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1. 发明申请

WO2008125116A2 UPAR INHIBITION 审中-公开
标题翻译：预防性抑制
公开(公告)号：WO2008125116A2
公开(公告)日：2008-10-23
申请号：PCT/DK2008050075
申请日：2008-03-28
申请人： UNIV AARHUS , KJEMS JOERGEN , DUPONT DANIEL MIOTTO , ANDREASEN PETER A
发明人： KJEMS JOERGEN , DUPONT DANIEL MIOTTO , ANDREASEN PETER A
IPC分类号： A61K31/713 , C07H21/00 , C12N15/115
CPC分类号： C12N15/115 , C12N2310/16 , C12N2310/322 , C12Y304/21073
摘要： The present invention relates to aptamers capable of binding to a receptor-binding form of urokinase-type plasminogen activator protein, u-PA. Furthermore, the present invention relates to use of the aptamers for prevention of u-PA-mediated proteolytic activity at the cell surface for the preparation of a composition for preventing or counteracting proteolytic activity on the surface of a cell. The aptamers of the present invention may additionally be used as imaging agents or used for the treatment or prevention of cancer and/or metastatic spread. Within the scope of the present invention is also pharmaceutical compositions and diagnostic kits comprising aptamers.
摘要翻译：本发明涉及能够结合尿激酶型纤溶酶原激活蛋白u-PA的受体结合形式的适体。此外，本发明涉及用于预防细胞表面的u-PA介导的蛋白水解活性的适体用于制备用于预防或抵消细胞表面的蛋白水解活性的组合物的用途。本发明的适体可另外用作显像剂或用于治疗或预防癌症和/或转移性扩散。在本发明的范围内，还包括药物组合物和包含适体的诊断试剂盒。

2. 发明申请

WO1986005614A1 ANALOGUE SIMULATOR FOR CONTROL CIRCUITS, ACTUATED FROM AN OPERATING STATION OR COCKPIT 审中-公开
标题翻译：控制电路的模拟仿真器，由操作台或机构执行
公开(公告)号：WO1986005614A1
公开(公告)日：1986-09-25
申请号：PCT/FR1986000096
申请日：1986-03-20
申请人： DUPONT, Daniel
IPC分类号： G09B09/08
CPC分类号： G09B9/08
摘要： The simulator is used for the training of personnel. In the case of the controls of an aircraft, the simulator contains an exact reproduction of the command cockpit (1) with all its controls (2), and capable of ensuring the actuation of circuit simulation devices by a student-operator (3). Simulation devices (4) consist of at least one instruction panel (51, 52) representing at least one control circuit and used to display various parameters or simulation motifs visible to the student-operator. An operating console (6) ensures contact between the simulation devices (4) and the cockpit (1). The console makes it possible to carry out a training programme administered by an instructor-operator.
摘要翻译：模拟器用于培训人员。在飞行器的控制的情况下，模拟器包含具有其所有控制（2）的命令驾驶舱（1）的精确再现，并且能够确保学生操作者（3）对电路仿真设备的致动。模拟装置（4）由表示至少一个控制电路的至少一个指令面板（51,52）组成，并用于显示学生操作者可见的各种参数或模拟图案。操作台（6）确保模拟装置（4）和驾驶舱（1）之间的接触。控制台可以执行由教师操作员管理的训练计划。

3. 发明申请

WO2008125116A3 UPAR INHIBITION 审中-公开
公开(公告)号：WO2008125116A3
公开(公告)日：2008-10-23
申请号：PCT/DK2008/050075
申请日：2008-03-28
申请人： AARHUS UNIVERSITET , KJEMS, Jørgen , DUPONT, Daniel Miotto , ANDREASEN, Peter A.
发明人： KJEMS, Jørgen , DUPONT, Daniel Miotto , ANDREASEN, Peter A.
IPC分类号： C12N15/11 , C07H21/00 , A61K31/713 , A61K31/7088
摘要： The present invention relates to aptamers capable of binding to a receptor-binding form of urokinase-type plasminogen activator protein, u-PA. Furthermore, the present invention relates to use of the aptamers for prevention of u-PA-mediated proteolytic activity at the cell surface for the preparation of a composition for preventing or counteracting proteolytic activity on the surface of a cell. The aptamers of the present invention may additionally be used as imaging agents or used for the treatment or prevention of cancer and/or metastatic spread. Within the scope of the present invention is also pharmaceutical compositions and diagnostic kits comprising aptamers.

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