INSTITUT DE CARDIOLOGIE DE MONTRÉAL , DUPUIS, Jocelyn , FOURNIER, Alain
发明人： DUPUIS, Jocelyn , FOURNIER, Alain
IPC分类号： C07K14/435
CPC分类号： A61K51/08 , A61K51/088 , C07K14/575
摘要： The present invention relates to an adrenomedullin derivative including an adrenomedullin peptide chelated with at least one active agent. Examples of active agents include a paramagnetic element, a radioactive element and a fibrinolytic agent, among others. Paramagnetic agents have a distribution that is relatively easily shown through Magnetic Resonnance Imaging (MRI). Radioactive agents have applications in imaging and delivery of radiations, depending on the specific element included in the active agent. Delivery of fibrinolytic agents mainly to a specific organ, such as for example to the lungs, allows to substantially improve the specificity and efficacy of thrombolytic therapy by allowing local delivery of the fibrinolytic agent, thereby reducing the risks of major bleeding in the therapy of the organ. If the organ is the lungs, a non-limiting example of pathology treatable with the fibrinolytic is pulmonary embolus.
摘要翻译：本发明涉及包含与至少一种活性剂螯合的肾上腺髓质肽的肾上腺髓质素衍生物。活性剂的实例包括顺磁元件，放射性元素和纤维蛋白溶解剂等。顺磁剂具有通过磁共振成像（MRI）相对容易地显示的分布。取决于活性剂中包含的特定元素，放射性剂可用于成像和辐射辐射。纤维蛋白溶解剂主要递送到特定器官，例如肺，允许通过允许局部输送纤维蛋白溶解剂来大大改善溶栓治疗的特异性和功效，从而降低治疗中的大出血的风险器官。如果器官是肺，则可用纤维蛋白溶解治疗的病理学的非限制性实例是肺栓塞。

2. 发明申请

WO2008138141A1 LABELLED ADRENOMEDULLIN DERIVATIVES AND THEIR USE FOR IMAGING AND THERAPY. 审中-公开
标题翻译：标记的ADRENOMEDULLIN衍生物及其用于成像和治疗的用途。
公开(公告)号：WO2008138141A1
公开(公告)日：2008-11-20
申请号：PCT/CA2008/000934
申请日：2008-05-12
申请人： INSTITUT DE CARDIOLOGIE DE MONTRÉAL , DUPUIS, Jocelyn , FOURNIER, Alain
发明人： DUPUIS, Jocelyn , FOURNIER, Alain
IPC分类号： C07K14/575 , A61K49/00 , A61K51/08 , C07K14/47
CPC分类号： C07K14/575 , A61K47/64 , A61K51/08 , A61K51/088
摘要： The present invention relates to an adrenomedullin derivative including an adrenomedullin peptide, or a fragment thereof chelated or otherwise bound to at least one active agent. Examples of active agents include a paramagnetic element, a radioactive element and a fibrinolytic agent, among others. Paramagnetic agents have a distribution that is relatively easily shown through Magnetic Resonance Imaging (MRI). Radioactive agents have applications in imaging and delivery of radiations, depending on the specific element included in the active agent. Delivery of fibrinolytic agents mainly to a specific organ, such as for example to the lungs, allows to substantially improve the specificity and efficacy of thrombolytic therapy by allowing local delivery of the fibrinolytic agent, thereby reducing the risks of major bleeding in the therapy of the organ. If the organ is the lungs, a non-limiting example of pathology treatable with the fibrinolytic agent is pulmonary embolus.
摘要翻译：本发明涉及包含与至少一种活性剂螯合或以其他方式结合的肾上腺髓质素肽或其片段的肾上腺髓质素衍生物。活性剂的实例包括顺磁元件，放射性元素和纤维蛋白溶解剂等。顺磁剂具有通过磁共振成像（MRI）相对容易地显示的分布。取决于活性剂中包含的具体元素，放射性剂可用于成像和辐射辐射。纤维蛋白溶解剂主要递送到特定器官，例如肺，允许通过允许局部输送纤维蛋白溶解剂来显着改善溶栓治疗的特异性和功效，从而降低治疗中的大出血的风险器官。如果器官是肺，则可用纤维蛋白溶解剂治疗的病理学的非限制性实例是肺栓塞。

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