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1. 发明申请

WO2007133637A3 AMIDE DERIVATIVES AS ION-CHANNEL LIGANDS AND PHARMACEUTICAL COMPOSITIONS AND METHODS OF USING THE SAME 审中-公开
标题翻译：作为离子通道配体和药物组合物的酰胺衍生物及其使用方法
公开(公告)号：WO2007133637A3
公开(公告)日：2008-01-03
申请号：PCT/US2007011310
申请日：2007-05-10
申请人： RENOVIS INC , PFIZER , SHISHIDO YUJI , NAKAO KAZUNARI , NAGAYAMA SATOSHI , TANAKA HIROTAKA , DUNCTON MATTHEW ALEXANDER JAME , COX MATTHEW , KINCAID JOHN , SAHASRABUDHE KIRAN , ESTIARTE-MARTINEZ MARIA DE LOS
发明人： SHISHIDO YUJI , NAKAO KAZUNARI , NAGAYAMA SATOSHI , TANAKA HIROTAKA , DUNCTON MATTHEW ALEXANDER JAME , COX MATTHEW , KINCAID JOHN , SAHASRABUDHE KIRAN , ESTIARTE-MARTINEZ MARIA DE LOS
IPC分类号： A61K31/497
CPC分类号： C07D215/48 , C07C311/08 , C07C2601/02 , C07D205/04 , C07D215/54 , C07D217/26 , C07D231/12 , C07D239/94 , C07D241/44 , C07D295/155 , C07D401/04 , C07D401/14 , C07D403/04 , C07D405/12 , C07D471/04 , C07D498/04 , C07D498/12
摘要： Compounds are disclosed that have a formula represented by the following: Formula (I). The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.
摘要翻译：公开了具有由下式表示的式的化合物：式（I）。化合物可以制备成药物组合物，并且可以用于预防和治疗包括人在内的哺乳动物中的各种病症，包括作为非限制性实例，疼痛，炎症，创伤性损伤等。

2. 发明申请

WO2008059370A2 SUBSTITUTED BICYCLOCARBOXYAMIDE COMPOUNDS 审中-公开
标题翻译：取代的双环碳酰胺化合物
公开(公告)号：WO2008059370A2
公开(公告)日：2008-05-22
申请号：PCT/IB2007003559
申请日：2007-11-09
申请人： PFIZER JAPAN INC , PFIZER , RENOVIS INC , CALABRESE ANDREW ANTONY , DUNCTON MATTHEW ALEXANDER JAME , FUTATSUGI KENTARO , HIRANO MISATO , NAGAYAMA SATOSHI
发明人： CALABRESE ANDREW ANTONY , DUNCTON MATTHEW ALEXANDER JAME , FUTATSUGI KENTARO , HIRANO MISATO , NAGAYAMA SATOSHI
IPC分类号： C07D401/12 , A61K31/415 , A61K31/4155 , A61K31/47 , C07D231/12
CPC分类号： C07D401/12 , C07D231/12
摘要： This invention provides a compound of the formula (I). These compounds are useful for the treatment of disease conditions caused by overactivation of the VR1 receptor such as pain, or the like in mammal. This invention also provides a pharmaceutical composition comprising the above compound.
摘要翻译：本发明提供了式（I）的化合物。这些化合物可用于治疗由哺乳动物中VR1受体的过度激活引起的疾病，如疼痛等。本发明还提供了包含上述化合物的药物组合物。

3. 发明申请

WO2008059370A8 SUBSTITUTED BICYCLOCARBOXYAMIDE COMPOUNDS 审中-公开
标题翻译：取代的双环氧基酰胺化合物
公开(公告)号：WO2008059370A8
公开(公告)日：2009-06-04
申请号：PCT/IB2007003559
申请日：2007-11-09
申请人： PFIZER JAPAN INC , PFIZER , RENOVIS INC , ANDO KOJI , CALABRESE ANDREW ANTONY , DUNCTON MATTHEW ALEXANDER JAME , FUTATSUGI KENTARO , HIRANO MISATO , NAGAYAMA SATOSHI
发明人： ANDO KOJI , CALABRESE ANDREW ANTONY , DUNCTON MATTHEW ALEXANDER JAMES , FUTATSUGI KENTARO , HIRANO MISATO , NAGAYAMA SATOSHI
IPC分类号： C07D401/12 , A61K31/415 , A61K31/4155 , A61K31/47 , C07D231/12
CPC分类号： C07D401/12 , C07D231/12
摘要： This invention provides a compound of the formula (I). These compounds are useful for the treatment of disease conditions caused by overactivation of the VR1 receptor such as pain, or the like in mammal. This invention also provides a pharmaceutical composition comprising the above compound.
摘要翻译：本发明提供式（I）化合物。这些化合物可用于治疗哺乳动物VR1受体过度活化（如疼痛等）引起的疾病状况。本发明还提供了包含上述化合物的药物组合物。

4. 发明申请

WO0017170A3 N1-SUBSTITUTED BENZOPYRAZOLES AS INHIBITORS OF 5-HT2 RECEPTORS 审中-公开
标题翻译：作为5-HT2受体的抑制剂的N-取代的苯并噻唑
公开(公告)号：WO0017170A3
公开(公告)日：2000-08-03
申请号：PCT/GB9903187
申请日：1999-09-23
申请人： CEREBRUS PHARM LTD , ADAMS DAVID REGINALD , BENTLEY JONATHAN MARK , ROFFEY JONATHAN RICHARD ANTHON , DUNCTON MATTHEW ALEXANDER JAME
发明人： ADAMS DAVID REGINALD , BENTLEY JONATHAN MARK , ROFFEY JONATHAN RICHARD ANTHON , DUNCTON MATTHEW ALEXANDER JAME
IPC分类号： C07D231/56 , A61K31/415
CPC分类号： C07D231/56
摘要： A chemical compound of formula (I): wherein R1 to R3 are independently selected from hydrogen and alkyl; R5 is selected from alkylthio, arylthio, alkylsulfoxyl, arylsulfoxyl, alkylsulfonyl and arylsulfonyl; R4, R6, and R7 are independently selected from hydrogen, halogen, hydroxy, alkyl, aryl, alkoxy, aryloxy, alkylthio, arylthio, arylsulfoxyl, alkylsulfoxyl, alkylsulfonyl, arylsulfonyl, amino, monoalkylamino, dialkylamino, nitro, cyano, carboxaldehyde, alkylcarbonyl, arylcarbonyl, aminocarbonyl, monoalkylaminocarbonyl, dialkylaminocarbonyl, alkoxycarbonylamino, aminocarbonyloxy, monoalkylaminocarbonyloxy, dialkylaminocarbonyloxy, monoalkylaminocarbonylamino and dialkylaminocarbonylamino, and pharmaceutically acceptable salts and prodrugs thereof, and the use thereof in therapy, particularly for the treatment of disorders of the central nervous system; damage to the central nervous system; cardiovascular disorders; gastrointestinal disorders; diabetes insipidus; and sleep apnea, and particularly for the treatment of obesity.
摘要翻译：式（I）的化合物：其中R 1至R 3独立地选自氢和烷基; R5选自烷硫基，芳硫基，烷基亚磺酰基，芳基亚砜基，烷基磺酰基和芳基磺酰基; R4，R6和R7独立地选自氢，卤素，羟基，烷基，芳基，烷氧基，芳氧基，烷硫基，芳硫基，芳基亚砜基，烷基磺酰基，烷基磺酰基，芳基磺酰基，氨基，单烷基氨基，二烷基氨基，硝基，氰基，芳基羰基，氨基羰基，单烷基氨基羰基，二烷基氨基羰基，烷氧基羰基氨基，氨基羰基氧基，单烷基氨基羰基氧基，二烷基氨基羰基氧基，单烷基氨基羰基氨基和二烷基氨基羰基氨基及其药学上可接受的盐和前药，以及其在治疗中的用途，特别是用于治疗中枢神经系统疾病。损害中枢神经系统; 心血管疾病; 胃肠道疾病; 尿崩症并且睡眠呼吸暂停，特别是用于治疗肥胖。

5. 发明申请

WO2006099410A3 AMIDE DERIVATIVES AS ION-CHANNEL LIGANDS AND PHARMACEUTICAL COMPOSITIONS AND METHODS OF USING THE SAME 审中-公开
标题翻译：作为离子通道配体和药物组合物的酰胺衍生物及其使用方法
公开(公告)号：WO2006099410A3
公开(公告)日：2006-11-23
申请号：PCT/US2006009112
申请日：2006-03-14
申请人： RENOVIS INC , KELLY MICHAEL G , KINCAID JOHN , JANAGANI SATYANARAYANA , DUNCTON MATTHEW ALEXANDER JAME
发明人： KELLY MICHAEL G , KINCAID JOHN , JANAGANI SATYANARAYANA , DUNCTON MATTHEW ALEXANDER JAME
IPC分类号： C07C239/00 , A61K31/44 , A61K31/505 , C07C237/00 , C07D213/02
CPC分类号： C07C233/65 , A61K31/165 , A61K31/428 , A61K31/4412 , A61K31/4706 , C07C233/75 , C07C2601/02 , C07C2602/10 , C07D213/75 , C07D215/38 , C07D277/62 , C07D319/18
摘要： Compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.
摘要翻译：公开了具有下列化学式的化合物：化合物可以制备成药物组合物，并且可以用于预防和治疗哺乳动物包括人的多种病症，包括作为非限制性实例的疼痛，炎症，创伤性损伤等。

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