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1. 发明申请

WO2013040087A2 PLATFORM FOR ENGINEERED IMPLANTABLE TISSUES AND ORGANS AND METHODS OF MAKING THE SAME 审中-公开
标题翻译：用于工程化植入式组织和器官的平台及其制造方法
公开(公告)号：WO2013040087A2
公开(公告)日：2013-03-21
申请号：PCT/US2012/054935
申请日：2012-09-12
申请人： ORGANOVO, INC. , MURPHY, Keith , KHATIWALA, Chirag , DORFMAN, Scott , SHEPHERD, Benjamin , PRESNELL, Sharon
发明人： MURPHY, Keith , KHATIWALA, Chirag , DORFMAN, Scott , SHEPHERD, Benjamin , PRESNELL, Sharon
IPC分类号： A61F2/02 , A61F2/08 , A61L27/54
CPC分类号： A61L27/3826 , A61L27/3891 , A61L2430/22 , B33Y10/00
摘要： Disclosed are engineered tissues and organs comprising one or more layers of muscle, the engineered tissue or organ consisting essentially of cellular material, provided that the engineered tissue or organ is implantable in a vertebrate subject and not a vascular tube.
摘要翻译：公开了包含一层或多层肌肉的工程化组织和器官，工程化组织或器官基本上由细胞材料组成，条件是工程化组织或器官可植入脊椎动物受试者而不是血管管。

2. 发明申请

WO2013040078A2 ENGINEERED TISSUES FOR IN VITRO RESEARCH USES, ARRAYS THEREOF, AND METHODS OF MAKING THE SAME 审中-公开
标题翻译：用于体外研究用途的工程组合，其阵列及其制备方法
公开(公告)号：WO2013040078A2
公开(公告)日：2013-03-21
申请号：PCT/US2012/054923
申请日：2012-09-12
申请人： ORGANOVO, INC. , MURPHY, Keith , KHATIWALA, Chirag , DORFMAN, Scott , SHEPHERD, Benjamin , PRESNELL, Sharon , ROBBINS, Justin
发明人： MURPHY, Keith , KHATIWALA, Chirag , DORFMAN, Scott , SHEPHERD, Benjamin , PRESNELL, Sharon , ROBBINS, Justin
IPC分类号： C12N5/07 , G01N33/50 , G01N33/15 , A61L27/54
CPC分类号： G01N33/5088 , A61L27/34 , A61L27/38 , A61L27/3891 , A61L27/50 , C12N5/0691 , C12N5/0697 , C12N2502/27 , C12N2502/28 , C12N2513/00 , G01N33/5082
摘要： Disclosed are living, three-dimensional tissue constructs for in vitro scientific and medical research, arrays thereof, and methods of making said tissues and arrays.
摘要翻译：公开了用于体外科学和医学研究的活体三维组织结构，其阵列，以及制备所述组织和阵列的方法。

3. 发明申请

WO2012054195A3 DEVICES, SYSTEMS, AND METHODS FOR THE FABRICATION OF TISSUE 审中-公开
标题翻译：用于组织制造的装置，系统和方法
公开(公告)号：WO2012054195A3
公开(公告)日：2012-06-21
申请号：PCT/US2011053515
申请日：2011-09-27
申请人： ORGANOVO INC , MURPHY KEITH , DORFMAN SCOTT , SMITH NATHAN , BAUWENS LARRY , SOHN IAN , MCDONALD TIM , LEIGH-LANCASTER CHRIS , LAW RICHARD JIN
发明人： MURPHY KEITH , DORFMAN SCOTT , SMITH NATHAN , BAUWENS LARRY , SOHN IAN , MCDONALD TIM , LEIGH-LANCASTER CHRIS , LAW RICHARD JIN
IPC分类号： B41J2/01 , B41J2/175 , G01N35/00
CPC分类号： A61L27/3808 , A61L27/3826 , B01L3/0268 , B28B1/001 , B29C64/106 , B29C64/112 , B29C64/118 , B29C64/20 , B33Y30/00 , B33Y50/02 , B33Y70/00 , B41J3/407 , C12M21/08 , C12M33/00
摘要： Described herein are bioprinters comprising: one or more printer heads, wherein a printer head comprises a means for receiving and holding at least one cartridge, and wherein said cartridge comprises contents selected from one or more of: bio-ink and support material; a means for calibrating the position of at least one cartridge; and a means for dispensing the contents of at least one cartridge. Further described herein are methods for fabricating a tissue construct, comprising: a computer module receiving input of a visual representation of a desired tissue construct; a computer module generating a series of commands, wherein the commands are based on the visual representation and are readable by a bioprinter; a computer module providing the series of commands to a bioprinter; and the bioprinter depositing bio-ink and support material according to the commands to form a construct with a defined geometry.
摘要翻译：本文描述的是生物打印机，其包括：一个或多个打印机头，其中打印机头包括用于接收和保持至少一个筒的装置，并且其中所述筒包括选自以下一种或多种的内容物：生物墨水和支撑材料; 用于校准至少一个盒的位置的装置; 以及用于分配至少一个筒的内容物的装置。本文进一步描述了用于制造组织构建体的方法，包括：接收期望组织构建体的视觉表示的输入的计算机模块; 产生一系列命令的计算机模块，其中所述命令基于所述可视表示并且可由生物打印机读取; 向生物打印机提供一系列命令的计算机模块; 并且生物打印机根据命令沉积生物墨水和支持材料以形成具有限定几何形状的构造。

4. 发明申请

WO2013040087A3 PLATFORM FOR ENGINEERED IMPLANTABLE TISSUES AND ORGANS AND METHODS OF MAKING THE SAME 审中-公开
标题翻译：工程可植入组织和机构的平台及其制造方法
公开(公告)号：WO2013040087A3
公开(公告)日：2013-05-10
申请号：PCT/US2012054935
申请日：2012-09-12
申请人： ORGANOVO INC , MURPHY KEITH , KHATIWALA CHIRAG , DORFMAN SCOTT , SHEPHERD BENJAMIN , PRESNELL SHARON
发明人： MURPHY KEITH , KHATIWALA CHIRAG , DORFMAN SCOTT , SHEPHERD BENJAMIN , PRESNELL SHARON
IPC分类号： A61F2/02 , A61F2/08 , A61L27/54
CPC分类号： A61L27/3826 , A61L27/3891 , A61L2430/22 , B33Y10/00
摘要： Disclosed are engineered tissues and organs comprising one or more layers of muscle, the engineered tissue or organ consisting essentially of cellular material, provided that the engineered tissue or organ is implantable in a vertebrate subject and not a vascular tube.
摘要翻译：公开的工程组织和器官包括一层或多层肌肉，工程组织或器官基本上由细胞材料组成，条件是工程组织或器官可植入脊椎动物受试者而不是血管内。

5. 发明申请

WO2012054195A2 DEVICES, SYSTEMS, AND METHODS FOR THE FABRICATION OF TISSUE 审中-公开
标题翻译：用于制造组织的装置，系统和方法
公开(公告)号：WO2012054195A2
公开(公告)日：2012-04-26
申请号：PCT/US2011/053515
申请日：2011-09-27
申请人： ORGANOVO, INC. , MURPHY, Keith , DORFMAN, Scott , SMITH, Nathan , BAUWENS, Larry , SOHN, Ian , MCDONALD, Tim , LEIGH-LANCASTER, Chris , LAW, Richard, Jin
发明人： MURPHY, Keith , DORFMAN, Scott , SMITH, Nathan , BAUWENS, Larry , SOHN, Ian , MCDONALD, Tim , LEIGH-LANCASTER, Chris , LAW, Richard, Jin
IPC分类号： B41J2/01 , B41J2/175 , G01N35/00
CPC分类号： A61L27/3808 , A61L27/3826 , B01L3/0268 , B28B1/001 , B29C64/106 , B29C64/112 , B29C64/118 , B29C64/20 , B33Y30/00 , B33Y50/02 , B33Y70/00 , B41J3/407 , C12M21/08 , C12M33/00
摘要： Described herein are bioprinters comprising: one or more printer heads, wherein a printer head comprises a means for receiving and holding at least one cartridge, and wherein said cartridge comprises contents selected from one or more of: bio-ink and support material; a means for calibrating the position of at least one cartridge; and a means for dispensing the contents of at least one cartridge. Further described herein are methods for fabricating a tissue construct, comprising: a computer module receiving input of a visual representation of a desired tissue construct; a computer module generating a series of commands, wherein the commands are based on the visual representation and are readable by a bioprinter; a computer module providing the series of commands to a bioprinter; and the bioprinter depositing bio-ink and support material according to the commands to form a construct with a defined geometry.
摘要翻译：本文描述的生物打印机包括：一个或多个打印头，其中打印头包括用于接收和保持至少一个盒的装置，并且其中所述盒包括从以下中的一个或多个选择的内容：生物油墨和支撑材料; 用于校准至少一个盒的位置的装置; 以及用于分配至少一个盒的内容物的装置。本文进一步描述的是用于制造组织结构的方法，包括：计算机模块，其接收所需组织结构的视觉表示的输入; 生成一系列命令的计算机模块，其中所述命令基于所述视觉表示，并且可由生物打印机读取; 为生物打印机提供一系列命令的计算机模块; 并且生物印刷机根据命令沉积生物油墨和支撑材料以形成具有确定的几何形状的构造。

6. 发明申请

WO2010111169A1 SYSTEMS AND METHODS FOR CHALLENGE-RESPONSE ANIMATION AND RANDOMIZATION TESTING 审中-公开
标题翻译：用于挑战响应动画和随机测试的系统和方法
公开(公告)号：WO2010111169A1
公开(公告)日：2010-09-30
申请号：PCT/US2010/028116
申请日：2010-03-22
申请人： AOL, INC. , DORFMAN, Scott
发明人： DORFMAN, Scott
IPC分类号： G06F21/20
CPC分类号： G06F21/31 , G06F21/36 , G06F2221/2113
摘要： Systems and methods are provided for challenge/response animation. In one implementation, a request for protected content may be received from a client, and the protected content may comprise data. A challenge phrase comprising a plurality of characters may be determined, and a computer processor may divide the challenge phrase into at least two character subsets selected from the characters comprising the challenge phrase. Each of the at least two character subsets may include less than all of the characters comprising the challenge phrase. The at least two character subsets may be sent to the client in response to the request; and an answer to the challenge phrase may be received from the client in response to the at least two character subsets. Access to the protected content may be limited based on whether the answer correctly solves the challenge phrase.
摘要翻译：系统和方法用于挑战/响应动画。在一个实现中，可以从客户端接收对受保护内容的请求，并且受保护内容可以包括数据。可以确定包括多个字符的挑战短语，并且计算机处理器可以将挑战短语划分为从包括挑战短语的字符中选择的至少两个字符子集。所述至少两个字符子集中的每一个可以包括小于包括所述挑战短语的所有字符。可以响应于该请求将至少两个字符子集发送给客户端; 并且可以响应于该至少两个字符子集从客户端接收到该挑战短语的答案。可以基于答案是否正确地解决挑战短语来限制对受保护内容的访问。

7. 发明申请

WO2013040078A3 ENGINEERED TISSUES FOR IN VITRO RESEARCH USES, ARRAYS THEREOF, AND METHODS OF MAKING THE SAME 审中-公开
标题翻译：用于体外研究用途的工程组织，其阵列以及制备该组合物的方法
公开(公告)号：WO2013040078A3
公开(公告)日：2013-05-10
申请号：PCT/US2012054923
申请日：2012-09-12
申请人： ORGANOVO INC , MURPHY KEITH , KHATIWALA CHIRAG , DORFMAN SCOTT , SHEPHERD BENJAMIN , PRESNELL SHARON , ROBBINS JUSTIN
发明人： MURPHY KEITH , KHATIWALA CHIRAG , DORFMAN SCOTT , SHEPHERD BENJAMIN , PRESNELL SHARON , ROBBINS JUSTIN
IPC分类号： C12N5/07 , A61L27/54 , G01N33/15 , G01N33/50
CPC分类号： G01N33/5088 , A61L27/34 , A61L27/38 , A61L27/3891 , A61L27/50 , C12N5/0691 , C12N5/0697 , C12N2502/27 , C12N2502/28 , C12N2513/00 , G01N33/5082
摘要： Disclosed are living, three-dimensional tissue constructs for in vitro scientific and medical research, arrays thereof, and methods of making said tissues and arrays.
摘要翻译：公开了用于体外科学和医学研究的活体三维组织构建体，其阵列以及制造所述组织和阵列的方法。

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